Gian Paolo D Rossi

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi Primary aldosteronism: part II: subtype differentiation and treatment
    G P Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padua, Padua Italy
    J Nephrol 21:455-62. 2008
  2. ncbi Prospective appraisal of the prevalence of primary aldosteronism in hypertensive patients presenting with atrial flutter or fibrillation (PAPPHY Study): rationale and study design
    G P Rossi
    Department of Medicine DIMED, Internal Medicine 4, University of Padua, Padua, Italy
    J Hum Hypertens 27:158-63. 2013
  3. ncbi Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma
    Giacomo Rossitto
    Department of Medicine DIMED, Internal Medicine 4, Padua University School of Medicine, Padova, Italy
    Hypertension 61:526-33. 2013
  4. ncbi Somatic mutations in the KCNJ5 gene raise the lateralization index: implications for the diagnosis of primary aldosteronism by adrenal vein sampling
    Teresa M Seccia
    Internal Medicine 4, Department of Medicine DIMED, University of Padua, 35126 Padua, Italy
    J Clin Endocrinol Metab 97:E2307-13. 2012
  5. ncbi The Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS) study: rationale and study design
    G P Rossi
    Department of DMCS Internal Medicine 4, Padova, Italy
    J Hum Hypertens 26:507-16. 2012
  6. ncbi Hyperparathyroidism can be useful in the identification of primary aldosteronism due to aldosterone-producing adenoma
    Gian Paolo Rossi
    Department of Medicine DIMED, Internal Medicine 4, University Hospital, Via Giustiniani 2, 35126 Padova, Italy
    Hypertension 60:431-6. 2012
  7. ncbi The Adrenal Vein Sampling International Study (AVIS) for identifying the major subtypes of primary aldosteronism
    Gian Paolo Rossi
    University of Padova, Department of Medicine DIMED Internal Medicine 4, Padova, 35128 Italy
    J Clin Endocrinol Metab 97:1606-14. 2012
  8. ncbi Drug-related hypertension and resistance to antihypertensive treatment: a call for action
    Gian P Rossi
    Department of Clinical and Experimental Medicine, Gino Patrassi Internal Medicine 4 University Hospital, Padua, Italy
    J Hypertens 29:2295-309. 2011
  9. ncbi PLCβ1-SHP-2 complex, PLCβ1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling?
    Lorenzo A Calo
    Department of Clinical and Experimental Medicine, Clinica Medica University of Padova, School of Medicine, Italy
    J Biomed Sci 18:38. 2011
  10. ncbi Aldosterone breakthrough during RAS blockade: a role for endothelins and their antagonists?
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University Hospital, Via Giustiniani, 2, 35126 Padova, Italy
    Curr Hypertens Rep 8:262-8. 2006

Collaborators

Detail Information

Publications90

  1. ncbi Primary aldosteronism: part II: subtype differentiation and treatment
    G P Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padua, Padua Italy
    J Nephrol 21:455-62. 2008
    ..Clinical usefulness and accuracy of adrenal vein sampling, imaging tests (e.g., computed tomography and magnetic resonance) and mineralocorticoid adrenocortical scintigraphy are discussed in detail...
  2. ncbi Prospective appraisal of the prevalence of primary aldosteronism in hypertensive patients presenting with atrial flutter or fibrillation (PAPPHY Study): rationale and study design
    G P Rossi
    Department of Medicine DIMED, Internal Medicine 4, University of Padua, Padua, Italy
    J Hum Hypertens 27:158-63. 2013
    ..The hormonal values and ARR will be compared within patient between AFF and sinus rhythm. Organ damage, cardiovascular events and recurrence of AFF will also be assessed during follow-up in patients with PA...
  3. ncbi Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary aldosteronism as a result of aldosterone-producing adenoma
    Giacomo Rossitto
    Department of Medicine DIMED, Internal Medicine 4, Padua University School of Medicine, Padova, Italy
    Hypertension 61:526-33. 2013
    ..Thus, a higher serum AT1AA titer in patients with APA than in IHA and PH patients can be useful in differentiating APA patients from either PH or IHA, and thus in selecting PA patients to be submitted to adrenal vein sampling...
