D Ribatti

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. doi request reprint Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma
    Michele Moschetta
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Italy
    Eur J Cancer 46:420-9. 2010
  2. doi request reprint B16-F10 melanoma cells contribute to the new formation of blood vessels in the chick embryo chorioallantoic membrane through vasculogenic mimicry
    Domenico Ribatti
    Section of Human Anatomy and Histology, Department of Basic Medical Sciences, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Clin Exp Med 13:143-7. 2013
  3. ncbi request reprint Antiangiogenic therapeutic approaches in multiple myeloma
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Bari, Italy
    Curr Cancer Drug Targets 12:768-75. 2012
  4. doi request reprint Cancer stem cells and tumor angiogenesis
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cancer Lett 321:13-7. 2012
  5. doi request reprint Angiogenic activity of classical hematopoietic cytokines
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Leuk Res 36:537-43. 2012
  6. doi request reprint Mast cells, angiogenesis, and tumour growth
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy
    Biochim Biophys Acta 1822:2-8. 2012
  7. ncbi request reprint Inflammation and antiangiogenesis in cancer
    D Ribatti
    Department of Basic Medical Sciences, University of Bari Medical School, Policlinico, Bari, Italy
    Curr Med Chem 19:955-60. 2012
  8. pmc VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex
    Vincenzo Benagiano
    Dipartimento Scienze Mediche di Base, Sezione di Anatomia e Istologia, Università Bari, Italy
    BMC Neurosci 12:118. 2011
  9. ncbi request reprint The discovery of antiangiogenic molecules: a historical review
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Curr Pharm Des 15:345-52. 2009
  10. ncbi request reprint Mast cell contribution to angiogenesis related to tumour progression
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 34:1660-4. 2004

Detail Information

Publications173 found, 100 shown here

  1. doi request reprint Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma
    Michele Moschetta
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Italy
    Eur J Cancer 46:420-9. 2010
    ....
  2. doi request reprint B16-F10 melanoma cells contribute to the new formation of blood vessels in the chick embryo chorioallantoic membrane through vasculogenic mimicry
    Domenico Ribatti
    Section of Human Anatomy and Histology, Department of Basic Medical Sciences, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Clin Exp Med 13:143-7. 2013
    ..Finally, we have shown that CAMs new-formed blood vessels are lined by both pigmented melanoma cells and cells immunoreactive to MART-1/Melan-A and PAS, suggesting the occurrence of a vasculogenic mimicry process...
  3. ncbi request reprint Antiangiogenic therapeutic approaches in multiple myeloma
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Bari, Italy
    Curr Cancer Drug Targets 12:768-75. 2012
    ..This review article summarizes the literature data concerning the employment of the most important antiangiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of MM...
  4. doi request reprint Cancer stem cells and tumor angiogenesis
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cancer Lett 321:13-7. 2012
    ..In this context, the development of agents that eliminate or control CSC may be an effective strategy for cancer prevention...
  5. doi request reprint Angiogenic activity of classical hematopoietic cytokines
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Leuk Res 36:537-43. 2012
    ..This review article summarizes the most important literature data concerning this inconvertible relationship...
  6. doi request reprint Mast cells, angiogenesis, and tumour growth
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy
    Biochim Biophys Acta 1822:2-8. 2012
    ..This review will focus on the most recent acquisitions about this intriguing field of research. This article is part of a Special Issue entitled: Mast cells in inflammation...
  7. ncbi request reprint Inflammation and antiangiogenesis in cancer
    D Ribatti
    Department of Basic Medical Sciences, University of Bari Medical School, Policlinico, Bari, Italy
    Curr Med Chem 19:955-60. 2012
    ..In this review article, we will focus on some angiogenenic and anti-angiogenic molecules properties of immune cells that may be utilized for a potential parmacological use as anti-angiogenic agents in cancer...
  8. pmc VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex
    Vincenzo Benagiano
    Dipartimento Scienze Mediche di Base, Sezione di Anatomia e Istologia, Università Bari, Italy
    BMC Neurosci 12:118. 2011
    ....
