D Ribatti


Affiliation: University of Bari
Country: Italy


  1. Ribatti D, Belloni A, Nico B, Di Comite M, Crivellato E, Vacca A. Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma. Peptides. 2008;29:1596-602 pubmed publisher
    ..Taken together, these findings indicate that leptin/Ob-R correlate with angiogenesis and tumor progression in patients with HCC and that an anti-leptin antibody exerts an angiostatic activity in HCC. ..
  2. Ribatti D. The seminal work of Werner Risau in the study of the development of the vascular system. Int J Dev Biol. 2010;54:567-72 pubmed publisher
    ..This review is dedicated to a retrospective analysis of the most important contributions of Risaus work in the field of angiogenesis during embryonic development and in post-natal life, in both physiological and pathological conditions. ..
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    Ribatti D. The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review. Br J Haematol. 2005;128:303-9 pubmed
    ..Moreover, different strategies, designed to stimulate and to inhibit VEGF production in the context of several potential therapeutical implications, are discussed. ..
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    Ribatti D, Vacca A, Dammacco F. New non-angiogenesis dependent pathways for tumour growth. Eur J Cancer. 2003;39:1835-41 pubmed
    ..Finally, lymphoangiogenesis as a mechanism of de novo formation of lymphatics, favouring the metastatic dissemination of tumour cells, is summarised. Potential therapeutic applications are also discussed. ..
  5. Ribatti D, Poliani P, Longo V, Mangieri D, Nico B, Vacca A. Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma. Histopathology. 2007;50:636-41 pubmed
    ..Understanding the mechanisms of NB angiogenesis provides the basis for a rational approach to the development of antiangiogenic therapy in patients affected by NB. ..
  6. Marinaccio C, Giudice G, Nacchiero E, Robusto F, Opinto G, Lastilla G, et al. Interval sentinel lymph nodes in melanoma: a digital pathology analysis of Ki67 expression and microvascular density. Clin Exp Med. 2016;16:383-9 pubmed publisher
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    Ribatti D, Raffaghello L, Marimpietri D, Cosimo E, Montaldo P, Nico B, et al. Fenretinide as an anti-angiogenic agent in neuroblastoma. Cancer Lett. 2003;197:181-4 pubmed
    ..This mini-review summarizes our literature and experimental data concerning the use of anti-angiogenic molecules, such as TNP-470 and fenretinide, in neuroblastoma treatment. ..
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    Ribatti D, Vacca A, Roncali L, Dammacco F. The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis. Curr Pharm Biotechnol. 2000;1:73-82 pubmed
    ..Angiogenesis or anti-angiogenesis is evaluated quantitatively or semiquantitatively. The fields of application of CAM in the study of anti-angiogenesis, including our personal experience, are illustrated in this paper. ..
  9. Ribatti D. The controversial role of placental growth factor in tumor growth. Cancer Lett. 2011;307:1-5 pubmed publisher
    ..Depending on the model, PlGF overexpression has been shown to result in tumor growth promotion or inhibition. This review article summarizes the most relevant literature data concerning this still unsolved important question. ..

More Information


  1. Ribatti D, De Falco G, Nico B, Ria R, Crivellato E, Vacca A. In vivo time-course of the angiogenic response induced by multiple myeloma plasma cells in the chick embryo chorioallantoic membrane. J Anat. 2003;203:323-8 pubmed
  2. Ribatti D, Nico B, Pezzolo A, Vacca A, Meazza R, Cinti R, et al. Angiogenesis in a human neuroblastoma xenograft model: mechanisms and inhibition by tumour-derived interferon-gamma. Br J Cancer. 2006;94:1845-52 pubmed
    ..Once the dual origin of tumour vasculature is confirmed in NB patients, the xenograft model described here will prove useful in testing the efficacy of different antiangiogenic compounds. ..
  3. Ribatti D, Crivellato E, Vacca A. Miller's seminal studies on the role of thymus in immunity. Clin Exp Immunol. 2006;144:371-5 pubmed
    ..This review article summarizes the seminal work of the Australian scientist Francis Albert Pierre Miller concerning the description for the first time of the crucial role of the thymus for normal development of the immune system. ..