  4. ncbi Somatic mutations in the KCNJ5 gene raise the lateralization index: implications for the diagnosis of primary aldosteronism by adrenal vein sampling
    Teresa M Seccia
    Internal Medicine 4, Department of Medicine DIMED, University of Padua, 35126 Padua, Italy
    J Clin Endocrinol Metab 97:E2307-13. 2012
    ..Somatic mutations in the selectivity filter of KCNJ5 K(+) channel were found to be associated with higher plasma aldosterone concentrations in the patients with an aldosterone-producing adenoma (APA)...
  5. ncbi The Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS) study: rationale and study design
    G P Rossi
    Department of DMCS Internal Medicine 4, Padova, Italy
    J Hum Hypertens 26:507-16. 2012
    ..Primary experimental endpoint will be the GFR of the ischemic kidney, assessed as quantitative variable by 99TcDTPA, and the loss of ischemic kidney defined as a categorical variable...
  6. ncbi Hyperparathyroidism can be useful in the identification of primary aldosteronism due to aldosterone-producing adenoma
    Gian Paolo Rossi
    Department of Medicine DIMED, Internal Medicine 4, University Hospital, Via Giustiniani 2, 35126 Padova, Italy
    Hypertension 60:431-6. 2012
    ..Hence, these findings indicate that raised serum parathyroid hormone levels are a feature of APA that can be useful for selecting the PA patients to be submitted to adrenal vein sampling...
  7. ncbi The Adrenal Vein Sampling International Study (AVIS) for identifying the major subtypes of primary aldosteronism
    Gian Paolo Rossi
    University of Padova, Department of Medicine DIMED Internal Medicine 4, Padova, 35128 Italy
    J Clin Endocrinol Metab 97:1606-14. 2012
    ....
  8. ncbi Drug-related hypertension and resistance to antihypertensive treatment: a call for action
    Gian P Rossi
    Department of Clinical and Experimental Medicine, Gino Patrassi Internal Medicine 4 University Hospital, Padua, Italy
    J Hypertens 29:2295-309. 2011
    ..The strategy for selecting the most appropriate treatment and the reasons for 'a call of action' of research in this area are also examined...
  9. ncbi PLCβ1-SHP-2 complex, PLCβ1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling?
    Lorenzo A Calo
    Department of Clinical and Experimental Medicine, Clinica Medica University of Padova, School of Medicine, Italy
    J Biomed Sci 18:38. 2011
    ..SHP-2 is one such important PTP that also functions as an adaptor to promote downstream signaling pathway. Its role in Ang II signaling remains to be clarified...
  10. ncbi Aldosterone breakthrough during RAS blockade: a role for endothelins and their antagonists?
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University Hospital, Via Giustiniani, 2, 35126 Padova, Italy
    Curr Hypertens Rep 8:262-8. 2006
    ..Therefore, findings suggesting a role for the ET-1 system as an aldosterone secretagogue, along with the potential usefulness of endothelin antagonists for the prevention of "aldosterone breakthrough," are discussed...
  11. ncbi Clinical use of laboratory tests for the identification of secondary forms of arterial hypertension
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
    Crit Rev Clin Lab Sci 44:1-85. 2007
    ..Finally, the tests for diagnosing some rarer monogenic forms and other renal and endocrine causes of arterial hypertension are explored...
  12. ncbi New concepts in adrenal vein sampling for aldosterone in the diagnosis of primary aldosteronism
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Internal Medicine 4, University Hospital, Via Giustiniani, 2, Padova, Italy
    Curr Hypertens Rep 9:90-7. 2007
    ..The criteria for selecting patients to undergo AVS, the technique for performing AVS, and the criteria for analyzing and interpreting its results are summarized here...
  13. ncbi Prospective evaluation of the saline infusion test for excluding primary aldosteronism due to aldosterone-producing adenoma
    Gian Paolo Rossi
    DMCS Clinica Medica 4, University Hospital, Padova, Italy
    J Hypertens 25:1433-42. 2007
    ..Data on the performance of the tests used to confirm the diagnosis of primary aldosteronism (PA) are limited...
  14. ncbi Surgically correctable hypertension caused by primary aldosteronism
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, University of Padova, Via Giustiniani 2, 35126 Padova, Italy
    Best Pract Res Clin Endocrinol Metab 20:385-400. 2006
    ....
  15. ncbi Tissue kallikrein gene polymorphisms induce no change in endothelium-dependent or independent vasodilation in hypertensive and normotensive subjects
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University of Padova, Padova, Italy
    J Hypertens 24:1955-63. 2006
    ....
