Luigi Ricciardiello

Summary

Affiliation: University of Bologna
Location: Bologna, Italy
URL: http://www.unibo.it/docenti/luigi.ricciardiello
Summary:
Colon cancer chemoprevention
Colon cancer genetics
Hereditary colorectal cancer
Grants:
AIRC Associazione Italiana Ricerca Sul Cancro 2011-2014.

Publications

  1. doi request reprint Chemoprevention of colorectal cancer: a role for ursodeoxycholic acid, folate and hormone replacement treatment?
    Riccardo Solimando
    Department of Clinical Medicine, University of Bologna, Via Massarenti 9, Bologna, Italy
    Best Pract Res Clin Gastroenterol 25:555-68. 2011
  2. ncbi request reprint Lynch syndrome (hereditary non-polyposis colorectal cancer): current concepts and approaches to management
    Luigi Ricciardiello
    Gastrointestinal Cancer Research Laboratory, Department of Medicine, Division of Gastroenterology, Baylor University Medical Center, Dallas, TX 75246, USA
    Curr Gastroenterol Rep 7:412-20. 2005
  3. ncbi request reprint High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies
    Luigi Ricciardiello
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Clin Cancer Res 11:4234-40. 2005
  4. ncbi request reprint Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence
    F Perri
    Department and Research Laboratory of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo, Italy
    Cytokine 30:293-302. 2005
  5. ncbi request reprint Measuring dyspepsia: a new severity index validated in Bologna
    L De Luca
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Via Massarenti n 9, 40138 Bologna, Italy
    Dig Liver Dis 36:806-10. 2004
  6. ncbi request reprint Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus
    Luigi Ricciardiello
    Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti 9, Pad 5 Stanza 28, 40138 Bologna, Italy
    Cancer Res 63:7256-62. 2003
  7. ncbi request reprint The VEPSY UPDATED Project: clinical rationale and technical approach
    G Riva
    Applied Technology for Neuro Psychology Laboratory, Istituto Auxologico Italiano, Verbania, Italy
    Cyberpsychol Behav 6:433-9. 2003
  8. ncbi request reprint Effect of H(2)O(2) on cell cycle and survival in DNA mismatch repair-deficient and -proficient cell lines
    Dong Kyung Chang
    Department of Medicine and Comprehensive Cancer Center, University of California San Diego, 4028 Basic Science Building, 9500 Gilman Drive, La Jolla 92093 0688, USA
    Cancer Lett 195:243-51. 2003
  9. ncbi request reprint Characterization of sporadic colon cancer by patterns of genomic instability
    Ajay Goel
    Department of Medicine and Cancer Center, University of California at San Diego, La Jolla, California, USA
    Cancer Res 63:1608-14. 2003
  10. ncbi request reprint Endoscopic surveillance in Barrett's esophagus
    V Lunedei
    Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi Bologna
    Minerva Gastroenterol Dietol 48:63-71. 2002

