Antonio Rosato

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells
    Paola Castiglioni
    Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H San Raffaele, Milan Italy, 20132
    Cancer Res 62:1116-22. 2002
  2. ncbi request reprint A large number of T lymphocytes recognize Moloney-murine leukemia virus-induced antigens, but a few mediate long-lasting tumor immunosurveillance
    Antonella Facchinetti
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    J Immunol 174:5398-406. 2005
  3. pmc Differential down-modulation of HLA class I and II molecule expression on human tumor cell lines upon in vivo transfer
    Riccardo Turrini
    Department of Oncology and Surgical Sciences, University of Padova, Italy
    Cancer Immunol Immunother 60:1639-45. 2011
  4. pmc Survivin expression and prognostic significance in pediatric malignant peripheral nerve sheath tumors (MPNST)
    Rita Alaggio
    Department of Medicine, University of Padova, Padova, Italy
    PLoS ONE 8:e80456. 2013
  5. doi request reprint Survivin expression impacts prognostically on NSCLC but not SCLC
    Antonio Rosato
    Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
    Lung Cancer 79:180-6. 2013
  6. ncbi request reprint HYTAD1-p20: a new paclitaxel-hyaluronic acid hydrosoluble bioconjugate for treatment of superficial bladder cancer
    Antonio Rosato
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padua, Padua, Italy
    Urol Oncol 24:207-15. 2006
  7. ncbi request reprint The cytotoxic T-lymphocyte response against a poorly immunogenic mammary adenocarcinoma is focused on a single immunodominant class I epitope derived from the gp70 Env product of an endogenous retrovirus
    Antonio Rosato
    Department of Oncology and Surgical Sciences, University of Padova, Italy
    Cancer Res 63:2158-63. 2003
  8. ncbi request reprint Individual analysis of mice vaccinated against a weakly immunogenic self tumor-specific antigen reveals a correlation between CD8 T cell response and antitumor efficacy
    Antonio Rosato
    Immunology Section, Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
    J Immunol 171:5172-9. 2003
  9. doi request reprint Virus-specific cytotoxic CD4+ T cells for the treatment of EBV-related tumors
    Anna Merlo
    Department of Oncology and Surgical Sciences, University of Padova, Italy
    J Immunol 184:5895-902. 2010
  10. doi request reprint A paclitaxel-hyaluronan bioconjugate targeting ovarian cancer affords a potent in vivo therapeutic activity
    Alessandra Banzato
    Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, I 35128 Padua, Italy
    Clin Cancer Res 14:3598-606. 2008

Detail Information

Publications43

  1. ncbi request reprint Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells
    Paola Castiglioni
    Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H San Raffaele, Milan Italy, 20132
    Cancer Res 62:1116-22. 2002
    ..Therefore, subversion of the epitope hierarchy in apoptotic tumor cells might be relevant in the induction of tumor-specific T-lymphocyte responses...
  2. ncbi request reprint A large number of T lymphocytes recognize Moloney-murine leukemia virus-induced antigens, but a few mediate long-lasting tumor immunosurveillance
    Antonella Facchinetti
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    J Immunol 174:5398-406. 2005
    ..Although T cells expressing alternative Vbeta chains were activated and expanded, they were not able to control tumor growth in a long-lasting manner due to their incapacity of conversion and accumulation in the T central memory pool...
  3. pmc Differential down-modulation of HLA class I and II molecule expression on human tumor cell lines upon in vivo transfer
    Riccardo Turrini
    Department of Oncology and Surgical Sciences, University of Padova, Italy
    Cancer Immunol Immunother 60:1639-45. 2011
    ....
  4. pmc Survivin expression and prognostic significance in pediatric malignant peripheral nerve sheath tumors (MPNST)
    Rita Alaggio
    Department of Medicine, University of Padova, Padova, Italy
    PLoS ONE 8:e80456. 2013
    ..0038). Overall, these data support the concept that survivin can be regarded as a useful prognostic marker for pediatric MPNST and a promising target for therapeutic interventions. ..
  5. doi request reprint Survivin expression impacts prognostically on NSCLC but not SCLC
    Antonio Rosato
    Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
    Lung Cancer 79:180-6. 2013
    ....
  6. ncbi request reprint HYTAD1-p20: a new paclitaxel-hyaluronic acid hydrosoluble bioconjugate for treatment of superficial bladder cancer
    Antonio Rosato
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padua, Padua, Italy
    Urol Oncol 24:207-15. 2006
    ..To report the development of a new water-soluble paclitaxel-hyaluronic acid bioconjugate, HYTAD1-p20, for intravesical treatment of superficial bladder cancer...