  16. ncbi Genetic variation in the endothelin system: do polymorphisms affect the therapeutic strategies?
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1069:34-50. 2006
    ..Thus, even though ET antagonists are being used for the treatment of pulmonary hypertension, there is no convincing evidence for a role of SNPs in affecting the therapeutic strategies...
  17. ncbi Renal damage in primary aldosteronism: results of the PAPY Study
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, Via Giustiniani, 2, 35126 Padova, Italy
    Hypertension 48:232-8. 2006
    ..Thus, hypertension because of excess autonomous aldosterone secretion features an early and more prominent renal damage than PH...
  18. ncbi Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    Int J Mol Med 17:975-80. 2006
    ..This novel finding suggests that adiponectin could play a regulatory role in adrenocortical function and growth in humans...
  19. ncbi Hyperhomocysteinemia predicts total and cardiovascular mortality in high-risk women
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Internal Medicine 4, University Hospital, Padua, Italy
    J Hypertens 24:851-9. 2006
    ....
  20. ncbi Dynamic testing with high-dose adrenocorticotrophic hormone does not improve lateralization of aldosterone oversecretion in primary aldosteronism patients
    Gian Paolo Rossi
    DMCS Internal Medicine 4 bInstitute of Radiology, Legnano, Italy
    J Hypertens 24:371-9. 2006
    ..We, therefore, prospectively investigated the usefulness of AVS with dynamic testing in primary aldosteronism (PA) patients...
  21. ncbi Homocysteine, left ventricular dysfunction and coronary artery disease: is there a link?
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine DMCS Internal Medicine 4, School of Medicine, University of Padua, Padua, Italy
    Clin Chem Lab Med 45:1645-51. 2007
    ..Thus, additional mechanistic investigation taking into consideration the effects of tHcy on LV function is necessary to further explore the potential therapeutic usefulness of tHcy lowering treatment in CAD...
  22. ncbi Primary aldosteronism: an update on screening, diagnosis and treatment
    Gian Paolo Rossi
    DMCS, Clinica Medica 4, Policlinico Universitario, Padova, Italy
    J Hypertens 26:613-21. 2008
    ..These two features, along with the fact that the arterial hypertension and the hypokalemia can be corrected with a timely diagnosis and an appropriate therapy, warrant an aggressive diagnostic approach in hypertensive patients...
  23. ncbi Vascular remodeling and duration of hypertension predict outcome of adrenalectomy in primary aldosteronism patients
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, University Hospital, University of Padova Medical School, Padova, Italy
    Hypertension 51:1366-71. 2008
    ....
  24. ncbi A comprehensive review of the clinical aspects of primary aldosteronism
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine DMCS Gino Patrassi, Internal Medicine 4, Policlinico Universitario, Via Giustiniani 2, 35126 Padova, Italy
    Nat Rev Endocrinol 7:485-95. 2011
    ..In some subgroups of patients with hypertension who are at high risk of primary aldosteronism or can benefit most from an accurate diagnosis, an aggressive diagnostic approach is necessary...
  25. ncbi Diagnosis and treatment of primary aldosteronism
    Gian Paolo Rossi
    Molecular Hypertension Laboratory, Dipartimento di Medicina Clinica e Sperimentale G Patrassi Internal Medicine 4, University of Padua, University Hospital Padua, Via Giustiniani, 2, 35126 Padua, Italy
    Endocrinol Metab Clin North Am 40:313-32, vii-viii. 2011
    ....
  26. ncbi Evidence-based management of hypertension
    Gp Rossi
    University of Padua, DMCS Internal Medicine 4, University Hospital, 31526 Padova, Italy
    Future Cardiol 7:161-2. 2011
    ....
  27. ncbi Diagnosis and treatment of primary aldosteronism
    Gian Paolo D Rossi
    DMCS Gino Patrassi Clinica Medica 4, University of Padua, Padua, Italy
    Rev Endocr Metab Disord 12:27-36. 2011
    ..The purpose of this review is to provide up-dated information on the strategy for case detection, the subtype differentiation and the management of primary aldosteronism...
  28. ncbi The aldosterone-renin ratio based on the plasma renin activity and the direct renin assay for diagnosing aldosterone-producing adenoma
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University Hospital, Padova, Italy
    J Hypertens 28:1892-9. 2010
    ..A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains unclear...
