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Genomes and Genes | S RomagnaniSummaryAffiliation: University of Florence Country: Italy Publications
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Publications
Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursorLorenzo Cosmi
Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
J Exp Med 205:1903-16. 2008..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor...- Heterogeneity of human effector CD4+ T cellsFrancesco Annunziato
Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel Therapies DENOthe, Department of Internal Medicine, University of Florence, Viale Morgagni 85, Florence 50134, Italy
Arthritis Res Ther 11:257. 2009..Despite the heterogeneity of CD4+ effector Th cells being higher than previously thought and some of their subsets exhibiting high plasticity, the Th1/Th2 paradigm still maintains a strong validity... 
Properties and origin of human Th17 cellsSergio Romagnani
Department of Internal Medicine and Excellence Center DENOTHE, University of Florence, Firenze 50134, Italy
Mol Immunol 47:3-7. 2009..By contrast, TGF-beta does not play a direct role in human Th17 differentiation, but can only favour their expansion by inhibiting T-bet expression and the development of Th1 cells...
Regulation of the T cell responseS Romagnani
Center of Excellence for Research, Transfer, and High Education DENOthe, University of Florence, Florence, Italy
Clin Exp Allergy 36:1357-66. 2006..The development of Th17 cells is also down-regulated by IL-4 produced by Th2 cells and by IFN-gamma produced by Th1 cells...- Immunological tolerance and autoimmunitySergio Romagnani
Department of Internal Medicine, Excellence Centre Denothe, University of Florence, Florence, Italy
Intern Emerg Med 1:187-96. 2006.... - The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both?Sergio Romagnani
Center for Research, Transfer and High Education MCIDNENT, University of Florence, Florence, Italy
Immunology 112:352-63. 2004..A better understanding of this question is important not only from a theoretical point of view, but also because of its therapeutic implications... - New therapeutic strategies in allergic diseasesSergio Romagnani
Department of Internal Medicine, University of Florence, Italy
Drugs Today (Barc) 39:849-65. 2003.... - Human Th17 cellsSergio Romagnani
Department of Internal Medicine, University of Florence, Viale Morgagni, 85 Firenze 50134, Italy
Arthritis Res Ther 10:206. 2008..In contrast, it is unlikely that Th17 cells contribute to the pathogenesis of human allergic IgE-mediated disorders, because IL-4 and IL-25 (a powerful inducer of IL-4) are both potent inhibitors of Th17 cell development... - Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ P Romagnani
Department of Physiopathology, Endocrinology Unit, and the Department of Internal Medicine, University of Florence, Florence, Italy
Blood 97:601-7. 2001.... - Reversal of human allergen-specific CRTH2+ T(H)2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotideF Annunziato
Department of Internal Medicine, Section of Clinical Immunology, Allergy and Respiratory Diseases, University of Florence, Italy
J Allergy Clin Immunol 108:815-21. 2001.... - Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-productionL Cosmi
Center of Research, Transfer, High Education 'DENOTHE, University of Florence, Firenze, Italy
Clin Exp Allergy 36:261-72. 2006.... - Defective production of LIF, M-CSF and Th2-type cytokines by T cells at fetomaternal interface is associated with pregnancy lossM P Piccinni
Department of Internal Medicine, Immunoallergology Unit, University of Florence, 85 viale Morgagni, 50134, Florence, Italy
J Reprod Immunol 52:35-43. 2001..Finally, a direct cause-and-effect relationship between the defective production of LIF, M-CSF and Th2-type cytokines by T cells present at feto maternal interface and the pregnancy loss has been observed... - Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine productionP Parronchi
Department of Allergology and Clinical Immunology, University of Florence, Italy
Proc Natl Acad Sci U S A 88:4538-42. 1991.... - Anti-infliximab IgE and non-IgE antibodies and induction of infusion-related severe anaphylactic reactionsA Vultaggio
Department of Biomedicine, Policlinico di Careggi, Florence, Italy
Allergy 65:657-61. 2010..Severe anaphylaxis has been reported during therapy, although the exact mechanism has not been fully defined. The reactions have been related to the infliximab immunogenicity and development of specific antibodies... - Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancyM P Piccinni
Department of Internal Medicine, Immunoallergology Unit, University of Florence, 85 viale Morgagni, 50134, Florence, Italy
J Neuroimmunol 109:30-3. 2000..Our results suggest that relaxin and progesterone may contribute to the regulation of the immune homeostasis during pregnancy... - Chemokines and lymphopoiesis in human thymusF Annunziato
