Menico Rizzi

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi A novel deamido-NAD+-binding site revealed by the trapped NAD-adenylate intermediate in the NAD+ synthetase structure
    M Rizzi
    Department of Pharmaceutical Science and Technology University of Torino, Italy
    Structure 6:1129-40. 1998
  2. ncbi A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis
    Silvia Garavaglia
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche, Farmacologiche Istituto Nazionale Fisica della Materia, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Biol Chem 279:40980-6. 2004
  3. ncbi Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia
    Franca Rossi
    DiSCAFF INFM, University of Piemonte Orientale A Avogadro, 28100 Novara, Italy
    J Biol Chem 283:3559-66. 2008
  4. doi Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli
    Alessandra Paglino
    DiSCAFF, University of Piemonte Orientale A Avogadro, Via Bovio, 6, 28100 Novara, Italy
    Insect Biochem Mol Biol 38:871-6. 2008
  5. ncbi Biochemical and structural investigations on kynurenine aminotransferase II: an example of conformation-driven species-specific inhibition?
    Valentina Casazza
    DiSCAFF, University of Piemonte Orientale, Via Bovio 6, Novara, Italy
    Curr Top Med Chem 11:148-57. 2011
  6. ncbi Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis
    Menico Rizzi
    DiSCAFF INFM, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy
    Curr Opin Struct Biol 12:709-20. 2002
  7. doi The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism
    Silvia Garavaglia
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    Biochem J 441:131-41. 2012
  8. pmc Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase
    Franca Rossi
    Dipartimento di Scienze Chimiche, Alimentari Farmaceutiche e Farmacologiche Drug and Food Biotechnology Center, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    Proc Natl Acad Sci U S A 103:5711-6. 2006
  9. pmc The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action
    Franca Rossi
    DiSCAFF, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    Nucleic Acids Res 39:7316-28. 2011
  10. ncbi Crystal structure of human kynurenine aminotransferase I
    Franca Rossi
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche, Farmacologiche Istituto Nazionale di Fisica della Materia, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Biol Chem 279:50214-20. 2004