  29. ncbi Prevalence and diagnosis of primary aldosteronism
    Gian Paolo Rossi
    DMCS Clinica Medica 4, Policlinico Universitario, Via Giustiniani 2, 35126, Padova, Italy
    Curr Hypertens Rep 12:342-8. 2010
    ..Therefore, an early diagnosis is crucial to achieve cure. This review discusses the implications of the high prevalence of PA for its diagnostic strategy...
  30. ncbi Secondary hypertension: the ways of management
    Gian P Rossi
    Department of Clinical and Experimental Medicine, Internal Medicine 4, University of Padova, Padova, Italy
    Curr Vasc Pharmacol 8:753-68. 2010
    ..Renovascular hypertension is also a common curable form of hypertension, which should be identified as early as possible to avoid the onset of cardiovascular target organ damage and events, is also discussed...
  31. ncbi Within-patient reproducibility of the aldosterone: renin ratio in primary aldosteronism
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University Hospital, Via Giustiniani 2, 35126 Padova, Italy
    Hypertension 55:83-9. 2010
    ..Hence, contrary to previously claimed poor reproducibility of the ARR, these data support its use for the screening of primary aldosteronism...
  32. ncbi Primary aldosteronism - part I: prevalence, screening, and selection of cases for adrenal vein sampling
    G P Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padua, Padua Italy
    J Nephrol 21:447-54. 2008
    ....
  33. ncbi Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients
    Gian Paolo Rossi
    DMCS Clinica Medica 4, University Hospital, Via Giustiniani 2, Padua, Italy
    J Clin Endocrinol Metab 93:2566-71. 2008
    ..Body mass index (BMI) shows a direct correlation with plasma aldosterone concentration (PAC) and urinary aldosterone excretion in normotensive individuals; whether the same applies to hypertensive patients is unknown...
  34. ncbi Adrenal vein sampling for primary aldosteronism: the assessment of selectivity and lateralization of aldosterone excess baseline and after adrenocorticotropic hormone (ACTH) stimulation
    Gian Paolo Rossi
    DMCS Clinica Medica 4, University Hospital, Via Giustiniani 2, 35126 Padova, Italy
    J Hypertens 26:989-97. 2008
    ..Adrenal vein sampling is crucial for identifying the primary aldosteronism subtypes, but the cutoff values for ascertaining selectivity of catheterization and lateralization of aldosterone secretion remain controversial...
  35. ncbi Eating the health of your endothelium: is it too early to say?
    Gian Paolo Rossi
    DMCS, Internal Medicine 4, University of Padova Medical School, Padova, Italy
    J Hypertens 24:259-61. 2006
  36. ncbi Comparison of the captopril and the saline infusion test for excluding aldosterone-producing adenoma
    Gian Paolo Rossi
    DMCS Internal Medicine 4, Padova, Italy
    Hypertension 50:424-31. 2007
    ..Thus, both the CAPT and the SAL are safe and moderately accurate for excluding APA; at a sodium intake >7.6 g per day, the SAL offers no advantage over the easier-to-perform CAPT...
  37. ncbi Primary aldosteronism: a needle in a haystack or a yellow cab on Fifth Avenue?
    Gian Paolo Rossi
    DMCS Clinica Medica 4, University Hospital, Via Giustiniani 2, 35126 Padua, Italy
    Curr Hypertens Rep 6:1-4. 2004
  38. ncbi Antibodies to oxidized low-density lipoproteins and angiographically assessed coronary artery disease in white patients
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, University of Padova, Italy
    Circulation 108:2467-72. 2003
    ..Thus, we aimed to investigate the association of antibodies with oxidized LDLs (oxLDL) (oxLDLAbs) with coronary artery disease (CAD) and acute coronary syndromes...
  39. ncbi The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Am Coll Cardiol 41:938-45. 2003
    ..We sought to investigate whether two polymorphisms located in the promoter (T(-786)C) and exon 7 (Glu298Asp) of the endothelial nitric oxide (NO) synthase (eNOS) gene affected agonists-mediated NO release...
  40. ncbi The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Am Coll Cardiol 41:930-7. 2003
    ..We investigated the association of polymorphisms in the promoter region and exon 7 endothelial nitric oxide synthase (eNOS) gene with coronary artery disease (CAD)...