Dept of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Viale Pieraccini 6, Florence-50134, Italy
Trends Immunol 22:277-81. 2001..We propose that, by selectively mobilizing cells, chemokines can sort positively selected cells from negatively selected cells, and that chemokines make distinctions among CD8+ subpopulations that previously have not been recognized... - Human bone marrow non-B, non-T cells produce interleukin 4 in response to cross-linkage of Fc epsilon and Fc gamma receptorsM P Piccinni
Department of Clinical Immunology and Allergology, University of Florence, Italy
Proc Natl Acad Sci U S A 88:8656-60. 1991..These data suggest that human BM cells, probably belonging to the mast cell and/or basophil lineage, are capable of producing IL-4 in response to Fc epsilon R or Fc gamma R cross-linkage... - T cell clones providing helper function for IgE synthesis release soluble factor(s) that induce IgE production in human B cells: possible role for interleukin 4 (IL-4)E Maggi
Division of Allergology and Clinical Immunology, University of Florence, Italy
Clin Exp Immunol 73:57-62. 1988..Such an activity appeared to be associated with the presence of interleukin 4 (IL-4) in supernatants and it was inhibited by adding both gamma-interferon and anti-human IL-4 antibody in culture... - Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selectionF Annunziato
Department of Internal Medicine Clinical Immunology, Allergy and Respiratory Disease Unit, University of Florence, Italy
J Immunol 165:238-46. 2000..By contrast, ELC production by CD30L-lacking medullary epithelial cells may induce the migration into periphery of mature thymocytes that have survived the process of negative selection... - CXCR3 and alphaEbeta7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytesF Annunziato
Center for Research, Transfer, and High Education DENOthe, Dipartimento di Medicina Interna, Universita di Firenze, Viale Morgagni 85, Firenze 50134 Italy
Gut 55:961-8. 2006.... - Influence of total serum IgE levels on the in vitro detection of beta-lactams-specific IgE antibodiesA Vultaggio
Department of Biomedicine, Immunoallergology Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
Clin Exp Allergy 39:838-44. 2009..Allergic reactions to beta-lactams are a frequent cause of adverse drug reactions; the diagnosis is based on history, clinical examination, skin testing (prick and intradermal) and demonstration of serum-specific IgE antibodies (Abs)... - Safety and tolerability of infliximab therapy: suggestions and criticisms based on wide clinical experienceA Vultaggio
Department of Biomedicine, Immunoallergology Unit, Policlinico di Careggi, Viale Morgagni 85, Florence, Italy
Int J Immunopathol Pharmacol 21:367-74. 2008.... - Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activityP Romagnani
Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
J Clin Invest 107:53-63. 2001..These data provide definitive evidence of CXCR3 expression by HMVEC and open new avenues for therapeutic interventions in all conditions in which an angiostatic effect may be beneficial... - Microchimerism and systemic sclerosisC Scaletti
Department of Internal Medicine, Section of Immunoallergology and Respiratory Disease, University of Florence, Italy
Int Arch Allergy Immunol 125:196-202. 2001..Both features are characteristics of cGVHD, supporting the hypothesis that SSc is a disease similar to cGVHD... - Chemoattractant receptors expressed on type 2 T cells and their role in diseaseL Cosmi
Department of Internal Medicine, Section of Clinical Immunology, Allergy and Respiratory Diseases, University of Florence, Viale Morgagni 85, I-50134 Florence, Italy
Int Arch Allergy Immunol 125:273-9. 2001..Additional studies, however, are required to understand its effective importance in the induction and maintenance of Th2- or Tc2-mediated response and inflammation... - Th1 and th2 responses, HIV-1 coreceptors, and HIV-1 infectionG Galli
Department of Internal Medicine, University of Florence, Italy
J Biol Regul Homeost Agents 15:308-13. 2001.... - Partial safety of the new COX-2 inhibitor rofecoxib in NSAIDs high sensitive patientsA Matucci
Department of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Policlinico di Careggi Viale Morgagni 85, 50134 Florence, Italy
Allergy 59:1133-4. 2004 - Production of IL-4 and leukemia inhibitory factor by T cells of the cumulus oophorus: a favorable microenvironment for pre-implantation embryo developmentM P Piccinni
Department of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Florence, Italy
Eur J Immunol 31:2431-7. 2001.... - Poly(I:C) promotes the production of IL-17A by murine CD1d-driven invariant NKT cells in airway inflammationA Vultaggio
Immunoallergology Unit, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy
Allergy 67:1223-32. 2012..The aim of the study was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A production by CD1d-activated iNKT cells... - Environmental factors favoring the allergen-specific Th2 response in allergic subjectsM P Piccinni
Department of Internal Medicine, Immunoallergology Unit, University of Florence, 85 viale Morgagni, 50134 Florence, Italy
Ann N Y Acad Sci 917:844-52. 2000.... - Th17 cells: new players in asthma pathogenesisL Cosmi
Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
Allergy 66:989-98. 2011.... - T-cell responses in allergy and asthmaS Romagnani
Section of Clinical Immunology, Allergy, and Respiratory Diseases, Department of Internal Medicine, University of Florence, Florence, Italy
Curr Opin Allergy Clin Immunol 1:73-8. 2001.... - Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cellsR Manetti
Division of Clinical Immunology and Allergy, University of Florence, Italy
J Exp Med 177:1199-204. 1993..Thus, IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses... - Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokinesP Romagnani
Department of Physiopathology, Section of Clinical Immunology, University of Florence, Florence, Italy
Am J Pathol 155:1195-204. 1999..Our findings indicate that these chemokines may play an important role in the differentiation and/or migration of this mast cell subset in connective tissues, as well as in sites of allergic inflammation... - Pharmacological modulation of stem cell functionP Romagnani
Excellence Center for Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
Curr Med Chem 14:1129-39. 2007.... - Cytokines and chemoattractants in allergic inflammationS Romagnani
Section of Clinical Immunology, Allergy, and Respiratory Diseases, Department of Internal Medicine, University of Florence, Viale Morgagni 85, Firenze 50134, Italy
Mol Immunol 38:881-5. 2002.... - Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine productionG F Del Prete
Division of Clinical Immunology and Allergology, University of Florence, Italy
J Clin Invest 88:346-50. 1991.... - Natural killer cell deficiencies in a consecutive series of children with herpetic encephalitisF Almerigogna
Department of Internal Medicine, University of Florence, Italy
Int J Immunopathol Pharmacol 24:231-8. 2011..These findings suggest a role for NK cell deficiencies as a predisposing factor for increased susceptibility and severe course of disease in these patients... - Regulatory T cells: which role in the pathogenesis and treatment of allergic disorders?S Romagnani
Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, Firenze, Italy
Allergy 61:3-14. 2006..At present, therapeutic strategies able to induce an immune deviation of allergen-specific type 2 T-helper responses to a less polarized phenotype rather than a general immune suppression appear more realistic... - High CD30 ligand expression by epithelial cells and Hassal's corpuscles in the medulla of human thymusP Romagnani
Department of Clinical Physiopathology, Endocrinology Unit the Institute of Internal Medicine and Immunoallergology and the Department of Anatomy, University of Florence, Italy
Blood 91:3323-32. 1998..These findings provide additional information on the nature and localization of CD30+ thymocytes and show that epithelial cells are the major holder of CD30L in the thymic medulla... - Coronary vasospasm during an acute allergic reactionO Rossi
Institute of Internal Medicine and Immunoallergology, Policlinco di Careggi/ University of Florence, Viale Morgagni 85, 50134, Florence, Italy
Allergy 57:867-8. 2002 - Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signalingFrancesco Liotta
Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
Stem Cells 26:279-89. 2008.... - Peripheral blood as a source of stem cells for regenerative medicinePaola Romagnani
University of Florence, Center for Research, Transfer and High Education DENOthe, Viale Pieraccini 6, Florence 50139, Italy
Expert Opin Biol Ther 6:193-202. 2006..This review analyses the different subsets of SCs described in PB, the different hypotheses suggested to explain their origin, and the possible mechanisms that provide the basis for their biological potential... - Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN releaseLucia Filì
DENOthe Center for Research, Transfer and High Education, University of Florence, Via Morgagni 85, 50134 Florence, Italy
J Allergy Clin Immunol 118:511-7. 2006.... - Phenotypic and functional features of human Th17 cellsFrancesco Annunziato
Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
J Exp Med 204:1849-61. 2007.... - Coming back to a missing immune deviation as the main explanatory mechanism for the hygiene hypothesisSergio Romagnani
J Allergy Clin Immunol 119:1511-3. 2007 - T cells specific for Candida albicans antigens and producing type 2 cytokines in lesional mucosa of untreated HIV-infected patients with pseudomembranous oropharyngeal candidiasisAlessandra Vultaggio
