G Rotilio

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. pmc Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials
    Alberto Ferri
    Institute of Neuroscience, Department of Psychobiology and Psychopharmacology, Consiglio Nazionale delle Ricerche, 00100 Rome, Italy
    Proc Natl Acad Sci U S A 103:13860-5. 2006
  2. doi request reprint Nutritional factors in human dispersals
    Giuseppe Rotilio
    Department of Biology, Tor Vergata University of Rome, Rome, Italy
    Ann Hum Biol 37:312-24. 2010
  3. ncbi request reprint Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes
    Giuseppe Rotilio
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    IUBMB Life 55:629-34. 2003
  4. ncbi request reprint Copper-dependent oxidative stress and neurodegeneration
    G Rotilio
    Dept of Biology, University of Rome Tor Vergata, Italy
    IUBMB Life 50:309-14. 2000
  5. ncbi request reprint Increased susceptibility of copper-deficient neuroblastoma cells to oxidative stress-mediated apoptosis
    L Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Free Radic Biol Med 30:1177-87. 2001
  6. ncbi request reprint Oxidative inactivation of calcineurin by Cu,Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral sclerosis
    A Ferri
    Fondazione S. Lucia IRCCS, Rome, Italy
    J Neurochem 79:531-8. 2001
  7. pmc Increased expression of periplasmic Cu,Zn superoxide dismutase enhances survival of Escherichia coli invasive strains within nonphagocytic cells
    A Battistoni
    Department of Biology, Universita di Roma Tor Vergata, 00133 Rome, Italy
    Infect Immun 68:30-7. 2000
  8. ncbi request reprint Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 85:1324-35. 2003
  9. ncbi request reprint Prolonged copper depletion induces expression of antioxidants and triggers apoptosis in SH-SY5Y neuroblastoma cells
    M F Lombardo
    Department of Biology, Tor Vergata University of Rome, Rome, Italy
    Cell Mol Life Sci 60:1733-43. 2003
  10. doi request reprint Transient cytoskeletal alterations after SOD1 depletion in neuroblastoma cells
    P Vigilanza
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, Rome, Italy
    Cell Mol Life Sci 65:991-1004. 2008

Collaborators

Detail Information

Publications80

  1. pmc Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials
    Alberto Ferri
    Institute of Neuroscience, Department of Psychobiology and Psychopharmacology, Consiglio Nazionale delle Ricerche, 00100 Rome, Italy
    Proc Natl Acad Sci U S A 103:13860-5. 2006
    ....
  2. doi request reprint Nutritional factors in human dispersals
    Giuseppe Rotilio
    Department of Biology, Tor Vergata University of Rome, Rome, Italy
    Ann Hum Biol 37:312-24. 2010
    ....
  3. ncbi request reprint Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes
    Giuseppe Rotilio
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    IUBMB Life 55:629-34. 2003
    ..A possible role for proteasome in the inhibition of neurodegenerative process by balancing ROS and RNS species is envisaged on the basis of evidence provided by results obtained from studies on this experimental model...
  4. ncbi request reprint Copper-dependent oxidative stress and neurodegeneration
    G Rotilio
    Dept of Biology, University of Rome Tor Vergata, Italy
    IUBMB Life 50:309-14. 2000
    ..Furthermore, a possible role of copper reactivity in inducing critical steps in the apoptotic pathways leading to neurodegeneration is envisaged...
  5. ncbi request reprint Increased susceptibility of copper-deficient neuroblastoma cells to oxidative stress-mediated apoptosis
    L Rossi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Free Radic Biol Med 30:1177-87. 2001
    ..Overall findings represent a contribution to the comprehension of the link between copper-imbalance and neurodegeneration, which has recently been repeatedly suggested for the most invalidating pathologies of the central nervous system...
  6. ncbi request reprint Oxidative inactivation of calcineurin by Cu,Zn superoxide dismutase G93A, a mutant typical of familial amyotrophic lateral sclerosis
    A Ferri
    Fondazione S. Lucia IRCCS, Rome, Italy
    J Neurochem 79:531-8. 2001
    ....
