Giuseppina Rose

Summary

Affiliation: University of Calabria
Country: Italy

Publications

  1. doi request reprint Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, Rende, Italy
    Exp Gerontol 46:897-904. 2011
  2. doi request reprint No evidence of association between frontotemporal dementia and major European mtDNA haplogroups
    G Rose
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Neurol 15:1006-8. 2008
  3. pmc The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    BMC Genomics 8:293. 2007
  4. pmc Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity
    Serena Dato
    Department of Biology, Ecology and Heart Science, University of Calabria, Ponte Pietro Bucci cubo 4C, Rende 87036, CS, Italy
    Int J Mol Sci 14:16443-72. 2013
  5. pmc MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping
    Fausta Di Cianni
    Department of Cell Biology, University of Calabria, 87036, Rende, Italy
    Age (Dordr) 35:1357-66. 2013
  6. ncbi request reprint Association of the mitochondrial DNA haplogroup J with longevity is population specific
    Serena Dato
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 12:1080-2. 2004
  7. doi request reprint Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans
    Alberto Montesanto
    Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy
    Biogerontology 14:177-86. 2013
  8. doi request reprint SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress
    Patrizia D'Aquila
    Department of Cell Biology, University of Calabria, Rende, Italy
    Gene 497:323-9. 2012
  9. pmc Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, Rende, Italy
    PLoS ONE 6:e29650. 2011
  10. ncbi request reprint A novel sampling design to explore gene-longevity associations: the ECHA study
    Francesco De Rango
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 16:236-42. 2008

Collaborators

Detail Information

Publications22

  1. doi request reprint Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, Rende, Italy
    Exp Gerontol 46:897-904. 2011
    ....
  2. doi request reprint No evidence of association between frontotemporal dementia and major European mtDNA haplogroups
    G Rose
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Neurol 15:1006-8. 2008
    ..Here we investigated the association of European mtDNA haplogroups/sub-haplogroups with frontotemporal dementia (FTD)...
  3. pmc The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    BMC Genomics 8:293. 2007
    ....
  4. pmc Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity
    Serena Dato
    Department of Biology, Ecology and Heart Science, University of Calabria, Ponte Pietro Bucci cubo 4C, Rende 87036, CS, Italy
    Int J Mol Sci 14:16443-72. 2013
    ....
  5. pmc MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping
    Fausta Di Cianni
    Department of Cell Biology, University of Calabria, 87036, Rende, Italy
    Age (Dordr) 35:1357-66. 2013
    ..Our data confirm that long-lived subjects are endowed with genetic variants that allow them to optimize these cellular responses and to better deal with environmental and internal stresses...
  6. ncbi request reprint Association of the mitochondrial DNA haplogroup J with longevity is population specific
    Serena Dato
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 12:1080-2. 2004
    ..This finding shows that, as for other genetic factors, the association of mtDNA inherited variability with longevity is population specific...
  7. doi request reprint Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans
    Alberto Montesanto
    Department of Biology, Ecology and Earth Science, University of Calabria, 87036 Rende, Italy
    Biogerontology 14:177-86. 2013
    ..On the whole, our study shows that genetic variability of NOS genes has an effect on common age related phenotypes and longevity in humans as well as previously reported for model organisms...
  8. doi request reprint SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress
    Patrizia D'Aquila
    Department of Cell Biology, University of Calabria, Rende, Italy
    Gene 497:323-9. 2012
    ..Overall, the data reported here highlight a link between SIRT3, mitochondrial DNA variability and mitochondrial functionality, three fundamental components of the cellular stress response...
  9. pmc Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, Rende, Italy
    PLoS ONE 6:e29650. 2011
    ....
  10. ncbi request reprint A novel sampling design to explore gene-longevity associations: the ECHA study
    Francesco De Rango
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 16:236-42. 2008
    ..This will allow to dimension future sampling campaigns to study-genetic basis of human longevity...
  11. pmc Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, Rende, Italy
    PLoS ONE 5:e13395. 2010
    ....
  12. ncbi request reprint Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines
    Dina Bellizzi
    Department of Cell Biology, 87030 Rende, University of Calabria, Italy
    Genes Cells 11:883-91. 2006
    ..These findings provide a first experimental evidence of a relationship between mtDNA common variability and expression pattern of stress responder nuclear genes in human cells...
  13. ncbi request reprint A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
    Dina Bellizzi
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    Genomics 85:258-63. 2005
    ..Thus the underexpression of a human sirtuin gene seems to be detrimental for longevity as it occurs in model organisms...
  14. doi request reprint Mitochondrial function, mitochondrial DNA and ageing: a reappraisal
    Giuseppe Passarino
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    Biogerontology 11:575-88. 2010
    ..The present paper aims to review the findings of the last few years in order to outline a general framework to understand how mitochondria can affect ageing and how ageing affects mitochondria...
  15. doi request reprint A common polymorphism in the UCP3 promoter influences hand grip strength in elderly people
    Paolina Crocco
    Department of Cell Biology, University of Calabria, Rende, Italy
    Biogerontology 12:265-71. 2011
    ..Since this allele has been reported to promote a higher expression of the gene, we conclude that a more efficient uncoupling process has a beneficial effect on the aging muscle by slowing down its age related decay...
  16. doi request reprint Epigenetics and aging
    Patrizia D'Aquila
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    Maturitas 74:130-6. 2013
    ..In this review we provide an overview on the current knowledge and the general features of the epigenetic modifications characterizing the aging process...
  17. pmc Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity
    Alberto Montesanto
    Department of Cell Biology, University of Calabria, Ponte Pietro Bucci cubo 4 C, 87036 Rende, CS, Italy
    Immun Ageing 9:6. 2012
    ..Finally, we illustrated the recent approaches to define healthy ageing and underlined the role that the emerging field of epigenetics is gaining in the search for the determinants of healthy ageing and longevity...
  18. pmc A novel similarity-measure for the analysis of genetic data in complex phenotypes
    Vincenzo Lagani
    Department of Electronis, Informatics and Systems, University of Calabria, Via Ponte Pietro Bucci 41C, 87036, Rende, Italy
    BMC Bioinformatics 10:S24. 2009
    ..e., cases and controls) taking into account that genetic profiles are usually distributed in a population group according to the Hardy Weinberg equilibrium...
  19. pmc Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis
    Francesca Pisani
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, United Kingdom Department of Biology, Ecology and Earth Science, University of Calabria, Rende, Italy
    PLoS ONE 9:e85533. 2014
    ....
  20. ncbi request reprint The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biotechnol J 3:740-9. 2008
    ....
  21. ncbi request reprint Mitochondrial DNA involvement in human longevity
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Biochim Biophys Acta 1757:1388-99. 2006
    ..To test this hypothesis is one of the main challenge in the genetics of aging and longevity in the next future...
  22. ncbi request reprint An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Gene 286:121-6. 2002
    ....