G Rindi

Summary

Affiliation: University of Parma
Country: Italy

Publications

  1. ncbi TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system
    G Rindi
    Dipartimento di Patologia e, Medicina di Laboratorio, Sezione di Anatomia Patologica, Universita di Parma, Via Gramsci, 14, 43100, Parma, Italy, and Department of Internal Medicine, Royal Free Hospital, London, UK
    Virchows Arch 449:395-401. 2006
  2. ncbi The phenotype of gut endocrine tumours
    G Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, Via Gramsci 14, I 43100 Parma, Italy
    Dig Liver Dis 36:S26-30. 2004
  3. ncbi Ghrelin expression and actions: a novel peptide for an old cell type of the diffuse endocrine system
    Guido Rindi
    Department of Pathology, University of Parma, Italy
    Exp Biol Med (Maywood) 229:1007-16. 2004
  4. ncbi Endocrine tumors of the gut and pancreas tumor biology and classification
    G Rindi
    Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Parma, Italy
    Neuroendocrinology 80:12-5. 2004
  5. ncbi Sudden onset of colitis after ablation of secretin-expressing lymphocytes in transgenic mice
    Guido Rindi
    Department of Pathology, University of Parma, Italy
    Exp Biol Med (Maywood) 229:826-34. 2004
  6. ncbi Endocrine tumours of the gastrointestinal tract: aetiology, molecular pathogenesis and genetics
    Guido Rindi
    Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Italy
    Best Pract Res Clin Gastroenterol 19:519-34. 2005
  7. ncbi The "normal" endocrine cell of the gut: changing concepts and new evidences
    Guido Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, Italy
    Ann N Y Acad Sci 1014:1-12. 2004
  8. ncbi [Practical notes for the evaluation of malignancy in digestive endocrine tumors]
    Guido Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, Parma, Italy
    Ann Pathol 25:487-98. 2005
  9. ncbi Highlights of the biology of endocrine tumours of the gut and pancreas
    G Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, Via Gramsci 14, I 43100 Parma, Italy
    Endocr Relat Cancer 10:427-36. 2003
  10. ncbi Consensus guidelines for the management of patients with digestive neuroendocrine tumors: why such guidelines and how we went about It
    Guido Rindi
    Department of Pathology and Laboratory Medicine, , Parma, Italy
    Neuroendocrinology 84:155-7. 2006

Detail Information

Publications55

  1. ncbi TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system
    G Rindi
    Dipartimento di Patologia e, Medicina di Laboratorio, Sezione di Anatomia Patologica, Universita di Parma, Via Gramsci, 14, 43100, Parma, Italy, and Department of Internal Medicine, Royal Free Hospital, London, UK
    Virchows Arch 449:395-401. 2006
    ..This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients...
  2. ncbi The phenotype of gut endocrine tumours
    G Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, Via Gramsci 14, I 43100 Parma, Italy
    Dig Liver Dis 36:S26-30. 2004
    ..p53 gene abnormality appears as restricted to poorly differentiated endocrine carcinomas...
  3. ncbi Ghrelin expression and actions: a novel peptide for an old cell type of the diffuse endocrine system
    Guido Rindi
    Department of Pathology, University of Parma, Italy
    Exp Biol Med (Maywood) 229:1007-16. 2004
    ..This review aims to summarize recent data on ghrelin cell distribution in the diffuse endocrine system and discuss local and general ghrelin function during development, adulthood, and endocrine tumor development...
  4. ncbi Endocrine tumors of the gut and pancreas tumor biology and classification
    G Rindi
    Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Parma, Italy
    Neuroendocrinology 80:12-5. 2004
    ..Their clinical behavior spans from benign, uncertain malignant potential, low-grade malignant to high-grade malignant. Currently, extensive work is performed to unravel the genetic background...
  5. ncbi Sudden onset of colitis after ablation of secretin-expressing lymphocytes in transgenic mice
    Guido Rindi
    Department of Pathology, University of Parma, Italy
    Exp Biol Med (Maywood) 229:826-34. 2004
    ..We conclude that GVH-like colitis in ganciclovir-treated Sec-HSVTK mice arises from depletion of secretin gene-expressing lymphoid cells and not from the failure of secretin production...
  6. ncbi Endocrine tumours of the gastrointestinal tract: aetiology, molecular pathogenesis and genetics
    Guido Rindi
    Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Italy
    Best Pract Res Clin Gastroenterol 19:519-34. 2005
    ..For poorly differentiated carcinomas, a high degree of chromosomal instability is the common genetic trait independent of tumour site and frequently involving the p53 gene...