  9. ncbi request reprint The discovery of antiangiogenic molecules: a historical review
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Curr Pharm Des 15:345-52. 2009
    ..Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials...
  10. ncbi request reprint Mast cell contribution to angiogenesis related to tumour progression
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 34:1660-4. 2004
    ....
  11. doi request reprint The paracrine role of Tie-2-expressing monocytes in tumor angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare 11, Policlinico, Bari, Italy
    Stem Cells Dev 18:703-6. 2009
    ....
  12. ncbi request reprint Chick embryo chorioallantoic membrane as a useful tool to study angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    Int Rev Cell Mol Biol 270:181-224. 2008
    ..Finally, advantages and limitations of CAM as an experimental model to study angiogenesis and antiangiogenesis are discussed...
  13. ncbi request reprint The involvement of endothelial progenitor cells in tumor angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari I 70124, Italy
    J Cell Mol Med 8:294-300. 2004
    ..This review article will summarize the literature data concerning this new role played by EPCs in tumor angiogenesis...
  14. doi request reprint Co-localization of tryptase and cathepsin-G in mast cells in cutaneous mastocytosis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Cancer Lett 279:209-12. 2009
    ....
  15. ncbi request reprint [Is the end of the physician-patient relation the medicine crisis?]
    Domenico Ribatti
    Dipartimento di Anatomia Umana Normale e Istologia, Policlinico, Bari
    Recenti Prog Med 95:1-2. 2004
  16. pmc Correlation between NGF/TrkA and microvascular density in human pterygium
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare 11, Bari, Italy
    Int J Exp Pathol 90:615-20. 2009
    ..Understanding the mechanism of angiogenesis in pterygium provides a basis for a rational approach to the development of anti-angiogenic therapy in patients affected by this disease...
  17. doi request reprint The contribution of Roberto Montesano to the study of interactions between epithelial sheets and the surrounding extracellular matrix
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Dev Biol 54:1-6. 2010
    ..e. paracrine-acting growth factors and insoluble extracellular matrix components...
  18. pmc Mast cells and macrophages in duodenal mucosa of mice overexpressing erythropoietin
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Anat 215:548-54. 2009
    ....
  19. doi request reprint Immune cells and angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Cell Mol Med 13:2822-33. 2009
    ....
  20. ncbi request reprint Fenretinide as an anti-angiogenic agent in neuroblastoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, 11 I 70124 Bari, Italy
    Cancer Lett 197:181-4. 2003
    ..This mini-review summarizes our literature and experimental data concerning the use of anti-angiogenic molecules, such as TNP-470 and fenretinide, in neuroblastoma treatment...
  21. ncbi request reprint New non-angiogenesis dependent pathways for tumour growth
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, 70124 Bari, Italy
    Eur J Cancer 39:1835-41. 2003
    ..Finally, lymphoangiogenesis as a mechanism of de novo formation of lymphatics, favouring the metastatic dissemination of tumour cells, is summarised. Potential therapeutic applications are also discussed...
  22. doi request reprint Sir Frank Macfarlane Burnet and the clonal selection theory of antibody formation
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11 Policlinico, 70124, Bari, Italy
    Clin Exp Med 9:253-8. 2009
    ..At the time of writing the clonal selection theory, Burnet was 57 years old and the Director of the Water and Eliza Hall Institute in Melbourne, Australia...
  23. ncbi request reprint Angiogenic response induced by acellular brain scaffolds grafted onto the chick embryo chorioallantoic membrane
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, I 70124, Bari, Italy
    Brain Res 989:9-15. 2003
    ..In addition, the angiogenic response may depend, in part, also on the presence in the acellular matrix of transforming growth factor beta 1 (TGFbeta1)...
  24. doi request reprint Mast cells and angiogenesis in haematological malignancies
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11 Policlinico, 70124 Bari, Italy
    Leuk Res 33:876-9. 2009
    ....
  25. pmc The role of microenvironment in tumor angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, 70124, Bari, Italy
    Genes Nutr 3:29-34. 2008
    ..The encouraging results of pre-clinical and clinical trials in which tumors have been treated by targeting the tumor microenvironment are also discussed...