  7. pmc Increased expression of periplasmic Cu,Zn superoxide dismutase enhances survival of Escherichia coli invasive strains within nonphagocytic cells
    A Battistoni
    Department of Biology, Universita di Roma Tor Vergata, 00133 Rome, Italy
    Infect Immun 68:30-7. 2000
    ..We propose that Cu,Zn superoxide dismutase could offer an important selective advantage in survival within host cells to bacteria expressing high levels of this enzyme...
  8. ncbi request reprint Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    J Neurochem 85:1324-35. 2003
    ..Overall these results confirm the pro-oxidant activity of G93A Cu,Zn SOD mutant and, at the same time, suggest a cross-talk between reactive oxygen and nitrogen species via the proteasome pathway...
  9. ncbi request reprint Prolonged copper depletion induces expression of antioxidants and triggers apoptosis in SH-SY5Y neuroblastoma cells
    M F Lombardo
    Department of Biology, Tor Vergata University of Rome, Rome, Italy
    Cell Mol Life Sci 60:1733-43. 2003
    ..We conclude that prolonged copper starvation in these replicating cells leads to mitochondrial damage and oxidative stress and ultimately, apoptosis...
  10. doi request reprint Transient cytoskeletal alterations after SOD1 depletion in neuroblastoma cells
    P Vigilanza
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, Rome, Italy
    Cell Mol Life Sci 65:991-1004. 2008
    ..Our data demonstrate that SOD1 is essential for the preservation of cytoskeleton integrity, by maintaining physiological concentration of reactive oxygen species and inhibiting the activation of the neuronal specific Cdk5/p35 pathway...
  11. pmc Lipid modification of the Cu,Zn superoxide dismutase from Mycobacterium tuberculosis
    M D'Orazio
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Biochem J 359:17-22. 2001
    ..Evidence is also provided for an up-regulation of M. tuberculosis sodC in response to phagocytosis by human macrophages, suggesting that Cu,ZnSOD is involved in the mechanisms that facilitate mycobacterial intracellular growth...
  12. ncbi request reprint Neurodegeneration in the animal model of Menkes' disease involves Bcl-2-linked apoptosis
    L Rossi
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Neuroscience 103:181-8. 2001
    ..On the basis of these findings, we propose that down-regulation of Bcl-2 can cause neurodegeneration triggered by mitochondrial damage due to copper depletion during brain development in Mo(br/y) mice...
  13. ncbi request reprint Decrease of cytochrome c oxidase protein in heart mitochondria of copper-deficient rats
    L Rossi
    Department of Biology, University of Rome Tor Vergata, Italy
    Biometals 11:207-12. 1998
    ....
  14. ncbi request reprint Neuronal nitric oxide synthase protects neuroblastoma cells from oxidative stress mediated by garlic derivatives
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, Italy
    J Neurochem 101:1327-37. 2007
    ..Overall these results demonstrate that garlic derivatives may modulate nNOS and suggest an important contribution of nitric oxide in counteracting their reactive oxygen species-mediated cytotoxicity...
  15. ncbi request reprint Apoptosome inactivation rescues proneural and neural cells from neurodegeneration
    M Cozzolino
    Dulbecco Telethon Institute, Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Cell Death Differ 11:1179-91. 2004
    ..Indeed, the ETNA cell model is ideally suited for exploring the potential of novel cell therapies for the treatment of human neurodegenerations...
  16. ncbi request reprint Apaf1 mediates apoptosis and mitochondrial damage induced by mutant human SOD1s typical of familial amyotrophic lateral sclerosis
    Mauro Cozzolino
    Lab di Neurochimica, Centro di Neurobiologia Sperimentale Mondino Tor Vergata Santa Lucia, Rome, Italy
    Neurobiol Dis 21:69-79. 2006
    ..This death pathway may be crucial also for the pathogenesis of the sporadic form of the disease, where markers of increased oxidative stress and mitochondria damage have been found...
  17. ncbi request reprint Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases
    Arianna Casciati
    Fondazione S Lucia IRCCS, Rome, Italy
    J Neurochem 83:1019-29. 2002
    ..All of these modifications might be relevant to signaling pathways involved in the pathogenesis of fALS...
  18. pmc The Cu,Zn superoxide dismutase from Escherichia coli retains monomeric structure at high protein concentration. Evidence for altered subunit interaction in all the bacteriocupreins
    A Battistoni
    Department of Biology, University of Rome Tor Vergata, Italy
    Biochem J 320:713-6. 1996
    ..The substitution of hydrophobic residues with charged ones at positions located at the dimer interface of all known Cu,Zn superoxide dismutases could be specifically responsible for the monomeric structure of the E. coli enzyme...