Collaborators

Detail Information

Publications44

  1. doi request reprint Chemoprevention of colorectal cancer: a role for ursodeoxycholic acid, folate and hormone replacement treatment?
    Riccardo Solimando
    Department of Clinical Medicine, University of Bologna, Via Massarenti 9, Bologna, Italy
    Best Pract Res Clin Gastroenterol 25:555-68. 2011
    ..In this review experimental and clinical data on UDCA, folate and HRT as potential chemopreventive agents are discussed...
  2. ncbi request reprint Lynch syndrome (hereditary non-polyposis colorectal cancer): current concepts and approaches to management
    Luigi Ricciardiello
    Gastrointestinal Cancer Research Laboratory, Department of Medicine, Division of Gastroenterology, Baylor University Medical Center, Dallas, TX 75246, USA
    Curr Gastroenterol Rep 7:412-20. 2005
    ..Specialists should be aware of the significance of inherited colon cancer and should become familiar with the molecular diagnostic tests now widely available...
  3. ncbi request reprint High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategies
    Luigi Ricciardiello
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Clin Cancer Res 11:4234-40. 2005
    ..The reasons why MSI tumors are clinically less aggressive and do not respond to 5-FU-based therapies have not been fully elucidated...
  4. ncbi request reprint Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence
    F Perri
    Department and Research Laboratory of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo, Italy
    Cytokine 30:293-302. 2005
    ..An epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population...
  5. ncbi request reprint Measuring dyspepsia: a new severity index validated in Bologna
    L De Luca
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Via Massarenti n 9, 40138 Bologna, Italy
    Dig Liver Dis 36:806-10. 2004
    ..Measurement of the severity of dyspepsia symptoms before and after treatment and determining what is a significant change is a major problem in designing dyspepsia treatment studies...
  6. ncbi request reprint Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus
    Luigi Ricciardiello
    Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti 9, Pad 5 Stanza 28, 40138 Bologna, Italy
    Cancer Res 63:7256-62. 2003
    ..In conclusion, we demonstrate that JC virus Mad-1 and Delta98 are able to induce chromosomal instability in colonic cells with a hit and run mechanism that involves an early interaction with beta-catenin and p53...
  7. ncbi request reprint The VEPSY UPDATED Project: clinical rationale and technical approach
    G Riva
    Applied Technology for Neuro Psychology Laboratory, Istituto Auxologico Italiano, Verbania, Italy
    Cyberpsychol Behav 6:433-9. 2003
    ..Moreover, the paper focuses its analysis on the possible role of VR in clinical psychology and how it can be used for therapeutic change...
  8. ncbi request reprint Effect of H(2)O(2) on cell cycle and survival in DNA mismatch repair-deficient and -proficient cell lines
    Dong Kyung Chang
    Department of Medicine and Comprehensive Cancer Center, University of California San Diego, 4028 Basic Science Building, 9500 Gilman Drive, La Jolla 92093 0688, USA
    Cancer Lett 195:243-51. 2003
    ..However, this sensitivity appears not to be a direct result of a deficient MMR function, but is more likely attributable to spectrum of target gene mutations that occurs in MMR-deficient tumors...
  9. ncbi request reprint Characterization of sporadic colon cancer by patterns of genomic instability
    Ajay Goel
    Department of Medicine and Cancer Center, University of California at San Diego, La Jolla, California, USA
    Cancer Res 63:1608-14. 2003
    ..Our data suggest that molecular mechanisms of genomic instability are not necessarily independent and may not be fully defined by either the MSI or CIN pathways...
  10. ncbi request reprint Endoscopic surveillance in Barrett's esophagus
    V Lunedei
    Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi Bologna
    Minerva Gastroenterol Dietol 48:63-71. 2002
    ..At present a marker other than dysplasia identifying a high risk group for cancer on which to focus endoscopic surveillance has not yet been established...
  11. ncbi request reprint Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers
    Ajay Goel
    Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
    Gastroenterology 130:1950-61. 2006
    ..This study tests the hypothesis that JCV T-Ag expression correlates with one or more forms of genomic or epigenetic instability in sporadic CRCs...
  12. ncbi request reprint Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines
    Lucia Fini
    Department of Internal Medicine, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA
    Carcinogenesis 29:139-46. 2008
    ..The Mediterranean diet is rich in extra virgin olive oil (EVOO) and associated with a lower incidence of colorectal cancer. EVOO contains phenolic extracts with potential anticarcinogenic activity...
  13. doi request reprint Phytochemicals and colorectal cancer prevention--myth or reality?
    Luigi Ricciardiello
    Department of Clinical Medicine, University of Bologna, Via Massarenti 9, Bologna 40138, Italy
    Nat Rev Gastroenterol Hepatol 8:592-6. 2011
    ....
  14. pmc Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract
    Lucia Fini
    Department of Internal Medicine, Baylor Research Institute, Sammons Cancer Center, USA
    Cancer Prev Res (Phila) 4:907-15. 2011