  26. ncbi request reprint Antiangiogenesis by chemotherapeutic agents
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Mini Rev Med Chem 5:313-7. 2005
    ..This review summarizes the literature concerning the antiangiogenic effects of these agents when administered alone or in combination with other angiogenesis inhibitors...
  27. doi request reprint Inflammatory angiogenesis in atherogenesis--a double-edged sword
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Ann Med 40:606-21. 2008
    ....
  28. ncbi request reprint Nonclassic endogenous novel [corrected] regulators of angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, School of Medicine, University of Bari, Bari, Italy
    Pharmacol Rev 59:185-205. 2007
    ..Investigations on "nonclassic" regulators of angiogenesis could open new perspectives in the therapy of diseases coupled to dysregulation of angiogenesis...
  29. ncbi request reprint The discovery of endothelial progenitor cells. An historical review
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Leuk Res 31:439-44. 2007
    ..Questions persist regarding their functional characteristics, as well as the precise panel of cell surface markers that define this cell population...
  30. ncbi request reprint Angiogenesis and anti-angiogenesis in hepatocellular carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124 Bari, Italy
    Cancer Treat Rev 32:437-44. 2006
    ..Accordingly, anti-angiogenic tumor therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block HCC progression are reviewed...
  31. ncbi request reprint The structure of the vascular network of tumors
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cancer Lett 248:18-23. 2007
    ..This review will focus on the factors influencing this heterogeneity...
  32. pmc Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 50:636-41. 2007
    ..The aim of this study was to correlate microvascular density and Epo/Epo-receptor (EpoR) expression in endothelial and tumour cells to the clinical stage of NB...
  33. ncbi request reprint The history of the angiogenic switch concept
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Leukemia 21:44-52. 2007
    ....
  34. pmc The fundamental contribution of Robert A. Good to the discovery of the crucial role of thymus in mammalian immunity
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Immunology 119:291-5. 2006
    ....
  35. ncbi request reprint Giulio Bizzozero and the discovery of platelets
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
    Leuk Res 31:1339-41. 2007
    ..Moreover, he carefully described platelet function in flowing conditions and the relationship between platelet adhesion, aggregation and subsequent fibrin formation and deposition...
  36. pmc The contribution of Bruce Glick to the definition of the role played by the bursa of Fabricius in the development of the B cell lineage
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 145:1-4. 2006
    ..Their demonstration that antibody responses are suppressed in the majority of bursectomized chickens became the cornerstone of modern immunology. Bursa research increased considerably during the 1960s and early 1970s...
  37. ncbi request reprint The contribution of Harold F. Dvorak to the study of tumor angiogenesis and stroma generation mechanisms
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Endothelium 14:131-5. 2007
    ..This work is again extremely significant for patients worldwide, as Dvorak's scientific research is leading his colleagues all over the world to examine how to treat a tumor through its blood supply...
  38. ncbi request reprint Microvascular density, vascular endothelial growth factor immunoreactivity in tumor cells, vessel diameter and intussusceptive microvascular growth in primary melanoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, 11 Piazza Giulio Cesare, Policlinico, I 70124 Bari, Italy
    Oncol Rep 14:81-4. 2005
    ....
  39. ncbi request reprint Therapeutic renaissance of thalidomide in the treatment of haematological malignancies
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Bari, Italy
    Leukemia 19:1525-31. 2005
    ..More recently, structural analogues of thalidomide have been synthesized in order to explore potential molecular targets of thalidomide, as well as to identify new agents with improved therapeutic efficacy...
  40. ncbi request reprint The role of adrenomedullin in angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
    Peptides 26:1670-5. 2005
    ..Finally, the role of AM as a potential target of antiangiogenic therapy is discussed...
  41. ncbi request reprint Endothelial progenitor cells in health and disease
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Histol Histopathol 20:1351-8. 2005
    ..Recent evidence, however, indicates that EPC contribute to vessel growth in the embryo and in ischemic, malignant or inflammed tissues in the adult, and can even be therapeutically used to stimulate vessel growth in ischemic tissues...
