Research Topics
Species | Antonio RosatoSummaryAffiliation: University of Padova Country: Italy Publications
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Detail Information
Publications
Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cellsPaola Castiglioni
Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H San Raffaele, Milan Italy, 20132
Cancer Res 62:1116-22. 2002..Therefore, subversion of the epitope hierarchy in apoptotic tumor cells might be relevant in the induction of tumor-specific T-lymphocyte responses...- A large number of T lymphocytes recognize Moloney-murine leukemia virus-induced antigens, but a few mediate long-lasting tumor immunosurveillanceAntonella Facchinetti
Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
J Immunol 174:5398-406. 2005..Although T cells expressing alternative Vbeta chains were activated and expanded, they were not able to control tumor growth in a long-lasting manner due to their incapacity of conversion and accumulation in the T central memory pool... 
Survivin expression impacts prognostically on NSCLC but not SCLCAntonio Rosato
Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
Lung Cancer 79:180-6. 2013....- The cytotoxic T-lymphocyte response against a poorly immunogenic mammary adenocarcinoma is focused on a single immunodominant class I epitope derived from the gp70 Env product of an endogenous retrovirusAntonio Rosato
Department of Oncology and Surgical Sciences, University of Padova, Italy
Cancer Res 63:2158-63. 2003.... - HYTAD1-p20: a new paclitaxel-hyaluronic acid hydrosoluble bioconjugate for treatment of superficial bladder cancerAntonio Rosato
Department of Oncology and Surgical Sciences, Oncology Section, University of Padua, Padua, Italy
Urol Oncol 24:207-15. 2006..To report the development of a new water-soluble paclitaxel-hyaluronic acid bioconjugate, HYTAD1-p20, for intravesical treatment of superficial bladder cancer... - Individual analysis of mice vaccinated against a weakly immunogenic self tumor-specific antigen reveals a correlation between CD8 T cell response and antitumor efficacyAntonio Rosato
Immunology Section, Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
J Immunol 171:5172-9. 2003..These results highlight the critical need to identify reliable, specific immunological parameters that may predict success or failure of an immune response against cancer... - Virus-specific cytotoxic CD4+ T cells for the treatment of EBV-related tumorsAnna Merlo
Department of Oncology and Surgical Sciences, University of Padova, Italy
J Immunol 184:5895-902. 2010..These findings pave the way to use cultures of pure CD4(+) T cells in immunotherapeutic approaches for EBV-related malignancies... - Predicting tumor outcome following cancer vaccination by monitoring quantitative and qualitative CD8+ T cell parametersAntonio Rosato
Department of Oncology and Surgical Sciences, University of Padova, Italy
J Immunol 176:1999-2006. 2006..These findings should be considered in the design of new immune monitoring systems used in cancer immunotherapy studies... - A paclitaxel-hyaluronan bioconjugate targeting ovarian cancer affords a potent in vivo therapeutic activityAlessandra Banzato
Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, I 35128 Padua, Italy
Clin Cancer Res 14:3598-606. 2008..This study was designed to evaluate the pharmacologic and biological properties of a paclitaxel-hyaluronan bioconjugate (ONCOFID-P) against IGROV-1 and OVCAR-3 human ovarian cancer xenografts following i.p. administration... - Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectorsSara Bobisse
Department of Oncology, University of Padova, Padova, Italy
Cancer Res 69:9385-94. 2009..Overall, our results indicate that lentiviral vectors represent a valid tool for stable and high-intensity expression of transgenic TCR and support clinical exploitation of this approach for therapeutic application... - Biodistribution imaging of a paclitaxel-hyaluronan bioconjugateAlessandra Banzato
Department of Oncology and Surgical Sciences, University of Padua, Padova, Italy
Nucl Med Biol 36:525-33. 2009..This study aimed to assess the imaging biodistribution of a [(99m)Tc]-radiolabelled new prototype bioconjugate composed of paclitaxel linked to hyaluronan (ONCOFID-P)... - Survivin in esophageal cancer: An accurate prognostic marker for squamous cell carcinoma but not adenocarcinomaAntonio Rosato
Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
Int J Cancer 119:1717-22. 2006..0147). In esophageal adenocarcinoma, survivin expression and pattern of distribution had no prognostic relevance. Thus, quantifying survivin expression provides a prognostic marker only for esophageal squamous tumors... 
