S Romagnani

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
  2. pmc Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    Francesco Annunziato
    Department of Internal Medicine, University Florence, Italy
    J Exp Med 196:379-87. 2002
  3. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
  4. pmc Heterogeneity of human effector CD4+ T cells
    Francesco Annunziato
    Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel Therapies DENOthe, Department of Internal Medicine, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Arthritis Res Ther 11:257. 2009
  5. pmc Human Th17 cells
    Sergio Romagnani
    Department of Internal Medicine, University of Florence, Viale Morgagni, 85 Firenze 50134, Italy
    Arthritis Res Ther 10:206. 2008
  6. ncbi request reprint Immunological tolerance and autoimmunity
    Sergio Romagnani
    Department of Internal Medicine, Excellence Centre Denothe, University of Florence, Florence, Italy
    Intern Emerg Med 1:187-96. 2006
  7. ncbi request reprint Regulation of the T cell response
    S Romagnani
    Center of Excellence for Research, Transfer, and High Education DENOthe, University of Florence, Florence, Italy
    Clin Exp Allergy 36:1357-66. 2006
  8. ncbi request reprint New therapeutic strategies in allergic diseases
    Sergio Romagnani
    Department of Internal Medicine, University of Florence, Italy
    Drugs Today (Barc) 39:849-65. 2003
  9. doi request reprint Properties and origin of human Th17 cells
    Sergio Romagnani
    Department of Internal Medicine and Excellence Center DENOTHE, University of Florence, Firenze 50134, Italy
    Mol Immunol 47:3-7. 2009
  10. pmc The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both?
    Sergio Romagnani
    Center for Research, Transfer and High Education MCIDNENT, University of Florence, Florence, Italy
    Immunology 112:352-63. 2004

Collaborators

Detail Information

Publications80

  1. pmc Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    Lorenzo Cosmi
    Department of Internal Medicine and DENOTHE Center, University of Florence, Florence 50134, Italy
    J Exp Med 205:1903-16. 2008
    ..These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor...
  2. pmc Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    Francesco Annunziato
    Department of Internal Medicine, University Florence, Italy
    J Exp Med 196:379-87. 2002
    ....
  3. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
    ....
  4. pmc Heterogeneity of human effector CD4+ T cells
    Francesco Annunziato
    Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel Therapies DENOthe, Department of Internal Medicine, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Arthritis Res Ther 11:257. 2009
    ..Despite the heterogeneity of CD4+ effector Th cells being higher than previously thought and some of their subsets exhibiting high plasticity, the Th1/Th2 paradigm still maintains a strong validity...
  5. pmc Human Th17 cells
    Sergio Romagnani
    Department of Internal Medicine, University of Florence, Viale Morgagni, 85 Firenze 50134, Italy
    Arthritis Res Ther 10:206. 2008
    ..In contrast, it is unlikely that Th17 cells contribute to the pathogenesis of human allergic IgE-mediated disorders, because IL-4 and IL-25 (a powerful inducer of IL-4) are both potent inhibitors of Th17 cell development...
  6. ncbi request reprint Immunological tolerance and autoimmunity
    Sergio Romagnani
    Department of Internal Medicine, Excellence Centre Denothe, University of Florence, Florence, Italy
    Intern Emerg Med 1:187-96. 2006
    ....
  7. ncbi request reprint Regulation of the T cell response
    S Romagnani
    Center of Excellence for Research, Transfer, and High Education DENOthe, University of Florence, Florence, Italy
    Clin Exp Allergy 36:1357-66. 2006
    ..The development of Th17 cells is also down-regulated by IL-4 produced by Th2 cells and by IFN-gamma produced by Th1 cells...
  8. ncbi request reprint New therapeutic strategies in allergic diseases
    Sergio Romagnani
    Department of Internal Medicine, University of Florence, Italy
    Drugs Today (Barc) 39:849-65. 2003
    ....
