Maria Grazia Revello

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi request reprint Lack of transmission to polymorphonuclear leukocytes and human umbilical vein endothelial cells as a marker of attenuation of human cytomegalovirus
    Giuseppe Gerna
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    J Med Virol 66:335-9. 2002
  2. ncbi request reprint Passive immunization against cytomegalovirus during pregnancy
    Maria Grazia Revello
    N Engl J Med 353:2818-20; author reply 2818-20. 2005
  3. ncbi request reprint Role of human cytomegalovirus (HCMV)-specific antibody in HCMV-infected pregnant women
    Maria Grazia Revello
    SC Ostetricia e Ginecologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy Electronic address
    Early Hum Dev 90:S32-4. 2014
  4. ncbi request reprint Diagnosis and outcome of preconceptional and periconceptional primary human cytomegalovirus infections
    Maria Grazia Revello
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    J Infect Dis 186:553-7. 2002
  5. doi request reprint Human cytomegalovirus (HCMV) DNAemia in the mother at amniocentesis as a risk factor for iatrogenic HCMV infection of the fetus
    Maria Grazia Revello
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Infect Dis 197:593-6. 2008
  6. ncbi request reprint Human cytomegalovirus immediate-early messenger RNA in blood of pregnant women with primary infection and of congenitally infected newborns
    M G Revello
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, 27100 Pavia, Italy
    J Infect Dis 184:1078-81. 2001
  7. doi request reprint Molecular epidemiology of primary human cytomegalovirus infection in pregnant women and their families
    Maria Grazia Revello
    Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    J Med Virol 80:1415-25. 2008
  8. ncbi request reprint Preconceptional primary human cytomegalovirus infection and risk of congenital infection
    Maria Grazia Revello
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    J Infect Dis 193:783-7. 2006
  9. ncbi request reprint Congenital rubella infection following rubella outbreak in northern Italy, 2002: need for an effective vaccination programme
    M G Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Eur J Clin Microbiol Infect Dis 23:780-3. 2004
  10. ncbi request reprint Lymphoproliferative response in primary human cytomegalovirus (HCMV) infection is delayed in HCMV transmitter mothers
    Maria Grazia Revello
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy
    J Infect Dis 193:269-76. 2006

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Lack of transmission to polymorphonuclear leukocytes and human umbilical vein endothelial cells as a marker of attenuation of human cytomegalovirus
    Giuseppe Gerna
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    J Med Virol 66:335-9. 2002
    ....
  2. ncbi request reprint Passive immunization against cytomegalovirus during pregnancy
    Maria Grazia Revello
    N Engl J Med 353:2818-20; author reply 2818-20. 2005
  3. ncbi request reprint Role of human cytomegalovirus (HCMV)-specific antibody in HCMV-infected pregnant women
    Maria Grazia Revello
    SC Ostetricia e Ginecologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy Electronic address
    Early Hum Dev 90:S32-4. 2014
    ..Ongoing phase III controlled trials as well as laboratory investigations will hopefully help in better defining the protective role of maternal antibodies. ..
  4. ncbi request reprint Diagnosis and outcome of preconceptional and periconceptional primary human cytomegalovirus infections
    Maria Grazia Revello
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    J Infect Dis 186:553-7. 2002
    ..Periconceptional primary HCMV infection seems to bear a higher risk of unfavorable outcome than preconceptional infection, and counseling should be adjusted accordingly...
  5. doi request reprint Human cytomegalovirus (HCMV) DNAemia in the mother at amniocentesis as a risk factor for iatrogenic HCMV infection of the fetus
    Maria Grazia Revello
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Infect Dis 197:593-6. 2008
    ..Therefore, maternal HCMV DNAemia is not a significant risk factor for iatrogenic HCMV transmission to the fetus during amniocentesis...
  6. ncbi request reprint Human cytomegalovirus immediate-early messenger RNA in blood of pregnant women with primary infection and of congenitally infected newborns
    M G Revello
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, 27100 Pavia, Italy
    J Infect Dis 184:1078-81. 2001
    ..IEmRNA was not detected in HCMV-immune individuals with remote or recurrent HCMV infection or in uninfected newborns. IEmRNA determination appears to be a valuable tool for early diagnosis of both primary and congenital HCMV infection...