  7. ncbi request reprint The cytotoxic T-lymphocyte response against a poorly immunogenic mammary adenocarcinoma is focused on a single immunodominant class I epitope derived from the gp70 Env product of an endogenous retrovirus
    Antonio Rosato
    Department of Oncology and Surgical Sciences, University of Padova, Italy
    Cancer Res 63:2158-63. 2003
    ....
  8. ncbi request reprint Individual analysis of mice vaccinated against a weakly immunogenic self tumor-specific antigen reveals a correlation between CD8 T cell response and antitumor efficacy
    Antonio Rosato
    Immunology Section, Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
    J Immunol 171:5172-9. 2003
    ..These results highlight the critical need to identify reliable, specific immunological parameters that may predict success or failure of an immune response against cancer...
  9. doi request reprint Virus-specific cytotoxic CD4+ T cells for the treatment of EBV-related tumors
    Anna Merlo
    Department of Oncology and Surgical Sciences, University of Padova, Italy
    J Immunol 184:5895-902. 2010
    ..These findings pave the way to use cultures of pure CD4(+) T cells in immunotherapeutic approaches for EBV-related malignancies...
  10. doi request reprint A paclitaxel-hyaluronan bioconjugate targeting ovarian cancer affords a potent in vivo therapeutic activity
    Alessandra Banzato
    Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, I 35128 Padua, Italy
    Clin Cancer Res 14:3598-606. 2008
    ..This study was designed to evaluate the pharmacologic and biological properties of a paclitaxel-hyaluronan bioconjugate (ONCOFID-P) against IGROV-1 and OVCAR-3 human ovarian cancer xenografts following i.p. administration...
  11. ncbi request reprint Predicting tumor outcome following cancer vaccination by monitoring quantitative and qualitative CD8+ T cell parameters
    Antonio Rosato
    Department of Oncology and Surgical Sciences, University of Padova, Italy
    J Immunol 176:1999-2006. 2006
    ..These findings should be considered in the design of new immune monitoring systems used in cancer immunotherapy studies...
  12. doi request reprint Reprogramming T lymphocytes for melanoma adoptive immunotherapy by T-cell receptor gene transfer with lentiviral vectors
    Sara Bobisse
    Department of Oncology, University of Padova, Padova, Italy
    Cancer Res 69:9385-94. 2009
    ..Overall, our results indicate that lentiviral vectors represent a valid tool for stable and high-intensity expression of transgenic TCR and support clinical exploitation of this approach for therapeutic application...
  13. doi request reprint Biodistribution imaging of a paclitaxel-hyaluronan bioconjugate
    Alessandra Banzato
    Department of Oncology and Surgical Sciences, University of Padua, Padova, Italy
    Nucl Med Biol 36:525-33. 2009
    ..This study aimed to assess the imaging biodistribution of a [(99m)Tc]-radiolabelled new prototype bioconjugate composed of paclitaxel linked to hyaluronan (ONCOFID-P)...
  14. ncbi request reprint Survivin in esophageal cancer: An accurate prognostic marker for squamous cell carcinoma but not adenocarcinoma
    Antonio Rosato
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Int J Cancer 119:1717-22. 2006
    ..0147). In esophageal adenocarcinoma, survivin expression and pattern of distribution had no prognostic relevance. Thus, quantifying survivin expression provides a prognostic marker only for esophageal squamous tumors...
  15. doi request reprint Paclitaxel-hyaluronan hydrosoluble bioconjugate: mechanism of action in human bladder cancer cell lines
    Isabella Monia Montagner
    Istituto Oncologico Veneto IRCCS, Padova, Italy
    Urol Oncol 31:1261-9. 2013
    ..The aim of this work was to assess the mechanism of action of the bioconjugate in UC cells...
  16. doi request reprint In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes
    Luigi Quintieri
    Department of Pharmacology and Anaesthesiology, University of Padova, Largo Meneghetti 2, 35131 Padova, Italy
    Biochem Pharmacol 76:784-95. 2008
    ....
  17. doi request reprint Immunotherapy for EBV-associated malignancies
    Anna Merlo
    Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata, 64, 35128 Padua, Italy
    Int J Hematol 93:281-93. 2011
    ..Moreover, by analyzing ongoing clinical trials, we also provide some insights on the potential future of a successful and paradigmatic history...
  18. ncbi request reprint Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literature
    Rita Alaggio
    Department of Diagnostic Medical Sciences and Special Therapies, General Surgical Pathology Unit, University of Padua, Padua 35121, Italy
    Hum Pathol 40:1600-10. 2009
    ....