  19. ncbi request reprint Unfolding and inactivation of monomeric superoxide dismutase from E. coli by SDS
    M Bozzi
    Department of Chemical Science and Technology, Tor Vergata University, Via della Ricerca Scientifica, 00133, Rome, Italy
    Int J Biol Macromol 29:99-105. 2001
    ..The unfolding is reversible and both, the tridimensional structure of the protein and the active site, can be restored upon dialysis. In addition, unfolding occurs without loss of metals in the solution...
  20. ncbi request reprint Involvement of reactive oxygen species in bacterial killing within epithelial cells
    A Battistoni
    Dipartmento di Biologia, Università di Rome Tor Vergata, Rome, Italy
    Int J Immunopathol Pharmacol 17:71-6. 2004
    ....
  21. ncbi request reprint Alteration of peripheral markers of copper homeostasis in Alzheimer's disease patients: implications in aetiology and therapy
    L Rossi
    Department of Biology Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy
    J Nutr Health Aging 11:408-17. 2007
    ....
  22. ncbi request reprint Role of the electrostatic loop of Cu,Zn superoxide dismutase in the copper uptake process
    M R Ciriolo
    Department of Biomedical Sciences, University of Chieti G D Annunzio, Via dei Vestini 66100 Chieti, Italy
    Eur J Biochem 268:737-42. 2001
    ....
  23. ncbi request reprint Cu,Zn-superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells
    M R Ciriolo
    Department of Biomedical Sciences, University of Chieti G D Annunzio, Via dei Vestini, 66100 Chieti, Italy
    J Biol Chem 275:5065-72. 2000
    ..These results demonstrate that resistance to NO-mediated apoptosis is strictly related to the level and integrity of Cu,Zn-SOD and that the balance between reactive nitrogen and reactive oxygen species regulates neuroblastoma apoptosis...
  24. ncbi request reprint A histidine-rich metal binding domain at the N terminus of Cu,Zn-superoxide dismutases from pathogenic bacteria: a novel strategy for metal chaperoning
    A Battistoni
    Dipartimento di Biologia, Universita di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    J Biol Chem 276:30315-25. 2001
    ..Particular biological importance for this domain is inferred by the observation that its presence enhances the protection offered by periplasmic Cu,Zn-superoxide dismutase toward phagocytic killing...
  25. ncbi request reprint Differential role of superoxide and glutathione in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants
    M R Ciriolo
    Department of Biomedical Sciences, University of Chieti G D Annunzio, Chieti, Italy
    J Neurochem 77:1433-43. 2001
    ..These results are relevant to explain a milder progression of the familial amyotrophic lateral sclerosis disease when associated with the H46R mutation...
  26. ncbi request reprint Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis
    L Ghibelli
    Dipartimento di Biologia, Universita di Roma Tor Vergata, 00133 Roma, Italy
    FASEB J 13:2031-6. 1999
    ..These results show that cytochrome c release is not a terminal event leading cells to apoptosis, but rather is the consequence of a redox disequilibrium that, under some circumstances, may be associated with apoptosis...
  27. doi request reprint Glutathione and copper, zinc superoxide dismutase are modulated by overexpression of neuronal nitric oxide synthase
    Sara Baldelli
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
    Int J Biochem Cell Biol 40:2660-70. 2008
    ..Actually, this study demonstrates that nNOS directly interacts with Sp1, both in the cytosol as well as in the nucleus, forming a stable heterocomplex that could have an important physiological role in the modulation of Sp1 activity...
  28. doi request reprint Tau dephosphorylation and microfilaments disruption are upstream events of the anti-proliferative effects of DADS in SH-SY5Y cells
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
    J Cell Mol Med 14:564-77. 2010
    ....
  29. ncbi request reprint Copper imbalance and oxidative stress in neurodegeneration
    Luisa Rossi
    Department of Biology, Tor Vergata University of Rome, Italy
    Ital J Biochem 55:212-21. 2006
    ....
