Vittorio Rosti

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. doi request reprint Spleen endothelial cells from patients with myelofibrosis harbor the JAK2V617F mutation
    Vittorio Rosti
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo Foundation, Viale Golgi 19, Pavia, Italy
    Blood 121:360-8. 2013
  2. pmc Cell fusion in tumor progression: the isolation of cell fusion products by physical methods
    Filippo Pedrazzoli
    Department of Internal Medicine IRCCS Policlinico San Matteo, Viale Golgi 19, Pavia 27100 Italy and University of Pavia, Strada Nuova, Pavia 27100 Italy
    Cancer Cell Int 11:32. 2011
  3. doi request reprint Canonical transient receptor potential 3 channel triggers vascular endothelial growth factor-induced intracellular Ca2+ oscillations in endothelial progenitor cells isolated from umbilical cord blood
    Silvia Dragoni
    1 Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    Stem Cells Dev 22:2561-80. 2013
  4. pmc JAK2 V617F genotype is a strong determinant of blast transformation in primary myelofibrosis
    Giovanni Barosi
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    PLoS ONE 8:e59791. 2013
  5. pmc Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients
    Francesco Lodola
    Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    PLoS ONE 7:e42541. 2012
  6. pmc Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis
    Stefania Badalucco
    Biotechnology Laboratories, Department of Molecular Medicine, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
    Haematologica 98:514-7. 2013
  7. ncbi request reprint JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
    Giovanni Barosi
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    Blood 110:4030-6. 2007
  8. pmc A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation
    Valentina Poletto
    Unit of Clinical Epidemiology, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    Blood 120:3112-7. 2012
  9. pmc Evidence that prefibrotic myelofibrosis is aligned along a clinical and biological continuum featuring primary myelofibrosis
    Giovanni Barosi
    Laboratory of Clinical Epidemiology and Centre for the Study of Myelofibrosis, IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    PLoS ONE 7:e35631. 2012
  10. doi request reprint Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration
    Silvia Dragoni
    Department of Physiology, University of Pavia, Pavia, Italy
    Stem Cells 29:1898-907. 2011