  42. doi request reprint Erythropoietin, the first century
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Bari, Italy
    Leuk Res 32:1169-72. 2008
  43. pmc Judah Folkman, a pioneer in the study of angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124, Bari, Italy
    Angiogenesis 11:3-10. 2008
    ..Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases...
  44. doi request reprint Hemangioblast does exist
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Leuk Res 32:850-4. 2008
  45. ncbi request reprint In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histol Histopathol 22:285-9. 2007
    ..Sinergy on the part of these well-known drugs when used in combination as antiangiogenics at very low doses may be of significance in the designing of new ways of treating HCC...
  46. ncbi request reprint The contribution of Gianni Bonadonna to the history of chemotherapy
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Cancer Chemother Pharmacol 60:309-12. 2007
    ..This review article summarizes the seminal work of the Italian scientist Gianni Bonadonna on the treatment of breast cancer and Hodgkin's disease...
  47. ncbi request reprint Erythropoietin as an angiogenic factor in gastric carcinoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 42:246-50. 2003
    ..In this study we correlated microvascular density and Epo receptor (Epo-R) expression in endothelial and tumour cells with histopathological type in gastric cancer...
  48. ncbi request reprint Localization of factor VIII-related antigen in the endothelium of the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Histochem Cell Biol 112:447-50. 1999
    ..The application of this antibody may be useful for quantifying neovascularization in response to various angiogenic stimuli applied to the CAM...
  49. ncbi request reprint The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Curr Pharm Biotechnol 1:73-82. 2000
    ..Angiogenesis or anti-angiogenesis is evaluated quantitatively or semiquantitatively. The fields of application of CAM in the study of anti-angiogenesis, including our personal experience, are illustrated in this paper...
  50. ncbi request reprint Angiogenesis, angiogenic factor expression and hematological malignancies
    D Ribatti
    Department of Human Anatomy and Histology, and University of Bari Medical School, Italy
    Anticancer Res 21:4333-9. 2001
    ..In B-cell non-Hodgkin's lymphomas, angiogenesis is significantly enhanced in relation to progression. Angiostatic molecules, such as thalidomide, could also be considered for the clinical management of hematological tumors...
  51. doi request reprint Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Dev Biol 55:99-102. 2011
    ....
  52. ncbi request reprint An experimental study in the chick embryo chorioallantoic membrane of the anti-angiogenic activity of cyclosporine in rheumatoid arthritis versus osteoarthritis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari, Medical School, Italy
    Inflamm Res 49:418-23. 2000
    ....
  53. ncbi request reprint Postnatal vasculogenesis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, I 70124, Bari, Italy
    Mech Dev 100:157-63. 2001
    ..The potential biomedical applications of endothelial precursor cells and the new opportunities for the development of new forms of tumor-targeted treatments are discussed...
  54. ncbi request reprint Endothelial cell heterogeneity and organ specificity
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Hematother Stem Cell Res 11:81-90. 2002
    ....
  55. ncbi request reprint Macrophages and mast cells are involved in carotid plaque instability
    A Marzullo
    Department Pathology, University of Bari Medical School, Bari, Italy
    Rom J Morphol Embryol 52:981-4. 2011
    ....
  56. ncbi request reprint Coordinate immunoreactivity to vascular endothelial growth factor receptor-2 and its ligand suggests a paracrine regulation during the development of the vascular system in the chick embryo bursa of Fabricius
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, I 70124 Bari, Italy
    Int J Mol Med 7:365-8. 2001
    ..These data support the view that VEGF acts as a paracrine stimulator of angiogenesis in the avian embryo and confirm the requirement of the endodermal layer for the normal formation of blood vessels by mesodermal cells...
  57. ncbi request reprint Mast cells and their secretory granules are angiogenic in the chick embryo chorioallantoic membrane
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 31:602-8. 2001
    ..Many data suggest that the density of mast cells is highly correlated with the extent of both normal and pathological angiogenesis...