  9. doi request reprint Properties and origin of human Th17 cells
    Sergio Romagnani
    Department of Internal Medicine and Excellence Center DENOTHE, University of Florence, Firenze 50134, Italy
    Mol Immunol 47:3-7. 2009
    ..By contrast, TGF-beta does not play a direct role in human Th17 differentiation, but can only favour their expansion by inhibiting T-bet expression and the development of Th1 cells...
  10. pmc The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both?
    Sergio Romagnani
    Center for Research, Transfer and High Education MCIDNENT, University of Florence, Florence, Italy
    Immunology 112:352-63. 2004
    ..A better understanding of this question is important not only from a theoretical point of view, but also because of its therapeutic implications...
  11. ncbi request reprint Reversal of human allergen-specific CRTH2+ T(H)2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide
    F Annunziato
    Department of Internal Medicine, Section of Clinical Immunology, Allergy and Respiratory Diseases, University of Florence, Italy
    J Allergy Clin Immunol 108:815-21. 2001
    ....
  12. ncbi request reprint Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+
    P Romagnani
    Department of Physiopathology, Endocrinology Unit, and the Department of Internal Medicine, University of Florence, Florence, Italy
    Blood 97:601-7. 2001
    ....
  13. ncbi request reprint Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production
    L Cosmi
    Center of Research, Transfer, High Education DENOTHE, University of Florence, Firenze, Italy
    Clin Exp Allergy 36:261-72. 2006
    ....
  14. ncbi request reprint Defective production of LIF, M-CSF and Th2-type cytokines by T cells at fetomaternal interface is associated with pregnancy loss
    M P Piccinni
    Department of Internal Medicine, Immunoallergology Unit, University of Florence, 85 viale Morgagni, 50134, Florence, Italy
    J Reprod Immunol 52:35-43. 2001
    ..Finally, a direct cause-and-effect relationship between the defective production of LIF, M-CSF and Th2-type cytokines by T cells present at feto maternal interface and the pregnancy loss has been observed...
  15. pmc Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production
    P Parronchi
    Department of Allergology and Clinical Immunology, University of Florence, Italy
    Proc Natl Acad Sci U S A 88:4538-42. 1991
    ....
  16. doi request reprint Anti-infliximab IgE and non-IgE antibodies and induction of infusion-related severe anaphylactic reactions
    A Vultaggio
    Department of Biomedicine, Policlinico di Careggi, Florence, Italy
    Allergy 65:657-61. 2010
    ..Severe anaphylaxis has been reported during therapy, although the exact mechanism has not been fully defined. The reactions have been related to the infliximab immunogenicity and development of specific antibodies...
  17. ncbi request reprint Role of hormone-controlled Th1- and Th2-type cytokines in successful pregnancy
    M P Piccinni
    Department of Internal Medicine, Immunoallergology Unit, University of Florence, 85 viale Morgagni, 50134, Florence, Italy
    J Neuroimmunol 109:30-3. 2000
    ..Our results suggest that relaxin and progesterone may contribute to the regulation of the immune homeostasis during pregnancy...
  18. ncbi request reprint Chemokines and lymphopoiesis in human thymus
    F Annunziato
    Dept of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Viale Pieraccini 6, Florence-50134, Italy
    Trends Immunol 22:277-81. 2001
    ..We propose that, by selectively mobilizing cells, chemokines can sort positively selected cells from negatively selected cells, and that chemokines make distinctions among CD8+ subpopulations that previously have not been recognized...
  19. ncbi request reprint Th1 and th2 responses, HIV-1 coreceptors, and HIV-1 infection
    G Galli
    Department of Internal Medicine, University of Florence, Italy
    J Biol Regul Homeost Agents 15:308-13. 2001
    ....
