Antonia Ratti

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint C9ORF72 repeat expansion in a large Italian ALS cohort: evidence of a founder effect
    Antonia Ratti
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 33:2528.e7-14. 2012
  2. pmc The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability
    Silvia Moncini
    Department of Biology and Genetics, Medical Faculty, University of Milan, via Viotti 3 5, 20133 Milan, Italy
    BMC Mol Biol 8:111. 2007
  3. ncbi request reprint A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA
    Antonia Ratti
    Department of Neuroscience, Dino Ferrari Centre, University of Milan IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Italy
    J Cell Sci 119:1442-52. 2006
  4. doi request reprint Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV
    Antonia Ratti
    Department of Neurological Sciences, Dino Ferrari Centre, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, 20095 Cusano, Milan, Italy
    J Biol Chem 283:7531-41. 2008
  5. doi request reprint Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis
    Daniela Calini
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Milan, Italy
    Neurobiol Aging 34:2695.e11-2. 2013
  6. doi request reprint Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis
    Cinzia Tiloca
    Department of Neurology and Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 33:630.e1-2. 2012
  7. doi request reprint Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia
    Cinzia Gellera
    Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
    J Neurol Neurosurg Psychiatry 84:183-7. 2013
  8. pmc TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells
    Claudia Colombrita
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy
    J Biol Chem 287:15635-47. 2012
  9. doi request reprint TDP-43 is recruited to stress granules in conditions of oxidative insult
    Claudia Colombrita
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, Milan, Italy
    J Neurochem 111:1051-61. 2009
  10. doi request reprint C9orf72 repeat expansions are restricted to the ALS-FTD spectrum
    Nicola Ticozzi
    Department of Neurology and Laboratory of Neuroscience, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy Department of Pathophysiology and Transplantation, Dino Ferrari Center, Universita degli Studi di Milano, Milan, Italy Electronic address
    Neurobiol Aging 35:936.e13-7. 2014

Collaborators

Detail Information

Publications18

  1. doi request reprint C9ORF72 repeat expansion in a large Italian ALS cohort: evidence of a founder effect
    Antonia Ratti
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 33:2528.e7-14. 2012
    ....
  2. pmc The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability
    Silvia Moncini
    Department of Biology and Genetics, Medical Faculty, University of Milan, via Viotti 3 5, 20133 Milan, Italy
    BMC Mol Biol 8:111. 2007
    ..The remarkable size of CDK5R1 3'-untranslated region (3'-UTR) suggests a role in post-transcriptional regulation of CDK5R1 expression...
  3. ncbi request reprint A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA
    Antonia Ratti
    Department of Neuroscience, Dino Ferrari Centre, University of Milan IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Italy
    J Cell Sci 119:1442-52. 2006
    ..We propose that ELAV RNA-binding proteins exert an important post-transcriptional control on Musashi-1 expression in the transition from proliferation to neural differentiation of stem/progenitor cells...
  4. doi request reprint Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV
    Antonia Ratti
    Department of Neurological Sciences, Dino Ferrari Centre, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, 20095 Cusano, Milan, Italy
    J Biol Chem 283:7531-41. 2008
    ....
  5. doi request reprint Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis
    Daniela Calini
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Milan, Italy
    Neurobiol Aging 34:2695.e11-2. 2013
    ..We failed to find variants in each cohort. Our results suggest that mutations in hnRNPA1, A2/B1, and A3 genes are a rare finding in ALS. ..
  6. doi request reprint Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis
    Cinzia Tiloca
    Department of Neurology and Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 33:630.e1-2. 2012
    ..Bioinformatical analyses predicted no changes in splicing process or microRNA binding sites. Our results do not confirm a main contribution of VCP gene to familial ALS in the Italian population...
  7. doi request reprint Ubiquilin 2 mutations in Italian patients with amyotrophic lateral sclerosis and frontotemporal dementia
    Cinzia Gellera
    Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
    J Neurol Neurosurg Psychiatry 84:183-7. 2013
    ..The aim of our study was to analyse the UBQLN2 gene in a large cohort of patients with familial (FALS) and sporadic (SALS) amyotrophic lateral sclerosis, with or without frontotemporal dementia (FTD), and in patients with FTD...
  8. pmc TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells
    Claudia Colombrita
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy
    J Biol Chem 287:15635-47. 2012
    ....
  9. doi request reprint TDP-43 is recruited to stress granules in conditions of oxidative insult
    Claudia Colombrita
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, Milan, Italy
    J Neurochem 111:1051-61. 2009
    ..Although SGs were not evident in ALS brains, we speculate that an altered control of mRNA translation in stressful conditions may trigger motor neuron degeneration at early stages of the disease...
  10. doi request reprint C9orf72 repeat expansions are restricted to the ALS-FTD spectrum
    Nicola Ticozzi
    Department of Neurology and Laboratory of Neuroscience, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Auxologico Italiano, Milan, Italy Department of Pathophysiology and Transplantation, Dino Ferrari Center, Universita degli Studi di Milano, Milan, Italy Electronic address
    Neurobiol Aging 35:936.e13-7. 2014
    ....
  11. doi request reprint Oligoclonal bands in the cerebrospinal fluid of amyotrophic lateral sclerosis patients with disease-associated mutations
    Nicola Ticozzi
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Piazzale Brescia 20, 20149, Milan, Italy
    J Neurol 260:85-92. 2013
    ..The role of mutant TARDBP and ANG genes on BBB integrity of ALS patients warrants further investigation...
  12. ncbi request reprint Stem cell therapy for neurodegenerative diseases: the issue of transdifferentiation
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Stem Cells Dev 13:121-31. 2004
    ..This review summarizes recent advances gained in stem cell research applied to neurodegenerative diseases with a special emphasis to the criticisms put forward...
  13. pmc Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and in frontotemporal dementia
    Cinzia Tiloca
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 34:1517.e9-10. 2013
    ..G15G in another patient, but none in a panel of 1512 control subjects. Our results suggest that PFN1 mutations in sporadic ALS and in FTD are rare, at least in the Italian population...
  14. ncbi request reprint Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
    Cinzia Gellera
    Division of Biochemistry and Genetics, Fondazione IRCCS Instituto Neurologico Carlo Besta, Milan, Italy
    Neurogenetics 9:33-40. 2008
    ..Our results provide further evidence of a tight link between angiogenesis and ALS pathogenesis and suggest that mutations in ANG gene are associated with an increased risk to develop ALS...
  15. ncbi request reprint Stem cells in the treatment of amyotrophic lateral sclerosis (ALS)
    Vincenzo Silani
    Department of Neurology, Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Via Spagnoletto 3, 1 20149 Milano, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:173-81. 2002
    ..Stem cell technology is at an early stage but the desperate need for a therapy in ALS patients may legitimize clinical trials in absence of conclusive scientific evidence. This paper discusses the premises for stem cell therapy in ALS...
  16. ncbi request reprint ELAV proteins along evolution: back to the nucleus?
    Claudia Colombrita
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Via Zucchi, 18, 20095 Cusano Milanino Milan, Italy Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Dino Ferrari Center, Universita degli Studi di Milano, Via Sforza, 35, 20122 Milan, Italy
    Mol Cell Neurosci 56:447-55. 2013
    ..This article is part of a Special Issue entitled 'RNA and splicing regulation in neurodegeneration'. ..
  17. doi request reprint Dysregulation of axonal transport and motorneuron diseases
    Daniela Sau
    Dipartimento di Endocrinologia, Fisiopatologia e Biologia Applicata, and Centre of Excellence on Neurodegenerative Diseases, Universita degli Studi di Milano, Milan, Italy
    Biol Cell 103:87-107. 2011
    ..In the present review, we will summarize what is currently known about the alterations of axonal transport found to be either causative or a consequence of MNDs...
  18. ncbi request reprint hnRNPA2/B1 and nELAV proteins bind to a specific U-rich element in CDK5R1 3'-UTR and oppositely regulate its expression
    Paola Zuccotti
    Dipartimento di Biotecnologie mediche e Medicina traslazionale, Universita degli Studi di Milano, Milan, Italy
    Biochim Biophys Acta 1839:506-16. 2014
    ..This study, by providing new insights on the combined action of different regulatory factors, contributes to clarify the complex post-transcriptional control of CDK5R1 gene expression...