  7. ncbi The "normal" endocrine cell of the gut: changing concepts and new evidences
    Guido Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, Italy
    Ann N Y Acad Sci 1014:1-12. 2004
    ....
  8. ncbi [Practical notes for the evaluation of malignancy in digestive endocrine tumors]
    Guido Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, Parma, Italy
    Ann Pathol 25:487-98. 2005
    ....
  9. ncbi Highlights of the biology of endocrine tumours of the gut and pancreas
    G Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, Via Gramsci 14, I 43100 Parma, Italy
    Endocr Relat Cancer 10:427-36. 2003
    ..Genetic abnormalities associated with either induction or progression of tumours may vary depending on the site of origin...
  10. ncbi Consensus guidelines for the management of patients with digestive neuroendocrine tumors: why such guidelines and how we went about It
    Guido Rindi
    Department of Pathology and Laboratory Medicine, , Parma, Italy
    Neuroendocrinology 84:155-7. 2006
  11. ncbi [Guidelines and minimal diagnostic criteria for the histological diagnosis of endocrine tumors of the gastroenteropancreatic type]
    G Rindi
    Dipartimento Materno Infantile e Tecnologie Biomediche, Sezione di Anatomia Patologica, Universita di Brescia, Italia
    Pathologica 94:142-7. 2002
    ..The present paper aims at defining simple guidelines for the practical, routine approach to the histopathological diagnosis of the endocrine tumors of the digestive system according to the new W.H.O. criteria...
  12. ncbi Prognostic factors in gastrointestinal endocrine tumors
    Guido Rindi
    Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Via Gramsci, 14, 43100, Parma, Italy
    Endocr Pathol 18:145-9. 2007
    ..A recent proposal of tumor grading and tumor, nodes, and metastases (TNM) staging aims at a simple and practical system for patients stratification. Application of such proposal should be implemented in routine clinical practice...
  13. ncbi Endocrine hyperplasia and dysplasia in the pathogenesis of gastrointestinal and pancreatic endocrine tumors
    Guido Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, I 43100 Parma, Italy
    Gastroenterol Clin North Am 36:851-65, vi. 2007
    ..Similarly, in spite of reports of carcinoid-associated endocrine cell hyperplasia, there is no systematic definition of nonneoplastic lesions of the endocrine cells of the ileum, appendix and colorectum...
  14. ncbi Consensus guidelines for the management of patients with digestive neuroendocrine tumors: the second event and some final considerations
    Guido Rindi
    Department of Pathology and Laboratory Medicine, , Parma, Italy
    Neuroendocrinology 87:5-7. 2008
  15. ncbi TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system
    G Rindi
    Department of Pathology, University of Parma, Parma, Italy
    Virchows Arch 451:757-62. 2007
    ..These proposals need to be validated and are meant to help clinicians in the stratification, treatment and follow-up of patients...
  16. ncbi Peptide products of the neurotrophin-inducible gene vgf are produced in human neuroendocrine cells from early development and increase in hyperplasia and neoplasia
    Guido Rindi
    Department of Pathology and Laboratory Medicine, University of Parma, 43100 Parma, Italy
    J Clin Endocrinol Metab 92:2811-5. 2007
    ..Although the neurotrophin-inducible gene vgf is expressed in mammalian neurons and endocrine cells, limited data is available in man...
  17. ncbi Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues
    Guido Rindi
    Department of Pathology, University of Brescia, Italy
    Histochem Cell Biol 117:511-9. 2002
    ..In man ghrelin cells develop during early fetal life...
  18. ncbi Ghrelin expression in gut endocrine growths
    Guido Rindi
    Department of Pathology, University of Brescia, Italy
    Histochem Cell Biol 117:521-5. 2002
    ..We conclude that ghrelin cells may take part in gut endocrine growths, with special reference to well-differentiated endocrine tumours of the stomach, independently from associated signs of endocrine hyperfunction...
  19. ncbi RASSF1A promoter methylation and 3p21.3 loss of heterozygosity are features of foregut, but not midgut and hindgut, malignant endocrine tumours
    S Pizzi
    Department of Pathology and Laboratory Medicine, University of Parma, Parma, Italy
    J Pathol 206:409-16. 2005
    ..3 deletion is associated with malignancy. These results may provide a rationale for foregut-targeted therapy for aggressive endocrine carcinomas entailing the use of demethylating agents...
