Genomes and Genes
Affiliation: University of Milan
- Focal degeneration of astrocytes in amyotrophic lateral sclerosisD Rossi
Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
Cell Death Differ 15:1691-700. 2008..We propose that excitotoxicity in ALS affects both motor neurons and astrocytes, favouring their local interactive degeneration. This new mechanistic hypothesis has implications for therapeutic interventions...
- Astrocytic dysfunction: insights on the role in neurodegenerationDaniela Rossi
Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
Brain Res Bull 80:224-32. 2009....
- The peroxisome proliferator-activated receptor γ (PPARγ) controls natural protective mechanisms against lipid peroxidation in amyotrophic lateral sclerosisValeria Benedusi
Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy
J Biol Chem 287:35899-911. 2012..Our findings indicate that anticipating natural protective reactions by pharmacologically modulating PPARγ transcriptional activity may attenuate neurodegeneration by limiting the damage induced by lipid peroxidation derivatives...
- Defective tumor necrosis factor-alpha-dependent control of astrocyte glutamate release in a transgenic mouse model of Alzheimer diseaseDaniela Rossi
Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti, 9, 20133 Milan, Italy
J Biol Chem 280:42088-96. 2005..Reduced expression of DENN/MADD, a mediator of TNFalpha-PG coupling, might account for the defect. Alteration of this neuromodulatory astrocytic pathway is described here for the first time in relation to Alzheimer disease...