F Roviello

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. doi request reprint Influence of age on soluble E-cadherin serum levels prevents its utility as a disease marker in gastric cancer patients
    Corrado Pedrazzani
    Scand J Gastroenterol 43:765-6. 2008
  2. pmc Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature
    Giovanni Corso
    Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Viale Bracci, 53100 Siena, Italy
    BMC Cancer 12:8. 2012
  3. pmc The CHOLEGAS study: multicentric randomized, blinded, controlled trial of gastrectomy plus prophylactic cholecystectomy versus gastrectomy only, in adults submitted to gastric cancer surgery with curative intent
    Marco Farsi
    General and Oncologic Surgery, Careggi Hospital, Florence, Italy
    Trials 10:32. 2009
  4. pmc Primary non-Hodgkin's breast lymphoma: Surgical approach
    Alessandro Neri
    Department of Human Pathology and Oncology Section of General Surgery and Surgical Oncology, Division of Hematology, University of Siena, viale Bracci Policlinico Le Scotte 53100, Siena, Italy
    Cases J 1:311. 2008
  5. doi request reprint Treatment of peritoneal carcinomatosis with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: state of the art and future developments
    Franco Roviello
    Department of Human Pathology and Oncology, University of Siena, Italy
    Surg Oncol 20:e38-54. 2011
  6. ncbi request reprint Number of lymph node metastases and its prognostic significance in early gastric cancer: a multicenter Italian study
    Franco Roviello
    Dipartimento di Chirurgia Generale ed Oncologica, Universita di Siena, Siena, Italia
    J Surg Oncol 94:275-80; discussion 274. 2006
  7. ncbi request reprint Iron deficiency anemia after subtotal gastrectomy for gastric cancer
    Franco Roviello
    Department of Human Pathology and Oncology, Section of Surgical Oncology, University of Siena, Siena, Italy
    Hepatogastroenterology 51:1510-4. 2004
  8. ncbi request reprint Survival benefit of extended D2 lymphadenectomy in gastric cancer with involvement of second level lymph nodes: a longitudinal multicenter study
    Franco Roviello
    Unit of Surgical Oncology, University of Siena, Italy
    Ann Surg Oncol 9:894-900. 2002
  9. ncbi request reprint Treatment of peritoneal carcinomatosis by cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion (IHCP): postoperative outcome and risk factors for morbidity
    Franco Roviello
    Department of Human Pathology and Oncology, Advanced Surgical Oncology Unit, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    World J Surg 30:2033-40; discussion 2041-2. 2006
  10. ncbi request reprint P53 accumulation is a prognostic factor in intestinal-type gastric carcinoma but not in the diffuse type
    F Roviello
    Istituto di Scienze Chirurgiche, University of Siena, Italy
    Ann Surg Oncol 6:739-45. 1999

Collaborators

Detail Information

Publications87

  1. doi request reprint Influence of age on soluble E-cadherin serum levels prevents its utility as a disease marker in gastric cancer patients
    Corrado Pedrazzani
    Scand J Gastroenterol 43:765-6. 2008
  2. pmc Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature
    Giovanni Corso
    Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Viale Bracci, 53100 Siena, Italy
    BMC Cancer 12:8. 2012
    ..The goal of this study was to assess the worldwide frequency of CDH1 germline mutations in gastric cancers coming from low- and high-risk areas...
  3. pmc The CHOLEGAS study: multicentric randomized, blinded, controlled trial of gastrectomy plus prophylactic cholecystectomy versus gastrectomy only, in adults submitted to gastric cancer surgery with curative intent
    Marco Farsi
    General and Oncologic Surgery, Careggi Hospital, Florence, Italy
    Trials 10:32. 2009
    ..At the present, no randomized study has been published and the decision of gallbladder management is left to each surgeon preference...
  4. pmc Primary non-Hodgkin's breast lymphoma: Surgical approach
    Alessandro Neri
    Department of Human Pathology and Oncology Section of General Surgery and Surgical Oncology, Division of Hematology, University of Siena, viale Bracci Policlinico Le Scotte 53100, Siena, Italy
    Cases J 1:311. 2008
    ..Our experience stresses the importance of a radical surgical approach in a locally advanced non-Hodgkin's lymphoma of the breast unresponsive to radio and chemotherapy...
  5. doi request reprint Treatment of peritoneal carcinomatosis with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: state of the art and future developments
    Franco Roviello
    Department of Human Pathology and Oncology, University of Siena, Italy
    Surg Oncol 20:e38-54. 2011
    ..To offer a comprehensive review, we summarized the present status and possible future progress of this treatment modality, in particular outlining its rationale, current practice and general outcome...
