T Rubino

Summary

Affiliation: University of Insubria
Country: Italy

Publications

  1. ncbi Changes in the expression of G protein-coupled receptor kinases and beta-arrestins in mouse brain during cannabinoid tolerance: a role for RAS-ERK cascade
    Tiziana Rubino
    DBSF, Pharmacology Section, and Neuroscience Center, University of Insubria, Busto Arsizio VA, Italy
    Mol Neurobiol 33:199-213. 2006
  2. ncbi Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects
    Tiziana Rubino
    DBSF, Pharmacology Section, and Neuroscience Center, University of Insubria, Busto Arsizio, Italy
    J Neurochem 93:984-91. 2005
  3. ncbi Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood
    Tiziana Rubino
    DBSF and Neuroscience Center, University of Insubria, Busto Arsizio, VA, Italy
    Hippocampus 19:763-72. 2009
  4. ncbi The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex
    T Rubino
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052, Busto Arsizio, VA, Italy
    Neurotox Res 15:291-302. 2009
  5. ncbi Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats
    Tiziana Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, Varese, Italy
    Neuropsychopharmacology 32:2036-45. 2007
  6. ncbi CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour
    T Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Neuropharmacology 54:151-60. 2008
  7. ncbi Cellular mechanisms underlying the interaction between cannabinoid and opioid system
    D Parolaro
    Department of Structural and Functional Biology and Center of Neuroscience, University of Insubria, Busto Arsizio VA, Italy
    Curr Drug Targets 11:393-405. 2010
  8. ncbi Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems
    Daniela Vigano
    DBSF, Pharmacology Section and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052, Busto Arsizio, VA, Italy
    Psychopharmacology (Berl) 182:527-36. 2005
  9. ncbi Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats
    N Realini
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, VA, Italy
    Neuropharmacology 60:235-43. 2011
  10. ncbi Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine
    Daniela Vigano
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Eur J Neurosci 20:1849-57. 2004