Differential down-modulation of HLA class I and II molecule expression on human tumor cell lines upon in vivo transferRiccardo Turrini
Department of Oncology and Surgical Sciences, University of Padova, Italy
Cancer Immunol Immunother 60:1639-45. 2011....- In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomesLuigi Quintieri
Department of Pharmacology and Anaesthesiology, University of Padova, Largo Meneghetti 2, 35131 Padova, Italy
Biochem Pharmacol 76:784-95. 2008.... - Immunotherapy for EBV-associated malignanciesAnna Merlo
Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata, 64, 35128 Padua, Italy
Int J Hematol 93:281-93. 2011..Moreover, by analyzing ongoing clinical trials, we also provide some insights on the potential future of a successful and paradigmatic history... - Impact of γ-chain cytokines on EBV-specific T cell culturesAnna Merlo
University of Padova, Dept of Oncology and Surgical Sciences, Via Gattamelata 64, 35128 Padova, Italy
J Transl Med 8:121. 2010..Such requirements can be achieved by modifying culture conditions, namely using less "differentiating" cytokines than IL-2... - Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomesLuigi Quintieri
Department of Pharmacology and Anesthesiology, University of Padua, Largo Meneghetti 2, I 35131 Padua, Italy
Clin Cancer Res 11:1608-17. 2005..The aims of this study were to obtain information about MMDX biotransformation to PNU-159682 in humans, and to explore the antitumor activity of PNU-159682... - A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cellsSamantha Solito
Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy
Blood 118:2254-65. 2011.... - Identifying type Vicenza von Willebrand diseaseAlessandra Casonato
Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
J Lab Clin Med 147:96-102. 2006..Thus, low-plasma VWF associated with a normal platelet VWF content may be a first useful indicator for identifying type Vicenza VWD patients... - Glutathione transferases as targets for cancer therapyPaolo Ruzza
Institute of Biomolecular Chemistry of CNR, Padova, Italy
Anticancer Agents Med Chem 9:763-77. 2009..In the present review we discuss the current structural and pharmacological knowledge of both types of GST-targeting compounds... - Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literatureRita Alaggio
Department of Diagnostic Medical Sciences and Special Therapies, General Surgical Pathology Unit, University of Padua, Padua 35121, Italy
Hum Pathol 40:1600-10. 2009.... - Quantitative imaging of the T cell antitumor response by positron-emission tomographyPurnima Dubey
Department of Microbiology and Molecular Genetics, Molecular Biology Institute, University of Padua, I 35128 Padua, Italy
Proc Natl Acad Sci U S A 100:1232-7. 2003.... - The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disordersAnna Merlo
Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, Padova, Italy
Haematologica 95:1769-77. 2010.... - T-cell receptor gene transfer by lentiviral vectors in adoptive cell therapySara Bobisse
University of Padova, Department of Oncology and Surgical Sciences, Padova, Italy
Expert Opin Biol Ther 7:893-906. 2007..In this regard, HIV-based vectors are emerging as good alternative candidates over the most widely used oncoretroviral vectors due to their peculiar molecular features that fit the ideal conditions for donor T cell in vitro manipulation... - Suppression of tumor growth and cell proliferation by p13II, a mitochondrial protein of human T cell leukemia virus type 1Micol Silic-Benussi
Department of Oncology and Surgical Sciences, University of Padua, Via Gattamelata 64, 35128 Padua, Italy
Proc Natl Acad Sci U S A 101:6629-34. 2004..These findings provide clues into the function of p13(II) as a negative regulator of cell growth and underscore a link between mitochondria, Ca(2+) signaling, and tumorigenicity... - Expression of survivin, p53, and caspase 3 in Barrett's esophagus carcinogenesisAnna Parenti
Section of Pathologic Anatomy, Department of Oncological and Surgical Sciences, University of Padova, 35100, Italy
Hum Pathol 37:16-22. 2006..Expression of caspase 3 in BE and dysplasia may be ascribed to accumulation of the nonactivated form, as the antibody used detects both cleaved and uncleaved caspase 3... - Adoptive cell therapy against EBV-related malignancies: a survey of clinical resultsAnna Merlo