  20. pmc T cell clones providing helper function for IgE synthesis release soluble factor(s) that induce IgE production in human B cells: possible role for interleukin 4 (IL-4)
    E Maggi
    Division of Allergology and Clinical Immunology, University of Florence, Italy
    Clin Exp Immunol 73:57-62. 1988
    ..Such an activity appeared to be associated with the presence of interleukin 4 (IL-4) in supernatants and it was inhibited by adding both gamma-interferon and anti-human IL-4 antibody in culture...
  21. pmc Human bone marrow non-B, non-T cells produce interleukin 4 in response to cross-linkage of Fc epsilon and Fc gamma receptors
    M P Piccinni
    Department of Clinical Immunology and Allergology, University of Florence, Italy
    Proc Natl Acad Sci U S A 88:8656-60. 1991
    ..These data suggest that human BM cells, probably belonging to the mast cell and/or basophil lineage, are capable of producing IL-4 in response to Fc epsilon R or Fc gamma R cross-linkage...
  22. ncbi request reprint Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection
    F Annunziato
    Department of Internal Medicine Clinical Immunology, Allergy and Respiratory Disease Unit, University of Florence, Italy
    J Immunol 165:238-46. 2000
    ..By contrast, ELC production by CD30L-lacking medullary epithelial cells may induce the migration into periphery of mature thymocytes that have survived the process of negative selection...
  23. pmc CXCR3 and alphaEbeta7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes
    F Annunziato
    Center for Research, Transfer, and High Education DENOthe, Dipartimento di Medicina Interna, Universita di Firenze, Viale Morgagni 85, Firenze 50134 Italy
    Gut 55:961-8. 2006
    ....
  24. doi request reprint Influence of total serum IgE levels on the in vitro detection of beta-lactams-specific IgE antibodies
    A Vultaggio
    Department of Biomedicine, Immunoallergology Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
    Clin Exp Allergy 39:838-44. 2009
    ..Allergic reactions to beta-lactams are a frequent cause of adverse drug reactions; the diagnosis is based on history, clinical examination, skin testing (prick and intradermal) and demonstration of serum-specific IgE antibodies (Abs)...
  25. ncbi request reprint Safety and tolerability of infliximab therapy: suggestions and criticisms based on wide clinical experience
    A Vultaggio
    Department of Biomedicine, Immunoallergology Unit, Policlinico di Careggi, Viale Morgagni 85, Florence, Italy
    Int J Immunopathol Pharmacol 21:367-74. 2008
    ....
  26. ncbi request reprint Chemoattractant receptors expressed on type 2 T cells and their role in disease
    L Cosmi
    Department of Internal Medicine, Section of Clinical Immunology, Allergy and Respiratory Diseases, University of Florence, Viale Morgagni 85, I-50134 Florence, Italy
    Int Arch Allergy Immunol 125:273-9. 2001
    ..Additional studies, however, are required to understand its effective importance in the induction and maintenance of Th2- or Tc2-mediated response and inflammation...
  27. pmc Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity
    P Romagnani
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
    J Clin Invest 107:53-63. 2001
    ..These data provide definitive evidence of CXCR3 expression by HMVEC and open new avenues for therapeutic interventions in all conditions in which an angiostatic effect may be beneficial...
  28. ncbi request reprint Microchimerism and systemic sclerosis
    C Scaletti
    Department of Internal Medicine, Section of Immunoallergology and Respiratory Disease, University of Florence, Italy
    Int Arch Allergy Immunol 125:196-202. 2001
    ..Both features are characteristics of cGVHD, supporting the hypothesis that SSc is a disease similar to cGVHD...
  29. ncbi request reprint Partial safety of the new COX-2 inhibitor rofecoxib in NSAIDs high sensitive patients
    A Matucci
    Department of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Policlinico di Careggi Viale Morgagni 85, 50134 Florence, Italy
    Allergy 59:1133-4. 2004
  30. ncbi request reprint Production of IL-4 and leukemia inhibitory factor by T cells of the cumulus oophorus: a favorable microenvironment for pre-implantation embryo development
    M P Piccinni
    Department of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Florence, Italy
    Eur J Immunol 31:2431-7. 2001
    ....