  19. pmc Impact of γ-chain cytokines on EBV-specific T cell cultures
    Anna Merlo
    University of Padova, Dept of Oncology and Surgical Sciences, Via Gattamelata 64, 35128 Padova, Italy
    J Transl Med 8:121. 2010
    ..Such requirements can be achieved by modifying culture conditions, namely using less "differentiating" cytokines than IL-2...
  20. ncbi request reprint Adoptive cell therapy against EBV-related malignancies: a survey of clinical results
    Anna Merlo
    University of Padova, Department of Oncology and Surgical Sciences, Via Gattamelata 64, I 35128 Padova, Italy
    Expert Opin Biol Ther 8:1265-94. 2008
    ....
  21. ncbi request reprint Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes
    Luigi Quintieri
    Department of Pharmacology and Anesthesiology, University of Padua, Largo Meneghetti 2, I 35131 Padua, Italy
    Clin Cancer Res 11:1608-17. 2005
    ..The aims of this study were to obtain information about MMDX biotransformation to PNU-159682 in humans, and to explore the antitumor activity of PNU-159682...
  22. pmc Quantitative imaging of the T cell antitumor response by positron-emission tomography
    Purnima Dubey
    Department of Microbiology and Molecular Genetics, Molecular Biology Institute, University of Padua, I 35128 Padua, Italy
    Proc Natl Acad Sci U S A 100:1232-7. 2003
    ....
  23. pmc A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells
    Samantha Solito
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy
    Blood 118:2254-65. 2011
    ....
  24. ncbi request reprint Glutathione transferases as targets for cancer therapy
    Paolo Ruzza
    Institute of Biomolecular Chemistry of CNR, Padova, Italy
    Anticancer Agents Med Chem 9:763-77. 2009
    ..In the present review we discuss the current structural and pharmacological knowledge of both types of GST-targeting compounds...
  25. ncbi request reprint Identifying type Vicenza von Willebrand disease
    Alessandra Casonato
    Department of Medical and Surgical Sciences, University of Padua Medical School, Padua, Italy
    J Lab Clin Med 147:96-102. 2006
    ..Thus, low-plasma VWF associated with a normal platelet VWF content may be a first useful indicator for identifying type Vicenza VWD patients...
  26. pmc The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disorders
    Anna Merlo
    Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, Padova, Italy
    Haematologica 95:1769-77. 2010
    ....
  27. ncbi request reprint T-cell receptor gene transfer by lentiviral vectors in adoptive cell therapy
    Sara Bobisse
    University of Padova, Department of Oncology and Surgical Sciences, Padova, Italy
    Expert Opin Biol Ther 7:893-906. 2007
    ..In this regard, HIV-based vectors are emerging as good alternative candidates over the most widely used oncoretroviral vectors due to their peculiar molecular features that fit the ideal conditions for donor T cell in vitro manipulation...
  28. ncbi request reprint Optical and multimodal peptide-based probes for in vivo molecular imaging
    Laura Meléndez-Alafort
    Istituto Oncologico Veneto IRCCS, Padova, Italy
    Anticancer Agents Med Chem 12:476-99. 2012
    ..Lastly, the emphasis of this paper is on the new multimodal probes which can overcome individual limitations and exploit the individual strengths of the latest molecular imaging techniques...
  29. pmc Suppression of tumor growth and cell proliferation by p13II, a mitochondrial protein of human T cell leukemia virus type 1
    Micol Silic-Benussi
    Department of Oncology and Surgical Sciences, University of Padua, Via Gattamelata 64, 35128 Padua, Italy
    Proc Natl Acad Sci U S A 101:6629-34. 2004
    ..These findings provide clues into the function of p13(II) as a negative regulator of cell growth and underscore a link between mitochondria, Ca(2+) signaling, and tumorigenicity...
  30. ncbi request reprint CD8+ alpha beta+ T cells that lack surface CD5 antigen expression are a major lymphotactin (XCL1) source in peripheral blood lymphocytes
    Laura Stievano
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    J Immunol 171:4528-38. 2003
    ..In addition, they point to the CD3(+)CD8(+)CD5(-) population as a particular T cell subset within the CD8(+) compartment, whose functional properties deserve further attention...
  31. ncbi request reprint Expression of survivin, p53, and caspase 3 in Barrett's esophagus carcinogenesis
    Anna Parenti
    Section of Pathologic Anatomy, Department of Oncological and Surgical Sciences, University of Padova, 35100, Italy
    Hum Pathol 37:16-22. 2006
    ..Expression of caspase 3 in BE and dysplasia may be ascribed to accumulation of the nonactivated form, as the antibody used detects both cleaved and uncleaved caspase 3...