  30. ncbi request reprint Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells
    Alberto Ferri
    Istituto di Neuroscienze CNR, Sez Psicobiologia e Psicofarmacologia, Mondino Tor Vergata S Lucià, Rome, Italy
    FASEB J 18:1261-3. 2004
    ..This cross-talk may be crucial for the pathogenesis of SOD1-linked fALS but also for the more common sporadic form of the disease, where markers of increased oxidative stress and of glial activation have been found...
  31. pmc Redox mechanisms involved in the selective activation of Nrf2-mediated resistance versus p53-dependent apoptosis in adenocarcinoma cells
    Sara Piccirillo
    Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 284:27721-33. 2009
    ..Our data suggest that thiol-oxidizing agents could be exploited as inducers of apoptosis in tumor histotypes resistant to ROS-producing chemotherapeutics...
  32. ncbi request reprint Pro-apoptotic activity of novel Isatin-Schiff base copper(II) complexes depends on oxidative stress induction and organelle-selective damage
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    J Biol Chem 282:12010-21. 2007
    ....
  33. ncbi request reprint Effects of water garlic extracts on cell cycle and viability of HepG2 hepatoma cells
    Angelo De Martino
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    J Nutr Biochem 17:742-9. 2006
    ....
  34. ncbi request reprint Overexpression of superoxide dismutase 1 protects against beta-amyloid peptide toxicity: effect of estrogen and copper chelators
    Fulvio Celsi
    Fondazione Santa Lucia IRCCS, Rome, Italy
    Neurochem Int 44:25-33. 2004
    ..Our results further support the notion that anti-oxidant therapy might be beneficial in the treatment of AD by preventing activation of selected apoptotic pathways...
  35. ncbi request reprint Red blood cell copper, zinc superoxide dismutase activity is higher in Alzheimer's disease and is decreased by D-penicillamine
    Luisa Rossi
    Department of Biology, Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy
    Neurosci Lett 329:137-40. 2002
    ..These results support the hypothesis that a higher level of Cu, Zn SOD activity in RBC can be an early diagnostic peripheral marker of this disease and a sensor to monitor treatments with copper-chelating drugs...
  36. ncbi request reprint Cell signalling and the glutathione redox system
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00173 Rome, Italy
    Biochem Pharmacol 64:1057-64. 2002
    ..This paper summarises recent knowledge on the role played by several redox modulators in inducing signalling events that finally regulate cell cycle progression...
  37. pmc Regulatory and structural properties differentiating the chromosomal and the bacteriophage-associated Escherichia coli O157:H7 Cu, Zn superoxide dismutases
    Melania D'Orazio
    Department of Biology, University of Rome, Tor Vergata, Rome, Italy
    BMC Microbiol 8:166. 2008
    ..coli strains, and sodC-F1 and sodC-F2, two nearly identical genes located within lambdoid prophage sequences. The significance of this apparent sodC redundancy in E. coli O157:H7 has not yet been investigated...
  38. ncbi request reprint Under the ROS…thiol network is the principal suspect for autophagy commitment
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, Italy
    Autophagy 6:999-1005. 2010
    ....
  39. ncbi request reprint Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals
    Maria Teresa Carri
    Dipartimento di Biologia, Universita di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Brain Res Bull 61:365-74. 2003
    ..Metal-mediated oxidative stress would lead to several intracellular alterations and contribute to the induction of cell death pathways...
  40. ncbi request reprint Activation of c-Jun-N-terminal kinase is required for apoptosis triggered by glutathione disulfide in neuroblastoma cells
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata via della Ricerca Scientifica, 1, 00133 Rome, Italy
    Free Radic Biol Med 39:345-54. 2005
    ..Our data give support to the studies that indicate preferential requirements for the involvement of stress-activated kinases in apoptotic neuronal cells...
  41. doi request reprint Benefits from dietary polyphenols for brain aging and Alzheimer's disease
    L Rossi
    Department of Biology, Tor Vergata University of Rome, Via della Ricerca Scientifica, 1, 00133, Rome, Italy
    Neurochem Res 33:2390-400. 2008
    ..This commentary discusses recent data on these aspects, particularly focusing on effects of curcumin, resveratrol and catechins on Alzheimer's disease...
  42. ncbi request reprint Prevention by fructose-1,6-bisphosphate of cardiac oxidative damage induced in mice by subchronic doxorubicin treatment
    G Lazzarino
    Biomedica Foscama Research Laboratories, Rome, Italy
    Cancer Res 47:6511-6. 1987
    ....