  20. ncbi Endocrine tumors of the digestive tract and pancreas: histogenesis, diagnosis and molecular basis
    G Rindi
    Department of Pathology, Università di Brescia Spedali, Civili, Anatomia Patologica 2, Piazza Spedali Civili 1, I 25124 Brescia, Italy
    Expert Rev Mol Diagn 1:323-33. 2001
    ..Poorly differentiated carcinomas show frequent p53 gene hyperexpression/defects, characterizing severe cell abnormality and possibly accounting for the malignancy of such carcinomas...
  21. ncbi Biological and molecular aspects of gastroenteropancreatic neuroendocrine tumors
    G Rindi
    Department of Pathology, University of Brescia, Spedali Civili, Brescia, Italy
    Digestion 62:19-26. 2000
    ..Other genes are possibly involved, though the available data need support from studies on larger series of tumors...
  22. ncbi Introduction to a revised clinicopathological classification of neuroendocrine tumors of the gastroenteropancreatic tract
    G Rindi
    Pathology Service, University of Brescia, Italy
    Q J Nucl Med 44:13-21. 2000
    ....
  23. ncbi Involvement of HER-2/neu and metastasis-related proteins in the development of ileal neuroendocrine tumors
    Cinzia Azzoni
    Department of Pathology, Section of Anatomic Pathology, University of Parma, Parma, Italy
    Virchows Arch 458:525-36. 2011
    ..Ileal HER-2/neu overexpressing neuroendrocrine tumors may constitute potential candidates for target therapy with specific humanized monoclonal antibodies...
  24. ncbi Genetics of a combined lung small cell carcinoma and large cell neuroendocrine carcinoma with adenocarcinoma
    Giovanni Fellegara
    Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Via Gramsci, 14, Parma, Italy
    Virchows Arch 453:107-15. 2008
    ....
  25. ncbi Criteria for malignancy in gastrointestinal endocrine tumors
    Cesare Bordi
    Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Parma, Italy
    Endocr Pathol 17:119-29. 2006
    ....
  26. ncbi Malignancy-associated X chromosome allelic losses in foregut endocrine neoplasms: further evidence from lung tumors
    Lorena Bottarelli
    Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, University of Parma, Parma, Italy
    Mod Pathol 18:795-805. 2005
    ....
  27. ncbi Vesicular monoamine transporter 2 as a marker of gastric enterochromaffin-like cell tumors
    G Rindi
    Department of Pathology, University of Brescia, Italy
    Virchows Arch 436:217-23. 2000
    ..e., gastrin, somatostatin, EC cell and PDEC tumors, all of which proved essentially negative...
  28. ncbi Three different synchronous primary lung tumours: a case report with extensive genetic analysis and review of the literature
    Elisabetta Froio
    Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, Parma, Italy
    Lung Cancer 59:395-402. 2008
    ..28 in the SCC. Microallelotyping analysis did not reveal a common genetic profile, supporting the hypothesis that the three synchronous tumours are truly independent primaries with different histogenesis...
  29. ncbi Malignancy-associated allelic losses on the X-chromosome in foregut but not in midgut endocrine tumours
    Silvia Pizzi
    Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, University of Parma, Parma, Italy
    J Pathol 196:401-7. 2002
    ..These findings emphasize the need for further molecular studies on GEP endocrine tumours, carefully subdivided according to their anatomical site of origin...
  30. ncbi High resolution allelotype of nonfunctional pancreatic endocrine tumors: identification of two molecular subgroups with clinical implications
    G Rigaud
    Department of Pathology, , Italy
    Cancer Res 61:285-92. 2001
    ....
  31. ncbi Adenomatous polyposis coli alteration in digestive endocrine tumours: correlation with nuclear translocation of beta-catenin and chromosomal instability
    Silvia Pizzi
    Section of Pathological Anatomy, Department of Pathology and Laboratory Medicine, University of Parma, Via Gramsci, 14, I 43100 Parma, Italy
    Endocr Relat Cancer 15:1013-24. 2008
    ..Though with different alteration mechanisms according to anatomical site, APC plays a major role in Wnt pathway activation and in determining the high chromosomal instability observed in aggressive endocrine carcinomas...
  32. ncbi Xq25 and Xq26 identify the common minimal deletion region in malignant gastroenteropancreatic endocrine carcinomas
    Cinzia Azzoni
    Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Virchows Arch 448:119-26. 2006
    ..Overall, our data indicate that the two chromosomal regions, Xq25 and Xq26, may participate to the malignant progression of GEP endocrine carcinomas...