  41. ncbi The endothelin-aldosterone axis and cardiovascular diseases
    G P Rossi
    Department of Clinical and Experimental Medicine, University of Padua Medical School, Italy
    J Cardiovasc Pharmacol 38:S49-52. 2001
    ..In this paper, we review the findings suggesting a relationship between activation of the ET-1 system, enhanced aldosterone secretion and cardiac fibrosis and discuss the implications of endothelin antagonism for cardiovascular disease...
  42. ncbi Dual ACE and NEP inhibitors: a review of the pharmacological properties of MDL 100240
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, University of Padova, Italy
    Cardiovasc Drug Rev 21:51-66. 2003
    ..If the promises of this novel therapeutic strategy are fulfilled, clinical trials are expected to demonstrate advantages of MDL 100240 over pure ACE inhibitors...
  43. ncbi Altered regulation of endothelin A receptor subtype in the cerebral arterioles in response to a Japanese-style diet, in stroke-prone hypertensive rats
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, University of Padua, Via Giustiniani 2, 35126 Padua, Italy
    J Hypertens 21:105-13. 2003
    ....
  44. ncbi Endothelin receptor blockade lowers plasma aldosterone levels via different mechanisms in primary aldosteronism and high-to-normal renin hypertension
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University Hospital, Via Giustiniani 2, 35126 Padova, Italy
    Cardiovasc Res 57:277-83. 2003
    ..In the rat this latter effect occurs via ET(B) receptors; in humans in vitro studies implicated both ET(A) and ET(B) receptors, but there is no conclusive evidence in vivo...
  45. ncbi Dual ACE and NEP inhibitor MDL-100,240 prevents and regresses severe angiotensin II-dependent hypertension partially through bradykinin type 2 receptor
    Gian Paolo Rossi
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    J Hypertens 20:1451-9. 2002
    ..To investigate the effects of the dual angiotensin-converting enzyme (ACE) + neutral endopeptidase (NEP) inhibitor, MDL-100,240 (MDL), on hypertension and cardiovascular damage in male heterozygous transgenic Ren2 rats...
  46. ncbi Excess aldosterone is associated with alterations of myocardial texture in primary aldosteronism
    Gian Paolo Rossi
    Cardiac and Thoracic Department, University of Pisa, Italy
    Hypertension 40:23-7. 2002
    ..PA is associated with alterations of myocardial textures that suggest increased collagen deposition and that can explain both the dependence of LV diastolic filling from presystole and the prolongation of the PQ interval...
  47. ncbi Aortic smooth muscle cell phenotypic modulation and fibrillar collagen deposition in angiotensin II-dependent hypertension
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padua, Via Giustiniani 2, Italy
    Cardiovasc Res 55:178-89. 2002
    ..We investigated the effect of nifedipine, AT-1 and ET-1 receptor blockade on arterial smooth muscle cell phenotypes and collagen deposition in TGRen2 transgenic rat (TGR)...
  48. ncbi Renal vein renin measurements accurately identify renovascular hypertension caused by total occlusion of the renal artery
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, University of Padua Medical School, Padua, Italy
    J Hypertens 20:975-84. 2002
    ..To assess the usefulness of indexes derived from renal vein renin measurements...
  49. ncbi Comparative effects of the dual ACE-NEP inhibitor MDL-100,240 and ramipril on hypertension and cardiovascular disease in endogenous angiotensin II-dependent hypertension
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine Clinica Medica 4, University of Padova, University Hospital, Italy
    Am J Hypertens 15:181-8. 2002
    ..Thus, severe hypertension and related CVD were regressed by MDL-100,240, which resulted to be as effective as a full dosage of ramipril in TGRen2...
  50. ncbi Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEP
    Damiano Rizzoni
    Department of Medical and Surgical Sciences, University of Brescia, DMCS Clinica Medica 4, University of Padua, Italy
    J Hypertens 22:759-66. 2004
    ....
  51. ncbi The role of adrenal venous sampling in the surgical management of primary aldosteronism
    Antonio Toniato
    Department of Medical Surgical Sciences, School of Medicine, University of Padua, Padua 35128, Italy
    World J Surg 30:624-7. 2006
    ..Identification of a unilateral overproduction of aldosterone due to Conn's adenoma or unilateral hyperplasia is of utmost importance to the surgeon...
  52. ncbi The T(-786)C endothelial nitric oxide synthase genotype predicts cardiovascular mortality in high-risk patients
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University of Padua, Padua, Italy
    J Am Coll Cardiol 48:1166-74. 2006
    ..This study sought to investigate the impact of a common T(-786)C single-nucleotide polymorphism (SNP) in the promoter of the endothelial nitric oxide synthase (eNOS, NOS3) gene on cardiovascular (CV) death in a prospective cohort study...