  6. ncbi request reprint Number of lymph node metastases and its prognostic significance in early gastric cancer: a multicenter Italian study
    Franco Roviello
    Dipartimento di Chirurgia Generale ed Oncologica, Universita di Siena, Siena, Italia
    J Surg Oncol 94:275-80; discussion 274. 2006
    ..This study was aimed at evaluating the prognostic significance of the number of metastatic nodes in early gastric cancer (EGC)...
  7. ncbi request reprint Iron deficiency anemia after subtotal gastrectomy for gastric cancer
    Franco Roviello
    Department of Human Pathology and Oncology, Section of Surgical Oncology, University of Siena, Siena, Italy
    Hepatogastroenterology 51:1510-4. 2004
    ..The aim of the present study was to evaluate the role of different factors, such as sex, age, atrophic chronic gastritis, Helicobacter pylori infection and iron malabsorption, in iron deficiency after surgery for gastric cancer...
  8. ncbi request reprint Survival benefit of extended D2 lymphadenectomy in gastric cancer with involvement of second level lymph nodes: a longitudinal multicenter study
    Franco Roviello
    Unit of Surgical Oncology, University of Siena, Italy
    Ann Surg Oncol 9:894-900. 2002
    ..Results were compared with those in patients with involvement of first level lymph nodes...
  9. ncbi request reprint Treatment of peritoneal carcinomatosis by cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion (IHCP): postoperative outcome and risk factors for morbidity
    Franco Roviello
    Department of Human Pathology and Oncology, Advanced Surgical Oncology Unit, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    World J Surg 30:2033-40; discussion 2041-2. 2006
    ..Cytoreductive surgery with limited or extended peritonectomy associated with intraperitoneal hyperthermic chemoperfusion (IHCP) has been proposed for treatment of peritoneal carcinomatosis (PC) from abdominal neoplasms...
  10. ncbi request reprint P53 accumulation is a prognostic factor in intestinal-type gastric carcinoma but not in the diffuse type
    F Roviello
    Istituto di Scienze Chirurgiche, University of Siena, Italy
    Ann Surg Oncol 6:739-45. 1999
    ..In this study, we evaluated the correlation between p53 accumulation and long-term survival of patients resected for intestinal and diffuse-type gastric cancer...
  11. doi request reprint High incidence of familial gastric cancer in Tuscany, a region in Italy
    Franco Roviello
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Oncology 72:243-7. 2007
    ..We studied a large cohort of gastric cancer patients from Tuscany, a region in Italy, to evaluate the presence of familial clustering of gastric cancer...
  12. doi request reprint Prognostic relevance of proliferative activity evaluated by Mib-1 immunostaining in node negative breast cancer
    A Neri
    Department of Human Pathology and Oncology, Section of Surgical Oncology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    Eur J Surg Oncol 34:1299-303. 2008
    ..Correlations between Mib-1 expression and clinico-pathological characteristics as well as its prognostic value have been studied in a series of 432 node negative breast cancers...
  13. doi request reprint Changing clinical and pathological features of gastric cancer over time
    D Marrelli
    Department of Human Pathology and Oncology, Section of Surgical Oncology, University of Siena, Siena, Italy
    Br J Surg 98:1273-83. 2011
    ..The aim of the present multicentre observational study was to evaluate potential changes in clinical and pathological features of patients with gastric cancer (GC) treated in a 15-year interval...
  14. doi request reprint Super-extended (D3) lymphadenectomy in advanced gastric cancer
    F Roviello
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, ITT, Istituto Toscano Tumouri, Italy
    Eur J Surg Oncol 36:439-46. 2010
    ..To analyze our experience with D3 lymphadenectomy in the treatment of advanced GC with specific reference to post-operative morbidity and mortality, incidence of para-aortic node (PAN) metastases, and long-term prognosis...
  15. ncbi request reprint Preoperative positivity of serum tumor markers is a strong predictor of hematogenous recurrence of gastric cancer
    D Marrelli
    U.O. Chirurgia Oncologica, Istituto di Scienze Chirurgiche, University of Siena, Italy
    J Surg Oncol 78:253-8. 2001
    ....
  16. ncbi request reprint Factors influencing outcome in gastric cancer involving muscularis and subserosal layer
    G Fotia
    Department of General Surgery and Surgical Oncology, University of Siena, Siena, Italy
    Eur J Surg Oncol 30:930-4. 2004
    ..In terms of prognosis, pT2 AGC is considered intermediate between early gastric cancer (EGC) and gastric carcinoma with serosal invasion...