  33. ncbi Genetic alterations in combined neuroendocrine neoplasms of the lung
    Tiziana D'Adda
    Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, University of Parma, Parma, Italy
    Mod Pathol 21:414-22. 2008
    ..The genetic differences observed provide the basis for the divergent differentiation and parallel the morphological differences in the two components of these combined neuroendocrine neoplasms...
  34. ncbi Effects of 5 years of treatment with rabeprazole or omeprazole on the gastric mucosa
    Guido Rindi
    University of Parma, Parma, Italy bDepartment of Pathology, University of Genoa, Italy
    Eur J Gastroenterol Hepatol 17:559-66. 2005
    ....
  35. ncbi Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): study of a comprehensive panel of molecular markers
    Marcello Tiseo
    Division of Medical Oncology, University Hospital of Parma, Via Gramsci 14, 43100 Parma, Italy
    Lung Cancer 67:355-60. 2010
    ..Moreover, EGFR gene copy number and, potentially, also EGFR intron 1 polymorphism could aid in better prediction of EGFR TKI responsiveness in advanced NSCLC...
  36. ncbi Extra-adrenal composite paraganglioma with ganglioneuroma component presenting as a pancreatic mass
    Frediano Inzani
    Department of Pathology, University of Parma, Via Gramsci 14, 43100, Parma, Italy
    Endocr Pathol 20:191-5. 2009
    ....
  37. ncbi Refractory pleural small cell carcinoma in never smoker. A case report
    Marcello Tiseo
    Oncologia Medica, Azienda Ospedaliera Universitaria, Parma, Italy
    Tumori 94:434-6. 2008
    ..This case of a refractory pleural small cell carcinoma, which is an extremely rare disease, is the first reported in a never smoker and the first to be fully characterized for EGFR status...
  38. ncbi Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis
    Elisabetta Froio
    Department of Pathology and Laboratory Medicine, Anatomic Pathology Section, University of Parma, Italy
    Lung Cancer 64:371-7. 2009
    ..Systemic sarcoidosis was ruled out. To our knowledge this is the first case of uterine carcinosarcoma with LCNEC features metastatic to the lung and occurring in association with sarcoid reaction...
  39. ncbi Is cytology reliable for epidermal growth factor receptor gene evaluation in non-small cell lung cancer?
    Cecilia Bozzetti
    Oncologia Medica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    J Thorac Oncol 5:551-3. 2010
    ..Epidermal growth factor receptor (EGFR) gene copy number has been proposed as predictor of response to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer (NSCLC)...
  40. ncbi Comparison between epidermal growth factor receptor (EGFR) gene expression in primary non-small cell lung cancer (NSCLC) and in fine-needle aspirates from distant metastatic sites
    Cecilia Bozzetti
    Division of Medical Oncology, University Hospital of Parma, Parma, Italy
    J Thorac Oncol 3:18-22. 2008
    ..The possibility to perform FISH analysis on cytologic material obtained by fine-needle aspiration from superficial and visceral metastases would allow us to know the real EGFR status avoiding invasive diagnostic procedures...
  41. ncbi Sex chromosome alterations associate with tumor progression in sporadic colorectal carcinomas
    Lorena Bottarelli
    Department of Pathology and Laboratory Medicine, Medical School, Parma University, Parma, Italy
    Clin Cancer Res 13:4365-70. 2007
    ..The X and Y chromosomes have been associated with malignancy in different types of human tumors. This study attempts to determine the involvement of X chromosome and pseudoautosomal regions (PAR) in sporadic colorectal carcinogenesis...
  42. ncbi Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors
    Ulrich Frank Pape
    Department of Hepatology and Gastroenterology, Chariteé Campus Virchow Clinic, Berlin University of Medicine, Berlin, Germany
    Cancer 113:256-65. 2008
    ..In 2006, a new TNM classification system was proposed for the staging and grading of upper GEP NETs...
  43. ncbi Gastroenteropancreatic neuroendocrine tumours
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University, New Haven, CT 06520 8062, USA
    Lancet Oncol 9:61-72. 2008
    ..Progress is unlikely to occur without development of centers of excellence, with dedicated combined clinical teams to coordinate multicentre studies, maintain clinical and tissue databases, and refine molecularly targeted therapeutics...
  44. ncbi The grey zone between pure (neuro)endocrine and non-(neuro)endocrine tumours: a comment on concepts and classification of mixed exocrine-endocrine neoplasms
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Regione Gonzole10, 10043 Orbassano-Torino, Italy
    Virchows Arch 449:499-506. 2006
    ..The recognition of MEECs may be of relevance for a targeted therapeutic strategy, foreseeing the use of biotherapies similar to those proposed for pure NE tumours...