  43. ncbi request reprint Purification and characterization of Alpha-Fetoprotein from the human hepatoblastoma HepG2 cell line in serum-free medium
    Patrizia Carlini
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Biometals 20:869-78. 2007
    ..This result may provide further support to the idea that AFP is a bifunctional protein, acting in cellular defence against oxidative stress both as a copper buffer and as a superoxide radical scavenger...
  44. ncbi request reprint Mitochondrial damage due to SOD1 deficiency in SH-SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 1, Rome, 00133, Italy
    FASEB J 20:1683-5. 2006
    ..Overall, the results demonstrate that loss of SOD1 leads to severe damage of mitochondria, suggesting an important biological role for this enzyme in the preservation of mitochondrial homeostasis...
  45. pmc High-affinity Zn2+ uptake system ZnuABC is required for bacterial zinc homeostasis in intracellular environments and contributes to the virulence of Salmonella enterica
    Serena Ammendola
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Roma, Italy
    Infect Immun 75:5867-76. 2007
    ..These results shed new light on the complex functions of zinc in vertebrate and bacterial physiology and pave the way for a better comprehension of pathogenic mechanisms in Salmonella infections...
  46. ncbi request reprint Mitochondrial dysfunction in neurodegenerative diseases associated with copper imbalance
    Luisa Rossi
    Department of Biology, Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy
    Neurochem Res 29:493-504. 2004
    ....
  47. pmc trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways
    G Filomeni
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
    Genes Nutr 2:295-305. 2007
    ..The results obtained demonstrate a pro-apoptotic activity for trans-resveratrol, and suggest a preferential activation of different classes of MAP kinases in response to different oxidative stimuli (ROS versus GSH/GSSG alteration)...
  48. ncbi request reprint Modification of structure and digestibility of chestnut starch upon cooking: a solid state (13)C CP MAS NMR and enzymatic degradation study
    L Pizzoferrato
    National Institute of Nutrition, Rome, Italy
    J Agric Food Chem 47:4060-3. 1999
    ..In the system studied, the extension of the Maillard reaction is not such as to exert a significant influence on structure and/or digestibility of chestnut starch...
  49. ncbi request reprint Modelling the three-dimensional structure and electrostatic potential field of the two Cu,Zn superoxide dismutase variants from Xenopus laevis
    M Falconi
    Department of Biology, University of Rome Tor Vergata, Italy
    Proteins 10:149-55. 1991
    ....
  50. doi request reprint Thermal stability and redox properties of M. tuberculosis CuSOD
    Melania D'Orazio
    Department of Biology, University of Rome Tor Vergata, Italy
    Arch Biochem Biophys 486:119-24. 2009
    ..tuberculosis Cu,SOD compensate for the absence of zinc in achieving a fully active enzyme...
  51. doi request reprint Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy
    Neurochem Res 33:2416-26. 2008
    ..Here, we evaluate the involvement of NOS/NO in PD and explore the neuroprotective activity of natural polyphenol compounds in terms of anti-inflammatory and antioxidant action...
  52. ncbi request reprint Copper-dependent toxicity in SH-SY5Y neuroblastoma cells involves mitochondrial damage
    Mario Arciello
    Department of Biology, Tor Vergata University of Rome, Via della Ricerca Scientifica, 00133 Rome, Italy
    Biochem Biophys Res Commun 327:454-9. 2005
    ....
  53. doi request reprint p38(MAPK)/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration
    Simone Cardaci
    Department of Biology, University of Rome Tor Vergata, Italy
    Biochem J 430:439-51. 2010
    ..Inhibition of glucose uptake was also observed upon treatment with 6-hydroxydopamine, another redox-cycling molecule, suggesting a common mechanism of action for auto-oxidizable neurotoxins...
  54. ncbi request reprint Glutathione-related systems and modulation of extracellular signal-regulated kinases are involved in the resistance of AGS adenocarcinoma gastric cells to diallyl disulfide-induced apoptosis
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Italy
    Cancer Res 65:11735-42. 2005
    ..Altogether, our data show that ERK 1/2 participates in the active proliferation of AGS cells and that an efficient reactive oxygen species buffering system makes these cells resistant to DADS-mediated detrimental effects...
