R Saccardi

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi request reprint Autologous haematopoietic stem-cell transplantation in multiple sclerosis
    Gianluigi Mancardi
    Department of Neuroscience, Ophthalmology, and Genetics, and Centre of Excellence for Biomedical Research, San Martino Hospital, University of Genoa, Genoa, Italy
    Lancet Neurol 7:626-36. 2008
  2. ncbi request reprint Autologous stem cell transplantation for systemic lupus erythematosus
    David Jayne
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Lupus 13:168-76. 2004
  3. doi request reprint Haematopoietic stem cell transplantation for autoimmune disorders
    Riccardo Saccardi
    Department of Haematology, Careggi Hospital, University of Florence, Florence, Italy
    Curr Opin Hematol 15:594-600. 2008
  4. ncbi request reprint Autologous stem cell transplantation for progressive multiple sclerosis: update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database
    R Saccardi
    BMT Unit Department of Hematology, Ospedale di Careggi, Florence, Italy
    Mult Scler 12:814-23. 2006
  5. doi request reprint Hematopoietic stem cell transplantation procedures
    R Saccardi
    BMT Unit, Department of Hematology, Ospedale Careggi, Firenze, Italy
    Autoimmunity 41:570-6. 2008
  6. ncbi request reprint Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life
    Riccardo Saccardi
    Bone Marrow Transplantation Unit, Careggi Hospital, University of Florence, Italy
    Blood 105:2601-7. 2005
  7. ncbi request reprint Consensus statement concerning cardiotoxicity occurring during haematopoietic stem cell transplantation in the treatment of autoimmune diseases, with special reference to systemic sclerosis and multiple sclerosis
    R Saccardi
    Haematology Unit, University of Florence, Italy
    Bone Marrow Transplant 34:877-81. 2004
  8. ncbi request reprint An open evaluation of triple antibiotic therapy including vancomycin for febrile bone marrow transplant recipients with severe neutropenia
    A Bosi
    Division of Hematology, University of Florence, Careggi Hospital, Italy
    J Chemother 11:287-92. 1999
  9. ncbi request reprint Randomized trial comparing netilmicin plus imipenem-cilastatin versus netilmicin plus ceftazidime as empiric therapy for febrile neutropenic bone marrow transplant recipients
    D Laszlo
    Bone Marrow Transplant Unit, University of Florence, Careggi Hospital, Florence, Italy
    J Chemother 9:95-101. 1997
  10. ncbi request reprint Detection of bcr/abl transcripts by RT-PCR and their colorimetric evaluation in chronic myeloid leukemia patients receiving allogeneic bone marrow transplantation
    V Santini
    Department of Hematology, University of Florence, Italy
    Haematologica 81:201-7. 1996

Detail Information

Publications29

  1. ncbi request reprint Autologous haematopoietic stem-cell transplantation in multiple sclerosis
    Gianluigi Mancardi
    Department of Neuroscience, Ophthalmology, and Genetics, and Centre of Excellence for Biomedical Research, San Martino Hospital, University of Genoa, Genoa, Italy
    Lancet Neurol 7:626-36. 2008
    ..Patients with severe, rapidly worsening multiple sclerosis who are unresponsive to approved therapies could be candidates for this treatment, but its clinical efficacy has still to be shown in large, prospective, controlled studies...
  2. ncbi request reprint Autologous stem cell transplantation for systemic lupus erythematosus
    David Jayne
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Lupus 13:168-76. 2004
    ..The safety of this procedure is likely to be improved by patient selection and choice of conditioning regimen. The return of disease activity in one-third of patients might be reduced by long-term immunosuppressive therapy post-ASCT...
  3. doi request reprint Haematopoietic stem cell transplantation for autoimmune disorders
    Riccardo Saccardi
    Department of Haematology, Careggi Hospital, University of Florence, Florence, Italy
    Curr Opin Hematol 15:594-600. 2008
    ..To summarize recent evidence and current trends in the use of haematopoietic stem cell transplantation (HSCT) for autoimmune diseases...
  4. ncbi request reprint Autologous stem cell transplantation for progressive multiple sclerosis: update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database
    R Saccardi
    BMT Unit Department of Hematology, Ospedale di Careggi, Florence, Italy
    Mult Scler 12:814-23. 2006
    ....
  5. doi request reprint Hematopoietic stem cell transplantation procedures
    R Saccardi
    BMT Unit, Department of Hematology, Ospedale Careggi, Firenze, Italy
    Autoimmunity 41:570-6. 2008
    ..The greatest possible reduction of transplant-related-mortality and of the autoimmune aggression are being actively pursued. Here, the main procedural modalities will be analyzed and discussed...