    ....
  15. pmc Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) mice
    Lucia Fini
    Department of Internal Medicine, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, USA
    Clin Cancer Res 16:5703-11. 2010
    ..Experimental design: Apc(Min/+) and corresponding wild-type mice were fed control diet (Ctrl) or diets containing either EPA-FFA 2.5% or 5%, for 12 weeks while monitoring food intake and body weight...
  16. doi request reprint Chronic intestinal pseudo-obstruction related to viral infections
    R De Giorgio
    Department of Clinical Medicine, University of Bologna, Bologna, Italy
    Transplant Proc 42:9-14. 2010
    ..The review thus provides some new perspectives in the pathophysiology and perhaps targeted treatment of CIIPO...
  17. pmc JC virus infection in colorectal neoplasia that develops after liver transplantation
    Michael Selgrad
    Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246, USA
    Clin Cancer Res 14:6717-21. 2008
    ..JCV encodes for TAg and has been implicated in colorectal carcinogenesis. We hypothesized that the use of immunosuppression in LTRs facilitates activation of JCV and is responsible for the increased risk of neoplasia...
  18. pmc JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction
    M Selgrad
    GI Cancer Research Laboratory, 250 Hoblitzelle, Baylor University Medical Center, Dallas, TX 75246 USA
    Gut 58:25-32. 2009
    ..The hypothesis that JCV infects the myenteric plexuses of patients with CIIP was tested...
  19. pmc The role of viral and bacterial pathogens in gastrointestinal cancer
    Michael Selgrad
    Department of Internal Medicine, Gastroenterology, Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas 75246, USA
    J Cell Physiol 216:378-88. 2008
    ....
  20. ncbi request reprint Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells
    Lucia Fini
    GI Cancer Research Laboratory, Department of Internal Medicine, Sammons Cancer Center, Dallas, TX 75246, USA
    J Nutr 137:2622-8. 2007
    ..In conclusion, APE have potent demethylating activity through the inhibition of DNMT proteins. The lack of toxicity in Annurca extracts makes them excellent candidates for the chemoprevention of CRC...
  21. ncbi request reprint Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancer
    Luigi Ricciardiello
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita degli Studi di Bologna, 40138 Bologna, Italy
    Cancer Res 63:787-92. 2003
    ..02). Hypermethylation of the promoter of hMLH1, consequent loss of hMLH1 expression, and MSI are at the basis of approximately 25% of adenomatous polyps developed in subjects with a SFDR affected by colorectal cancer...
  22. ncbi request reprint A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells
    Ajay Goel
    Department of Medicine and Comprehensive Cancer Center, University of California San Diego, San Diego, California, USA
    Clin Cancer Res 9:383-90. 2003
    ..We hypothesized that aspirin treatment might alter expression of DNA mismatch repair (MMR) proteins, representing another potential non-COX mechanism for its action...
  23. ncbi request reprint The role of genomic instabilities in affecting treatment responses of colorectal cancer
    Luigi Ricciardiello
    Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
    Dig Dis 20:73-80. 2002
    ..In fact, the response to treatment with 5-FU or platinum compounds is dramatically different in both settings. In the future, the use of these compounds should require molecular testing of the specimen prior to treatment...
  24. ncbi request reprint Validation of the 13C-urea breath test for the diagnosis of Helicobacter pylori infection in children: a multicenter study
    F Bazzoli
    Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
    Am J Gastroenterol 95:646-50. 2000
    ..As yet, a validated, standardized 13C-UBT protocol for children has not been formulated...
  25. ncbi request reprint Helicobacter pylori: optimum diagnosis and test of cure
    F Bazzoli
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    J Chemother 11:601-5. 1999
    ..The Urea Breath Test is a simple, safe and highly accurate method ideal for evaluating the short-term follow-up of H. pylori eradication after therapy...
  26. pmc How many mutations does it take to make a tumor?
    C R Boland
    Department of Medicine, University of California, San Diego, CA 92093 0688, USA
    Proc Natl Acad Sci U S A 96:14675-7. 1999
  27. ncbi request reprint Efficacy of lansoprazole in eradicating Helicobacter pylori: a meta-analysis
    F Bazzoli
    Dipartimento di Medicina Interna e Gastroenterologia, Policlinico Universitario Sant Orsola, Bologna, Italy
    Helicobacter 3:195-201. 1998
    ..pylori and healing peptic ulcers, we have undertaken a meta-analysis of all the controlled studies published in the literature...
  28. ncbi request reprint Efficacy and safety of three 7-day Helicobacter pylori eradication regimens containing ranitidine bismuth citrate
    L Ricciardiello
    Gastroenterology Unit, Policlinico S Orsola, Bologna, Italy
    Aliment Pharmacol Ther 12:533-7. 1998
    ..This multicentre, randomized study was designed to assess the clinical efficacy, safety and tolerability of three novel 7-day triple therapies containing ranitidine bismuth citrate (RBC) and two antibiotics...
  29. ncbi request reprint Evaluation of short-term low-dose triple therapy for the eradication of Helicobacter pylori by factorial design in a randomized, double-blind, controlled study