  53. ncbi Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts
    Michele Antonello
    Department of Vascular Surgery, University of Padova, Padova, Italy
    Am J Hypertens 20:1321-8. 2007
    ..We investigated the effect of green tea extract (GTE) in arterial hypertension with high oxidative stress. Angiotensin (Ang) II induces endothelial dysfunction (ED) that is crucial for the development of atherosclerosis and hypertension...
  54. ncbi Mechanisms transducing the aldosterone secretagogue signal of endothelins in the human adrenal cortex
    Paola G Andreis
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, I-35121, Padua, Italy
    Peptides 23:561-6. 2002
    ....
  55. ncbi Heritability of plasma adiponectin levels and body mass index in twins
    Maurizio Cesari
    Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padova, Italy
    J Clin Endocrinol Metab 92:3082-8. 2007
    ..Adiponectin is suspected to exert antiatherogenic, antiinflammatory, and insulin-sensitizing effects. However, the relative importance of the genetic and environmental factors in influencing plasma adiponectin levels (ADPN) remains unclear...
  56. ncbi Impact of accessory hepatic veins on adrenal vein sampling for identification of surgically curable primary aldosteronism
    Diego Miotto
    Department of Clinical and Experimental Medicine Clinica Medica 4, University Hospital, Via Giustiniani 2, Padua, Italy
    Hypertension 54:885-9. 2009
    ..In the presence of this anatomic variation, superselective catheterization of the right adrenal vein should be undertaken to determine the lateralization of aldosterone secretion...
  57. ncbi Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER Project
    Maurizio Castellano
    Dipartimento di Scienze Mediche e Chirurgiche, University of Brescia, c o 2Medicina, Spedali Civili, 25100 Brescia, Italy
    J Hypertens 21:1853-60. 2003
    ..To detect the association of single polymorphisms of the renin-angiotensin-aldosterone system (RAAS), or different combinations thereof, with hypertension...
  58. ncbi Up-regulation of the adrenomedullin system mediates hypotension and hypoaldosteronism induced by simulated microgravity
    Paola G Andreis
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 13:551-5. 2004
    ....
  59. ncbi Role of the endogenous adrenomedullin system in regulating the secretion and growth of rat adrenal cortex
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Hypertens Res 26:S85-92. 2003
    ....
  60. ncbi Adrenocorticotropic hormone stimulation during adrenal vein sampling for identifying surgically curable subtypes of primary aldosteronism: comparison of 3 different protocols
    Teresa M Seccia
    Department of Clinical and Experimental Medicine Internal Medicine 4, University of Padua School of Medicine, Padua, Italy
    Hypertension 53:761-6. 2009
    ..However, this favorable effect was overridden by a confounding effect on the identification of lateralized aldosterone excess to the aldosterone-producing adenoma side. Hence, we do not recommend adrenocorticotropic hormone stimulation...
  61. ncbi Ghrelin and growth hormone secretagogue receptor are expressed in the rat adrenal cortex: Evidence that ghrelin stimulates the growth, but not the secretory activity of adrenal cells
    Paola G Andreis
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
    FEBS Lett 536:173-9. 2003
    ....
  62. ncbi Role of angiotensin II, endothelin-1 and L-type calcium channel in the development of glomerular, tubulointerstitial and perivascular fibrosis
    Teresa M Seccia
    DMCS Internal Medicine 4, University of Padova, Padova, Italy
    J Hypertens 26:2022-9. 2008
    ....
  63. ncbi Expression and functional role of urotensin-II and its receptor in the adrenal cortex and medulla: novel insights for the pathophysiology of primary aldosteronism
    Luisa Giuliani
    Department of Clinical and Experimental Medicine, Internal Medicine 4, School of Medicine, University of Padua, Padua, Italy
    J Clin Endocrinol Metab 94:684-90. 2009
    ..The involvement of urotensin II, a vasoactive peptide acting via the G protein-coupled urotensin II receptor, in arterial hypertension remains contentious...
  64. ncbi Hyperhomocysteinemia is inversely related with left ventricular ejection fraction and predicts cardiovascular mortality in high-risk coronary artery disease hypertensives
    Maurizio Cesari
    DMCS Clinica Medica 4, University of Padova, Italy
    Arterioscler Thromb Vasc Biol 25:115-21. 2005
    ..CONCLUSIONS: In arterial hypertensive but not in normotensive patients, HHcy predicts cardiovascular mortality and a low LVEF, independent of CAD and history of myocardial infarction...