  6. ncbi request reprint Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life
    Riccardo Saccardi
    Bone Marrow Transplantation Unit, Careggi Hospital, University of Florence, Italy
    Blood 105:2601-7. 2005
    ..HSCT is able to induce a prolonged clinical stabilization in severe progressive MS patients, resulting in both sustained treatment-free periods and quality of life improvement...
  7. ncbi request reprint Consensus statement concerning cardiotoxicity occurring during haematopoietic stem cell transplantation in the treatment of autoimmune diseases, with special reference to systemic sclerosis and multiple sclerosis
    R Saccardi
    Haematology Unit, University of Florence, Italy
    Bone Marrow Transplant 34:877-81. 2004
    ..A full cardiological assessment before and during the transplant emerged as the major recommendation...
  8. ncbi request reprint An open evaluation of triple antibiotic therapy including vancomycin for febrile bone marrow transplant recipients with severe neutropenia
    A Bosi
    Division of Hematology, University of Florence, Careggi Hospital, Italy
    J Chemother 11:287-92. 1999
    ..Death due to sepsis nor toxicity were observed. This triple antibiotic combination appears to be a very effective regimen for the empiric treatment of febrile episodes in severely neutropenic BMT recipients...
  9. ncbi request reprint Randomized trial comparing netilmicin plus imipenem-cilastatin versus netilmicin plus ceftazidime as empiric therapy for febrile neutropenic bone marrow transplant recipients
    D Laszlo
    Bone Marrow Transplant Unit, University of Florence, Careggi Hospital, Florence, Italy
    J Chemother 9:95-101. 1997
    ..In conclusion, both Net + Imi and Net + Cef are active and safe as empirical treatment of febrile episodes in neutropenic BMT pts...
  10. ncbi request reprint Detection of bcr/abl transcripts by RT-PCR and their colorimetric evaluation in chronic myeloid leukemia patients receiving allogeneic bone marrow transplantation
    V Santini
    Department of Hematology, University of Florence, Italy
    Haematologica 81:201-7. 1996
    ..Although the reverse transcriptase polymerase chain reaction (RT-PCR) method is largely employed, the clinical value and impact of a positive RT-PCR as a herald of hematological relapse has not yet been definitively ascertained...
  11. ncbi request reprint Ondansetron versus chlorpromazine for preventing emesis in bone marrow transplant recipients: a double-blind randomized study
    A Bosi
    Bone Marrow Transplant Unit, Careggi Hospital, Florence, Italy
    J Chemother 5:191-6. 1993
    ..002), the absence of extrapyramidal reactions (p < 0.001) and no need for dose reduction (p < 0.001) as compared with patients treated with chlorpromazine...
  12. doi request reprint Androgens and estrogens prevent rosiglitazone-induced adipogenesis in human mesenchymal stem cells
    S Benvenuti
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders, University of Florence, Viale Pieraccini 6, Florence, Italy
    J Endocrinol Invest 35:365-71. 2012
    ..Our data, yet preliminary, suggest the possibility to try to prevent the negative effects of TZD on bone, using steroid receptor modulators, such as plant-derived phytoestrogens, which lack evident adverse effects...
  13. ncbi request reprint Induction of differentiation of HL-60 cells along the monocytic pathway by 5-methyltetrahydrofolate
    P A Bernabei
    U O di Ematologia, U S L 10 D, Firenze, Italy
    J Chemother 1:359-64. 1989
    ....
  14. doi request reprint Autologous stem cell transplantation improves microcirculation in systemic sclerosis
    I Miniati
    Department of Biomedicine, Section of Rheumatology, Denothe Center, AOUC Florence, Viale Pieraccini 18, 50139 Florence, Italy
    Ann Rheum Dis 68:94-8. 2009
    ..We aimed to evaluate the improvement of microvasculature after HSCT using NVC...
  15. doi request reprint Treatment of experimental esophagogastric myotomy with bone marrow mesenchymal stem cells in a rat model
    B Mazzanti
    Haematology Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
    Neurogastroenterol Motil 25:e669-79. 2013
    ..In this study, we have developed an animal model of esophagogastric myotomy (MY) aimed at determining the role of autologous MSC in the regeneration of the lower esophageal sphincter (LES) after surgery...
  16. pmc A prospective, randomized, controlled trial of autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: a position paper
    R Saccardi
    Hematology Department, Careggi University Hospital, Florence, Italy
    Mult Scler 18:825-34. 2012
    ....
  17. ncbi request reprint Aztreonam versus colistin-neomycin for selective decontamination of the digestive tract in patients undergoing bone marrow transplantation: a randomized study
    A Bosi
    Department of Hematology, University of Florence, Italy
    J Chemother 4:30-4. 1992
    ..No significant differences were observed suggesting that Az is at least as effective as the CN regimen and may be considered as an alternative approach for intestinal decontamination in BMT patients...
