Research Topics
Genomes and GenesSpecies | Luigi RicciardielloSummaryAffiliation: University of Bologna Location: Bologna, Italy URL: http://www.unibo.it/docenti/luigi.ricciardiello Summary: Colon cancer chemoprevention Colon cancer genetics Hereditary colorectal cancer Grants: AIRC Associazione Italiana Ricerca Sul Cancro 2011-2014. Publications
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Detail Information
Publications
Chemoprevention of colorectal cancer: a role for ursodeoxycholic acid, folate and hormone replacement treatment?Riccardo Solimando
Department of Clinical Medicine, University of Bologna, Via Massarenti 9, Bologna, Italy
Best Pract Res Clin Gastroenterol 25:555-68. 2011..In this review experimental and clinical data on UDCA, folate and HRT as potential chemopreventive agents are discussed...
Lynch syndrome (hereditary non-polyposis colorectal cancer): current concepts and approaches to managementLuigi Ricciardiello
Gastrointestinal Cancer Research Laboratory, Department of Medicine, Division of Gastroenterology, Baylor University Medical Center, Dallas, TX 75246, USA
Curr Gastroenterol Rep 7:412-20. 2005..Specialists should be aware of the significance of inherited colon cancer and should become familiar with the molecular diagnostic tests now widely available...- High thymidylate synthase expression in colorectal cancer with microsatellite instability: implications for chemotherapeutic strategiesLuigi Ricciardiello
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
Clin Cancer Res 11:4234-40. 2005..These tumors have high expression of TS and retain fully functional p53 system. Thus, these data suggest why sporadic hMLH1-defective colon cancers often do not respond to 5-FU... - Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalenceF Perri
Department and Research Laboratory of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, 71013 San Giovanni Rotondo, Italy
Cytokine 30:293-302. 2005..An epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population... - Measuring dyspepsia: a new severity index validated in BolognaL De Luca
Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S. Orsola, Via Massarenti n 9, 40138 Bologna, Italy
Dig Liver Dis 36:806-10. 2004..001). CONCLUSIONS: This questionnaire is a reliable, valid and responsive instrument for measuring the presence, severity and frequency of dyspepsia... - Induction of chromosomal instability in colonic cells by the human polyomavirus JC virusLuigi Ricciardiello
Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti 9, Pad 5 Stanza 28, 40138 Bologna, Italy
Cancer Res 63:7256-62. 2003..In conclusion, we demonstrate that JC virus Mad-1 and Delta98 are able to induce chromosomal instability in colonic cells with a hit and run mechanism that involves an early interaction with beta-catenin and p53... - The VEPSY UPDATED Project: clinical rationale and technical approachG Riva
Applied Technology for Neuro Psychology Laboratory, Istituto Auxologico Italiano, Verbania, Italy
Cyberpsychol Behav 6:433-9. 2003..Moreover, the paper focuses its analysis on the possible role of VR in clinical psychology and how it can be used for therapeutic change... - Effect of H(2)O(2) on cell cycle and survival in DNA mismatch repair-deficient and -proficient cell linesDong Kyung Chang
Department of Medicine and Comprehensive Cancer Center, University of California San Diego, 4028 Basic Science Building, 9500 Gilman Drive, La Jolla 92093-0688, USA
Cancer Lett 195:243-51. 2003..However, this sensitivity appears not to be a direct result of a deficient MMR function, but is more likely attributable to spectrum of target gene mutations that occurs in MMR-deficient tumors... - Characterization of sporadic colon cancer by patterns of genomic instabilityAjay Goel
Department of Medicine and Cancer Center, University of California at San Diego, La Jolla, California, USA
Cancer Res 63:1608-14. 2003..Our data suggest that molecular mechanisms of genomic instability are not necessarily independent and may not be fully defined by either the MSI or CIN pathways... - Endoscopic surveillance in Barrett's esophagusV Lunedei
Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi Bologna
Minerva Gastroenterol Dietol 48:63-71. 2002..At present a marker other than dysplasia identifying a high risk group for cancer on which to focus endoscopic surveillance has not yet been established... - Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancersAjay Goel
Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
Gastroenterology 130:1950-61. 2006.... - Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell linesLucia Fini
Department of Internal Medicine, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, TX 75246, USA
Carcinogenesis 29:139-46. 2008..The Mediterranean diet is rich in extra virgin olive oil (EVOO) and associated with a lower incidence of colorectal cancer. EVOO contains phenolic extracts with potential anticarcinogenic activity... - Phytochemicals and colorectal cancer prevention--myth or reality?Luigi Ricciardiello
Department of Clinical Medicine, University of Bologna, Via Massarenti 9, Bologna 40138, Italy
Nat Rev Gastroenterol Hepatol 8:592-6. 2011.... - Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extractLucia Fini
Department of Internal Medicine, Baylor Research Institute, Sammons Cancer Center, USA
Cancer Prev Res (Phila) 4:907-15. 2011.... - Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in Apc(Min/+) miceLucia Fini
Department of Internal Medicine, Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, USA
Clin Cancer Res 16:5703-11. 2010..Experimental design: Apc(Min/+) and corresponding wild-type mice were fed control diet (Ctrl) or diets containing either EPA-FFA 2.5% or 5%, for 12 weeks while monitoring food intake and body weight... - Chronic intestinal pseudo-obstruction related to viral infectionsR De Giorgio
Department of Clinical Medicine, University of Bologna, Bologna, Italy
Transplant Proc 42:9-14. 2010..The review thus provides some new perspectives in the pathophysiology and perhaps targeted treatment of CIIPO... 
