Mario Romano


Affiliation: University of Chieti
Country: Italy


  1. request reprint
    Romano M. Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. Inflamm Allergy Drug Targets. 2006;5:81-90 pubmed
    ..Clinical evaluation of LXA4 and 15-epi-LXA4 formation and their pharmacological regulation may be now achieved using recently developed ELISA assays, that allow large-scale measurements in human biological fluids. ..
  2. request reprint
    Romano M, Claria J. Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J. 2003;17:1986-95 pubmed
    ..In this article we will review evidence of COX-2 and 5-LO involvement in cancer pathobiology, propose a model of integrated control of cell proliferation by these enzymes, and discuss the pharmacologic implications of this model. ..
  3. Romano M. Lipoxin and aspirin-triggered lipoxins. ScientificWorldJournal. 2010;10:1048-64 pubmed publisher
  4. Romano M, Cianci E, Simiele F, Recchiuti A. Lipoxins and aspirin-triggered lipoxins in resolution of inflammation. Eur J Pharmacol. 2015;760:49-63 pubmed publisher
    ..Counter-regulatory signaling by LXA4 and 15-epi-LXA4 follows the activation of a G protein-coupled receptor, termed ALX/FPR2, which is emerging as a key anti-inflammatory receptor. ..
  5. Cianci E, Recchiuti A, Trubiani O, Diomede F, Marchisio M, Miscia S, et al. Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins. Stem Cells Transl Med. 2016;5:20-32 pubmed publisher
    ..Moreover, the data may represent a more general template to explain the immunomodulatory functions of stem cells. ..
  6. Simiele F, Recchiuti A, Patruno S, Plebani R, Pierdomenico A, Codagnone M, et al. Epigenetic regulation of the formyl peptide receptor 2 gene. Biochim Biophys Acta. 2016;1859:1252-8 pubmed publisher
    ..Collectively, these results uncover unappreciated epigenetic regulation of ALX/FPR2 expression that can be exploited for innovative approaches to inflammatory disorders. ..
  7. Cianci E, Trubiani O, Diomede F, Merciaro I, Meschini I, Bruni P, et al. Immobilization and delivery of biologically active Lipoxin A4 using electrospinning technology. Int J Pharm. 2016;515:254-261 pubmed publisher
    ..These results demonstrate for the first time that LXA4 can be incorporated into biomembranes, which may be useful to combat local inflammation and promote tissue repair in selected clinical settings. ..
  8. Codagnone M, Recchiuti A, Lanuti P, Pierdomenico A, Cianci E, Patruno S, et al. Lipoxin A4 stimulates endothelial miR-126-5p expression and its transfer via microvesicles. FASEB J. 2017;31:1856-1866 pubmed publisher
    ..Lanuti, P., Pierdomenico, A. M., Cianci, E., Patruno, S., Mari, V. C., Simiele, F., Di Tomo, P., Pandolfi, A., Romano, M. Lipoxin A4 stimulates endothelial miR-126-5p expression and its transfer via microvesicles. ..
  9. Pierdomenico A, Recchiuti A, Simiele F, Codagnone M, Mari V, Davì G, et al. MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. J Biol Chem. 2015;290:3592-600 pubmed publisher
    ..These results unravel novel regulatory mechanisms of ALX/FPR2 expression and ligand-evoked macrophages proresolution responses mediated by miR-181b, thus uncovering novel components of the endogenous inflammation resolution circuits. ..

More Information


  1. Totani L, Plebani R, Piccoli A, Di Silvestre S, Lanuti P, Recchiuti A, et al. Mechanisms of endothelial cell dysfunction in cystic fibrosis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3243-3253 pubmed publisher
    ..Moreover, our findings open avenues for novel pharmacology to control endothelial dysfunction and its consequences in CF. ..
  2. Pierdomenico A, Patruno S, Codagnone M, Simiele F, Mari V, Plebani R, et al. microRNA-181b is increased in cystic fibrosis cells and impairs lipoxin A4 receptor-dependent mechanisms of inflammation resolution and antimicrobial defense. Sci Rep. 2017;7:13519 pubmed publisher
    ..Thus, targeting miR-181b may represent a strategy to enhance anti-inflammatory and anti-microbial defense mechanisms in CF. ..