Collaborators

Detail Information

Publications35

  1. ncbi Changes in the expression of G protein-coupled receptor kinases and beta-arrestins in mouse brain during cannabinoid tolerance: a role for RAS-ERK cascade
    Tiziana Rubino
    DBSF, Pharmacology Section, and Neuroscience Center, University of Insubria, Busto Arsizio VA, Italy
    Mol Neurobiol 33:199-213. 2006
    ....
  2. ncbi Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects
    Tiziana Rubino
    DBSF, Pharmacology Section, and Neuroscience Center, University of Insubria, Busto Arsizio, Italy
    J Neurochem 93:984-91. 2005
    ..These findings suggest that at least in the caudate putamen and cerebellum, the Ras/ERK pathway is essential for triggering the alteration in CB1 receptor function responsible for tolerance to THC-induced hypomotility...
  3. ncbi Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood
    Tiziana Rubino
    DBSF and Neuroscience Center, University of Insubria, Busto Arsizio, VA, Italy
    Hippocampus 19:763-72. 2009
    ....
  4. ncbi The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex
    T Rubino
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052, Busto Arsizio, VA, Italy
    Neurotox Res 15:291-302. 2009
    ..This picture demonstrates the presence of cognitive impairment in THC-induced depressive phenotype...
  5. ncbi Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats
    Tiziana Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, Varese, Italy
    Neuropsychopharmacology 32:2036-45. 2007
    ....
  6. ncbi CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour
    T Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Neuropharmacology 54:151-60. 2008
    ..The molecular underpinnings of these effects involve a direct stimulation of CB1 receptors ending in pCREB modulation and/or a possible alteration in the fine tuning of local neuromodulator release...
  7. ncbi Cellular mechanisms underlying the interaction between cannabinoid and opioid system
    D Parolaro
    Department of Structural and Functional Biology and Center of Neuroscience, University of Insubria, Busto Arsizio VA, Italy
    Curr Drug Targets 11:393-405. 2010
    ..Further insights about the cannabinoid/opioid interaction could pave the way for new and promising therapeutic approaches...
  8. ncbi Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems
    Daniela Vigano
    DBSF, Pharmacology Section and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052, Busto Arsizio, VA, Italy
    Psychopharmacology (Berl) 182:527-36. 2005
    ..This might open up new therapeutic opportunities for relief of chronic pain through cannabinoid-opioid coadministration...
  9. ncbi Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats
    N Realini
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, VA, Italy
    Neuropharmacology 60:235-43. 2011
    ..These results support a role for the endocannabinoid system in the neurobiology of depression and suggest the use of URB597 as a new therapeutic tool with antidepressant properties...
  10. ncbi Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine
    Daniela Vigano
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Eur J Neurosci 20:1849-57. 2004
    ....
  11. ncbi Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats
    E Zamberletti
    Department of Structural and Functional Biology and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, Varese, Italy
    Neuroscience 204:245-57. 2012
    ..Alterations in NMDA, D1 and D2 receptors might be involved in the behavioral responses induced by maternal deprivation and in their modulation by THC...
  12. ncbi Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex
    T Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Cereb Cortex 18:1292-301. 2008
    ....
  13. ncbi The psychoactive ingredient of marijuana induces behavioural sensitization
    T Rubino
    Department of Structural and Functional Biology, University of Insubria, Via Dunant 3, 21100 Varese, Italy
    Eur J Neurosci 14:884-6. 2001
    ....
  14. ncbi Cellular mechanisms of Delta 9-tetrahydrocannabinol behavioural sensitization
    T Rubino
    DBSF, Pharmacology Unit, University of Insubria, via A. da Giussano 10, 21052 Busto Arsizio (VA) Italy
    Eur J Neurosci 17:325-30. 2003
    ..The intracellular picture in sensitized rats suggests that besides the cAMP cascade, other signalling pathways may participate in the development of cannabinoid sensitization...
  15. ncbi Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment
    Tiziana Rubino
    DBSF, Pharmacology Unit and Center of Neuroscience, University of Insubria, 21052 Busto Arsizio (VA, Italy
    Mol Cell Neurosci 25:355-62. 2004
    ..In fact, Ras-GRF1 ko mice did not develop tolerance to THC analgesic and hypolocomotor effect. Our data suggest that ERK cascade could play a pivotal role in the induction of synaptic plasticity due to cannabinoid chronic exposure...
  16. ncbi Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids
    N Realini
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, VA, Italy
    Pharmacol Res 60:132-8. 2009
    ..There is an urgent need of multidisciplinary approaches combining behaviour with neurochemical and genetic studies to build a scientific based opinion on the long-lasting consequences of cannabis use in adolescence...
  17. ncbi Endocannabinoids in the immune system and cancer
    Daniela Parolaro
    Department of Structural and Functional Biology, Pharmacology Unit, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:319-32. 2002
    ..The experimental evidence reviewed in this article argues in favor of the therapeutic potential of these compounds in immune disorders and cancer...
  18. ncbi Endocannabinoids and drug dependence
    Daniela Parolaro
    DBSF, and Center of Neurosciences, Univ of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Curr Drug Targets CNS Neurol Disord 4:643-55. 2005