  58. doi request reprint Tryptase-positive mast cells and CD8-positive T cells in human endometrial cancer
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Pathol Int 61:442-4. 2011
    ..These data suggest that inhibition of inflammation or manipulation of inflammatory resolution pathways may be a new therapeutic approach for the treatment of endometrial adenocarcinoma...
  59. ncbi request reprint Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, Department of Biomedical Sciences and Human Oncology, University of Bari School of Medicine, Bari, Italy
    Blood 93:2627-36. 1999
    ..Taken together, these data demonstrate the ability of Epo to interact directly with endothelial cells and to elicit an angiogenic response in vitro and in vivo and thus act as a bona fide direct angiogenic factor...
  60. pmc Erythropoietin is involved in angiogenesis in human primary melanoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Exp Pathol 91:495-9. 2010
    ..These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis...
  61. ncbi request reprint In vivo angiogenic activity of neuroblastoma correlates with MYCN oncogene overexpression
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari, Policlinico, Bari, Italy
    Int J Cancer 102:351-4. 2002
    ....
  62. doi request reprint Vascular normalization: a real benefit?
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cancer Chemother Pharmacol 68:275-8. 2011
    ..In fact as in the case of cerebral tumors, the process of normalization may induce a re-establishment of the low permeability characteristics of normal brain microvasculature, preventing the delivery of chemotherapeutics...
  63. doi request reprint Angiogenesis in asthma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 39:1815-21. 2009
    ..This review provides recent data showing the contribution of allergic inflammation in increased airway vascularity and potential therapeutical approaches in asthma treatment by acting on bronchial microvascular changes...
  64. ncbi request reprint Systemic sclerosis stimulates angiogenesis in the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Clin Rheumatol 17:115-20. 1998
    ..Moreover, the role played in the angiogenic response by the inflammatory cells forming the cellular infiltrate is suggested by this study...
  65. ncbi request reprint The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Cell Mol Med 6:439-46. 2002
    ..The findings in all these studies support the importance of FGF-2 as an autocrine paracrine stimulator of angiogenesis and its key role in the development of the vascular system in the avian embryo...
  66. doi request reprint The seminal work of Werner Risau in the study of the development of the vascular system
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Dev Biol 54:567-72. 2010
    ..This review is dedicated to a retrospective analysis of the most important contributions of Risaus work in the field of angiogenesis during embryonic development and in post-natal life, in both physiological and pathological conditions...
  67. doi request reprint Novel angiogenesis inhibitors: addressing the issue of redundancy in the angiogenic signaling pathway
    Domenico Ribatti
    Dipartimento di Anatomia umana e Istologia, Universita degli Studi di Bari, Italy
    Cancer Treat Rev 37:344-52. 2011
    ..It would appear that the future of angiogenic inhibitors lies in the intelligent combination of multiple targeted agents with other angiogenic inhibitors, as well as more conventional therapies to maximise therapeutic effect...
  68. ncbi request reprint Pietro M. Gullino and angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Endothelium 9:227-30. 2002
  69. ncbi request reprint Human neuroblastoma cells produce extracellular matrix-degrading enzymes, induce endothelial cell proliferation and are angiogenic in vivo
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Int J Cancer 77:449-54. 1998
    ..Our data suggest that the 2 NB cell lines are angiogenic, to LAN-5 cells more than GI-LI-N ones. LAN-5 cells are indeed endowed with a more aggressive and invasive phenotype...
  70. ncbi request reprint Expression of tenascin is related to angiogenesis in pre-eclampsia
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Eur J Clin Invest 28:373-8. 1998
    ..In addition, pre-eclamptic and control samples were grafted onto the chick embryo chorioallantoic membrane (CAM) to study their possible angiogenic activity in vivo...
  71. pmc Erythropoietin/erythropoietin-receptor system is involved in angiogenesis in human hepatocellular carcinoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 50:591-6. 2007
    ..To correlate microvascular density and erythropoietin (Epo)/Epo-receptor (EpoR) expression in endothelial and tumour cells with histopathological type in hepatocellular carcinoma (HCC)...
  72. ncbi request reprint Anti-angiogenic activity of the purine analog 6-thioguanine
    M Presta
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy
    Leukemia 16:1490-9. 2002
    ..These results suggest a new rationale for the use of purine analogs in the management of AML...