  55. ncbi request reprint Primary structure from amino acid and cDNA sequences of two Cu,Zn superoxide dismutase variants from Xenopus laevis
    M E Schinina
    Department of Biology, Tor Vergata University of Rome, Italy
    Arch Biochem Biophys 272:507-15. 1989
    ..This is the first time complete sequences for Cu,Zn superoxide dismutase variants from the same organism have been found to be products of divergent genes and not simply allelic mutations...
  56. ncbi request reprint Isolation of an active and heat-stable monomeric form of Cu,Zn superoxide dismutase from the periplasmic space of Escherichia coli
    A Battistoni
    Department of Biology, University of Rome Tor Vergata, Italy
    FEBS Lett 374:199-202. 1995
    ..Furthermore the purified enzyme proved to be highly heat-stable and, uniquely among CuZnSODs, protease-sensitive. The latter property may explain the previously described lability of this protein in cell extracts...
  57. ncbi request reprint Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways
    G Filomeni
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Cell Death Differ 12:1555-63. 2005
    ....
  58. ncbi request reprint Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Autophagy 6:202-16. 2010
    ..Experiments performed with another carcinoma cell line yielded the same results, suggesting for kaempferol a unique mechanism of action...
  59. ncbi request reprint Molecular transduction mechanisms of the redox network underlying the antiproliferative effects of allyl compounds from garlic
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    J Nutr 138:2053-7. 2008
    ..This review discusses recent findings on such aspects, focusing on the chemistry of allyl compounds and their preferential cellular targets as well as on related nutritional aspects...
  60. pmc The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, Italy
    Carcinogenesis 30:1115-24. 2009
    ..This event results in mitochondrial dysfunction and ATP decrease, which in turn triggers AMPK-dependent apoptosis...
  61. doi request reprint Rhodanese-thioredoxin system and allyl sulfur compounds
    Renato Sabelli
    Department of Sciences and Chemical Technologies, University of Rome Tor Vergata, Italy
    FEBS J 275:3884-99. 2008
    ....
  62. ncbi request reprint Antiapoptotic response to induced GSH depletion: involvement of heat shock proteins and NF-kappaB activation
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy
    Antioxid Redox Signal 7:446-55. 2005
    ..Overall results suggest that activation of NF-kappaB and Hsp could allow cell adaptation and survival under exhaustive GSH depletion...
  63. doi request reprint trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Biochem Pharmacol 77:337-47. 2009
    ..We demonstrate that this property is not due to its antioxidant capacity but rather due to a specific inhibition of ERK1/2 phosphorylation by MEK1/2 and repression of c-Jun activation...
  64. ncbi request reprint Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP kinase pathway
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    FASEB J 17:64-6. 2003
    ..Results suggest that kinase cascade may serve as a primary transducer of cytoplasmic oxidative signals to the nucleus before apoptosis-inducing signals are activated...
  65. ncbi request reprint Activity of protein phosphatase calcineurin is decreased in sporadic and familial amyotrophic lateral sclerosispatients
    Alberto Ferri
    Ist di Neuroscienze CNR, Sez Psicobiologia e Psicofarmacologia, Rome, Italy
    J Neurochem 90:1237-42. 2004
    ..These data confirm that modification of calcineurin activity and possibly of calcineurin-mediated pathways of signal transduction (including modulation of apoptotic neuronal death) may contribute to the pathogenesis of ALS...
  66. ncbi request reprint Electron spin resonance characterization of the radicals produced by enzymatic or chemical cleavage of vicine
    J Z Pedersen
    Department of Biology, Tor Vergata University of Rome, Via O. Raimondo, 001 73 Rome, Italy
    Biochemistry 27:8534-6. 1988
    ....
  67. pmc Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
    Katia Aquilano
    Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 285:21590-9. 2010
    ..Finally, this work adds new knowledge on the function of SIRT1 and PGC-1alpha and highlights the direct involvement of such proteins in regulation of mitochondrial biogenesis...
  68. ncbi request reprint Isatin-Schiff base copper(II) complexes and their influence on cellular viability
    Giselle Cerchiaro
    Departamento de Quimica Fundamental, Instituto de Quimica, Universidade de Sao Paulo, P O Box 26077, CEP 05513 970, Sao Paulo, SP, Brazil
    J Inorg Biochem 99:1433-40. 2005
    ..Therefore, the results indicated that their activity seems to be cell type specific...