Department of Internal Medicine, University of Firenze, Viale Morgagni 85, 50134 Firenze, Italy
Microbes Infect 10:166-74. 2008..These findings, showing a non-protective Th0/Th2 response to C. albicans antigen in the blood and lesional mucosa of HIV-infected patients with POPC, may explain the high susceptibility of candidiasis in these subjects... - Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malariaMaria G Torcia
Department of Clinical Physiopathology, University of Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
Proc Natl Acad Sci U S A 105:646-51. 2008..The results suggest that the higher resistance to malaria of the Fulani could derive from a functional deficit of T regulatory cells... - An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4Laura Lasagni
Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
J Exp Med 197:1537-49. 2003.... - CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine productionPaola Romagnani
Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
J Allergy Clin Immunol 116:1372-9. 2005..This might represent an internal regulatory pathway of TH cell responses and might contribute to the modulation of chronic inflammatory reactions, including allergy... - CXC chemokines: the regulatory link between inflammation and angiogenesisPaola Romagnani
Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Trends Immunol 25:201-9. 2004 - Immunologic influences on allergy and the TH1/TH2 balanceSergio Romagnani
Section of Clinical Immunology, Allergy, and Respiratory Diseases, Department of Internal Medicine, University of Florence, Italy
J Allergy Clin Immunol 113:395-400. 2004..The solution to this question is very important not only from a theoretic point of view but also because of its therapeutic implications... - Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytesLorenzo Cosmi
Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
Blood 102:4107-14. 2003..These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells... - The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cellsFrancesca Brugnolo
Department of Internal Medicine, Immunoallergology and Respiratory Disease Unit, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
J Allergy Clin Immunol 111:380-8. 2003..CONCLUSIONS: These results suggest that R-848, and probably other imidazoquinolines, might be used as adjuvants in view of novel allergen-specific immunotherapeutic regimens for the treatment of allergic disorders... - ["Sarcoidosis-like" granulomatous disease in patients with common variable hypogammaglobulinemia]Andrea Matucci
Sezione di Immunoallergologia e Malattie Respiratorie, Cattedra di Allergologia e Immunologia Clinica, Dipartimento di Medicina Interna, Universita degli Studi di Firenze
Ann Ital Med Int 17:108-16. 2002..In turn, the latter could be responsible for a more efficacious effector phase of the immune response. This may explain the reduced rate of infectious diseases and consequently of bronchiectasies observed in CVI patients... - Type 1 T helper cells specific for Candida albicans antigens in peripheral blood and vaginal mucosa of women with recurrent vaginal candidiasisMarie-Pierre Piccinni
Immunoallergology Section, Department of Internal Medicine, University of Florence, Florence, Italy
J Infect Dis 186:87-93. 2002..These findings provide direct evidence that RVC is characterized by a highly polarized local and circulating type 1 T helper cell-like response against C. albicans antigens... - Role of low nuclear grading of renal carcinoma cells in the functional profile of tumor-infiltrating T cellsLuca Puccetti
Urology Unit, Department of Critical Medicine, Santa Maria Annunziata Hospital, University of Florence, Florence, Italy
Int J Cancer 98:674-81. 2002..These data address the association of the nuclear grading of neoplastic cells with different local tumor-specific T-cell responses in RCC... - LymphocytesSergio Romagnani
University of Florence, Florence, Italy
Clin Allergy Immunol 16:97-124. 2002 - Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokinesLorenzo Cosmi
Department of Internal Medicine, University of Florence, Florence, Italy
Blood 103:3117-21. 2004.... - Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaquesMarisa Benagiano
Department of Internal Medicine, University of Florence, Florence, Italy
J Immunol 174:6509-17. 2005..This hypothesis is in agreement with the notion that immunization with HSP exacerbates atherosclerosis, whereas immunosuppression and T cell depletion prevent the formation of arteriosclerotic lesions in experimental animals... - Thymic regulatory T cellsEnrico Maggi
Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
Autoimmun Rev 4:579-86. 2005..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens... - Functional features of human CD25+ regulatory thymocytesFrancesco Liotta
Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy
Microbes Infect 7:1017-22. 2005..This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes... - Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cellsMauro Krampera
Department of Clinical and Experimental Medicine, University of Verona, Italy
Stem Cells 24:386-98. 2006..These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma... - CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitorsPaola Romagnani
Center for Research, Transfer and High Education DENOthe, University of Florence, Italy
Circ Res 97:314-22. 2005.... - Introduction: characterization and functions of human T regulatory cellsSergio Romagnani
Microbes Infect 7:1015-6. 2005..However, it is clear that Treg cells play an important role in human diseases, such as autoimmune disorders, allergy, HIV infection, tumors and graft-versus-host disease... - Regenerative and immunomodulatory potential of mesenchymal stem cellsMauro Krampera
Department of Clinical and Experimental Medicine, Section of Haematology, P le L A Scuro 10, 37134 Verona, Italy
Curr Opin Pharmacol 6:435-41. 2006..Thus, MSCs appear to be a very promising tool for regenerative and immunoregulatory cell therapy... - Th2-oriented profile of male offspring T cells present in women with systemic sclerosis and reactive with maternal major histocompatibility complex antigensCristina Scaletti
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, Florence 50134, Italy
Arthritis Rheum 46:445-50. 2002.... - Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytesFrancesco Annunziato
Department of Internal Medicine, University Florence, Italy
J Exp Med 196:379-87. 2002.... - Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosisLorenzo Cosmi
Center for High Research DENOthe, University of Florence, Florence, Italy
Int Arch Allergy Immunol 143:1-9. 2007.... - T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesionsMarisa Benagiano
Department of Internal Medicine, University of Florence, Viale Morgagni, Italy
Proc Natl Acad Sci U S A 100:6658-63. 2003..Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition... - PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretionLaura Lasagni
Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Florence, Italy
Blood 109:4127-34. 2007..These results demonstrate that CXCL4 and CXCL4L1 exhibit a distinct subcellular localization and are secreted in a differentially regulated manner, suggesting distinct roles in inflammatory or homeostatic processes... - Selective deficiency of naïve CD4+ T-lymphocytes in a child with congenital lymphoedemaElena Chiappini
Division of Paediatrics and Infectious Diseases, Department of Paediatrics, University of Florence, Via Luca Giordano 13, 50132 Florence, Italy
Eur J Pediatr 162:752-4. 2003..A high proportion of naïve CD4+ T-lymphocytes was found in the ascitic fluid, supporting the hypothesis of extra-vascular sequestration of these cells into lymphoedematous tissue... - Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interactionFrancesco Liotta
Excellence Center for Research, Transfer, and High Education, De Novo Therapy, University of Florence, Florence, Italy
J Allergy Clin Immunol 121:1000-5.e8. 2008..The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear... - Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cellsBenedetta Mazzinghi
Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50121 Florence, Italy
J Exp Med 205:479-90. 2008.... - Role of chemokines in endocrine autoimmune diseasesMario Rotondi
Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, 50121 Florence, Italy
Endocr Rev 28:492-520. 2007.... - Immune regulation by mesenchymal stem cells derived from adult spleen and thymusMauro Krampera
Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
Stem Cells Dev 16:797-810. 2007..Our data suggest that not only do spleen and thymus have a stem cell reservoir to build up their stromal architecture, but also contain microenviromental immunoregulatory cells with the same properties of BM-MSCs... - Regenerative potential of embryonic renal multipotent progenitors in acute renal failureElena Lazzeri
Excellence Center for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy
J Am Soc Nephrol 18:3128-38. 2007..The ability of these cells to repair renal damage, together with their apparent lack of tumorigenicity, suggests their potential in the treatment of renal failure... - Association between "sarcoidosis-like" disease and common variable immunodeficiency (CVI): a new CVI variant showing an activation of the immune systemAlessandra Vultaggio
Department of Biomedicine, Immunoallergology Unit, Policlinico di Careggi, AOUC Firenze, Italy
Sarcoidosis Vasc Diffuse Lung Dis 24:127-33. 2007..Particular interest has been recently addressed to the association between a Granulomatous Sarcoidosis-like Disease (GSa-LD) and Common Variable Immunodeficiency (CVI)...