  73. ncbi request reprint Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process
    M Presta
    Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Italy
    Cancer Res 59:2417-24. 1999
    ..These results provide a new rationale for the use of selected purine analogues in combination therapy of solid cancer...
  74. ncbi request reprint A VEGF-dependent autocrine loop mediates proliferation and capillarogenesis in bone marrow endothelial cells of patients with multiple myeloma
    Roberto Ria
    Department of Internal Medicine and Clinical Oncology, Piazza Giulio Cesare, 11, Policlinico, I 70124, Bari, Italy
    Thromb Haemost 92:1438-45. 2004
    ..Since this is very likely a mechanism for the amplification of VEGF activity in neovascularization, it would constitute an appropriate target for antiangiogenic management in MM...
  75. doi request reprint Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling
    A De Luisi
    Dept of Internal Medicine and Clinical Oncology, Unit of Allergology and Clinical Immunology, Bari, Italy
    Eur Respir J 34:958-66. 2009
    ....
  76. ncbi request reprint Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in the chick embryo area vasculosa
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Histochem J 33:283-6. 2001
    ..In accord with other literature data, this suggests that vascular endothelial growth factor is required not only for proliferation, but also for the survival of endothelial cells...
  77. pmc Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas
    A Vacca
    Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Italy
    Br J Cancer 79:965-70. 1999
    ....
  78. ncbi request reprint Vascular endothelial growth factor and its receptors in multiple myeloma
    R Ria
    Department of Biomedical Sciences and Human Oncology, Bari, Italy
    Leukemia 17:1961-6. 2003
    ..Recent applications of antiangiogenic agents that interfere with VEGF signaling and block MM progression are also described...
  79. ncbi request reprint In vivo absence of synergism between fibroblast growth factor-2 and vascular endothelial growth factor
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Hematother Stem Cell Res 10:905-12. 2001
    ..Thus, in an in vivo system, evaluation of synergistic action between two cytokines and discrimination of their specific activity are more difficult than in an in vitro assay...
  80. ncbi request reprint Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma
    Claudio Scavelli
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Mol Cancer Ther 6:3256-62. 2007
    ..Tentatively, we suggest that the zoledronic acid antitumoral activity in multiple myeloma is also sustained by antiangiogenesis, which would partly account for its therapeutic efficacy in multiple myeloma...
  81. ncbi request reprint Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic
    Girolamo Ranieri
    Department of Clinical and Experimental Oncology, National Cancer Institute of Bari, Bari, Italy
    Curr Med Chem 13:1845-57. 2006
    ..This review summarises the critical role of VEGF and discusses the data available on bevacizumab, from the humanisation of its parent murine monoclonal antibody (mAb) A.4.6.1 to its use in cancer clinical trials...
  82. doi request reprint Mast cells contribute to vasculogenic mimicry in multiple myeloma
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Stem Cells Dev 17:19-22. 2008
    ....
  83. ncbi request reprint Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in mdx mouse brain
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Brain Res 953:12-6. 2002
    ..Our data suggest that increased vascularity in the brain of mdx mouse may be due, at least in part, to proliferation of endothelial cells in response to VEGF secreted by neuronal cells...
  84. doi request reprint Angiogenic activity of multiple myeloma endothelial cells in vivo in the chick embryo chorioallantoic membrane assay is associated to a down-regulation in the expression of endogenous endostatin
    Domenica Mangieri
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Cell Mol Med 12:1023-8. 2008
    ..These data suggest that angiogenic switch in MM may involve loss of an endogenous angiogenesis inhibitor, such as endostatin...
  85. ncbi request reprint Desmin-positive pericytes in the chick embryo chorioallantoic membrane in response to fibroblast growth factor-2
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    Microvasc Res 68:13-9. 2004
    ....
  86. ncbi request reprint Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and rapamycin
    Danilo Marimpietri
    Differentiation Therapy Unit Laboratory of Oncology, G Gaslini Childrens Hospital, Genoa 16148, and Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Oncogene 24:6785-95. 2005
    ..The observation that these well-known drugs display synergistic effects as antiangiogenics when administered frequently at very low dose may be of significance in the designing of new ways of treating NB...