    F Bazzoli
    Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di Bologna, Italy
    Aliment Pharmacol Ther 12:439-45. 1998
    ..Simpler regimens using the component drugs have not been evaluated...
  30. ncbi request reprint Urea breath tests for the detection of Helicobacter pylori infection
    F Bazzoli
    Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
    Helicobacter 2:S34-7. 1997
    ..Helicobacter pylori is recognized as an important human pathogen. The urea breath test, using either 13C or 14C, provides a noninvasive diagnostic method for the detection of active H. pylori infection...
  31. ncbi request reprint Update on Helicobacter pylori research. Dyspepsia
    P Malfertheiner
    Eur J Gastroenterol Hepatol 9:624-5. 1997
  32. ncbi request reprint Fine structure of active ribosomal genes
    C L Woodcock
    Chromosoma 58:33-9. 1976
    ..These results are discussed in the light of the recently discovered subunit structure of chromatin, and in relation to the question of the disposition of histones during transcription...
  33. ncbi request reprint Steady-state regulation of the human DNA mismatch repair system
    D K Chang
    Department of Medicine and Cancer Center, University of California, San Diego, California 92093, USA
    J Biol Chem 275:18424-31. 2000
    ..A balanced up-regulation of all of the components was seen after viral transformation in a fibroblast model. Quantitative changes of the MMR components are a potential mechanism to modify the DNA MMR capabilities of a cell...
  34. ncbi request reprint Chemoprevention in colorectal neoplasias: what is practical and feasible?
    Luigi Ricciardiello
    Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
    Dig Dis 20:70-2. 2002
    ..In the future, we might expect these drugs to be used in the prevention of colon cancer in patients at increased risk, such as those with a positive family history...
  35. ncbi request reprint Oxidative stress inactivates the human DNA mismatch repair system
    Christina L Chang
    Department of Medicine and Cancer Center University of California at San Diego, La Jolla, California 92093 0688, USA
    Am J Physiol Cell Physiol 283:C148-54. 2002
    ..We speculate that inactivation of the MMR function in response to oxidative stress may be responsible for the MSI-L seen in nonneoplastic and cancer tissues associated with chronic inflammation...
  36. pmc Helicobacter pylori and functional dyspepsia: review of previous studies and commentary on new data
    F Bazzoli
    Department of Gastroenterology, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
    Gut 50:iv33-5. 2002
    ..Several mechanisms have been postulated for how H pylori associated inflammation disturbs antral and duodenal function but no pathophysiological explanation of how H pylori may cause dyspeptic symptoms is presently available...
  37. ncbi request reprint Low-dose lansoprazole and clarithromycin plus metronidazole vs. full-dose lansoprazole and clarithromycin plus amoxicillin for eradication of Helicobacter pylori infection
    F Bazzoli
    Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di Bologna, Italy
    Aliment Pharmacol Ther 16:153-8. 2002
    ..To compare, in a randomized controlled trial, the efficacy and tolerability of two 1-week triple therapies for Helicobacter pylori eradication...
  38. ncbi request reprint The Loiano-Monghidoro population-based study of Helicobacter pylori infection: prevalence by 13C-urea breath test and associated factors
    F Bazzoli
    Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
    Aliment Pharmacol Ther 15:1001-7. 2001
    ....
  39. ncbi request reprint Incidence and recurrence rates of colorectal adenomas in first-degree asymptomatic relatives of patients with colon cancer
    S Fossi
    Dipartimento di Medicina Interna e Gastroenterologia, , Italy
    Am J Gastroenterol 96:1601-4. 2001
    ..79) and those without (odds ratio = 8.95, CI = 1.29-62.22). CONCLUSION: A history of one first-degree relative with colorectal cancer is associated with a significant increase in 3-yr cumulative incidence and recurrence rates of adenomas...
  40. pmc Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissues
    L Ricciardiello
    Department of Medicine, University of California, San Diego, La Jolla, California 92093-0688, USA
    J Virol 75:1996-2001. 2001
    ..This strain may be involved in the development of chromosomal instability...
  41. ncbi request reprint Genetic heterogeneity in familial juvenile polyposis
    S C Huang
    Department of Pediatrics, Universitv of California, San Diego 92093, USA
    Cancer Res 60:6882-5. 2000
    ....
  42. ncbi request reprint JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract
    L Ricciardiello
    Department of Medicine and Cancer Center, University of California San Diego, and San Diego Veteran Affairs Medical Center, La Jolla, California 92093 0688, USA
    Gastroenterology 119:1228-35. 2000
    ..The mode of transmission of this virus is unclear, and we hypothesized that the gastrointestinal (GI) tract may be a reservoir for the virus...
  43. pmc Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention
    Dora Colussi
    Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, Pad 5, Bologna 40138, Italy
    Int J Mol Sci 14:16365-85. 2013
    ..Thus, in the near future, we could be able to predict disease behavior based on molecular markers found on tumors, and direct the best treatment options for patients. ..