Giovanni Ravaglia

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    Exp Gerontol 41:85-92. 2006
  2. ncbi Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Dement Geriatr Cogn Disord 21:51-8. 2006
  3. ncbi Homocysteine and folate as risk factors for dementia and Alzheimer disease
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 82:636-43. 2005
  4. ncbi Serum C-reactive protein and cognitive function in healthy elderly Italian community dwellers
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    J Gerontol A Biol Sci Med Sci 60:1017-21. 2005
  5. ncbi Incidence and etiology of dementia in a large elderly Italian population
    G Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    Neurology 64:1525-30. 2005
  6. ncbi Metabolic Syndrome: prevalence and prediction of mortality in elderly individuals
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
    Diabetes Care 29:2471-6. 2006
  7. ncbi Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 84:1473-80. 2006
  8. ncbi Folate, but not homocysteine, predicts the risk of fracture in elderly persons
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology University Hospital S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    J Gerontol A Biol Sci Med Sci 60:1458-62. 2005
  9. ncbi Risk factors for dementia: data from the Conselice study of brain aging
    G Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology University Hospital S Orsola Malpighi, Bologna, Italy
    Arch Gerontol Geriatr 44:311-20. 2007
  10. ncbi Endogenous sex hormones as risk factors for dementia in elderly men and women
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola, Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    J Gerontol A Biol Sci Med Sci 62:1035-41. 2007

Detail Information

Publications43

  1. ncbi Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    Exp Gerontol 41:85-92. 2006
    ..The relationship between the AD risk factor plasma tHcy and the IL-1beta-511 polymorphism was never reported before and might explain previous cross-sectional reports of an association between this polymorphism and AD...
  2. ncbi Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Dement Geriatr Cogn Disord 21:51-8. 2006
    ..Our results show that current diagnostic criteria for MCI define heterogeneous populations, but some potentially treatable vascular risk factors may be of help in predicting conversion to dementia...
  3. ncbi Homocysteine and folate as risk factors for dementia and Alzheimer disease
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 82:636-43. 2005
    ..In cross-sectional studies, elevated plasma total homocysteine (tHcy) concentrations have been associated with cognitive impairment and dementia. Incidence studies of this issue are few and have produced conflicting results...
  4. ncbi Serum C-reactive protein and cognitive function in healthy elderly Italian community dwellers
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    J Gerontol A Biol Sci Med Sci 60:1017-21. 2005
    ..Chronic low-grade inflammation, as measured with the peripheral serum marker C-reactive protein (sCRP), may be a risk factor for dementia in elderly persons...
  5. ncbi Incidence and etiology of dementia in a large elderly Italian population
    G Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    Neurology 64:1525-30. 2005
    ....
  6. ncbi Metabolic Syndrome: prevalence and prediction of mortality in elderly individuals
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
    Diabetes Care 29:2471-6. 2006
    ....
  7. ncbi Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 84:1473-80. 2006
    ..Homocysteine, another risk factor for vascular disease and dementia, also binds to VLDL in blood. However, the association between APOE4 and hyperhomocysteinemia has never been thoroughly investigated...
  8. ncbi Folate, but not homocysteine, predicts the risk of fracture in elderly persons
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology University Hospital S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    J Gerontol A Biol Sci Med Sci 60:1458-62. 2005
    ..These studies, however, did not take into account folate and vitamin B12, which are the major nutritional determinants of homocysteinemia...
  9. ncbi Risk factors for dementia: data from the Conselice study of brain aging
    G Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology University Hospital S Orsola Malpighi, Bologna, Italy
    Arch Gerontol Geriatr 44:311-20. 2007
    ..These data have been used to estimate prevalence and incidence of dementia in the elderly Italian population and to investigate the possible role of homocysteine as a predictor of dementia...
  10. ncbi Endogenous sex hormones as risk factors for dementia in elderly men and women
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola, Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    J Gerontol A Biol Sci Med Sci 62:1035-41. 2007
    ..The associations of endogenous sex hormones with risk of dementia in the elderly population are not well known...
  11. ncbi Screening for mild cognitive impairment in elderly ambulatory patients with cognitive complaints
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Aging Clin Exp Res 17:374-9. 2005
    ..Two brief global cognitive instruments, the Mini Mental State Examination (MMSE) and the Clock Drawing Test (CDT), were examined as useful screening methods for MCI...
  12. ncbi Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    J Am Geriatr Soc 56:51-8. 2008
    ..To investigate prevalence and incidence of mild cognitive impairment (MCI) and its risk of progression to dementia in an elderly Italian population...
  13. doi Development of an easy prognostic score for frailty outcomes in the aged
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Italy
    Age Ageing 37:161-6. 2008
    ..identification of frailty is recommended in geriatric practice. However, there is a lack of frailty scores combining easy-to-collect predictors from multiple domains...
  14. ncbi Associations of the -174 G/C interleukin-6 gene promoter polymorphism with serum interleukin 6 and mortality in the elderly
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138, Bologna, Italy
    Biogerontology 6:415-23. 2005
    ..31, 95%CI: 0.13-0.76]. In conclusion, although associated with increased sIL6 levels in presence of major diseases, the IL6-174 C-allele does not seem to have direct detrimental effects on survival in older age...