  4. Ribatti D. The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis. Pharmaceuticals (Basel). 2010;3:482-513 pubmed
    ..The fields of application of CAM in the study of antiangiogenesis, including our personal experience, are illustrated in this review article. ..
  5. Ribatti D. Tyrosine Kinase Inhibitors as Antiangiogenic Drugs in Multiple Myeloma. Pharmaceuticals (Basel). 2010;3:1225-1231 pubmed
    ..This review article is focused on the use of tyrosine kinase inhibitors as antiangiogenic molecules in the treatment of multiple myeloma. ..
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    Ribatti D. The discovery of antiangiogenic molecules: a historical review. Curr Pharm Des. 2009;15:345-52 pubmed
    ..Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. ..
  7. Ribatti D, Nico B, Crivellato E. The role of pericytes in angiogenesis. Int J Dev Biol. 2011;55:261-8 pubmed publisher
    ..We will then consider the complex and multivarious contribution of pericytes to the different aspects of angiogenesis with particular emphasis on the potential role of these cells as targets in tumor therapy. ..
  8. Ribatti D. Endogenous inhibitors of angiogenesis: a historical review. Leuk Res. 2009;33:638-44 pubmed publisher
    ..This review summarizes the present knowledge about endogenous inhibitors of angiogenesis. ..
  9. Ribatti D. Transgenic mouse models of angiogenesis and lymphangiogenesis. Int Rev Cell Mol Biol. 2008;266:1-35 pubmed publisher
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    Ribatti D. The fundamental contribution of Jan C. Waldenström to the discovery and study of the so-called "Waldenström macroglobulinemia". Leuk Res. 2007;31:435-8 pubmed
    ..This historical review article summarizes the fundamental contribution of Jan Costa Waldenström to the discovery and study of this lymphoproliferative disorder. ..
  11. Ribatti D. The discovery of the placental growth factor and its role in angiogenesis: a historical review. Angiogenesis. 2008;11:215-21 pubmed publisher
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    Ribatti D, Crivellato E, Vacca A. Inflammation and antiangiogenesis in cancer. Curr Med Chem. 2012;19:955-60 pubmed
    ..In this review article, we will focus on some angiogenenic and anti-angiogenic molecules properties of immune cells that may be utilized for a potential parmacological use as anti-angiogenic agents in cancer. ..
  13. Guidolin D, Marinaccio C, Tortorella C, Annese T, Ruggieri S, Finato N, et al. Non-random spatial relationships between mast cells and microvessels in human endometrial carcinoma. Clin Exp Med. 2017;17:71-77 pubmed publisher
    ..However, this spatial association between vessels and MCs might simply reflect migrating MCs from the blood stream at vessel growing sites. ..
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    Ribatti D, Alessandri G, Baronio M, Raffaghello L, Cosimo E, Marimpietri D, et al. Inhibition of neuroblastoma-induced angiogenesis by fenretinide. Int J Cancer. 2001;94:314-21 pubmed
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    Ribatti D, Vacca A, Rusnati M, Presta M. The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies. Cytokine Growth Factor Rev. 2007;18:327-34 pubmed
    ..This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as traced by the main contributions to the international medical literature. ..
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    Ribatti D, Vacca A, Roccaro A, Crivellato E, Presta M. Erythropoietin as an angiogenic factor. Eur J Clin Invest. 2003;33:891-6 pubmed
    ..New sites of Epo production have been found, such as the female reproductive organs and central nervous system. This review summarizes the involvement of Epo in the regulation of angiogenesis in both normal and pathological conditions. ..
  17. Ribatti D, Nico B, Cimpean A, Raica M. Podoplanin and LYVE-1 expression in lymphatic vessels of human neuroblastoma. J Neurooncol. 2010;100:151-2 pubmed publisher
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    Ribatti D, Vacca A. Models for studying angiogenesis in vivo. Int J Biol Markers. 1999;14:207-13 pubmed
    ..In this review we describe and evaluate the methodology and specific features of some of the most frequently used in vivo assays...
