Research Topics
| Gian Paolo RossiniSummaryAffiliation: University of Modena and Reggio Emilia Country: Italy Publications
| Collaborators
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Detail Information
Publications
Phycotoxins: chemistry, mechanisms of action and shellfish poisoningGian Paolo Rossini
Universita di Modena e Reggio Emilia, Dipartimento di Scienze Biomediche, Italy
EXS 100:65-122. 2010..Based on recorded symptoms, the major poisonings recognized so far include paralytic, neurotoxic, amnesic, diarrheic shellfish poisonings, ciguatera, as well as palytoxin and azaspiracid poisonings...- Addendum to "A cytolytic assay for the measurement of palytoxin based on a cultured monolayer cell line" [Anal. Biochem. 374 (2008) 48-55]Mirella Bellocci
Dipartimento di Scienze Biomediche, , Via Campi 287, 1-41100 Modena, Italy
Anal Biochem 381:178. 2008 
Azaspiracid-1 inhibits endocytosis of plasma membrane proteins in epithelial cellsMirella Bellocci
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Modena, Italy
Toxicol Sci 117:109-21. 2010..The effects of AZA-1 on the E-cadherin system were confirmed in Caco-2 and Madin Darby canine kidney epithelial cell lines. We conclude that AZA-1 inhibits endocytosis of plasma membrane proteins in epithelial cells...- Yessotoxin inhibits the complete degradation of E-cadherinFederica Callegari
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, via G Campi 287, I 41100 Modena, Italy
Toxicology 244:133-44. 2008..These findings reconcile the apparent contradictions of previous studies, showing that YTX does not promote E-cadherin degradation per se, but interferes with its complete disposal... - Yessotoxin induces the accumulation of altered E-cadherin dimers that are not part of adhesive structures in intact cellsGiuseppe Ronzitti
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Via Campi 287, I 41100 Modena, Italy
Toxicology 244:145-56. 2008..ECRA100 heterodimers that are not participating to cell adhesive structures but are located in other membranous fractions of intact cells... - Protein markers of algal toxin contamination in shellfishGiuseppe Ronzitti
Universita di Modena e Reggio Emilia, Dipartimento di Scienze Biomediche, via G Campi 287, I 41100 Modena, Italy
Toxicon 52:705-13. 2008.... - Proteomic analysis reveals multiple patterns of response in cells exposed to a toxin mixtureGian Luca Sala
Centro Interdisciplinare di Scienze e Tecnologie per la Qualità e Sicurezza degli Alimenti, Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, I 41100 Modena, Italy
Chem Res Toxicol 22:1077-85. 2009..Multiple patterns of responses to the toxin mixture were recorded in the two sets, consisting of both independent and interacting actions, among which we detected synergistic, similar, and antagonistic effects... - The cytotoxic pathway triggered by palytoxin involves a change in the cellular pool of stress response proteinsGian Luca Sala
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, via G Campi 287, I 41125 Modena, Italy, Italy
Chem Res Toxicol 22:2009-16. 2009.... - Palytoxin induces cell lysis by priming a two-step process in mcf-7 cellsSimone Prandi
Dipartimento di Scienze Biomediche, Università di Modena e Reggio Emilia, Via Campi 287, I 41125 Modena, Italy
Chem Res Toxicol 24:1283-96. 2011..A model of the two-step process of PlTX-induced cytolysis is presented... - Azaspiracid-1 inhibits the maturation of cathepsin D in mammalian cellsGian Luca Sala
Dipartimento di Scienze della Vita, Universita di Modena e Reggio Emilia, Via Campi 287, Modena, Italy
Chem Res Toxicol 26:444-55. 2013..The data we obtained corroborated our hypothesis and provide a unified molecular frame for the mode of action of AZAs in animal models, involving a primary alteration of endocytic processes... - Palytoxin action on the Na(+),K(+)-ATPase and the disruption of ion equilibria in biological systemsGian Paolo Rossini
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, via G Campi 287, I 41125 Modena, Italy
Toxicon 57:429-39. 2011.... - The total activity of a mixture of okadaic acid-group compounds can be calculated by those of individual analogues in a phosphoprotein phosphatase 2A assayClara Albano
Universita di Modena e Reggio Emilia, Dipartimento di Scienze Biomediche, Via Campi 287, 1 41100 Modena, Italy
Toxicon 53:631-7. 2009..Our findings show that an additive model based on the use of toxicity equivalence factors of individual toxins is appropriate for the calculation of the total activity of multi-component mixtures of OA-group compounds in unknown samples... - A cytolytic assay for the measurement of palytoxin based on a cultured monolayer cell lineMirella Bellocci
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, I 41100 Modena, Italy
Anal Biochem 374:48-55. 2008..We conclude that our cytolytic assay based on the use of MCF-7 cell monolayers is a viable alternative to animal-based methods for the determination of palytoxin and its congeners in contaminated materials... - Azaspiracid-1 alters the E-cadherin pool in epithelial cellsGiuseppe Ronzitti
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, I 41100 Modena, Italy
Toxicol Sci 95:427-35. 2007..The possibility that azaspiracids and YTXs might share their molecular mechanism(s) of action in defined biological settings should be considered...