  65. ncbi Isolation of human adrenocortical aldosterone-producing cells by a novel immunomagnetic beads method
    Brasilina Caroccia
    Department of Clinical and Experimental Medicine, University of Padua, 35126 Padua, Italy
    Endocrinology 151:1375-80. 2010
    ..Hence, this novel methodology allows isolation of a pure population of ZG and APA cells exhibiting multiple characteristics of the aldosterone-producing cells...
  66. ncbi Under treatment with lipid-lowering drugs of high-risk coronary heart disease patients of the GENICA study
    Maurizio Cesari
    Department of Clinical and Experimental Medicine, University of Padova Medical School, Italy
    J Cardiovasc Pharmacol 42:484-90. 2003
    ..Accordingly, in the field of secondary prevention of coronary artery disease, the implementation of guidelines that emerged from scientific evidence into clinical practice with LLDT still requires major efforts...
  67. ncbi Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis
    Livia Lenzini
    Department of Experimental and Clinical Medicine DMCS Internal Medicine 4, School of Medicine, University of Padua, Padua, Italy
    Hypertension 50:1106-13. 2007
    ..Whether the molecular signature of APA carries prognostic information is worth further investigation...
  68. ncbi Primary aldosteronism: cardiovascular, renal and metabolic implications
    Gian Paolo Rossi
    DMCS Clinica Medica 4 and University of Padua, 35126, Padua, Italy
    Trends Endocrinol Metab 19:88-90. 2008
    ....
  69. ncbi Adrenomedullin, ANP and BNP are colocalized in a subset of endocrine cells in the rat heart
    Anna S Belloni
    Department of Human Anatomy and Physiology, School of Medicine, University of Padua, I-35121 Padova, Italy
    Int J Mol Med 15:567-71. 2005
    ..Taken together, our present findings support the hypothesis that these cells may represent a novel subset of endocrine cells, strategically located near blood vessels in the mammalian heart, where they can release vasoactive peptides...
  70. ncbi Identification of the mineralocorticoid receptor in human spermatozoa
    Cristina Fiore
    Department of Medical and Surgical Sciences Endocrinology, University of Padua, 35128 Padua, Italy
    Int J Mol Med 18:649-52. 2006
    ..Further studies should be performed in order to elucidate a possible physiological role of aldosterone in regulating electrolyte concentration, and the pro-oxidant effect of excess aldosterone in this new target tissue...
  71. ncbi Expression of telomerase (hTERT) in aldosterone-producing adrenocortical tumors
    Daniele Sticchi
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    Int J Mol Med 17:469-74. 2006
    ..In conclusion, RT-PCR measurement of hTERT mRNA is a hallmark of malignant adrenocortical tumors, but identifies also a subset of hTERT-expressing APAs that might show metastatic spread at long-term follow-up...
  72. ncbi Urotensin-II and UII-receptor expression and function in the rat adrenal cortex
    Giovanna Albertin
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, Italy
    Int J Mol Med 17:1111-5. 2006
    ....
  73. ncbi Is homocysteine important as risk factor for coronary heart disease?
    Maurizio Cesari
    Department of Clinical and Experimental Medicine, Clinica Medica 4, University of Padova, Padova, Italy
    Nutr Metab Cardiovasc Dis 15:140-7. 2005
    ....
  74. ncbi Biological properties of the angiotensin peptides other than angiotensin II: implications for hypertension and cardiovascular diseases
    Maurizio Cesari
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    J Hypertens 20:793-9. 2002
    ..Available knowledge on the pathways leading to synthesis and degradation of angiotensin fragments, as well as on their interactions with receptors and on their possible role in cardiovascular homeostasis and disease are reviewed...
  75. ncbi Urotensin-II and its receptor (UT-R) are expressed in rat brain endothelial cells, and urotensin-II via UT-R stimulates angiogenesis in vivo and in vitro
    Raffaella Spinazzi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 18:1107-12. 2006
    ..Collectively, our findings allow us to include UII in the group of cytokines (e.g. endothelin-1 and adrenomedullin), which are expressed in endothelial cells and exert a pro-angiogenic effect acting in an autocrine-paracrine manner...