  31. ncbi request reprint Th1/Th2 cells
    S Romagnani
    Department of Internal Medicine, University of Florence, Italy
    Inflamm Bowel Dis 5:285-94. 1999
    ..The Th1/Th2 paradigm also provides the rationale for the development of new types of vaccines against infectious agents and of novel strategies for the therapy of allergic and autoimmune disorders...
  32. doi request reprint Poly(I:C) promotes the production of IL-17A by murine CD1d-driven invariant NKT cells in airway inflammation
    A Vultaggio
    Immunoallergology Unit, Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy
    Allergy 67:1223-32. 2012
    ..The aim of the study was to evaluate the activity of polyinosinic-polycytidylic acid [poly(I:C)] on IL-17A production by CD1d-activated iNKT cells...
  33. doi request reprint Th17 cells: new players in asthma pathogenesis
    L Cosmi
    Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy
    Allergy 66:989-98. 2011
    ....
  34. ncbi request reprint Environmental factors favoring the allergen-specific Th2 response in allergic subjects
    M P Piccinni
    Department of Internal Medicine, Immunoallergology Unit, University of Florence, 85 viale Morgagni, 50134 Florence, Italy
    Ann N Y Acad Sci 917:844-52. 2000
    ....
  35. ncbi request reprint T-cell responses in allergy and asthma
    S Romagnani
    Section of Clinical Immunology, Allergy, and Respiratory Diseases, Department of Internal Medicine, University of Florence, Florence, Italy
    Curr Opin Allergy Clin Immunol 1:73-8. 2001
    ....
  36. pmc Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines
    P Romagnani
    Department of Physiopathology, Section of Clinical Immunology, University of Florence, Florence, Italy
    Am J Pathol 155:1195-204. 1999
    ..Our findings indicate that these chemokines may play an important role in the differentiation and/or migration of this mast cell subset in connective tissues, as well as in sites of allergic inflammation...
  37. ncbi request reprint Cytokines and chemoattractants in allergic inflammation
    S Romagnani
    Section of Clinical Immunology, Allergy, and Respiratory Diseases, Department of Internal Medicine, University of Florence, Viale Morgagni 85, Firenze 50134, Italy
    Mol Immunol 38:881-5. 2002
    ....
  38. pmc Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    R Manetti
    Division of Clinical Immunology and Allergy, University of Florence, Italy
    J Exp Med 177:1199-204. 1993
    ..Thus, IL-12 and CD16+ cells appear to have inhibitory effects on the development of IL-4-producing cells and to play an inductive role in promoting Th1-like responses...
  39. ncbi request reprint High CD30 ligand expression by epithelial cells and Hassal's corpuscles in the medulla of human thymus
    P Romagnani
    Department of Clinical Physiopathology, Endocrinology Unit the Institute of Internal Medicine and Immunoallergology and the Department of Anatomy, University of Florence, Italy
    Blood 91:3323-32. 1998
    ..These findings provide additional information on the nature and localization of CD30+ thymocytes and show that epithelial cells are the major holder of CD30L in the thymic medulla...
  40. ncbi request reprint Pharmacological modulation of stem cell function
    P Romagnani
    Excellence Center for Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    Curr Med Chem 14:1129-39. 2007
    ....
  41. doi request reprint Potential pathogenetic role of Th17, Th0, and Th2 cells in erosive and reticular oral lichen planus
    M P Piccinni
    Department of Experimental and Clinical Medicine, Center of Excellence DeNothe, University of Florence, Florence, Italy
    Oral Dis 20:212-8. 2014
    ..The role of Th17 cells and associated cytokines was investigated in oral lichen planus...
  42. pmc Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
    G F Del Prete
    Division of Clinical Immunology and Allergology, University of Florence, Italy
    J Clin Invest 88:346-50. 1991
    ....