  87. pmc Lymphatics at the crossroads of angiogenesis and lymphangiogenesis
    Claudio Scavelli
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bar Medical School, Italy
    J Anat 204:433-49. 2004
    ..Finally, molecular mechanisms involved in the regulation of lymphangiogenesis are described...
  88. ncbi request reprint In situ hybridization and immunogold localization of vascular endothelial growth factor receptor-2 on the pericytes of the chick chorioallantoic membrane
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cytokine 17:262-5. 2002
    ....
  89. doi request reprint An alternative in vivo system for testing angiogenic potential of human neuroblastoma cells
    Domenica Mangieri
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare 11, Policlinico, Bari, Italy
    Cancer Lett 277:199-204. 2009
    ..This experimental model could be employed for further research on human tumor progression and anti-angiogenic molecules screening...
  90. ncbi request reprint Angiogenesis under normal and pathological conditions
    D Ribatti
    Istituto di Anatomia Umana Normale e di Istologia ed Embriologia, Universita, Facoltà, Medica, Bari, Italy
    Haematologica 76:311-20. 1991
    ..Anti-angiogenic factors have also been identified, particularly a new class of nonglucocorticoid steroids. Their employment in tumour therapy is a possibility, since neoplastic expansion is essentially dependent on angiogenesis...
  91. ncbi request reprint A possible role of tryptase in angiogenesis in the brain of mdx mouse, a model of Duchenne muscular dystrophy
    B Nico
    Department of Human Anatomy, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124, Bari, Italy
    Neuroscience 123:585-8. 2004
    ....
  92. ncbi request reprint Bone marrow angiogenesis in patients with active multiple myeloma
    A Vacca
    Department of Biomedical Sciences and Oncology, University of Bari Medical School, Policlinico-Piazza Giulio Cesare, 11, I-70124 Bari, Italy
    Semin Oncol 28:543-50. 2001
    ..Both angiogenesis and MMP-2 secretion can account for intramedullary and extramedullary spreading of plasma cells in patients with active MM...
  93. ncbi request reprint Microvessel overexpression of aquaporin 1 parallels bone marrow angiogenesis in patients with active multiple myeloma
    A Vacca
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University School, Bari, Italy
    Br J Haematol 113:415-21. 2001
    ..It may, perhaps, favour angiogenesis in a positive loop and, hence, MM progression, and thus be applied for therapeutic vascular targeting...
  94. doi request reprint Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma
    Roberto Ria
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Cancer Res 15:5369-78. 2009
    ..To determine a "gene/molecular fingerprint" of multiple myeloma endothelial cells and identify vascular mechanisms governing the malignant progression from quiescent monoclonal gammopathy of undetermined significance...
  95. ncbi request reprint Cross talk between haematopoiesis and angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, 1 70124 Bari, Italy
    Adv Exp Med Biol 522:25-36. 2003
  96. doi request reprint Endothelial differentiation of hematopoietic stem and progenitor cells from patients with multiple myeloma
    Roberto Ria
    Department of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Cancer Res 14:1678-85. 2008
    ..Here, we show that hematopoietic stem and progenitor cells (HSPC) of multiple myeloma (MM) patients are able to differentiate into cells with endothelial phenotype on exposure to angiogenic cytokines...
  97. ncbi request reprint Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma
    Roberto Ria
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Haematologica 87:836-45. 2002
    ..We studied these mechanisms in fresh bone marrow plasma cells of patients with MM after adhesion to the ECM proteins vitronectin (VN) and fibronectin (FN)...
  98. ncbi request reprint CXCR3-binding chemokines in multiple myeloma
    Antonio Pellegrino
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari I 70124, Italy
    Cancer Lett 207:221-7. 2004
    ..Data suggest that CXCR3/chemokine loop may be important for progression of MM in terms of intramedullary and extramedullary dissemination...
  99. ncbi request reprint Nerve growth factor as an angiogenic factor
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Microvasc Res 75:135-41. 2008
    ..This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions...