Mario Romano

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi request reprint Urinary excretion of lipoxin A(4) and related compounds: development of new extraction techniques for lipoxins
    Mario Romano
    Center of Excellence of Aging, Department of Biomedical Sciences, University G D Annunzio, Chieti, Italy
    Lab Invest 82:1253-4. 2002
  2. doi request reprint Lipoxins and aspirin-triggered lipoxins in resolution of inflammation
    Mario Romano
    Department of Medical, Oral and Biotechnological Sciences, G D Annunzio University of Chieti Pescara, Chieti, Italy Center of Excellence on Aging, G D Annunzio University of Chieti Pescara, Chieti, Italy Electronic address
    Eur J Pharmacol 760:49-63. 2015
  3. ncbi request reprint Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy
    Mario Romano
    Department of Biomedical Sciences, University G D Annunzio, Ce S I, 66013 Chieti, Italy
    FASEB J 17:1986-95. 2003
  4. ncbi request reprint Lipoxin analogs and lipoxin formation in vivo
    M Romano
    Department of Biomedical Sciences, Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Via dei Vestini 31, 66013 Chieti, Italy
    Prostaglandins Leukot Essent Fatty Acids 73:239-43. 2005
  5. ncbi request reprint Lipoxin receptors
    Mario Romano
    Department of Biomedical Sciences, Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Chieti, Italy
    ScientificWorldJournal 7:1393-412. 2007
  6. doi request reprint Lipoxin and aspirin-triggered lipoxins
    Mario Romano
    Department of Biomedical Sciences, Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Chieti, Italy
    ScientificWorldJournal 10:1048-64. 2010
  7. ncbi request reprint Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins
    Mario Romano
    Department of Biomedical Sciences, Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Via dei Vestini, 31, 66013, Chieti, Italy
    Inflamm Allergy Drug Targets 5:81-90. 2006
  8. ncbi request reprint 5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor
    M Romano
    Department of Human Pathology, University of Messina, Messina, Italy
    FASEB J 15:2326-36. 2001
  9. doi request reprint Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response
    Domenico Mattoscio
    Department of Biomedical Sciences, Aging Research Center, CeSI, Gabriele D Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy
    FASEB J 24:3970-80. 2010
  10. doi request reprint Lipoxin A4 stimulates endothelial miR-126-5p expression and its transfer via microvesicles
    Marilina Codagnone
    Department of Medical, Oral and Biotechnological Sciences, G D Annunzio University of Chieti Pescara, Chieti, Italy
    FASEB J . 2017

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Urinary excretion of lipoxin A(4) and related compounds: development of new extraction techniques for lipoxins
    Mario Romano
    Center of Excellence of Aging, Department of Biomedical Sciences, University G D Annunzio, Chieti, Italy
    Lab Invest 82:1253-4. 2002
    ....
  2. doi request reprint Lipoxins and aspirin-triggered lipoxins in resolution of inflammation
    Mario Romano
    Department of Medical, Oral and Biotechnological Sciences, G D Annunzio University of Chieti Pescara, Chieti, Italy Center of Excellence on Aging, G D Annunzio University of Chieti Pescara, Chieti, Italy Electronic address
    Eur J Pharmacol 760:49-63. 2015
    ..Counter-regulatory signaling by LXA4 and 15-epi-LXA4 follows the activation of a G protein-coupled receptor, termed ALX/FPR2, which is emerging as a key anti-inflammatory receptor. ..
  3. ncbi request reprint Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy
    Mario Romano
    Department of Biomedical Sciences, University G D Annunzio, Ce S I, 66013 Chieti, Italy
    FASEB J 17:1986-95. 2003
    ..In this article we will review evidence of COX-2 and 5-LO involvement in cancer pathobiology, propose a model of integrated control of cell proliferation by these enzymes, and discuss the pharmacologic implications of this model...
  4. ncbi request reprint Lipoxin analogs and lipoxin formation in vivo
    M Romano
    Department of Biomedical Sciences, Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Via dei Vestini 31, 66013 Chieti, Italy
    Prostaglandins Leukot Essent Fatty Acids 73:239-43. 2005
    ..This chapter reviews the current literature on the use of lipoxin analogs, in vivo, and on measurements of lipoxin A4 in health and disease...
  5. ncbi request reprint Lipoxin receptors
    Mario Romano
    Department of Biomedical Sciences, Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Chieti, Italy
    ScientificWorldJournal 7:1393-412. 2007
    ..This review summarizes the current knowledge on ALX expression, signaling, and potential pathophysiological role. The involvement of additional recognition sites in LX bioactions is also discussed...
  6. doi request reprint Lipoxin and aspirin-triggered lipoxins
    Mario Romano
    Department of Biomedical Sciences, Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Chieti, Italy
    ScientificWorldJournal 10:1048-64. 2010
    ....
  7. ncbi request reprint Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins
    Mario Romano
    Department of Biomedical Sciences, Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Via dei Vestini, 31, 66013, Chieti, Italy
    Inflamm Allergy Drug Targets 5:81-90. 2006
    ..Clinical evaluation of LXA4 and 15-epi-LXA4 formation and their pharmacological regulation may be now achieved using recently developed ELISA assays, that allow large-scale measurements in human biological fluids...
  8. ncbi request reprint 5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor
    M Romano
    Department of Human Pathology, University of Messina, Messina, Italy
    FASEB J 15:2326-36. 2001
    ..Arachidonic acid and 5(S)-HETE also potently stimulated the activity of a VEGF promoter construct. Thus, 5-LO is a key regulator of MM cell proliferation and survival via a VEGF-related circuit...
  9. doi request reprint Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response
    Domenico Mattoscio
    Department of Biomedical Sciences, Aging Research Center, CeSI, Gabriele D Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy
    FASEB J 24:3970-80. 2010
    ..650±0.09 vs. 1.04±0.24 U; P=0.03). Taken together, these findings indicate that PLTs from CF patients are affected by the molecular defect of CFTR. Moreover, this CF PLT abnormality may explain the failure of resolution in CF...
  10. doi request reprint Lipoxin A4 stimulates endothelial miR-126-5p expression and its transfer via microvesicles
    Marilina Codagnone
    Department of Medical, Oral and Biotechnological Sciences, G D Annunzio University of Chieti Pescara, Chieti, Italy
    FASEB J . 2017
    ..Lanuti, P., Pierdomenico, A. M., Cianci, E., Patruno, S., Mari, V. C., Simiele, F., Di Tomo, P., Pandolfi, A., Romano, M. Lipoxin A4 stimulates endothelial miR-126-5p expression and its transfer via microvesicles...
  11. pmc Wnt signaling behaves as a "master regulator" in the osteogenic and adipogenic commitment of human amniotic fluid mesenchymal stem cells
    Iolanda D'Alimonte
    Department of Experimental and Clinical Sciences, University G d Annunzio of Chieti Pescara, Chieti, Italy
    Stem Cell Rev 9:642-54. 2013
    ....
  12. ncbi request reprint Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels
    Sebastiano Gangemi
    Department of Human Pathology, University of Messina, Italy
    Exp Gerontol 40:612-4. 2005
    ..0026). We conclude that aging is associated with a switch in arachidonic acid metabolism that prevents formation of key 'stop signals' of the inflammatory reaction. This may contribute to promote the development of disease in elderly...
  13. ncbi request reprint Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin
    Caterina Pettinella
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Thromb Haemost 101:687-90. 2009
    ..Platelet cyclooxygenase activity, as reflected by serum TXB(2), was uniformly and persistently suppressed by low-dose aspirin in both carriers and non carriers of these polymorphisms...
  14. doi request reprint Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity
    Felice Simiele
    Department of Biomedical Sciences, Center of Excellence on Aging, Ce S I, G d Annunzio University Foundation, Via Colle dell Ara, 66013 Chieti, Italy
    FASEB J 26:1323-33. 2012
    ..These results uncover FPR2/ALX transcriptional regulation and provide the first evidence of mutations that affect FPR2/ALX transcription, thus opening new opportunities for the understanding of the LXA(4)-FPR2/ALX axis in human disease...
  15. pmc MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages
    Anna Maria Pierdomenico
    From the Department of Medicine and Aging Sciences and Center of Excellence on Aging G D Annunzio University Foundation, 66013 Chieti, Italy
    J Biol Chem 290:3592-600. 2015
    ..These results unravel novel regulatory mechanisms of ALX/FPR2 expression and ligand-evoked macrophages proresolution responses mediated by miR-181b, thus uncovering novel components of the endogenous inflammation resolution circuits. ..
  16. doi request reprint Endogenous secretory RAGE in obese women: association with platelet activation and oxidative stress
    Natale Vazzana
    Internal Medicine and Center of Excellence on Aging, Gabriele d Annunzio University of Chieti, 66013 Chieti, Italy
    J Clin Endocrinol Metab 97:E1726-30. 2012
    ..The receptor for advanced glycation end-products (RAGE) has been implicated in obesity-related metabolic disease and accelerated atherothrombosis...
  17. ncbi request reprint Physical exercise increases urinary excretion of lipoxin A4 and related compounds
    Sebastiano Gangemi
    Department of Human Pathology, University of Messina, 98125 Messina, Italy
    J Appl Physiol 94:2237-40. 2003
    ..This may be the reflection of an enhanced LX biosynthesis, which may represent a safeguard mechanism that keeps the inflammatory reaction triggered by physical stress under control...
  18. ncbi request reprint Lower platelet count in healthy centenarians correlates with dispersion of the QT interval
    Sebastiano Gangemi
    School of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina, Messina, Italy
    Aging Clin Exp Res 16:169-71. 2004
    ..The aim of this study was to evaluate platelet count and QTd in healthy centenarians and to establish correlations between these two indices...
  19. doi request reprint Epigenetic regulation of the formyl peptide receptor 2 gene
    Felice Simiele
    Department of Medical, Oral, and Biotechnological Science, G D Annunzio University of Chieti Pescara, Via Luigi Polacchi 11 13, 66100 Chieti, Italy Center of Aging Sciences and Translational Medicine CeSI MeT, G D Annunzio University of Chieti Pescara, Via Luigi Polacchi 11 13, 66100 Chieti, Italy
    Biochim Biophys Acta 1859:1252-8. 2016
    ..Collectively, these results uncover unappreciated epigenetic regulation of ALX/FPR2 expression that can be exploited for innovative approaches to inflammatory disorders. ..
  20. doi request reprint Molecular and phenotypic characterization of human amniotic fluid-derived cells: a morphological and proteomic approach
    Caterina Pipino
    1Department of Medical, Oral and Biotechnological Sciences, School of Medicine and Health Sciences G d Annunzio University Chieti Pescara, Chieti, Italy
    Stem Cells Dev 24:1415-28. 2015
    ..This may be valuable information with a view to the therapeutic use of AFMSCs. ..
  21. doi request reprint Calcium sensing receptor activation by calcimimetic R-568 in human amniotic fluid mesenchymal stem cells: correlation with osteogenic differentiation
    Caterina Pipino
    1 Department of Experimental and Clinical Sciences, School of Medicine and Health Sciences, G d Annunzio University Chieti Pescara, Chieti, Italy
    Stem Cells Dev 23:2959-71. 2014
    ..Thus, this study provides significant information on the mechanisms of hAFMSC osteogenesis, which could provide additional molecular basis for the use of calcimimetics in bone regenerative medicine. ..
  22. doi request reprint Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients
    Francesca Santilli
    Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    Blood 112:1085-90. 2008
    ..Thus, additional antithrombotic strategies may be beneficial in PV...
  23. pmc Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins
    Eleonora Cianci
    Department of Medicine and Aging Science, G D Annunzio University of Chieti Pescara, Chieti, Italy StemTeCh Group, G D Annunzio University of Chieti Pescara, Chieti, Italy Department of Medical, Oral and Biotechnological Sciences, G D Annunzio University of Chieti Pescara, Chieti, Italy
    Stem Cells Transl Med 5:20-32. 2016
    ....
  24. doi request reprint Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages
    Antonio Recchiuti
    Department of Experimental and Clinical Science, Center of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    FASEB J 28:3090-102. 2014
    ..Pierdomenico, A. M., Rossi, C., Mari, V. C., Cianci, E., Simiele, F., Gatta, V., Romano, M. Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages. ..
  25. ncbi request reprint Homocysteine modulates the CD40/CD40L system
    Cesaria Prontera
    Department of Medicine, Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    J Am Coll Cardiol 49:2182-90. 2007
    ..This study evaluated the impact of hyperhomocysteinemia (HHcy) on the CD40/CD40 ligand (CD40L) dyad in vivo and in vitro...
  26. pmc Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors
    Giulia Renda
    G D Annunzio University, Chieti, Italy
    Br J Clin Pharmacol 69:303-6. 2010
    ..We tested the hypothesis that the co-administration of aspirin with either the selective COX-2 inhibitor celecoxib or the nonselective COX inhibitor ibuprofen reduces ATL biosynthesis...
  27. ncbi request reprint Increased levels of soluble P-selectin in hypercholesterolemic patients
    G Davi
    Department of Medicine, University of Chieti G D Annunzio School of Medicine, Italy
    Circulation 97:953-7. 1998
    ..P-selectin may play an important role in the pathogenesis of multicellular events, including atherosclerosis. We studied the impact of hypercholesterolemia and oxidative stress on plasma levels of P-selectin...
  28. doi request reprint Immobilization and delivery of biologically active Lipoxin A4 using electrospinning technology
    Eleonora Cianci
    Department of Medical, Oral and Biotechnological Sciences, G D Annunzio University of Chieti Pescara, Chieti, Italy StemTeCh Group, G D Annunzio University of Chieti Pescara, Chieti, Italy Center of Aging Sciences and Translational Medicine CeSI MeT, G D Annunzio University of Chieti Pescara, Chieti, Italy
    Int J Pharm 515:254-261. 2016
    ..These results demonstrate for the first time that LXA4 can be incorporated into biomembranes, which may be useful to combat local inflammation and promote tissue repair in selected clinical settings...