JC virus infection in colorectal neoplasia that develops after liver transplantationMichael Selgrad
Department of Internal Medicine, Baylor University Medical Center, Dallas, TX 75246, USA
Clin Cancer Res 14:6717-21. 2008..JCV encodes for TAg and has been implicated in colorectal carcinogenesis. We hypothesized that the use of immunosuppression in LTRs facilitates activation of JCV and is responsible for the increased risk of neoplasia...- JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstructionM Selgrad
GI Cancer Research Laboratory, 250 Hoblitzelle, Baylor University Medical Center, Dallas, TX 75246 USA
Gut 58:25-32. 2009..The hypothesis that JCV infects the myenteric plexuses of patients with CIIP was tested... - The role of viral and bacterial pathogens in gastrointestinal cancerMichael Selgrad
Department of Internal Medicine, Gastroenterology, Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas 75246, USA
J Cell Physiol 216:378-88. 2008.... - Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cellsLucia Fini
GI Cancer Research Laboratory, Department of Internal Medicine, Sammons Cancer Center, Dallas, TX 75246, USA
J Nutr 137:2622-8. 2007..In conclusion, APE have potent demethylating activity through the inhibition of DNMT proteins. The lack of toxicity in Annurca extracts makes them excellent candidates for the chemoprevention of CRC... - Frequent loss of hMLH1 by promoter hypermethylation leads to microsatellite instability in adenomatous polyps of patients with a single first-degree member affected by colon cancerLuigi Ricciardiello
Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, , 40138 Bologna, Italy
Cancer Res 63:787-92. 2003..02). Hypermethylation of the promoter of hMLH1, consequent loss of hMLH1 expression, and MSI are at the basis of approximately 25% of adenomatous polyps developed in subjects with a SFDR affected by colorectal cancer... - A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cellsAjay Goel
Department of Medicine and Comprehensive Cancer Center, University of California San Diego, San Diego, California, USA
Clin Cancer Res 9:383-90. 2003.... - The role of genomic instabilities in affecting treatment responses of colorectal cancerLuigi Ricciardiello
Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
Dig Dis 20:73-80. 2002..In fact, the response to treatment with 5-FU or platinum compounds is dramatically different in both settings. In the future, the use of these compounds should require molecular testing of the specimen prior to treatment... - Validation of the 13C-urea breath test for the diagnosis of Helicobacter pylori infection in children: a multicenter studyF Bazzoli
Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
Am J Gastroenterol 95:646-50. 2000..As yet, a validated, standardized 13C-UBT protocol for children has not been formulated... - Helicobacter pylori: optimum diagnosis and test of cureF Bazzoli
Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
J Chemother 11:601-5. 1999..The Urea Breath Test is a simple, safe and highly accurate method ideal for evaluating the short-term follow-up of H. pylori eradication after therapy... - How many mutations does it take to make a tumor?C R Boland
Department of Medicine, University of California, San Diego, CA 92093 0688, USA
Proc Natl Acad Sci U S A 96:14675-7. 1999 - Efficacy of lansoprazole in eradicating Helicobacter pylori: a meta-analysisF Bazzoli
Dipartimento di Medicina Interna e Gastroenterologia, Policlinico Universitario Sant Orsola, Bologna, Italy
Helicobacter 3:195-201. 1998..pylori and healing peptic ulcers, we have undertaken a meta-analysis of all the controlled studies published in the literature... - Efficacy and safety of three 7-day Helicobacter pylori eradication regimens containing ranitidine bismuth citrateL Ricciardiello
Gastroenterology Unit, Policlinico S Orsola, Bologna, Italy
Aliment Pharmacol Ther 12:533-7. 1998..This multicentre, randomized study was designed to assess the clinical efficacy, safety and tolerability of three novel 7-day triple therapies containing ranitidine bismuth citrate (RBC) and two antibiotics... - Evaluation of short-term low-dose triple therapy for the eradication of Helicobacter pylori by factorial design in a randomized, double-blind, controlled studyF Bazzoli
Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di Bologna, Italy
Aliment Pharmacol Ther 12:439-45. 1998..Simpler regimens using the component drugs have not been evaluated... - Urea breath tests for the detection of Helicobacter pylori infectionF Bazzoli
Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
Helicobacter 2:S34-7. 1997..Helicobacter pylori is recognized as an important human pathogen. The urea breath test, using either 13C or 14C, provides a noninvasive diagnostic method for the detection of active H. pylori infection... - Update on Helicobacter pylori research. DyspepsiaP Malfertheiner
Eur J Gastroenterol Hepatol 9:624-5. 1997 - Steady-state regulation of the human DNA mismatch repair systemD K Chang
Department of Medicine and Cancer Center, University of California, San Diego, California 92093, USA
J Biol Chem 275:18424-31. 2000..A balanced up-regulation of all of the components was seen after viral transformation in a fibroblast model. Quantitative changes of the MMR components are a potential mechanism to modify the DNA MMR capabilities of a cell... - JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tractL Ricciardiello
Department of Medicine and Cancer Center, University of California San Diego, and San Diego Veteran Affairs Medical Center, La Jolla, California 92093 0688, USA
Gastroenterology 119:1228-35. 2000..The mode of transmission of this virus is unclear, and we hypothesized that the gastrointestinal (GI) tract may be a reservoir for the virus... - Chemoprevention in colorectal neoplasias: what is practical and feasible?Luigi Ricciardiello
Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
Dig Dis 20:70-2. 2002..In the future, we might expect these drugs to be used in the prevention of colon cancer in patients at increased risk, such as those with a positive family history... - Oxidative stress inactivates the human DNA mismatch repair systemChristina L Chang
Department of Medicine and Cancer Center; University of California at San Diego, La Jolla, California 92093 - 0688, USA
Am J Physiol Cell Physiol 283:C148-54. 2002..We speculate that inactivation of the MMR function in response to oxidative stress may be responsible for the MSI-L seen in nonneoplastic and cancer tissues associated with chronic inflammation... - Helicobacter pylori and functional dyspepsia: review of previous studies and commentary on new dataF Bazzoli
Department of Gastroenterology, Policlinico S Orsola, Via Massarenti 9, 40138 Bologna, Italy
Gut 50:iv33-5. 2002..Several mechanisms have been postulated for how H pylori associated inflammation disturbs antral and duodenal function but no pathophysiological explanation of how H pylori may cause dyspeptic symptoms is presently available... - Low-dose lansoprazole and clarithromycin plus metronidazole vs. full-dose lansoprazole and clarithromycin plus amoxicillin for eradication of Helicobacter pylori infectionF Bazzoli
Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di Bologna, Italy
Aliment Pharmacol Ther 16:153-8. 2002..To compare, in a randomized controlled trial, the efficacy and tolerability of two 1-week triple therapies for Helicobacter pylori eradication... - The Loiano-Monghidoro population-based study of Helicobacter pylori infection: prevalence by 13C-urea breath test and associated factorsF Bazzoli
Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
Aliment Pharmacol Ther 15:1001-7. 2001.... - Incidence and recurrence rates of colorectal adenomas in first-degree asymptomatic relatives of patients with colon cancerS Fossi
Dipartimento di Medicina Interna e Gastroenterologia, , Italy
Am J Gastroenterol 96:1601-4. 2001..79) and those without (odds ratio = 8.95, CI = 1.29-62.22). CONCLUSION: A history of one first-degree relative with colorectal cancer is associated with a significant increase in 3-yr cumulative incidence and recurrence rates of adenomas... - Mad-1 is the exclusive JC virus strain present in the human colon, and its transcriptional control region has a deleted 98-base-pair sequence in colon cancer tissuesL Ricciardiello
Department of Medicine, University of California, San Diego, La Jolla, California 92093-0688, USA
J Virol 75:1996-2001. 2001..This strain may be involved in the development of chromosomal instability... - Genetic heterogeneity in familial juvenile polyposisS C Huang
Department of Pediatrics, Universitv of California, San Diego 92093, USA
Cancer Res 60:6882-5. 2000.... - Fine structure of active ribosomal genesC L Woodcock
Chromosoma 58:33-9. 1976..These results are discussed in the light of the recently discovered subunit structure of chromatin, and in relation to the question of the disposition of histones during transcription...