  7. doi request reprint Molecular epidemiology of primary human cytomegalovirus infection in pregnant women and their families
    Maria Grazia Revello
    Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    J Med Virol 80:1415-25. 2008
    ..A child rather than the husband was the virus source for the great majority of pregnant women. No association was observed between UL144 polymorphisms and intrauterine transmission...
  8. ncbi request reprint Preconceptional primary human cytomegalovirus infection and risk of congenital infection
    Maria Grazia Revello
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    J Infect Dis 193:783-7. 2006
    ..Although a safe time interval between primary infection and initiation of pregnancy still needs to be defined, documented information can now be provided during counseling...
  9. ncbi request reprint Congenital rubella infection following rubella outbreak in northern Italy, 2002: need for an effective vaccination programme
    M G Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Eur J Clin Microbiol Infect Dis 23:780-3. 2004
    ..The remaining infant remained asymptomatic at 14 months. Congenital rubella remains a serious health problem in Italy and a successful vaccination strategy is required...
  10. ncbi request reprint Lymphoproliferative response in primary human cytomegalovirus (HCMV) infection is delayed in HCMV transmitter mothers
    Maria Grazia Revello
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy
    J Infect Dis 193:269-76. 2006
    ..The T cell-mediated immune response to human cytomegalovirus (HCMV) after primary infection, as well as the determinants of intrauterine transmission, are poorly understood...
  11. doi request reprint Human cytomegalovirus-specific CD4+ and CD8+ T cell responses in primary infection of the immunocompetent and the immunocompromised host
    Daniele Lilleri
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Clin Immunol 131:395-403. 2009
    ..Thus, the development of cell-mediated immune response in primary HCMV infection may be missed when looking at pp65 and IE-1 peptide-stimulated T-cells only...
  12. ncbi request reprint Development of human cytomegalovirus-specific T cell immunity during primary infection of pregnant women and its correlation with virus transmission to the fetus
    Daniele Lilleri
    Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy
    J Infect Dis 195:1062-70. 2007
    ..We sought to study the development of human cytomegalovirus (HCMV)-specific T cell-mediated immune responses during primary HCMV infection in pregnancy...
  13. doi request reprint Role of prenatal diagnosis and counseling in the management of 735 pregnancies complicated by primary human cytomegalovirus infection: a 20-year experience
    Maria Grazia Revello
    SC Ostetricia e Ginecologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Clin Virol 50:303-7. 2011
    ..The burden of congenital human cytomegalovirus (HCMV) infection is well recognized. However, screening for maternal infection remains controversial in view of diagnostic challenges, counseling difficulties, and absence of medical treatment...
  14. ncbi request reprint Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+ T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells
    Laura Lozza
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    Eur J Immunol 35:1795-804. 2005
    ..The novel ex vivo assay enables the simultaneous evaluation of HCMV-specific CD4(+) and CD8(+) T cell responses and may be a useful tool for monitoring HCMV-specific T cell activity in immunocompromised transplanted patients...
  15. doi request reprint Comparative evaluation of eight commercial human cytomegalovirus IgG avidity assays
    Maria Grazia Revello
    SC Ostetricia e Ginecologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Clin Virol 48:255-9. 2010
    ..Determination of HCMV-specific IgG avidity is considered an useful approach for distinguishing IgM antibody due to primary HCMV infection from IgM antibody elicited during non-primary infection...
  16. doi request reprint Slow increase in IgG avidity correlates with prevention of human cytomegalovirus transmission to the fetus
    Milena Furione
    SS Virologia Molecolare, SC Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Med Virol 85:1960-7. 2013
    ..Pregnant women with pattern H (rapid IgG avidity increase) appear to be at higher risk for fetal infection, whereas, pregnant women developing early antibody with high avidity appear to be at a lower risk of vertical transmission...
  17. pmc Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection
    Daniele Lilleri
    Laboratori Sperimentali di Ricerca, Area Trapiantologica, Fondazione Istituto Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    PLoS ONE 8:e59863. 2013
    ..Taken together, these findings indicate that the HCMV pentamer complex is a major target of the antibody-mediated maternal immunity...
  18. doi request reprint Human cytomegalovirus-specific memory CD8+ and CD4+ T cell differentiation after primary infection
    Daniele Lilleri
    Servizio di Virologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    J Infect Dis 198:536-43. 2008
    ..The development of human cytomegalovirus (HCMV)-specific T cell immunity after primary infection and its correlation with virus transmission to the fetus were investigated...
  19. ncbi request reprint Monitoring of human cytomegalovirus (HCMV)-specific CD4+ T cell frequency by cytokine flow cytometry as a possible indicator for discontinuation of HCMV secondary prophylaxis in HAART-treated AIDS patients
    Daniele Lilleri
    Servizio di Virologia, IRCCS Policlinico San Matteo, Via Taramelli 5, 27100 Pavia, Italy
    J Clin Virol 29:297-307. 2004
    ....
  20. pmc Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
    Maria Grazia Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Clin Microbiol Rev 15:680-715. 2002
    ....
  21. ncbi request reprint Pathogenesis and prenatal diagnosis of human cytomegalovirus infection
    Maria Grazia Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    J Clin Virol 29:71-83. 2004
    ..Finally, the identification of reliable prognostic markers of fetal disease remains the ultimate goal and a major challenge...
  22. ncbi request reprint Rising antigenemia levels may be misleading in pre-emptive therapy of human cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
    Giuseppe Gerna
    Servizio di Virologia, Oncoematologia Pediatrica, and Centro Trapianti di Midollo Osseo, Divisione di Ematologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Haematologica 90:526-33. 2005
    ..This raises some doubts about the therapeutic decisions to be taken...
  23. ncbi request reprint Human cytomegalovirus pp67 mRNAemia versus pp65 antigenemia for guiding preemptive therapy in heart and lung transplant recipients: a prospective, randomized, controlled, open-label trial
    Giuseppe Gerna
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Transplantation 75:1012-9. 2003
    ..However, standardized protocols are not available. In particular, whether a qualitative molecular assay for detection of a late (pp67) HCMV mRNA represents a valuable alternative to quantitative antigenemia remains to be defined...
  24. ncbi request reprint Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates
    F Baldanti
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    Arch Virol 151:1225-33. 2006
    ..The conservation of the UL131A-UL128 locus is consistent with the conclusion that the three encoded proteins are all essential for growth of HCMV in endothelial cells and virus transfer to leukocytes...
  25. ncbi request reprint Human cytomegalovirus in blood of immunocompetent persons during primary infection: prognostic implications for pregnancy
    M G Revello
    Institute of Infectious Diseases, University of Pavia, IRCCS Policlinico San Matteo, Italy
    J Infect Dis 177:1170-5. 1998
    ..Invasive procedures in the presence of maternal leukoDNAemia did not seem to interfere with vertical transmission of HCMV infection...
  26. pmc Clinical evaluation of a chemiluminescence immunoassay for determination of immunoglobulin g avidity to human cytomegalovirus
    Maria Grazia Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Clin Diagn Lab Immunol 11:801-5. 2004
    ..8% sensitivity and 84.7% specificity in detecting a recent (< or =90 days) primary HCMV infection. The assay appears useful for accurately diagnosing recent primary HCMV infections...
  27. pmc Human cytomegalovirus immediate-early mRNA detection by nucleic acid sequence-based amplification as a new parameter for preemptive therapy in bone marrow transplant recipients
    G Gerna
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Universita di Pavia, 27100 Pavia, Italy
    J Clin Microbiol 38:1845-53. 2000
    ..HCMV IE mRNA detection may represent a useful parameter for initiation of preemptive therapy in BMT recipients...
  28. ncbi request reprint Changing circulation rate of human metapneumovirus strains and types among hospitalized pediatric patients during three consecutive winter-spring seasons. Brief report
    G Gerna
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    Arch Virol 150:2365-75. 2005
    ..In conclusion, the 4 hMPV subtypes circulated yearly in Northern Italy flanking hRSV as major respiratory pathogens in the infantile patient population...
  29. ncbi request reprint Declining levels of rescued lymphoproliferative response to human cytomegalovirus (HCMV) in AIDS patients with or without HCMV disease following long-term HAART
    G Gerna
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    J Acquir Immune Defic Syndr 28:320-31. 2001
    ..All patients had previously undergone antiretroviral monotherapy or dual therapy before initiating HAART...
  30. ncbi request reprint Diagnostic and prognostic value of human cytomegalovirus load and IgM antibody in blood of congenitally infected newborns
    M G Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    J Clin Virol 14:57-66. 1999
    ..However, very little is known about the presence, levels and duration of HCMV pp65 antigenemia, viremia and DNAemia in congenitally infected newborns...