  43. ncbi request reprint Natural killer cell deficiencies in a consecutive series of children with herpetic encephalitis
    F Almerigogna
    Department of Internal Medicine, University of Florence, Italy
    Int J Immunopathol Pharmacol 24:231-8. 2011
    ..These findings suggest a role for NK cell deficiencies as a predisposing factor for increased susceptibility and severe course of disease in these patients...
  44. ncbi request reprint Regulatory T cells: which role in the pathogenesis and treatment of allergic disorders?
    S Romagnani
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, Firenze, Italy
    Allergy 61:3-14. 2006
    ..At present, therapeutic strategies able to induce an immune deviation of allergen-specific type 2 T-helper responses to a less polarized phenotype rather than a general immune suppression appear more realistic...
  45. ncbi request reprint Coronary vasospasm during an acute allergic reaction
    - Matucci
    Institute of Internal Medicine and Immunoallergology, Policlinco di Careggi University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Allergy 57:867-8. 2002
  46. ncbi request reprint Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling
    Francesco Liotta
    Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
    Stem Cells 26:279-89. 2008
    ....
  47. ncbi request reprint Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release
    Lucia Filì
    DENOthe Center for Research, Transfer and High Education, University of Florence, Via Morgagni 85, 50134 Florence, Italy
    J Allergy Clin Immunol 118:511-7. 2006
    ....
  48. doi request reprint T cells specific for Candida albicans antigens and producing type 2 cytokines in lesional mucosa of untreated HIV-infected patients with pseudomembranous oropharyngeal candidiasis
    Alessandra Vultaggio
    Department of Internal Medicine, University of Firenze, Viale Morgagni 85, 50134 Firenze, Italy
    Microbes Infect 10:166-74. 2008
    ..These findings, showing a non-protective Th0/Th2 response to C. albicans antigen in the blood and lesional mucosa of HIV-infected patients with POPC, may explain the high susceptibility of candidiasis in these subjects...
  49. ncbi request reprint Coming back to a missing immune deviation as the main explanatory mechanism for the hygiene hypothesis
    Sergio Romagnani
    J Allergy Clin Immunol 119:1511-3. 2007
  50. pmc Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria
    Maria G Torcia
    Department of Clinical Physiopathology, University of Firenze, Viale Pieraccini 6, 50139 Firenze, Italy
    Proc Natl Acad Sci U S A 105:646-51. 2008
    ..The results suggest that the higher resistance to malaria of the Fulani could derive from a functional deficit of T regulatory cells...
  51. ncbi request reprint CXC chemokines: the regulatory link between inflammation and angiogenesis
    Paola Romagnani
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Trends Immunol 25:201-9. 2004
  52. ncbi request reprint Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    Lorenzo Cosmi
    Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
    Blood 102:4107-14. 2003
    ..These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells...
  53. pmc An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4
    Laura Lasagni
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Exp Med 197:1537-49. 2003
    ....
  54. ncbi request reprint Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines
    Lorenzo Cosmi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Blood 103:3117-21. 2004
    ....
  55. ncbi request reprint Peripheral blood as a source of stem cells for regenerative medicine
    Paola Romagnani
    University of Florence, Center for Research, Transfer and High Education DENOthe, Viale Pieraccini 6, Florence 50139, Italy
    Expert Opin Biol Ther 6:193-202. 2006
    ..This review analyses the different subsets of SCs described in PB, the different hypotheses suggested to explain their origin, and the possible mechanisms that provide the basis for their biological potential...
  56. ncbi request reprint The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells
    Francesca Brugnolo
    Department of Internal Medicine, Immunoallergology and Respiratory Disease Unit, University of Florence, Policlinico di Careggi, Viale Morgagni 85, 50134 Florence, Italy
    J Allergy Clin Immunol 111:380-8. 2003
    ..In experimental models, imidazoquinolines exhibit several immunomodulatory activities via Toll-like receptor signaling on cells of the innate immunity...