  17. ncbi request reprint Clinical utility of CEA, CA 19-9, and CA 72-4 in the follow-up of patients with resectable gastric cancer
    D Marrelli
    Istituto di Scienze Chirurgiche, U.O. Chirurgia Oncologica, University of Siena, 53100, Siena, Italy
    Am J Surg 181:16-9. 2001
    ..CONCLUSIONS: The combined assay of CEA, CA 19-9, and CA 72-4 may be useful for early diagnosis of recurrence of gastric cancer; however, only CA 72-4 positivity should be considered a specific predictor of tumor recurrence...
  18. ncbi request reprint Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family
    F Roviello
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Viale Bracci 2, 53100 Siena, Italy
    Eur J Surg Oncol 33:448-51. 2007
    ..Fourteen pedigrees with Diffuse Gastric Cancer that fulfilled the International Gastric Cancer Linkage Consortium (IGCLC) criteria were selected and screened for CDH1 germline mutations...
  19. doi request reprint Familial gastric cancer and Li-Fraumeni syndrome
    G Corso
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, Translational Research Laboratory, University of Siena Istituto Toscano Tumori, Siena, Italy
    Eur J Cancer Care (Engl) 19:377-81. 2010
    ....
  20. ncbi request reprint A case of small-cell gastric carcinoma with an adenocarcinoma component and hepatic metastases: treatment with systemic and intra-hepatic chemotherapy
    T Cioppa
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Siena, Italy
    Eur J Cancer Care (Engl) 16:453-7. 2007
    ....
  21. ncbi request reprint Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management
    G Corso
    Department of Human Pathology and Oncology, Division of Surgical Oncology, University of Siena, Siena, Italy
    Eur J Surg Oncol 33:1061-7. 2007
    ..A new germline missense mutation (P373L) was recently identified in a HDGC Italian family. The present work aimed at addressing the disease-causative nature of the P373L mutant...
  22. doi request reprint Treatment and prevention of peritoneal carcinomatosis from gastric cancer by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: overview and rationale
    F Roviello
    Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, University of Siena, Viale Bracci Policlinico Le Scotte, 53100 Siena, Italy
    Eur J Surg Oncol 39:1309-16. 2013
    ..To offer a baseline guide, we summarized the actual status and general outcome obtained by this multimodal technique, in association or not with CRS as treatment of advanced GC. ..
  23. ncbi request reprint Breast cancer local recurrence: risk factors and prognostic relevance of early time to recurrence
    A Neri
    Dipartimento di Patologia Generale ed Umana, Sezione di Chirurgia Oncologica, Universita degli Studi di Siena, Viale Bracci 1, 53100 Siena, Italy
    World J Surg 31:36-45. 2007
    ..The aim of the present study was to investigate breast cancer local recurrence, potential risk factors, and prognostic impact...
  24. doi request reprint Correlation of microsatellite instability at multiple loci with long-term survival in advanced gastric carcinoma
    Giovanni Corso
    Sezione di Chirurgia Oncologica, Dipartimento di Patologia Umana e Oncologia, Policlinico Le Scotte, University of Siena, 53100 Siena, Italy
    Arch Surg 144:722-7. 2009
    ..Microsatellite instability (MSI) correlates with clinicopathologic characteristics and long-term prognosis in patients having gastric carcinoma...
  25. ncbi request reprint Pharmacokinetics of mitomycin C after resection of peritoneal carcinomatosis and intraperitoneal chemohyperthermic perfusion
    D Cerretani
    Department of Pharmacology G Segre, University of Siena, Siena, Italy
    J Chemother 17:668-73. 2005
    ..21 +/- 3.73%. We conclude that ICHP in patients with peritoneal surface malignancies seems to have clinical value since it gives high peritoneal and tumor MMC concentrations with limited systemic exposure and toxicity...
  26. ncbi request reprint Increased phospholipase activity in Helicobacter pylori strains isolated from patients with gastric carcinoma
    P Lusini
    Department of Molecular Biology, University of Siena, 53100 Siena, Italy
    Dig Liver Dis 37:232-9. 2005
    ..In the present work, we have compared the whole phospholipase activity of H. pylori strains isolated from patients with gastric carcinoma with that of strains isolated from dyspeptic patients without gastric carcinoma...
  27. ncbi request reprint Elastofibroma dorsi: three cases of personal experience
    Annasilvia Neri
    University of Siena, Policlinico Le Scotte, Siena, Italy
    G Chir 30:96-9. 2009
    ..We report our experience of three cases of elastofibroma, two of which typically located in the infrascapular region and one located in the supra-clavicle fossa, atypical site never reported so far...
  28. ncbi request reprint Prospective study of peritoneal recurrence after curative surgery for gastric cancer
    F Roviello
    Unit of Surgical Oncology, University of Siena, Via da Gasperi 5, 53100 Siena, Italy
    Br J Surg 90:1113-9. 2003
    ..The present longitudinal study was designed to evaluate the incidence and potential predictors of peritoneal recurrence after curative resection for gastric cancer...