  19. Ribatti D. Chicken chorioallantoic membrane angiogenesis model. Methods Mol Biol. 2012;843:47-57 pubmed publisher
    ..The cells invade the epithelium and the mesenchymal connective tissue below, where they are found in the form of a dense bed of blood vessels, which is a target for intravasation...
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    Ribatti D, Crivellato E, Candussio L, Vacca A, Nico B, Benagiano V, et al. Angiogenic activity of rat mast cells in the chick embryo chorioallantoic membrane is down-regulated by treatment with recombinant human alpha-2a interferon and partly mediated by fibroblast growth factor-2. Haematologica. 2002;87:465-71 pubmed
    ..Finally, the morphologic features of MC treated with rhIFN-alpha2a, characterized by an atypical secretory pathway, are compatible with a slow release of the angiogenic cytokines stored in MC granules. ..
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    Ribatti D, Presta M. The role of fibroblast growth factor-2 in the vascularization of the chick embryo chorioallantoic membrane. J Cell Mol Med. 2002;6:439-46 pubmed
    ..The findings in all these studies support the importance of FGF-2 as an autocrine paracrine stimulator of angiogenesis and its key role in the development of the vascular system in the avian embryo...
  22. Ribatti D, Nico B, Perra M, Longo V, Maxia C, Annese T, et al. Erythropoietin is involved in angiogenesis in human primary melanoma. Int J Exp Pathol. 2010;91:495-9 pubmed publisher
    ..These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis. ..
  23. Ribatti D, Nico B, Finato N, Crivellato E, Beltrami C. Co-localization of tryptase and cathepsin-G in mast cells in cutaneous mastocytosis. Cancer Lett. 2009;279:209-12 pubmed publisher
  24. Ribatti D, Crivellato E, Vacca A. The contribution of Bruce Glick to the definition of the role played by the bursa of Fabricius in the development of the B cell lineage. Clin Exp Immunol. 2006;145:1-4 pubmed
    ..Their demonstration that antibody responses are suppressed in the majority of bursectomized chickens became the cornerstone of modern immunology. Bursa research increased considerably during the 1960s and early 1970s...
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    Ribatti D, Cantatore F, Vacca A, D Amore M, Ria R, Roncali L, et al. Systemic sclerosis stimulates angiogenesis in the chick embryo chorioallantoic membrane. Clin Rheumatol. 1998;17:115-20 pubmed
    ..Moreover, the role played in the angiogenic response by the inflammatory cells forming the cellular infiltrate is suggested by this study...
  26. Ribatti D, Nico B, Maxia C, Longo V, Murtas D, Mangieri D, et al. Neovascularization and mast cells with tryptase activity increase simultaneously in human pterygium. J Cell Mol Med. 2007;11:585-9 pubmed
    ..These results suggest that the characteristic neovascularization observed in pterygium may be sustained, at least in part, by MC angiogenic mediators, in particular tryptase...
  27. Ribatti D, Ranieri G, Nico B, Benagiano V, Crivellato E. Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay. Int J Dev Biol. 2011;55:99-102 pubmed publisher
  28. Ribatti D, Nico B, Perra M, Maxia C, Piras F, Murtas D, et al. Correlation between NGF/TrkA and microvascular density in human pterygium. Int J Exp Pathol. 2009;90:615-20 pubmed publisher
    ..Understanding the mechanism of angiogenesis in pterygium provides a basis for a rational approach to the development of anti-angiogenic therapy in patients affected by this disease. ..
  29. Ribatti D. The paracrine role of Tie-2-expressing monocytes in tumor angiogenesis. Stem Cells Dev. 2009;18:703-6 pubmed publisher
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    Ribatti D, Vacca A, Cantatore F, Ria R, Benagiano V, Roncali L, et al. An experimental study in the chick embryo chorioallantoic membrane of the anti-angiogenic activity of cyclosporine in rheumatoid arthritis versus osteoarthritis. Inflamm Res. 2000;49:418-23 pubmed