  32. ncbi request reprint Magneto-Plasmonic Au-Fe Alloy Nanoparticles Designed for Multimodal SERS-MRI-CT Imaging
    Vincenzo Amendola
    Department of Chemical Sciences, University of Padova, Padova, Italy
    Small 10:2476-86. 2014
    ..Taken together, these results show that Au-Fe nanoalloys are excellent candidates as multimodal MRI-CT-SERS imaging agents. ..
  33. ncbi request reprint Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system
    Paola Brun
    Department of Molecular Medicine, University of Padova, Padova, Italy
    Gastroenterology 145:1323-33. 2013
    ..We assessed the effects of TLR2 signaling on the enteric nervous system (ENS) in mice...
  34. doi request reprint Combination of sorafenib and everolimus impacts therapeutically on adrenocortical tumor models
    Barbara Mariniello
    Endocrinology Unit, Department of Medicine, University of Padua, Via Ospedale Civile 105, 35128 Padua, Italy
    Endocr Relat Cancer 19:527-39. 2012
    ..Furthermore, a combination of molecularly targeted agents may have both antiangiogenic and direct antitumor effects and thus could represent a new therapeutic tool for the treatment of ACC...
  35. ncbi request reprint In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cells
    Ilaria Cavallari
    Department of Oncology and Surgical Sciences, University of Padova, I 35128 Padova, Italy
    J Clin Endocrinol Metab 88:3893-901. 2003
    ..This report thus provides the first description of the expression pattern of menin in human pancreas in situ and lays the groundwork for further studies of other tissues and tumors...
  36. ncbi request reprint Wet sol-gel derived silica for controlled release of proteins
    Deborah Teoli
    University of Padova, Department of Pharmaceutical Sciences, Via Marzolo 5, 35131 Padova, Italy
    J Control Release 116:295-303. 2006
    ..These data indicate that wet silica polymers obtained by the sol-gel route are promising matrices for the sustained release of protein drugs...
  37. ncbi request reprint Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy
    Chiara Di Meo
    Department of Chemistry, University of Rome, La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
    Biomacromolecules 8:552-9. 2007
    ..Thus, HApCB may be regarded as a promising new BNCT agent for specific targeting of cancer cells overexpressing the CD44 receptor...
  38. doi request reprint Novel types of carborane-carrier hyaluronan derivatives via "click chemistry"
    Chiara Di Meo
    Department of Chemistry, University of Rome La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
    Macromol Biosci 8:670-81. 2008
    ....
  39. ncbi request reprint Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer
    Zsolt Sebestyen
    Unit Clinical and Tumor Immunology, Department of Medical Oncology, Erasmus Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Immunol 180:7736-46. 2008
    ..Taken together, our data support the use of TCRalphabeta:CD3zeta to prevent TCR mispairing, which may provide an adequate strategy to enhance efficacy and safety of TCR gene transfer...
  40. ncbi request reprint The different intermolecular interactions of the soluble copper-binding domains of the menkes protein, ATP7A
    Lucia Banci
    Magnetic Resonance Center, Via L Sacconi 6, and Department of Chemistry, Via della Lastruccia 3, University of Florence, Italy
    J Biol Chem 282:23140-6. 2007
    ....
  41. ncbi request reprint A NMR study of the interaction of a three-domain construct of ATP7A with copper(I) and copper(I)-HAH1: the interplay of domains
    Lucia Banci
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019 Sesto Fiorentino, Italy
    J Biol Chem 280:38259-63. 2005
    ..This dependence could constitute the molecular mechanism to trigger copper(I) translocation and/or ATP7A relocalization from the trans-Golgi network to the plasmatic membrane...
  42. ncbi request reprint Solution structure and characterization of the heme chaperone CcmE
    Fabio Arnesano
    Magnetic Resonance Center, University of Florence, Sesto Fiorentino, Italy
    Biochemistry 41:13587-94. 2002
    ..The data available suggest that the heme transfer process is likely to involve a heterooligomeric protein complex and occur under a tight enzymatic control...
  43. ncbi request reprint Hydrogen exchange in a bacterial cytochrome c: a fingerprint of the cytochrome c fold
    Ilaria Bartalesi
    Magnetic Resonance Center, University of Florence, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy
    Biochemistry 42:10923-30. 2003
    ..It is proposed that the observed distribution represents a fingerprint of the cytochrome c fold and has a role in directing the folding/unfolding of the protein...