  57. ncbi request reprint Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques
    Marisa Benagiano
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Immunol 174:6509-17. 2005
    ..This hypothesis is in agreement with the notion that immunization with HSP exacerbates atherosclerosis, whereas immunosuppression and T cell depletion prevent the formation of arteriosclerotic lesions in experimental animals...
  58. ncbi request reprint ["Sarcoidosis-like" granulomatous disease in patients with common variable hypogammaglobulinemia]
    Andrea Matucci
    Sezione di Immunoallergologia e Malattie Respiratorie, Cattedra di Allergologia e Immunologia Clinica, Dipartimento di Medicina Interna, Universita degli Studi di Firenze
    Ann Ital Med Int 17:108-16. 2002
    ..In turn, the latter could be responsible for a more efficacious effector phase of the immune response. This may explain the reduced rate of infectious diseases and consequently of bronchiectasies observed in CVI patients...
  59. ncbi request reprint Functional features of human CD25+ regulatory thymocytes
    Francesco Liotta
    Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy
    Microbes Infect 7:1017-22. 2005
    ..This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes...
  60. ncbi request reprint Type 1 T helper cells specific for Candida albicans antigens in peripheral blood and vaginal mucosa of women with recurrent vaginal candidiasis
    Marie Pierre Piccinni
    Immunoallergology Section, Department of Internal Medicine, University of Florence, Florence, Italy
    J Infect Dis 186:87-93. 2002
    ..These findings provide direct evidence that RVC is characterized by a highly polarized local and circulating type 1 T helper cell-like response against C. albicans antigens...
  61. ncbi request reprint Lymphocytes
    Sergio Romagnani
    University of Florence, Florence, Italy
    Clin Allergy Immunol 16:97-124. 2002
  62. ncbi request reprint CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production
    Paola Romagnani
    Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
    J Allergy Clin Immunol 116:1372-9. 2005
    ..Two variants of the CXCR3 receptor exist, one (CXCR3-A) reactive with CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both variants are contemporarily expressed by human T cells...
  63. ncbi request reprint Thymic regulatory T cells
    Enrico Maggi
    Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
    Autoimmun Rev 4:579-86. 2005
    ..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens...
  64. ncbi request reprint Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    Stem Cells 24:386-98. 2006
    ..These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma...
  65. ncbi request reprint Role of low nuclear grading of renal carcinoma cells in the functional profile of tumor-infiltrating T cells
    Luca Puccetti
    Urology Unit, Department of Critical Medicine, Santa Maria Annunziata Hospital, University of Florence, Florence, Italy
    Int J Cancer 98:674-81. 2002
    ..These data address the association of the nuclear grading of neoplastic cells with different local tumor-specific T-cell responses in RCC...
  66. ncbi request reprint CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors
    Paola Romagnani
    Center for Research, Transfer and High Education DENOthe, University of Florence, Italy
    Circ Res 97:314-22. 2005
    ....
  67. ncbi request reprint Immunologic influences on allergy and the TH1/TH2 balance
    Sergio Romagnani
    Section of Clinical Immunology, Allergy, and Respiratory Diseases, Department of Internal Medicine, University of Florence, Italy
    J Allergy Clin Immunol 113:395-400. 2004
    ..The solution to this question is very important not only from a theoretic point of view but also because of its therapeutic implications...
  68. ncbi request reprint Th2-oriented profile of male offspring T cells present in women with systemic sclerosis and reactive with maternal major histocompatibility complex antigens
    Cristina Scaletti
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Arthritis Rheum 46:445-50. 2002
    ..To characterize the cytokine production profile of male-offspring T cells reactive against maternal major histocompatibility complex (MHC) antigens present in the peripheral blood and/or skin from women with systemic sclerosis (SSc)...