  29. ncbi request reprint Different patterns of recurrence in gastric cancer depending on Lauren's histological type: longitudinal study
    Daniele Marrelli
    Chirurgia Oncologica, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    World J Surg 26:1160-5. 2002
    ..The notable difference in the risk of peritoneal recurrence between the intestinal and diffuse types should be taken into consideration in the therapeutic approach to gastric cancer...
  30. pmc Prediction of recurrence after radical surgery for gastric cancer: a scoring system obtained from a prospective multicenter study
    Daniele Marrelli
    Department of General Surgery and Surgical Oncology, University of Siena, Siena, Italy
    Ann Surg 241:247-55. 2005
    ..The aim of this prospective multicenter study was to define a scoring system for the prediction of tumor recurrence after potentially curative surgery for gastric cancer...
  31. ncbi request reprint Lymph node involvement in advanced gastroesophageal junction adenocarcinoma
    Corrado Pedrazzani
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Siena, Italy
    J Thorac Cardiovasc Surg 134:378-85. 2007
    ..The present study was aimed at evaluating these key aspects in advanced gastroesophageal junction adenocarcinoma...
  32. doi request reprint Accuracy of transrectal ultrasound after preoperative radiochemotherapy compared to computed tomography and magnetic resonance in locally advanced rectal cancer
    Jacopo Martellucci
    Surgical Department, University of Siena, Siena, Italy
    Int J Colorectal Dis 27:967-73. 2012
    ....
  33. ncbi request reprint Mayer-Rokitansky-Küster-Hauser syndrome presenting as vaginal atresia: report of two cases
    B Rampone
    Department of General Surgery and Surgical Oncology, University of Siena, Siena, Italy
    G Chir 29:165-7. 2008
    ..Patients with MRKH can show different presentation from newborn period to adolescence. We report our experience in treatment of the vaginal atresia presenting in two young girls as a sign of MRKH syndrome...
  34. ncbi request reprint Antiphospholipid antibodies and acute-phase response in non-metastatic colorectal cancer patients
    S Battistelli
    Department of General Surgery, Policlinico Le Scotte, Siena Italy
    Int J Biol Markers 23:31-5. 2008
    ..To investigate the plasma levels and prevalence of the most common antiphospholipid antibodies, as well as their relationships with several plasma markers of inflammation, in order to characterize some aspects of cancer thrombophilia...
  35. doi request reprint Evidence of tumor microsatellite instability in gastric cancer with familial aggregation
    Corrado Pedrazzani
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Policlinico Le Scotte, 53100 Siena, Italy
    Fam Cancer 8:215-20. 2009
    ..Our data seem to suggest that familial aggregation for either GC alone or gastric and colon cancer share common etiological factors in contrast to families with gastric and lung cancers...
  36. doi request reprint CDH1 C-160A promoter polymorphism and gastric cancer risk
    Giovanni Corso
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, Translational Research Laboratory, Istituto Toscano Tumori, University of Siena, Siena, Italy
    Eur J Cancer Prev 18:46-9. 2009
    ..Similarly, genotype was not associated with intestinal or diffuse histotypes, or with cardia or noncardia carcinomas. In conclusion, the C-160A polymorphism is not associated with GC risk in the Italian population...
  37. doi request reprint Negative Helicobacter pylori status is associated with poor prognosis in patients with gastric cancer
    Daniele Marrelli
    Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Cancer 115:2071-80. 2009
    ..In the current study, the association between H. pylori status and clinical outcome was investigated in a large cohort of patients...
  38. ncbi request reprint Prognostic score in gastric cancer patients
    Daniele Marrelli
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Siena, Italy
    Ann Surg Oncol 14:362-4. 2007
  39. doi request reprint Ratio between metastatic and examined lymph nodes (N ratio) may have low clinical utility in gastric cancer patients treated by limited lymphadenectomy: results from a single-center experience of 526 patients
    Corrado Pedrazzani
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Siena, Italy
    World J Surg 34:85-91. 2010
    ..The aim of this study was to evaluate the prognostic value of the ratio of metastatic to examined lymph nodes (N ratio) in gastric cancer patients who underwent limited lymphadenectomy and had a small number (< or =15) of analyzed nodes...
  40. ncbi request reprint Risk factors for liver metastases after curative surgical procedures for gastric cancer: a prospective study of 208 patients treated with surgical resection
    Daniele Marrelli
    Department of General Surgery and Surgical Oncology, University of Siena, Siena, Italy
    J Am Coll Surg 198:51-8. 2004
    ..The aim of this study was to evaluate the risk of liver metastases after radical surgical treatment for gastric cancer, the potential risk factors involved, and the sensitivity of serum tumor markers during followup...