  15. ncbi Plasma tocopherols and risk of cognitive impairment in an elderly Italian cohort
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital Sant Orsola Malpighi, University of Bologna, Bologna, Italy
    Am J Clin Nutr 87:1306-13. 2008
    ..The most abundant and most investigated form of vitamin E in humans is alpha-tocopherol, but other antioxidant tocopherols (beta, gamma, and delta) exist in nature...
  16. ncbi Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9, 40138 Bologna, Italy
    Neurobiol Aging 28:1810-20. 2007
    ..91; 95%CI, 1.02-3.56) but not VaD risk. Blood inflammatory markers are associated with increased VaD risk but do not predict AD, which seems selectively associated with hyperhomocysteinemia...
  17. doi Metabolic syndrome and risk of dementia in older adults
    Paola Forti
    Department of Internal Medicine, Ageing, and Nephrology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    J Am Geriatr Soc 58:487-92. 2010
    ....
  18. ncbi Homocysteine and cognitive function in healthy elderly community dwellers in Italy
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 77:668-73. 2003
    ..Elevated plasma total homocysteine (tHcy) concentrations are common in the elderly and have been suggested to be a risk factor for dementia...
  19. ncbi Education, occupation, and prevalence of dementia: findings from the Conselice study
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Dement Geriatr Cogn Disord 14:90-100. 2002
    ..After adjustment for age and gender, education but not occupation was associated with both AD and VD. This association could not be explained by occupation, life habits, and previous history of hypertension or cardiovascular disease...
  20. ncbi Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status
    Erminia Mariani
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, IOR, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Biogerontology 7:449-59. 2006
    ....
  21. ncbi Different rates of telomere shortening and telomerase activity reduction in CD8 T and CD16 NK lymphocytes with ageing
    Erminia Mariani
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, I O R, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Exp Gerontol 38:653-9. 2003
    ..We can assume that preserved innate immune response in the elderly is due to the negligible telomere shortening and the maintained telomerase expression that could allow NK cells of octogenarians to delay replicative senescence...
  22. ncbi Plasma amino acid concentrations in patients with amnestic mild cognitive impairment or Alzheimer disease
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Am J Clin Nutr 80:483-8. 2004
    ....
  23. doi Metabolic syndrome and all-cause mortality in older men and women
    Paola Forti
    Department of Internal Medicine, Ageing and Nephrology, University of Bologna, Bologna, Italy
    Eur J Clin Invest 42:1000-9. 2012
    ..This study investigated the association of all-cause mortality with MetS and its individual components in older men and women...
  24. doi Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort
    Giovanni Ravaglia
    Department of Internal Medicine, Ageing, and Nephrology, University Hospital S Orsola Malpighi, University of Bologna, Italy
    Am J Geriatr Psychiatry 16:834-43. 2008
    ..To examine the association between depressive symptoms and prevalent and incident mild cognitive impairment (MCI) in elderly individuals; to verify whether it is affected by MCI subtype...
  25. doi Serum thyroid-stimulating hormone as a predictor of cognitive impairment in an elderly cohort
    Paola Forti
    Department of Internal Medicine, Ageing and Nephrology, University of Bologna, Bologna, Italy
    Gerontology 58:41-9. 2012
    ..It is unclear whether in late life serum thyroid-stimulating hormone (TSH) predicts risk of developing cognitive impairment...
  26. doi Blood inflammatory proteins and risk of incident depression in the elderly
    Paola Forti
    Department of Internal Medicine, Ageing, and Nephrology, University Hospital St Orsola Malpighi, Bologna, Italy
    Dement Geriatr Cogn Disord 29:11-20. 2010
    ..It is unclear whether high levels of blood inflammatory proteins are associated with the risk of developing depression in late life...
  27. ncbi Chemokine production by natural killer cells from nonagenarians
    Erminia Mariani
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, IOR, Bologna, Italy
    Eur J Immunol 32:1524-9. 2002
    ....
  28. doi A comparison of frailty indexes for prediction of adverse health outcomes in an elderly cohort
    Paola Forti
    Department of Internal Medicine, Ageing, and Nephrology, University Hospital S Orsola Malpighi, University of Bologna, Via Massarenti 9, I 40138 Bologna, Italy
    Arch Gerontol Geriatr 54:16-20. 2012
    ..In conclusion, in this elderly cohort, the multidimensional CSBA index is a better predictor of frailty-related adverse health outcomes than the unidimensional mSOF index...
  29. ncbi Soluble receptor activator of nuclear factor- kappaB Ligand (sRANKL)/osteoprotegerin balance in ageing and age-associated diseases
    Lia Pulsatelli
    Laboratorio Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biogerontology 5:119-27. 2004
    ..Hence, in ageing, the sRANKL/OPG system appears to be modified, with prominent changes in circulating OPG levels; in OA and PMR, the sRANKL/OPG balance alteration was shown to be mainly due to the increase of plasma sRANKL concentration...