Collaborators

Detail Information

Publications20

  1. ncbi A novel deamido-NAD+-binding site revealed by the trapped NAD-adenylate intermediate in the NAD+ synthetase structure
    M Rizzi
    Department of Pharmaceutical Science and Technology University of Torino, Italy
    Structure 6:1129-40. 1998
    ....
  2. ncbi A novel fold revealed by Mycobacterium tuberculosis NAD kinase, a key allosteric enzyme in NADP biosynthesis
    Silvia Garavaglia
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche, Farmacologiche Istituto Nazionale Fisica della Materia, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Biol Chem 279:40980-6. 2004
    ..The conserved GGDG structural fingerprint of the catalytic site is reminiscent of the related region in 6-phosphofructokinase, supporting the hypothesis that NAD kinase belongs to a newly reported superfamily of kinases...
  3. ncbi Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia
    Franca Rossi
    DiSCAFF INFM, University of Piemonte Orientale A Avogadro, 28100 Novara, Italy
    J Biol Chem 283:3559-66. 2008
    ..The observed structural differences could be exploited for the rational design of highly selective hKAT II inhibitors...
  4. doi Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli
    Alessandra Paglino
    DiSCAFF, University of Piemonte Orientale A Avogadro, Via Bovio, 6, 28100 Novara, Italy
    Insect Biochem Mol Biol 38:871-6. 2008
    ..Our study could contribute to understanding TDO regulation in vivo and to the identification of inhibitors to be used to alter Tryptophan homeostasis in the malaria vector...
  5. ncbi Biochemical and structural investigations on kynurenine aminotransferase II: an example of conformation-driven species-specific inhibition?
    Valentina Casazza
    DiSCAFF, University of Piemonte Orientale, Via Bovio 6, Novara, Italy
    Curr Top Med Chem 11:148-57. 2011
    ..Our data further highlights that even in case of highly conserved molecular targets, the flexibility of catalytically important structural elements can have a significant impact on the selectivity of inhibitor action...
  6. ncbi Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis
    Menico Rizzi
    DiSCAFF INFM, University of Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy
    Curr Opin Struct Biol 12:709-20. 2002
    ..The recent progress made in the structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis presents a significant step toward these goals...
  7. doi The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism
    Silvia Garavaglia
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    Biochem J 441:131-41. 2012
    ..Our data may prove to be useful for inhibitor design and disclosed unanticipated fascinating evolutionary relationships...
  8. pmc Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase
    Franca Rossi
    Dipartimento di Scienze Chimiche, Alimentari Farmaceutiche e Farmacologiche Drug and Food Biotechnology Center, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    Proc Natl Acad Sci U S A 103:5711-6. 2006
    ..This study may be useful for the structure-based design of specific enzyme inhibitors of potential interest as antimalarial agents...
  9. pmc The biological and structural characterization of Mycobacterium tuberculosis UvrA provides novel insights into its mechanism of action
    Franca Rossi
    DiSCAFF, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    Nucleic Acids Res 39:7316-28. 2011
    ..tuberculosis...
  10. ncbi Crystal structure of human kynurenine aminotransferase I
    Franca Rossi
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche, Farmacologiche Istituto Nazionale di Fisica della Materia, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy
    J Biol Chem 279:50214-20. 2004
    ..Our data reveal a key structural role of Glu(27), providing a molecular basis for the reported loss of enzymatic activity displayed by the equivalent Glu --> Gly mutation in KAT-I of spontaneously hypertensive rats...
  11. ncbi Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase
    Marco Bellinzoni
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Protein Expr Purif 25:547-57. 2002
    ..tuberculosis NAD(+) synthetase. These results enable us to obtain a purified product for structure-function analysis and high throughput assays for rapid screening of compounds which inhibit enzymatic activity...
  12. ncbi Expression, purification and characterisation of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB)
    Sara Martignon
    DiSCAFF, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100, Novara, Italy
    Protein Pept Lett 14:822-7. 2007
    ..The observed enzyme inhibition by the reaction product NADH could represent a regulatory mechanism for 3IPMDH...
  13. pmc Crystal structure of Mycobacterium tuberculosis zinc-dependent metalloprotease-1 (Zmp1), a metalloprotease involved in pathogenicity
    Davide M Ferraris
    DiSCAFF Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences, University of Piemonte Orientale A Avogadro, 28100 Novara, Italy
    J Biol Chem 286:32475-82. 2011
    ....
  14. ncbi The structure of Rigidoporus lignosus Laccase containing a full complement of copper ions, reveals an asymmetrical arrangement for the T3 copper pair
    Silvia Garavaglia
    DiSCAFF INFM, University of Piemonte Orientale A Avogadro, 28100 Novara, Italy
    J Mol Biol 342:1519-31. 2004
    ..The observed structure could represent an intermediate along the process of four-electron reduction of oxygen to water taking place at the trinuclear copper cluster...
  15. pmc Allosteric regulation of Bacillus subtilis NAD kinase by quinolinic acid
    Silvia Garavaglia
    DiSCAFF INFM, University of Piemonte Orientale Amedeo Avogadro, 28100 Novara, Italy
    J Bacteriol 185:4844-50. 2003
    ..Therefore, we propose that NAD kinase is a key enzyme for both NADP metabolism and quinolinic acid metabolism...
  16. ncbi Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis
    Silvia Garavaglia
    Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
    J Biol Chem 277:8524-30. 2002
    ..Structural comparison of human and prokaryotic NMNATs may also lead to the rational design of highly selective antimicrobial drugs...
  17. pmc Target flexibility: an emerging consideration in drug discovery and design
    Pietro Cozzini
    Department of General and Inorganic Chemistry, University of Parma, Via G P Usberti 17 A 43100, Parma
    J Med Chem 51:6237-55. 2008
  18. ncbi Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase
    Franca Rossi
    DiSCAFF, University of Piemonte Orientale Amedeo Avogadro, Novara, Italy
    FEBS J 272:5653-62. 2005
    ..This study may be useful for the identification of 3-HK transaminase inhibitors of potential interest as malaria transmission-blocking drugs or effective insecticides...
  19. ncbi Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase
    Qian Han
    Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA
    J Biol Chem 281:37175-82. 2006
    ..Comparison of the AeAGT-alanine structure with that of the Anopheles HKT-inhibitor complex suggests that a Ser-Asn-Phe motif in the latter may be responsible for the substrate specificity of HKT enzymes for 3-HK...
  20. ncbi A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase
    Roberto T Bossi
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, via Abbiategrasso 207, 27100 Pavia, Italy
    Biochemistry 41:8807-18. 2002
    ..The physiological significance of this reaction is presently unknown. However, it could assist with drug-design studies in that the modified NADP+ could serve as a lead compound for the development of specific inhibitors...