  18. ncbi request reprint Autologous hematopoietic stem cell transplantation for very active relapsing-remitting multiple sclerosis: report of two cases
    E Portaccio
    Department of Neurology, University of Florence, and Bone Marrow Transplantation Unit, Careggi Hospital, Florence, Italy
    Mult Scler 13:676-8. 2007
    ..In this paper, we report two cases with very active, relapsing-remitting (RR) MS, who underwent AHSCT, and obtained a dramatic resolution to disease activity...
  19. ncbi request reprint A comparison of two assays for the in vitro chemosensitivity testing of human acute non-lymphoblastic leukemia cells
    O Dal Pozzo
    U O di Ematologia, , Firenze, Italy
    J Chemother 1:318-23. 1989
    ..A good correlation was demonstrated between the results of the two different methodological approaches, validating the recently described INT sensitivity test...
  20. doi request reprint Thyroid hormones promote cell differentiation and up-regulate the expression of the seladin-1 gene in in vitro models of human neuronal precursors
    S Benvenuti
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Florence, Italy
    J Endocrinol 197:437-46. 2008
    ..In view of its anti-apoptotic activity, it might be hypothesized that one of the functions of the increased seladin-1 levels in the developing brain may be to protect neuronal precursor cells from death...
  21. pmc Haematopoietic stem cell transplantation for vasculitis including Behcet's disease and polychondritis: a retrospective analysis of patients recorded in the European Bone Marrow Transplantation and European League Against Rheumatism databases and a review
    Thomas Daikeler
    Department of Rheumatology, University of Basle, Petersgraben 4, CH 4031 Basle, Switzerland
    Ann Rheum Dis 66:202-7. 2007
    ..To evaluate the feasibility of haematopoietic stem cell transplantation (HSCT) in vasculitis...
  22. ncbi request reprint Induction of CD83+CD14+ nondendritic antigen-presenting cells by exposure of monocytes to IFN-alpha
    Gianni Gerlini
    Plastic Surgery Unit, Regional Melanoma Referral Center, Tuscan Tumor Institute ITT, Santa Maria Annunziata Hospital, Florence, Italy
    J Immunol 181:2999-3008. 2008
    ..The present findings suggest that IFN-alpha alone promptly generates nondendritic APCs able to stimulate memory immune responses. This may represent an additional mode of action of IFN-alpha in vivo...
  23. doi request reprint Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: implication for assessment of disease activity and treatment
    Benedetta Mazzanti
    Department of Neurological Sciences, University of Florence, Viale Pieraccini, 6, 50134 Florence, Italy
    J Neuroimmunol 199:142-50. 2008
    ....
  24. ncbi request reprint Cochlear repair by transplantation of human cord blood CD133+ cells to nod-scid mice made deaf with kanamycin and noise
    Roberto P Revoltella
    Foundation onlus Staminali e Vita, Institute of Biomedical Technologies, CNR, 56127 Pisa, Italy
    Cell Transplant 17:665-78. 2008
    ....
  25. ncbi request reprint Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Cancer Research Institute, Genoa, Italy
    J Immunol 175:6352-60. 2005
    ..It appears that HLA-I molecules do not protect BMSC from NK cell-mediated injury. Thus, NK cells, activated upon binding with BMSC, may regulate BMSC survival...
  26. ncbi request reprint High dose immunotherapy with stem cell rescue in severe systemic sclerosis: an idea that is moving forward
    Daniel E Furst
    J Rheumatol 31:2331-5. 2004
  27. doi request reprint Prolonged human/sheep cellular chimerism following transplantation of human hemopoietic stem cells into the ewe celomic cavity
    Monica Michelini
    Foundation ONLUS Stem Cells and Life, Pisa and Institute of Biomedical Technologies, CNR, Unit of Pisa, Pisa, Italy
    Int J Dev Biol 52:365-70. 2008
    ..Controls born from un-transplanted ewes never revealed any human DNA sequences nor HLADQ alpha 1 expression...
  28. ncbi request reprint Feasibility of allogeneic hematopoietic stem cell transplantation for autoimmune disease: position statement from a National Institute of Allergy and Infectious Diseases and National Cancer Institute-Sponsored International Workshop, Bethesda, MD, March 1
    Linda M Griffith
    Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Biol Blood Marrow Transplant 11:862-70. 2005
  29. ncbi request reprint Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1
    Susanna Benvenuti
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    Exp Cell Res 312:2592-604. 2006
    ..These original results demonstrate for the first time that seladin-1 is abundantly expressed by stem cells and appear to suggest that reduced expression in AD might be due to an altered pool of multipotent cells...