  41. ncbi request reprint Prognostic value of extracapsular extension of axillary lymph node metastases in T1 to T3 breast cancer
    Alessandro Neri
    Department of General Surgery and Surgical Oncology, Surgical Oncology Unit, University of Siena, Policlinico Le Scotte, V le Bracci, 53100 Siena, Italy
    Ann Surg Oncol 12:246-53. 2005
    ....
  42. ncbi request reprint Mib-1 proliferation index is an independent predictor of lymph node metastasis in invasive breast cancer: a prospective study on 675 patients
    Daniele Marrelli
    Department of General Surgery, University of Siena, Viale Bracci, 53100 Siena, Italy
    Oncol Rep 15:425-9. 2006
    ..In conclusion, the MIB-1 proliferation index could provide additional information about the risk of lymph node metastasis in invasive breast cancer, and may be useful to identify grade-2 tumors with a more aggressive clinical behaviour...
  43. ncbi request reprint Bcl-2 expression correlates with lymphovascular invasion and long-term prognosis in breast cancer
    Alessandro Neri
    Department of General Surgery and Surgical Oncology, Surgical Oncology Unit, University of Siena, Siena, Italy
    Breast Cancer Res Treat 99:77-83. 2006
    ....
  44. ncbi request reprint Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases
    Corrado Pedrazzani
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena and ITT, Istituto Toscano Tumori, Siena, Italy
    Int J Biol Markers 25:171-6. 2010
    ..To evaluate the clinical impact of D-dimer (DD) as a tumor marker in patients with colorectal cancer (CRC). The prognostic value of preoperative DD measurement was assessed in relation to carcinoembryonic antigen (CEA) levels...
  45. pmc Impact of age-related comorbidity on results of colorectal cancer surgery
    Corrado Pedrazzani
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Policlinico Le Scotte, Siena, Italy
    World J Gastroenterol 15:5706-11. 2009
    ..To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC)...
  46. doi request reprint Different pathological features and prognosis in gastric cancer patients coming from high-risk and low-risk areas of Italy
    Daniele Marrelli
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Siena, Italy
    Ann Surg 250:43-50. 2009
    ..To compare clinicopathological features and long-term outcome in gastric cancer patients coming from high-risk and low-risk areas of Italy...
  47. doi request reprint CA19-9 serum levels in obstructive jaundice: clinical value in benign and malignant conditions
    Daniele Marrelli
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Viale Bracci Policlinico Le Scotte, Siena, Italy
    Am J Surg 198:333-9. 2009
    ..Obstructive jaundice is frequently associated with false CA19-9 elevation in benign conditions. The diagnostic accuracy of this tumor marker was evaluated in the present longitudinal study...
  48. ncbi request reprint Heterotopic pancreatic tissue in the gallbladder. Two case reports and brief review of the literature
    G Cerullo
    Department of Pathology and Oncology, University of Siena, Italy
    G Chir 32:259-62. 2011
    ..The surgical approach for the excision of a undefined lesion and the histological identification is a correct procedure in suspect case. We report 2 cases of heterotopic pancreatic tissue of the gallbladder...
  49. doi request reprint Safety and potential benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal carcinomatosis from primary or recurrent ovarian cancer
    Franco Roviello
    Department of Human Pathology and Oncology, Section of Advanced Surgical Oncology, University of Siena, Siena, Italy
    J Surg Oncol 102:663-70. 2010
    ..To analyze the outcomes of cytoreductive surgery and HIPEC in patients with peritoneal carcinomatosis from ovarian cancer...
  50. ncbi request reprint Postoperative complications and functional results after subtotal gastrectomy with Billroth II reconstruction for primary gastric cancer
    Corrado Pedrazzani
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Siena, Italy
    Dig Dis Sci 52:1757-63. 2007
    ..The incidence of late complications was low and the majority of patients recovered from them within one year after surgery, although the occurrence of postprandial abdominal fullness was not completely irrelevant...
  51. ncbi request reprint Nodal staging in adenocarcinoma of the gastro-esophageal junction. Proposal of a specific staging system
    Corrado Pedrazzani
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Policlinico Le Scotte, V Le Bracci 2, 53100, Siena, Italy
    Ann Surg Oncol 14:299-305. 2007
    ..This study was aimed at developing a proper nodal staging system for GEJ adenocarcinoma...
  52. doi request reprint Thymidine phosphorylase expression in metastatic sites is predictive for response in patients with colorectal cancer treated with continuous oral capecitabine and biweekly oxaliplatin
    Roberto Petrioli
    Medical Oncology Section, Department of Pharmacology, University of Siena, Siena, Italy
    Anticancer Drugs 21:313-9. 2010
    ..Moreover, these findings add to a growing body of evidence that patients with high levels of intratumoral TP expression are the ideal candidates for capecitabine-based chemotherapy...