  29. doi request reprint A novel flow cytometric approach to distinguish circulating endothelial cells from endothelial microparticles: relevance for the evaluation of endothelial dysfunction
    Paola Lanuti
    Department of Medicine and Aging Science D M S I, University G d Annunzio of Chieti Pescara, Via dei Vestini 31, 66013, Chieti Scalo CH, Italy
    J Immunol Methods 380:16-22. 2012
    ..A significant increase in both subsets was observed in patients with diabetes mellitus. Thus, this simple and highly reproducible method may be useful for monitoring endothelial dysfunction in clinical settings...
  30. ncbi request reprint Association of inflammation markers with impaired insulin sensitivity and coagulative activation in obese healthy women
    Mario Romano
    Department of Medicine and Aging, University of Chieti G D Annunzio, School of Medicine, 66013 Chieti, Italy
    J Clin Endocrinol Metab 88:5321-6. 2003
    ..The elevated TGF-beta 1 levels detected in the obese population may provide a biochemical link between insulin resistance and an increased risk for cardiovascular disease...
  31. ncbi request reprint Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
    Sebastiano Gangemi
    Department of Human Pathology, University of Messina, 98125, Messina, Italy
    Exp Gerontol 38:669-72. 2003
    ..The present results indicate that quenching of IL-18 by IL-18BP may explain the apparent paradox of elevated serum IL-18 with no vascular signs in centenarians...
  32. ncbi request reprint G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells
    Massimo Federici
    Department of Medicine and Aging Sciences, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini, 1, 66100 Chieti, Italy
    Circulation 109:399-405. 2004
    ....
  33. ncbi request reprint Endothelial perturbation in cystic fibrosis
    M Romano
    Department of Human Pathology, University of Messina, Italy
    Thromb Haemost 86:1363-7. 2001
    ....
  34. ncbi request reprint Endothelial perturbation in children and adolescents with type 1 diabetes: association with markers of the inflammatory reaction
    M Romano
    Department of Human Pathology, University of Messina, Messina, Italy
    Diabetes Care 24:1674-8. 2001
    ..A correlation might exist between the initial inflammatory reaction and the appearance of endothelial perturbation...
  35. ncbi request reprint Increased soluble CD40 ligand levels in cystic fibrosis
    A Falco
    Center of Excellence on Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    J Thromb Haemost 2:557-60. 2004
    ..0129). Our findings suggest that in CF patients, sCD40L could represent a biochemical link between the inflammatory state, and endothelial damage and coagulative activation, leading to progressive impairment of pulmonary function...
  36. pmc Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Italy
    Proc Natl Acad Sci U S A 100:10937-41. 2003
    ....
  37. ncbi request reprint Aspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells
    Esther Titos
    Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Barcelona 08036, Spain
    Adv Exp Med Biol 507:199-209. 2002
  38. ncbi request reprint Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    FASEB J 17:1171-3. 2003
    ..These findings indicate that the balance between the production of LTB4 and ATL modulates PMN recruitment/function and gastric mucosal responses to aspirin...
  39. ncbi request reprint Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica, Patologia e Farmacologia, Universita degli Studi di Perugia, Perugia, Italy
    Gastroenterology 123:1598-606. 2002
    ..Acetylation of COX-2 by aspirin can result in production of an antiinflammatory substance, 15(R)-epi-LXA4. We determined whether aspirin-triggered lipoxin (LX) production via COX-2 diminishes aspirin-induced damage in the rat stomach...
  40. ncbi request reprint Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen
    Alfonso Catalano
    Institute of Experimental Pathology, University of Ancona, Faculty of Medicine, Via Ranieri, 60131 Ancona, Italy
    Oncogene 21:2896-900. 2002
    ..These data indicate that VEGF regulation by SV40 transforming proteins can represent a key event in SV40 signaling relevant for tumor progression...
  41. ncbi request reprint Endogenous levels of mRNA for IFNs and IFN-related genes in hepatic biopsies of chronic HCV-infected and non-alcoholic steatohepatitis patients
    Isabella Abbate
    Microbiology and Virology Service, S Pertini Hospital, Rome, Italy
    J Med Virol 70:581-7. 2003
    ....
  42. ncbi request reprint 5-lipoxygenase antagonizes genotoxic stress-induced apoptosis by altering p53 nuclear trafficking
    Alfonso Catalano
    Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy
    FASEB J 18:1740-2. 2004
    ..Moreover, they provide a rationale to the therapeutic use of 5-LO inhibitors to enhance cancer chemosensitivity in selected tumors...
  43. ncbi request reprint Inflammation resolution: does the bone marrow have a say?
    Mario Romano
    Am J Hematol 83:435-6. 2008