  31. pmc Quantification of human cytomegalovirus DNA in amniotic fluid of mothers of congenitally infected fetuses
    M G Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    J Clin Microbiol 37:3350-2. 1999
    ..Although the median DNA level was higher in symptomatic fetuses, the difference was not statistically significant (P = 0.09)...
  32. pmc Human cytomegalovirus replicates abortively in polymorphonuclear leukocytes after transfer from infected endothelial cells via transient microfusion events
    G Gerna
    Servizio di Virologia, Area Infettivologica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, 27100 Pavia, Italy
    J Virol 74:5629-38. 2000
    ....
  33. pmc Comparative analysis of human cytomegalovirus-specific CD4(+) T-cell frequency and lymphoproliferative response in human immunodeficiency virus-positive patients
    G Piccinini
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    Clin Diagn Lab Immunol 8:1225-30. 2001
    ..It could facilitate wider screening of anti-HCMV T-helper activity in HIV-infected patients, with potential benefits for clinicians in deciding strategies of discontinuation or maintenance of anti-HCMV therapy...
  34. ncbi request reprint Human cytomegalovirus pp65 lower matrix phosphoprotein harbours two transplantable nuclear localization signals
    A Gallina
    Instituto di Genetica Biochimica ed Evoluzionistica, Consiglio Nazionale delle Ricerche, Pavia, Italy
    J Gen Virol 77:1151-7. 1996
    ..These findings indicate that pp65 includes two NLSs, one of which has the potential to be modulated by phosphorylation...
  35. pmc Rising levels of human cytomegalovirus (HCMV) antigenemia during initial antiviral treatment of solid-organ transplant recipients with primary HCMV infection
    G Gerna
    Viral Diagnostic Service, IRCCS Policlinico San Matteo, Pavia, Italy
    J Clin Microbiol 36:1113-6. 1998
    ..043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients...
  36. doi request reprint Maternal, fetal and neonatal diagnosis of congenital human cytomegalovirus infection
    Maria Grazia Revello
    Servizio di Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy 39 0382502644 39 0382502599
    Expert Opin Med Diagn 2:547-63. 2008
    ..Conclusions: Without an HCMV vaccine, diagnosis of primary infection in the mother and of congenital infection in the fetus/newborn are key factors for management of congenital HCMV infection...
  37. pmc Standardization of the human cytomegalovirus antigenemia assay by means of in vitro-generated pp65-positive peripheral blood polymorphonuclear leukocytes
    G Gerna
    Servizio di Virologia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S Matteo, 27100 Pavia, Italy
    J Clin Microbiol 36:3585-9. 1998
    ..In conclusion, the newly developed procedure for in vitro generation of pp65-positive PMN will provide the basis for standardization of the HCMV antigenemia assay and development of quality control programs...
  38. ncbi request reprint Optimized detection of respiratory viruses in nasopharyngeal secretions
    M Zavattoni
    Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy
    New Microbiol 26:133-40. 2003
    ..The combination of DFA and SVC allows diagnosis of the large majority of viral respiratory infections within 48h, while conventional virus isolation on CC may be limited to laboratories involved in research and epidemiological studies...
  39. pmc Human cytomegalovirus UL131-128 genes are indispensable for virus growth in endothelial cells and virus transfer to leukocytes
    Gabriele Hahn
    Max von Pettenkofer Institut, Abteilung Virologie, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Virol 78:10023-33. 2004
    ..Our findings suggest that a common mechanism of virus transfer may be involved in both endothelial cell tropism and leukocyte transfer and shed light on a crucial step in the pathogenesis of HCMV infection...
  40. ncbi request reprint Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection
    Laura Gibson
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 172:2256-64. 2004
    ..The temporal association between the detection of HCMV-specific CD8(+) T cell responses and the reduction in blood HCMV load supports the importance of CD8(+) T cells in controlling primary HCMV viremia...
  41. ncbi request reprint Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infants
    Laura Gibson
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, and Department of Pediatrics, Baystate Children s Hospital, Springfield, USA
    J Infect Dis 195:1789-98. 2007
    ..These data provide additional evidence that young infants can generate diverse CMV-specific CD8+ T cell responses but show that early responses may exhibit relatively focused peptide specificity and lower peptide avidity...