  53. ncbi request reprint Behavior of circulating endothelin-1 in a group of patients with acute myocardial infarction
    S Battistelli
    Istituto di Semeiotica Medica e Geriatria, University of Siena, Italy
    Angiology 50:629-38. 1999
    ..In the following phase the ET-1, being correlated with LVEF, could be a reliable index of systolic function...
  54. ncbi request reprint Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma
    Sandra Battistelli
    Dipartimento di Chirurgia e Specialità Chirurgiche, Universita degli Studi, Policlinico Le Scotte, Viale Bracci, Siena 53100, Italy
    World J Gastroenterol 12:6128-32. 2006
    ..To investigate the behaviour of total plasma homocysteine (tHcy) and its most common genetic determinant defect, the methylenetetrahydrofolate reductase C677T (C677TMTHFR) polymorphism in patients with early stage colorectal carcinoma...
  55. ncbi request reprint FOLFOX-4 stop and go and capecitabine maintenance chemotherapy in the treatment of metastatic colorectal cancer
    Roberto Petrioli
    Section of Medical Oncology, Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Oncology 70:345-50. 2006
    ..The aim of this study was to evaluate if FOLFOX-4 stop and go and capecitabine maintenance chemotherapy is associated with a low incidence of severe neurotoxicity in the treatment of MCC patients...
  56. ncbi request reprint Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis
    Paraskevi Vogiatzi
    Department of Molecular Biology, Medical Genetics, University of Siena, Siena, Italy
    J Cell Physiol 211:287-95. 2007
    ..This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy...
  57. ncbi request reprint Late recurrence of malignant melanoma presenting as small bowel intussusception
    Bernardino Rampone
    Department of General Surgery and Surgical Oncology, University of Siena, viale Bracci 25, Policlinico Le Scotte, 53100, Siena, Italy
    Dig Dis Sci 51:1047-8. 2006
  58. ncbi request reprint Total inhibin is a potential serum marker for epithelial ovarian cancer
    Anastasia Tsigkou
    Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, Policlinico, S Maria alle Scotte Viale Bracci, 53100 Siena, Italy
    J Clin Endocrinol Metab 92:2526-31. 2007
    ..Total inhibin is the sum of precursors, subunits, and mature molecules of inhibin, which the normal ovary nearly stops to produce after menopause, whereas ovarian tumors still release...
  59. ncbi request reprint Complications after extended (D2) and superextended (D3) lymphadenectomy for gastric cancer: analysis of potential risk factors
    Daniele Marrelli
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Siena, Italy
    Ann Surg Oncol 14:25-33. 2007
    ..The aim of the prospective observational study reported here was to analyze the postoperative outcome and potential risk factors for complications following D2 and D3 lymphadenectomy...
  60. ncbi request reprint Treatment of the intraabdominal abscesses through percutaneous ultrasound-guided drainage in oncological patients: Clinical and microbiological data
    Guido Cerullo
    Department of General Surgery and Surgical Oncology, University of Siena, Policlinico S Maria alle Scotte, Siena, Italy
    Surg Endosc 22:1200-5. 2008
    ..The aim of our study was to analyze clinical and microbiological data in a population of oncological patients, submitted to percutaneous ultrasound-guided drainage (PUD) for postoperative abdominal abscesses...
  61. ncbi request reprint Protein S in cancer patients with non-metastatic solid tumours
    S Battistelli
    Dipartimento di Chirurgia e Specialità Chirurgiche, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    Eur J Surg Oncol 31:798-802. 2005
    ..To study protein S, as an acute phase protein, for its relationships with C4b-BP (C4BP), fibrinogen and Factor VIII:C in a group of patients with solid tumours, without proven metastases...
  62. doi request reprint Gastric cardia carcinoma is associated with the promoter -77T>C gene polymorphism of X-ray cross-complementing group 1 (XRCC1)
    Giovanni Corso
    Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy
    J Gastrointest Surg 13:2233-8. 2009
    ..The aim of this study is to analyze the -77T>C allelic frequencies in a population composed of 456 primary gastric cancer patients (GC) and 507 blood donor controls...
  63. ncbi request reprint Prevalence of factor V Leiden and prothrombin G20210A in patients with gastric cancer
    Sandra Battistelli
    Dipartimento di Chirurgia e Specialità Chirurgiche, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    World J Gastroenterol 12:4179-80. 2006
    ..To analyze the prevalence of the two commonest thrombophilic mutations, factor V Leiden and prothrombin G20210A, in patients with gastric cancer...