  69. ncbi request reprint Selective deficiency of naïve CD4+ T-lymphocytes in a child with congenital lymphoedema
    Elena Chiappini
    Division of Paediatrics and Infectious Diseases, Department of Paediatrics, University of Florence, Via Luca Giordano 13, 50132 Florence, Italy
    Eur J Pediatr 162:752-4. 2003
    ..A high proportion of naïve CD4+ T-lymphocytes was found in the ascitic fluid, supporting the hypothesis of extra-vascular sequestration of these cells into lymphoedematous tissue...
  70. doi request reprint Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction
    Francesco Liotta
    Excellence Center for Research, Transfer, and High Education, De Novo Therapy, University of Florence, Florence, Italy
    J Allergy Clin Immunol 121:1000-5.e8. 2008
    ..The mechanisms by which human dendritic cells (DCs) activate a TH1-polarizing or TH2-polarizing program are still partially unclear...
  71. ncbi request reprint Regenerative and immunomodulatory potential of mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, P le L A Scuro 10, 37134 Verona, Italy
    Curr Opin Pharmacol 6:435-41. 2006
    ..Thus, MSCs appear to be a very promising tool for regenerative and immunoregulatory cell therapy...
  72. ncbi request reprint Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosis
    Lorenzo Cosmi
    Center for High Research DENOthe, University of Florence, Florence, Italy
    Int Arch Allergy Immunol 143:1-9. 2007
    ....
  73. ncbi request reprint PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion
    Laura Lasagni
    Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Florence, Italy
    Blood 109:4127-34. 2007
    ..These results demonstrate that CXCL4 and CXCL4L1 exhibit a distinct subcellular localization and are secreted in a differentially regulated manner, suggesting distinct roles in inflammatory or homeostatic processes...
  74. ncbi request reprint Role of chemokines in endocrine autoimmune diseases
    Mario Rotondi
    Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, 50121 Florence, Italy
    Endocr Rev 28:492-520. 2007
    ....
  75. ncbi request reprint Introduction: characterization and functions of human T regulatory cells
    Sergio Romagnani
    Microbes Infect 7:1015-6. 2005
    ..However, it is clear that Treg cells play an important role in human diseases, such as autoimmune disorders, allergy, HIV infection, tumors and graft-versus-host disease...
  76. ncbi request reprint Regenerative potential of embryonic renal multipotent progenitors in acute renal failure
    Elena Lazzeri
    Excellence Center for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy
    J Am Soc Nephrol 18:3128-38. 2007
    ..The ability of these cells to repair renal damage, together with their apparent lack of tumorigenicity, suggests their potential in the treatment of renal failure...
  77. ncbi request reprint Immune regulation by mesenchymal stem cells derived from adult spleen and thymus
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Stem Cells Dev 16:797-810. 2007
    ..Our data suggest that not only do spleen and thymus have a stem cell reservoir to build up their stromal architecture, but also contain microenviromental immunoregulatory cells with the same properties of BM-MSCs...
  78. pmc T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions
    Marisa Benagiano
    Department of Internal Medicine, University of Florence, Viale Morgagni, Italy
    Proc Natl Acad Sci U S A 100:6658-63. 2003
    ..Plaque-derived Th1 cells expressed cytotoxicity, proapoptotic activity, and help for monocyte tissue factor production. Although multifactorial, atherosclerosis can be regarded as a Th1-driven immunopathological condition...
  79. pmc Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells
    Benedetta Mazzinghi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50121 Florence, Italy
    J Exp Med 205:479-90. 2008
    ....
  80. ncbi request reprint Association between "sarcoidosis-like" disease and common variable immunodeficiency (CVI): a new CVI variant showing an activation of the immune system
    Alessandra Vultaggio
    Department of Biomedicine, Immunoallergology Unit, Policlinico di Careggi, AOUC Firenze, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 24:127-33. 2007
    ..Particular interest has been recently addressed to the association between a Granulomatous Sarcoidosis-like Disease (GSa-LD) and Common Variable Immunodeficiency (CVI)...