Collaborators

Detail Information

Publications28

  1. doi request reprint Spleen endothelial cells from patients with myelofibrosis harbor the JAK2V617F mutation
    Vittorio Rosti
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico San Matteo Foundation, Viale Golgi 19, Pavia, Italy
    Blood 121:360-8. 2013
    ..In conclusion, we provide evidence that some ECs from the spleen and splenic veins of patients with MF bear the JAK2V617F mutation. We suggest that splenic ECs are involved in the process of malignant transformation in MF...
  2. pmc Cell fusion in tumor progression: the isolation of cell fusion products by physical methods
    Filippo Pedrazzoli
    Department of Internal Medicine IRCCS Policlinico San Matteo, Viale Golgi 19, Pavia 27100 Italy and University of Pavia, Strada Nuova, Pavia 27100 Italy
    Cancer Cell Int 11:32. 2011
    ..abstract:..
  3. doi request reprint Canonical transient receptor potential 3 channel triggers vascular endothelial growth factor-induced intracellular Ca2+ oscillations in endothelial progenitor cells isolated from umbilical cord blood
    Silvia Dragoni
    1 Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    Stem Cells Dev 22:2561-80. 2013
    ..Therefore, the Ca(2+) response to VEGF in UCB-ECFCs is shaped by a different Ca(2+) machinery as compared with PB-ECFCs, and TRPC3 stands out as a promising target in EPC-based treatment of ischemic pathologies. ..
  4. pmc JAK2 V617F genotype is a strong determinant of blast transformation in primary myelofibrosis
    Giovanni Barosi
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    PLoS ONE 8:e59791. 2013
    ..In a large cohort of patients we applied competing risks analysis for studying the influence of JAK2V617F mutation on BT in PMF...
  5. pmc Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients
    Francesco Lodola
    Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    PLoS ONE 7:e42541. 2012
    ..As oncogenesis may be associated to the capability of tumor cells to grow independently on Ca(2+) influx, it is important to assess whether SOCE regulates EPC-dependent angiogenesis also in tumor patients...
  6. pmc Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis
    Stefania Badalucco
    Biotechnology Laboratories, Department of Molecular Medicine, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
    Haematologica 98:514-7. 2013
    ..Despite the increase in Transforming Growth Factor β1 this mechanism seems to be preserved in primary myelofibrosis...
  7. ncbi request reprint JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
    Giovanni Barosi
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    Blood 110:4030-6. 2007
    ..We conclude that JAK2 V617F genotype should be considered in any future risk stratification of patients with PMF...
  8. pmc A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation
    Valentina Poletto
    Unit of Clinical Epidemiology, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    Blood 120:3112-7. 2012
    ..3; P = .006). In conclusion, the glucocorticoid receptor A3669G is a susceptibility allele for PMF: it contributes to confer the phenotype of excess myeloproliferation, and it cooperates with the JAK2V617F mutation in determining BT...
  9. pmc Evidence that prefibrotic myelofibrosis is aligned along a clinical and biological continuum featuring primary myelofibrosis
    Giovanni Barosi
    Laboratory of Clinical Epidemiology and Centre for the Study of Myelofibrosis, IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    PLoS ONE 7:e35631. 2012
    ..In the WHO diagnostic classification, prefibrotic myelofibrosis (pre-MF) is included in the category of primary myelofibrosis (PMF). However, strong evidence for this position is lacking...
  10. doi request reprint Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration
    Silvia Dragoni
    Department of Physiology, University of Pavia, Pavia, Italy
    Stem Cells 29:1898-907. 2011
    ..This novel signaling pathway might be exploited to enhance the outcome of CBT and chemotherapy...
  11. ncbi request reprint Ca2+ signalling in endothelial progenitor cells: a novel means to improve cell-based therapy and impair tumour vascularisation
    Francesco Moccia
    Department of Physiology, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy
    Curr Vasc Pharmacol 12:87-105. 2014
    ..For example, genetic manipulation of the Ca(2+) signalling machinery could provide a novel approach to increase the extent of limb regeneration or preventing tumour vascularisation by EPCs. ..
  12. pmc High frequency of endothelial colony forming cells marks a non-active myeloproliferative neoplasm with high risk of splanchnic vein thrombosis
    Vittorio Rosti
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    PLoS ONE 5:e15277. 2010
    ..Due to inherent performance limitations of ECFCs assay, there is an urgent need to arrive to an acceptable standardization of ECFC assessment...
  13. doi request reprint Management of myeloproliferative neoplasms: from academic guidelines to clinical practice
    Giovanni Barosi
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, IRCCS Policlinico S Matteo Foundation, Viale Golgi 19, Pavia, Italy
    Curr Hematol Malig Rep 7:50-6. 2012
    ..Allogeneic stem cell transplantation remains the only potentially curative approach...
  14. doi request reprint Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors
    Rosangela Invernizzi
    Department of Internal Medicine, University of Pavia Medical School and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Br J Haematol 161:726-37. 2013
    ..In conclusion, experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis...