    ..This review will discuss the latest advances on the mechanisms of cannabinoid dependence and the possible role of the endocannabinoid system in the treatment of addiction, not only to marijuana but also to the other common illicit drugs...
  19. ncbi Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain
    Daniela Vigano
    DBSF, Pharmacology Unit, University of Insubria, Busto Arsizio VA, Italy
    Neuropsychopharmacology 28:1160-7. 2003
    ....
  20. ncbi Is cannabinoid transmission involved in rewarding properties of drugs of abuse?
    Daniela Parolaro
    DBSF, Pharmacology Unit, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, VA, Italy
    Br J Pharmacol 136:1083-4. 2002
  21. ncbi The endocannabinoid system and psychiatric disorders
    Daniela Parolaro
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Exp Neurol 224:3-14. 2010
    ..Besides all these limitations, SR141716A and cannabidiol show the most constant antipsychotic properties in dopamine- and glutamate-based models of schizophrenia, with profiles similar to an atypical antipsychotic drug...
  22. ncbi Chronic blockade of CB(1) receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation
    E Zamberletti
    Department of Theoretical and Applied Sciences, Biomedical Division and Center of Neuroscience, University of Insubria, Busto Arsizio VA, Italy Zardi Gori Foundation, Milan, Italy Endocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, Pozzuoli NA, Italy B B Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy
    Br J Pharmacol 167:1652-64. 2012
    ..LINKED ARTICLES This article is part of a themed section on Cannabinoids. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.167.issue-8...
  23. ncbi Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates
    Tiziana Rubino
    DBSF, Pharmacology Section, and Neuroscience Center, University of Insubria, Varese, Italy
    Neuropsychopharmacology 33:2760-71. 2008
    ....
  24. ncbi Molecular and cellular basis of cannabinoid and opioid interactions
    Daniela Vigano
    DBSF, Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Pharmacol Biochem Behav 81:360-8. 2005
    ..Further studies are needed since a better knowledge of the opioid-cannabinoid interaction may lead to exciting therapeutic possibilities...
  25. ncbi The role of the endogenous cannabinoid system in drug addiction
    D Parolaro
    DBSF and Neuroscience Center, University of Insubria, Busto Arsizio, Italy
    Drug News Perspect 21:149-57. 2008
    ....
  26. ncbi Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia
    Daniela Vigano
    DBSF and Neuroscience Center, University of Insubria, Busto Arsizio VA, Italy
    Int J Neuropsychopharmacol 12:599-614. 2009
    ....
  27. ncbi Long lasting consequences of cannabis exposure in adolescence
    T Rubino
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, Busto Arsizio VA, Italy
    Mol Cell Endocrinol 286:S108-13. 2008
    ..Therefore, the potential problems arising in relation to marijuana consumption in adolescence suggest that this developmental phase is a vulnerable period for persistent adverse effects of cannabinoids...
  28. ncbi Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
    Angelo Vaccani
    Department of Structural and Functional Biology, Pharmacology Section, Center of Neurosciences, University of Insubria, via A. da Giussano 10, Busto Arsizio (VA) 21052, Italy
    Br J Pharmacol 144:1032-6. 2005
    ..These results reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified...
  29. ncbi Comparative analysis of molecular strategies attenuating positional effects in lentiviral vectors carrying multiple genes
    Daniela Osti
    Department of Structural and Functional Biology, University of Insubria, Busto Arsizio 21052, Italy
    J Virol Methods 136:93-101. 2006
    ..These results indicate that chromatin insulator sequences can be useful molecular tools to overcome positional effects in the context of lentiviral vectors...
  30. ncbi Cannabinoids and opioids share cAMP pathway in rat splenocytes
    Paola Massi
    Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    J Neuroimmunol 145:46-54. 2003
    ..Thus, these results strengthen the hypothesis of cAMP as part of the common intracellular pathway shared by opiates and cannabinoids at immune cell level...
  31. ncbi ERK-dependent modulation of cerebellar synaptic plasticity after chronic Delta9-tetrahydrocannabinol exposure
    Raffaella Tonini
    Department of Cellular and Developmental Biology, University La Sapienza, 00185 Rome, Italy
    J Neurosci 26:5810-8. 2006
    ..This contributes to generation of forms of pathological synaptic plasticity that might play a role in cannabinoid dependence...
  32. ncbi Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward
    Daniela Braida
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy
    Biol Psychiatry 63:286-92. 2008
    ..The abuse of selective k-agonists is a novel phenomenon, the mechanism of which is not fully understood...
  33. ncbi A molecular basis of analgesic tolerance to cannabinoids
    Anke Tappe Theodor
    Pharmacology Institute, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 27:4165-77. 2007
    ..These results suggest that GASP1 is a key regulator of the fate of CB1 after agonist exposure in the nervous system and critically determines analgesic tolerance to cannabinoids...
  34. ncbi Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    Nitin Agarwal
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld, Heidelberg, 69120 Germany
    Nat Neurosci 10:870-9. 2007
    ....
  35. ncbi Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2
    Liana Fattore
    Institute of Neuroscience, National Research Council CNR, Section of Cagliari, Italy
    Eur J Neurosci 25:2191-200. 2007
    ....