  69. pmc Regulatory and structural differences in the Cu,Zn-superoxide dismutases of Salmonella enterica and their significance for virulence
    Serena Ammendola
    Dipartimento di Biologia, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Biol Chem 283:13688-99. 2008
    ..Our observations demonstrate that differences in expression, activity, and stability help to account for the unique contribution of the bacteriophage-encoded SodCI enzyme to Salmonella virulence...
  70. ncbi request reprint Periplasmic competition for zinc uptake between the metallochaperone ZnuA and Cu,Zn superoxide dismutase
    Giovanni Berducci
    Dipartimento di Biologia, Universita di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    FEBS Lett 569:289-92. 2004
    ..The effective ZnuA ability to sequester the available zinc ions from the periplasm suggests that zinc-containing cytoplasmic proteins are more important for bacterial viability than the periplasmic ones...
  71. ncbi request reprint Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site
    Laura Spagnolo
    Structural Biology Laboratory, ELETTRA, Sincrotrone Trieste, Italy
    J Biol Chem 279:33447-55. 2004
    ....
  72. ncbi request reprint Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide
    Giuseppe Filomeni
    Department of Biomedical Sciences, University of Chieti G D Annunzio via dei Vestini, 66013 Chieti, Italy
    Cancer Res 63:5940-9. 2003
    ....
  73. ncbi request reprint Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells
    Paolo Mondola
    Dipartimento di Neuroscienze e Scienze del Comportamento, Sezione di Fisiologia, Universita Degli Studi Di Napoli, Federico II, Via S Pansini, 5, 80131 Naples, Italy
    Biochem Biophys Res Commun 295:603-9. 2002
    ....
  74. ncbi request reprint Differential contribution of sodC1 and sodC2 to intracellular survival and pathogenicity of Salmonella enterica serovar Choleraesuis
    Serena Ammendola
    Dipartimento di Biologia, Universita di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Microbes Infect 7:698-707. 2005
    ..enterica serovar Typhimurium and suggest that the relative contributions of sodC1 and sodC2 to host-pathogen interactive biology may vary depending on the Salmonella serovar or strain...
  75. ncbi request reprint Resistance to striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice expressing human mutant Cu,Zn superoxide dismutase
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Neurosci Lett 325:124-8. 2002
    ..Our results indicate that overexpression of both wild-type and human mutant SOD1 induces comparable neuroprotective effects against striatal dopaminergic depletion...
  76. ncbi request reprint Distinctive functional features in prokaryotic and eukaryotic Cu,Zn superoxide dismutases
    Roberta Gabbianelli
    Servizio Biologico, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Biol Chem 385:749-54. 2004
    ..We suggest that differences between individual bacterial variants could be due to the influence of modifications at the dimer interface on the enzyme conformational flexibility...
  77. ncbi request reprint Analysis of Cu,ZnSOD conformational stability by differential scanning calorimetry
    Maria Carmela Bonaccorsi di Patti
    Department of Biochemical Sciences A Rossi Fanelli, University of Rome La Sapienza, 00185 Rome, Italy
    Methods Enzymol 349:49-61. 2002
  78. ncbi request reprint Superoxide dismutase 1 modulates expression of transferrin receptor
    Ruth Danzeisen
    Department of Neurology, University of Ulm, Ulm, Germany
    J Biol Inorg Chem 11:489-98. 2006
    ..We propose that changes in superoxide levels due to alteration of SOD1 activity affect iron metabolism in glial and neuronal cells from higher eukaryotes and that this may be relevant to diseases of the nervous system...
  79. ncbi request reprint Influenza A virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2
    Lucia Nencioni
    Department of Experimental Medicine and Biochemical Science, University of Rome La Sapienza, Italy
    FASEB J 17:758-60. 2003
    ..In certain cell populations, this form of down-regulation might conceivably favor the establishment of persistent viral infection...
  80. ncbi request reprint Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells
    Annamaria Biroccio
    Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Via delle Messi d oro, 00158 Rome, Italy
    J Biol Chem 277:43763-70. 2002
    ..The addition of N-acetyl-l-cysteine or glutathione ethyl ester inhibited the apoptotic process, thus confirming the key role of glutathione in programmed cell death induced by c-Myc...