  45. ncbi Consensus guidelines for the management of patients with digestive neuroendocrine tumors--well-differentiated jejunal-ileal tumor/carcinoma
    Barbro Eriksson
    Department of Medical Sciences, Endocrine Oncology Unit, University Hospital, Uppsala, Sweden
    Neuroendocrinology 87:8-19. 2008
  46. ncbi Primary mixed adenocarcinoma and small cell carcinoma of the appendix: a clinicopathologic, immunohistochemical, and molecular study of a hitherto unreported tumor
    Giulio Rossi
    Department of Pathologic Anatomy and Legal Medicine, Section of Pathology, University of Modena and Reggio Emilia, Italy
    Am J Surg Pathol 28:1233-9. 2004
    ..Clinical and molecular findings led us to consider this lesion as a clonal tumor in which the endocrine component seems to derive from a progressive differentiation of the adenocarcinoma following a glandular-to-endocrine sequence...
  47. ncbi Solitary microcarcinoid of the rectal stump in ulcerative colitis
    Riccardo Nascimbeni
    Cattedra di Chirurgia Generale, Universita degli Studi di Brescia, U O 1 Chirurgia Generale, Spedali Civili Brescia, Piazzale Spedali Civili 1, I 25100 Brescia, Italy
    Neuroendocrinology 81:400-4. 2005
    ..The association of intestinal carcinoid with ulcerative colitis has been reported previously in 26 patients. Pathogenic pathways are discussed according to the presence of multifocal carcinoid and/or gut endocrine cell hyperplasia...
  48. ncbi Mismatch repair system (MMR) status correlates with response and survival in non-small cell lung cancer (NSCLC) patients
    Mario Scartozzi
    Clinica di Oncologia Medica, , Ancona, Italy
    Lung Cancer 53:103-9. 2006
    ..031) and 10 months versus 9 months for hMSH2 (p=0.8330). Both the difference in response rate and in median survival observed according to MMR status seem to confirm what has been suggested by preclinical studies...
  49. ncbi Effects of 6-12 months of esomeprazole treatment on the gastric mucosa
    Robert M Genta
    Department of Pathology, Geneva University Hospitals, Geneva, Switzerland
    Am J Gastroenterol 98:1257-65. 2003
    ..Use of esomeprazole did not raise any safety concerns with respect to the development of atrophic gastritis, or cause clinically significant changes in enterochromaffin-like cells...
  50. ncbi Buccal mucosa cells as in vivo model to evaluate gefitinib activity in patients with advanced non small cell lung cancer
    Maura Loprevite
    Medical Oncology A, National Institute for Cancer Research, S Martino Hospital, Genoa, Italy
    Clin Cancer Res 13:6518-26. 2007
    ..Expression of the same proteins was also assessed on corresponding tissue samples for comparison. Moreover, EGFR gene mutations and copy number were analyzed...
  51. ncbi PYY-Tag transgenic mice displaying abnormal (H+-K+)ATPase activity and gastric mucosal barrier impairment
    Umberto Laforenza
    Department of Experimental Medicine, Section of Human Physiology, University of Pavia, Pavia, Italy
    Lab Invest 83:47-54. 2003
    ..The abnormal and unregulated levels of circulating peptide YY and glucagon led to gastric acid inhibition and an impairment of gastric barrier function as a result of a striking reduction in epithelial proliferation...
  52. ncbi Well-differentiated pancreatic tumor/carcinoma: insulinoma
    Wouter W de Herder
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Neuroendocrinology 84:183-8. 2006
  53. ncbi Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin
    Yang Wang
    Division of Gastroenterology, GRASP Digestive Disease Center, Tufts New England Medical Center, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 104:11328-33. 2007
    ....
  54. ncbi Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S9-27. 2007
    ..In addition, a tumor/nodes/metastases classification and a grading system are presented. In the light of these criteria, the various GEP-NET entities are reviewed...
  55. ncbi Transient expression of secretin in serotoninergic neurons of mouse brain during development
    Laura Lossi
    Department of Veterinary Morphophysiology, University of Turin, Via Leonardo da Vinci 44, 10095 Grugliasco, Torino, Italy
    Eur J Neurosci 20:3259-69. 2004
    ..In addition our data suggest a trophic role for secretin on neurons known to be involved in multiple superior functions in the normal brain, and lost in neurodegenerative disorders...