  30. doi Diagnostic performance of an Executive Clock Drawing Task (CLOX) as a screening test for mild cognitive impairment in elderly persons with cognitive complaints
    Paola Forti
    Department of Internal Medicine, Ageing, and Nephrology, University Hospital St Orsola Malpighi, University of Bologna, Bologna, Italy
    Dement Geriatr Cogn Disord 30:20-7. 2010
    ..CLOX, a clock drawing test protocol uniquely sensitive to impairment of executive functions, has been proposed as a screening tool for mild cognitive impairment (MCI), but data about its diagnostic efficiency are lacking...
  31. ncbi Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross-sectional Italian study of a general elderly population
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9, Bologna, Italy
    Exp Gerontol 37:701-12. 2002
    ..These data suggest that in elderly people low serum DHEAS levels are more a non-specific indicator of aging and health status than a risk indicator of specific diseases...
  32. doi Blood homocysteine and risk of depression in the elderly
    Paola Forti
    Department of Internal Medicine, Ageing, and Nephrology, University Hospital S Orsola Malpighi, Bologna, Italy
    Arch Gerontol Geriatr 51:21-5. 2010
    ..In conclusion, the data only moderately support the hypothesis that blood homocysteine is a predictor of depression...
  33. ncbi Plasma amino acid concentrations in healthy and cognitively impaired oldest-old individuals: associations with anthropometric parameters of body composition and functional disability
    Giovanni Ravaglia
    Department of Internal Medicine, University Hospital S Orsola Malpighi, Bologna, Italy
    Br J Nutr 88:563-72. 2002
    ....
  34. ncbi Telomere length and telomerase activity: effect of ageing on human NK cells
    Erminia Mariani
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, I O R, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Mech Ageing Dev 124:403-8. 2003
    ....
  35. ncbi Mismatch repair system and aging: microsatellite instability in peripheral blood cells from differently aged participants
    Simona Neri
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, IOR, Bologna, Italy
    J Gerontol A Biol Sci Med Sci 60:285-92. 2005
    ....
  36. ncbi Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patients
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9, Bologna 40138, Italy
    Exp Gerontol 38:589-95. 2003
    ..In conclusion, prevalence of CD is increased in AT but the association is limited to patients aged 65 years or older. Serological screening including anti-tTG-IgA is recommended in these patients...
  37. doi Serum dehydroepiandrosterone sulfate and adverse health outcomes in older men and women
    Paola Forti
    Department of Internal Medicine, Aging, and Nephrology, University of Bologna, Bologna, Italy
    Rejuvenation Res 15:349-58. 2012
    ..005) or preexisting major diseases (HR=0.57, 95% CI 0.33-0.98, p=0.041). These findings suggest that DHEAS is associated with incident frailty in older men and with fatal and nonfatal frailty-related adverse outcomes in older women...
  38. ncbi Effects of weight loss and risk factor treatment in subjects with elevated serum C3, an inflammatory predictor of myocardial infarction
    Antonio Muscari
    Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, M Malpighi Hospital Via Albertoni, Italy
    Int J Cardiol 100:217-23. 2005
    ..Serum C3 is an inflammatory predictor of myocardial infarction and a covariate of fasting insulin and several endogenous risk factors. This study was performed to ascertain whether risk factor control may reduce elevated C3 concentrations...
  39. ncbi Different classification systems yield different dementia occurrence among nonagenarians and centenarians
    Philippe Pioggiosi
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Dement Geriatr Cogn Disord 17:35-41. 2004
    ..In this light, classification systems, such as the ICD-10, that do not include impairment of social function as a criterion for assessing dementia become less adequate...
  40. doi Multivariable network associated with cognitive decline and dementia
    Federico Licastro
    Department of Experimental Pathology, 40126 Bologna, Italy
    Neurobiol Aging 31:257-69. 2010
    ..This data analysis method was compared with another mathematical model called mutual information relevance network and results are presented and discussed...
  41. pmc Multi factorial interactions in the pathogenesis pathway of Alzheimer's disease: a new risk charts for prevention of dementia
    Federico Licastro
    Department of Experimental Pathology, Via San Giacomo 14, 40126, Bologna, Italy
    Immun Ageing 7:S4. 2010
    ..CONCLUSION : This map of variables may be use to identify subjects with increased risk of developing cognitive decline end/or dementia and provide pivotal information for early intervention protocols for prevention of dementia...
  42. ncbi RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects
    Erminia Mariani
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, IOR Bologna, Dipartimento di Medicina Interna e Gastroenterologia, University of Bologna, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Exp Gerontol 37:219-26. 2002
    ..The diversity within PBMC might reflect their different states of activation and/or responsiveness, influencing the ability to develop rapid innate and long-lasting adaptive immune responses...
  43. pmc The conselice study of brain ageing
    Giovanni Ravaglia
    Department of Internal Medicine, Ageing, and Nephrology, University of Bologna, University Hospital S, Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Immun Ageing 7:S2. 2010
    ..These data have been used to estimate prevalence and incidence of dementia in the elderly Italian population and to investigate the possible role of baseline blood homocysteine as risk factors for dementia...