  64. ncbi request reprint Continuous oral capecitabine at fixed dose in patients older than 75 years with metastatic colorectal and gastric cancer: a study of the Multidisciplinary Oncology Group on Gastrointestinal Tumors
    Roberto Petrioli
    Department Human Pathology and Oncology, University of Siena, Siena, Italy
    Anticancer Drugs 19:91-6. 2008
    ..This study suggests that continuous oral capecitabine at a fixed daily dose of 2000 mg is well tolerated, and that it allows for the simplification and ease of dosing in elderly patients with metastatic colorectal and gastric cancer...
  65. ncbi request reprint Folinic acid, 5-fluorouracil and etoposide after curative resection for gastric cancer
    Roberto Petrioli
    Department of Medical Oncology, University of Siena, Italy
    Hepatogastroenterology 52:1626-30. 2005
    ..The aim of this study was to evaluate the survival benefit of adjuvant chemotherapy with etoposide, leucovorin and 5-fluorouracil (ELF) in gastric cancer patients undergoing previous surgery with a curative intent...
  66. ncbi request reprint E-cadherin and hereditary diffuse gastric cancer
    Corrado Pedrazzani
    Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Italy
    Surgery 142:645-57. 2007
  67. ncbi request reprint A clinical case of duodenal gastrointestinal stromal tumor with a peculiarity in the surgical approach
    Giovanni De Marco
    Department of General Surgery and Oncology, University of Siena, Unit of Surgical Oncology, Siena, Italy
    Tumori 91:261-3. 2005
    ..The technique reduces the morbidity and mortality correlated with duodenocefalopancreasectomy and improves postsurgical quality of life without worsening the risk of recurrence...
  68. ncbi request reprint A rare case of primary small bowel adenocarcinoma with intussusception
    Stefano Caruso
    Section of General Surgery and Surgical Oncology, Oncology University of Siena, Policlinico Santa Maria alle Scotte, Siena, Italy
    Tumori 96:355-7. 2010
    ..In adult intestinal intussusception, resection without reduction is considered the optimal management if an underlying primary malignancy cannot be excluded...
  69. ncbi request reprint Updates on abdominal desmoid tumors
    Bernardino Rampone
    Department of General Surgery and Surgical Oncology, Unit of Surgical Oncology, University of Siena, Policlinico Le Scotte, Viale Bracci, 1, 53100, Siena, Italy
    World J Gastroenterol 13:5985-8. 2007
    ..The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations difficult. This distinct pathological entity is reviewed with a specific focus on aetiology and management...
  70. ncbi request reprint Pharmacokinetics of intraarterial mitomycin C in hypoxic hepatic infusion with embolization in the treatment of liver metastases
    Daniela Cerretani
    Department of Pharmacology G Segre, University of Siena, Via delle Scotte 6, 53100 Siena, Italy
    Vascul Pharmacol 39:1-6. 2002
    ..001). 4. The reduction in AUC following HHMI explains the limited systemic toxicity in treated patients, with a greater total tumor exposure to the drug and improved drug activation...
  71. ncbi request reprint Presacral ganglioneuroma: a case report and review of literature
    Guido Cerullo
    Department of Pathology and Oncology, University of Siena, Siena, Italy
    World J Gastroenterol 13:2129-31. 2007
    ..We report a case of a 64-year-old man with a presacral ganglioneuroma...
  72. ncbi request reprint Giant liposarcoma of the mesentery. Report of a case
    Guido Cerullo
    Department of General Surgery and Surgical Oncology, U O Surgical Oncology, University of Siena, Siena, Italy
    Ann Ital Chir 78:443-5. 2007
    ..Surgery currently represents the only possibly curative therapy for this type of tumour but close long-term follow up and accurate evaluation of the clinicopathologic parameters are needed...
  73. ncbi request reprint Primary osteosarcoma of the kidney with retroperitoneal hemorrhage. Case report and review of the literature
    Tommaso Cioppa
    Department of Human Pathology and Oncology, Section of General Surgery, University of Siena, Siena, Italy
    Tumori 93:213-6. 2007
    ..To our knowledge this is the first case of bleeding renal osteosarcoma reported in the literature. The most important clinical findings, the pathogenesis and the treatment modalities of this rare neoplasm are discussed...
  74. ncbi request reprint Subtotal versus total gastrectomy for T3 adenocarcinoma of the antrum
    Giovanni de Manzoni
    First Division of Surgery, University of Verona, Verona, Italy
    Gastric Cancer 6:237-42. 2003
    ..The role of subtotal or total gastrectomy in the treatment of advanced gastric cancer of the antrum with serosal invasion was investigated...
  75. ncbi request reprint [Benefits of extended lymphadenectomy in patients with gastric carcinoma with metastasis to second level lymph nodes. An Italian multicenter study]
    Franco Roviello
    U O Chirurgia Oncologica Dipartimento di Patologia Umana e Oncologia, Universita di Siena
    Chir Ital 55:491-8. 2003
    ..The incidence of metastases in lymph node stations removed with this technique is by no means negligible. This procedure could be beneficial as regards long-term survival even in patients with involvement of regional lymph nodes...