  76. ncbi Identification and localization of adrenomedullin-storing cardiac mast cells
    Anna S Belloni
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 17:709-13. 2006
    ..Collectively, our findings provide evidence that at least a subset of cardiac mast cells are able to synthesize and store AM, and upon stimulation to release it near coronary arterioles and venules...
  77. ncbi Chromogranin a measurement for assessing the selectivity of adrenal venous sampling in primary aldosteronism
    Teresa M Seccia
    Clinical and Experimental Medicine DMCS Gino Patrassi Internal Medicine 4, University of Padua, 35126 Padova, Italy
    J Clin Endocrinol Metab 96:E825-9. 2011
    ..However, uncertainties remain on how to best achieve this goal...
  78. ncbi Clinical use and pathogenetic basis of laboratory tests for the evaluation of primary arterial hypertension
    Teresa M Seccia
    Department of Clinical Methodology and Medical-Surgical Technologies, University of Bari, Bari, Italy
    Crit Rev Clin Lab Sci 42:393-452. 2005
    ..Finally, a section is devoted to tests that are currently confined to research purposes, such as markers of endothelial function including endothelin-1, homocysteine and genetic analysis...
  79. ncbi The renal antifibrotic effects of angiotensin-converting enzyme inhibition involve bradykinin B2 receptor activation in angiotensin II-dependent hypertension
    Teresa M Seccia
    Department of Clinical Methodology, University of Bari, Italy
    J Hypertens 24:1419-27. 2006
    ..0001 versus placebo). CONCLUSION: Enhanced BK effect on B2 subtype receptors is essential for the prevention of tubulo-interstitial fibrosis with ACE or dual ACE + NEP inhibition in TGRen2 rats...
  80. ncbi Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn's syndrome with an ominous clinical course
    Teresa M Seccia
    Department of Clinical Methodology and Medical, Surgical Technologies, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    Endocr Relat Cancer 12:149-59. 2005
    ..We concluded that, although an ominous course with a poor survival rate is common, no sign accurately predicts the course of APAC. Thus, molecular studies to identify diagnostic markers of survival are mandatory...
  81. ncbi Cardiac consequences of aldosterone excess in human hypertension
    Gian Paolo Rossi
    Am J Hypertens 19:10-2. 2006
  82. ncbi Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension
    Hanspeter Brunner
    Division of Cardiology, University Hospital, Basel, Switzerland
    J Hypertens 23:233-46. 2005
    ..This paper will provide a concise overview of the mechanisms causing endothelial dysfunction in the different cardiovascular risk factors and disease conditions, and of the impact of the intervention measures and treatments...
  83. ncbi Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II
    Teresa M Seccia
    Department of Clinical Methodology and Clinical-Surgical Technologies, University of Bari, Bari, Italy
    J Am Coll Cardiol 41:666-73. 2003
    ..Only the latter treatment prevented both hypertension and LV hypertrophy. Thus, there is a dissociation between the mechanisms of cardiac fibrosis and hypertension, which do and do not entail ET-1, respectively...
  84. ncbi Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors
    Gian Paolo Rossi
    J Am Coll Cardiol 44:209; author reply 209-10. 2004
  85. ncbi More fuel to the debate on the "epidemics of primary aldosteronism"
    Gian Paolo Rossi
    Hypertension 51:e1-2; author reply e3. 2008
  86. ncbi A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients
    Gian Paolo Rossi
    For a list of author affiliations, please see the
    J Am Coll Cardiol 48:2293-300. 2006
    ..8%). The availability of AVS is essential for an accurate identification of the adrenocortical pathologies underlying PA...
  87. ncbi Do meta-analyses of association studies of endothelial nitric oxide synthase variants and ischemic heart disease provide conclusive answers?
    Gian Paolo Rossi
    Circulation 110:e305-6; author reply e305-6. 2004
  88. ncbi T-786C and G894T variants of the endothelial nitric oxide synthase gene and training-induced correction of endothelial dysfunction in coronary artery disease patient
    Gian Paolo Rossi
    Arterioscler Thromb Vasc Biol 24:e11; author reply e12. 2004
  89. ncbi Endothelial nitric oxide synthase gene polymorphisms and renal survival
    Teresa M Seccia
    Hypertension 41:e11-2; author reply e11-2. 2003
  90. ncbi Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure
    Giuseppe Maiolino
    Circulation 108:e112; author reply e112. 2003