  15. pmc Enhanced expression of Stim, Orai, and TRPC transcripts and proteins in endothelial progenitor cells isolated from patients with primary myelofibrosis
    Silvia Dragoni
    Laboratory of General Physioloy, Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy
    PLoS ONE 9:e91099. 2014
    ..SOCE is up-regulated in RCC-ECFCs due to the over-expression of its underlying molecular components, namely Stim1, Orai1, and TRPC1...
  16. doi request reprint High-dose erythropoietin in patients with acute myocardial infarction: a pilot, randomised, placebo-controlled study
    Maurizio Ferrario
    Cardiology Department, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Int J Cardiol 147:124-31. 2011
    ..Mortality and morbidity after acute myocardial infarction (AMI) remain high even when myocardial reperfusion is successful. Erythropoietin (EPO) protects against experimental MI...
  17. ncbi request reprint Orai1 and Transient Receptor Potential Channels as Novel Molecular Targets to Impair Tumor Neovascularization in Renal Cell Carcinoma and other Malignancies
    Francesco Moccia
    Laboratory of Physiology, Department of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Via Forlanini 6, 27100, Pavia, Italy
    Anticancer Agents Med Chem 14:296-312. 2014
    ..As a consequence, TRP channels and Orai1 might serve as novel molecular targets to develop alternative and more effective strategies of angiogenesis inhibition. ..
  18. pmc In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes
    Alessandra Balduini
    Department of Biochemistry, University of Pavia, Pavia, Italy
    PLoS ONE 6:e21015. 2011
    ..Although the pathogenesis of MPNs is still incompletely understood, an involvement of the megakaryocyte lineage is a distinctive feature...
  19. ncbi request reprint The expression of CXCR4 is down-regulated on the CD34+ cells of patients with myelofibrosis with myeloid metaplasia
    Vittorio Rosti
    Transplant Research Area, IRCCS Policlinico S Matteo, Viale Golgi 19, 27100 Pavia, Italy
    Blood Cells Mol Dis 38:280-6. 2007
    ..We studied the expression of the chemokine receptor CXCR4 on circulating CD34+ cells of patients with myelofibrosis with myeloid metaplasia (MMM), and examined its relationship to the severity of disease...
  20. doi request reprint Therapeutic approaches in myelofibrosis
    Giovanni Barosi
    IRCCS Policlinico S Matteo Foundation, Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Viale Golgi 19, 27100 Pavia, Italy
    Expert Opin Pharmacother 12:1597-611. 2011
    ..The discovery that a gain-of-function mutation of JAK2 (JAK2V617F) is present in more than 60% of patients with MPN-associated myelofibrosis has provided a new target for innovative treatment strategies...
  21. doi request reprint Store-operated Ca(2+) entry is expressed in human endothelial progenitor cells
    Yuly Sánchez-Hernández
    Department of Physiology, University of Pavia, Pavia, Italy
    Stem Cells Dev 19:1967-81. 2010
    ..These findings provide the first evidence that EPCs express SOCE, which might thus be regarded as a novel target to enhance the regenerative outcome of cell-based therapy...
  22. doi request reprint Novel strategies for patients with chronic myeloproliferative disorders
    Giovanni Barosi
    Unit of Clinical Epidemiology and Center for the Study of Myelofibrosis, Pavia, Italy
    Curr Opin Hematol 16:129-34. 2009
    ..This review focuses on new strategies for unmet clinical needs and on new targeted therapies in classical Philadelphia-negative myeloproliferative neoplasms...
  23. ncbi request reprint Altered expression of adhesion receptors after ex vivo short-term expansion of primitive progenitor cell
    Vittorio Rosti
    Laboratory of Organ Transplantation, IRCCS Policlinico San Matteo, Pavia, Italy
    Haematologica 90:433. 2005
  24. ncbi request reprint Modulation of in vitro hematopoieisis by a hemangiopoietin-expressing stromal cell line
    Vittorio Rosti
    Laboratory of Organ Transplantation, IRCCS Policlinico San Matteo, Pavia, Italy
    Haematologica 90:145. 2005
  25. ncbi request reprint Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction
    Margherita Massa
    Biotechnology Laboratory, Department of Cardiology, Internal Medicine and Mecical Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    Blood 105:199-206. 2005
    ..05). No significant difference was documented between patients with SA and CTRLs. Spontaneous mobilization of both HPCs and EPCs occurs within a few hours from the onset of AMI and is detectable until 2 months...
  26. doi request reprint From cancer patients to cancer survivors: the issue of Cardioncology--a biological perspective
    Alberto Zambelli
    Fondazione IRCCS Salvatore Maugeri, Pavia, Italy
    Eur J Cancer 46:697-702. 2010
    ....
  27. ncbi request reprint Biological and clinical relevance of matrix metalloproteinases 2 and 9 in acute myeloid leukaemias and myelodysplastic syndromes
    Erica Travaglino
    Department of Internal Medicine, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Eur J Haematol 80:216-26. 2008
    ..In MDS, the detection of MMP deregulated expression may be important also from the clinical point of view: it may provide a useful tool for diagnosis, prognosis and a possible target for experimental treatments...
  28. doi request reprint The strange case of the lost NRAS mutation in a child with juvenile myelomonocytic leukemia
    Paola De Filippi
    Genetica Medica, Universita degli Studi di Pavia, Pavia, Italy
    Pediatr Blood Cancer 59:580-2. 2012
    ..This case also indicates that molecular analysis on cell types other than peripheral blood leukocytes may be useful to obtain relevant biological information on JMML pathogenesis...