  76. ncbi request reprint Loss of Fhit expression is associated with poorer survival in gastric cancer but is not an independent prognostic marker
    Emma Bragantini
    Dipartimento di Patologia, Sezione Anatomia Patologica, Universita di Verona, Strada Le Grazie, 8, 37134, Verona, Italy
    J Cancer Res Clin Oncol 132:45-50. 2006
    ..050). While loss of Fhit correlates with poorer survival in univariate analysis, it is not an independent prognostic factor in multivariate analysis and is thus not of clinical utility...
  77. ncbi request reprint Microsatellite instability in gastric cancer is associated with better prognosis in only stage II cancers
    Stefania Beghelli
    Department of Pathology, Section of Anatomical Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Surgery 139:347-56. 2006
    ..The assessment of microsatellite instability (MSI) is not included yet in the routine evaluation of patients with gastric cancer, as controversial data exist regarding its prognostic value...
  78. ncbi request reprint Does resection line involvement affect prognosis in early gastric cancer patients? An Italian multicentric study
    Paolo Morgagni
    Department of General Surgery, Morgagni Pierantoni Hospital, Via Forlanini 34, Forli, 47100, Italy
    World J Surg 30:585-9. 2006
    ..Resection line involvement has been indicated as an important prognostic factor for gastric cancer. Its late detection renders the choice of treatment difficult for surgeons...
  79. ncbi request reprint Family history of gastric cancer: a correlation between epidemiologic findings and clinical data
    Marco Bernini
    First Department of General Surgery, University of Verona, Ospedale Civile Maggiore Verona, P zza Stefani n 1, 37126, Verona, Italy
    Gastric Cancer 9:9-13. 2006
    ..Its familial aggregation, on the other hand, has been very well documented by many epidemiologists. Nonetheless, only a limited number of studies have analyzed possible correlations between demographic and clinical data...
  80. pmc The ratio between metastatic and examined lymph nodes (N ratio) is an independent prognostic factor in gastric cancer regardless of the type of lymphadenectomy: results from an Italian multicentric study in 1853 patients
    Alberto Marchet
    Clinica Chirurgica Generale 2, University of Padova, Padova, Italy
    Ann Surg 245:543-52. 2007
    ....
  81. ncbi request reprint Lymph node involvement in gastric cancer for different tumor sites and T stage: Italian Research Group for Gastric Cancer (IRGGC) experience
    Alberto Di Leo
    First Division of General Surgery, University of Verona, Verona, Italy
    J Gastrointest Surg 11:1146-53. 2007
    ..The aim of lymphadenectomy is to clear all the metastatic nodes achieving a complete removal of the tumor; nevertheless, its role in gastric cancer has been very much debated...
  82. ncbi request reprint It is time for a proper staging system for adenocarcinoma of the gastroesophageal junction
    Corrado Pedrazzani
    J Clin Oncol 25:907-8; author reply 908-9. 2007
  83. ncbi request reprint [Surgical treatment of gastric cancer]
    Franco Roviello
    Dipartimento di Patologia Umana ed Oncologia, Sezione di Chirurgia Oncologica, Urriversità degli Studi di Siena
    Chir Ital 60:367-79. 2008
    ..This review examines the different issues related to the surgical treatment of early and advanced gastric adenocarcinoma as well as the most recent strategies for the treatment and prevention of peritoneal carcinomatosis...
  84. pmc Allelic imbalance of 8p indicates poor survival in gastric cancer
    Amy J French
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    J Mol Diagn 6:243-52. 2004
    ..Finally, gastric cancers with a high rate of microsatellite instability were significantly associated with noncardia tumors and with female gender...
  85. ncbi request reprint Development of an interactive module to enhance and understand cavity navigation
    Andrés A Navarro Newball
    Pontificia Universidad Javeriana, Cali, Colombia
    Stud Health Technol Inform 125:340-2. 2007
    ..This paper describes the making of IMCA and the potential use of genetic algorithms in path generation...
  86. ncbi request reprint Gastric resection Billroth or Rydygier?
    Andrzej L Komorowski
    Department of Surgical Oncology, Maria Sklodowska Curie Memorial Institute of Oncology, Cancer Centre, Krakow, Poland
    Chir Ital 58:231-4. 2006
    ..The Authors present the lives and major achievements of these two pioneering surgeons...
  87. ncbi request reprint Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands
    Gianpaolo Suriano
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto, 4200 Porto, Portugal
    Hum Mol Genet 12:575-82. 2003
    ....