University of Padova, Department of Oncology and Surgical Sciences, Via Gattamelata 64, I 35128 Padova, Italy
Expert Opin Biol Ther 8:1265-94. 2008.... - CD8+ alpha beta+ T cells that lack surface CD5 antigen expression are a major lymphotactin (XCL1) source in peripheral blood lymphocytesLaura Stievano
Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
J Immunol 171:4528-38. 2003..In addition, they point to the CD3(+)CD8(+)CD5(-) population as a particular T cell subset within the CD8(+) compartment, whose functional properties deserve further attention... - Combination of sorafenib and everolimus impacts therapeutically on adrenocortical tumor modelsBarbara Mariniello
Endocrinology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
Endocr Relat Cancer 19:527-39. 2012..Furthermore, a combination of molecularly targeted agents may have both antiangiogenic and direct antitumor effects and thus could represent a new therapeutic tool for the treatment of ACC... - Wet sol-gel derived silica for controlled release of proteinsDeborah Teoli
University of Padova, Department of Pharmaceutical Sciences, Via Marzolo 5, 35131-Padova, Italy
J Control Release 116:295-303. 2006..These data indicate that wet silica polymers obtained by the sol-gel route are promising matrices for the sustained release of protein drugs... - In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cellsIlaria Cavallari
Department of Oncology and Surgical Sciences, University of Padova, I 35128 Padova, Italy
J Clin Endocrinol Metab 88:3893-901. 2003..This report thus provides the first description of the expression pattern of menin in human pancreas in situ and lays the groundwork for further studies of other tissues and tumors... - Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"Chiara Di Meo
Department of Chemistry, University of Rome La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
Macromol Biosci 8:670-81. 2008.... - Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapyChiara Di Meo
Department of Chemistry, University of Rome, La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
Biomacromolecules 8:552-9. 2007..Thus, HApCB may be regarded as a promising new BNCT agent for specific targeting of cancer cells overexpressing the CD44 receptor... - Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transferZsolt Sebestyen
Unit Clinical and Tumor Immunology, Department of Medical Oncology, Erasmus Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
J Immunol 180:7736-46. 2008..Taken together, our data support the use of TCRalphabeta:CD3zeta to prevent TCR mispairing, which may provide an adequate strategy to enhance efficacy and safety of TCR gene transfer... - A NMR study of the interaction of a three-domain construct of ATP7A with copper(I) and copper(I)-HAH1: the interplay of domainsLucia Banci
Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019 Sesto Fiorentino, Italy
J Biol Chem 280:38259-63. 2005..This dependence could constitute the molecular mechanism to trigger copper(I) translocation and/or ATP7A relocalization from the trans-Golgi network to the plasmatic membrane... - Hydrogen exchange in a bacterial cytochrome c: a fingerprint of the cytochrome c foldIlaria Bartalesi
Magnetic Resonance Center, University of Florence, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy
Biochemistry 42:10923-30. 2003..It is proposed that the observed distribution represents a fingerprint of the cytochrome c fold and has a role in directing the folding/unfolding of the protein... - Solution structure and characterization of the heme chaperone CcmEFabio Arnesano
Magnetic Resonance Center, University of Florence, Sesto Fiorentino, Italy
Biochemistry 41:13587-94. 2002..The data available suggest that the heme transfer process is likely to involve a heterooligomeric protein complex and occur under a tight enzymatic control... - The different intermolecular interactions of the soluble copper-binding domains of the menkes protein, ATP7ALucia Banci
Magnetic Resonance Center, Via L Sacconi 6, and Department of Chemistry, Via della Lastruccia 3, University of Florence, Italy
J Biol Chem 282:23140-6. 2007....