Giorgio Racagni

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Reduced activation of intracellular signaling pathways in rat prefrontal cortex after chronic phencyclidine administration
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Res 57:296-302. 2008
  2. pmc Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes
    Marco Milanese
    Department of Pharmacy, Unit of Pharmacology and Toxicology and Center of Excellence for Biomedical Research, Universita degli Studi di Genova, Genova, Italy
    BMC Neurosci 14:75. 2013
  3. doi request reprint Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors
    Giorgio Racagni
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    World J Biol Psychiatry 12:574-87. 2011
  4. pmc Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways
    Daniela Tardito
    Center of Neuropharmacology Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    BMC Neurosci 11:68. 2010
  5. ncbi request reprint Consensus on the use of substituted benzamides in psychiatric patients
    Giorgio Racagni
    Center of Neuropharmacology, University of Milan, Milan, Italy
    Neuropsychobiology 50:134-43. 2004
  6. doi request reprint Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression
    Laura Musazzi
    Center of Neuropharmacology, Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    J Psychiatr Res 44:511-20. 2010
  7. doi request reprint Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms
    Francesca Calabrese
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Mol Pharmacol 77:846-53. 2010
  8. doi request reprint Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan 20133, Italy
    Neuropsychopharmacology 34:1523-32. 2009
  9. doi request reprint Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Eur Neuropsychopharmacol 19:898-904. 2009
  10. doi request reprint Prenatal stress alters glutamatergic system responsiveness in adult rat prefrontal cortex
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 109:1733-44. 2009

Detail Information

Publications86

  1. doi request reprint Reduced activation of intracellular signaling pathways in rat prefrontal cortex after chronic phencyclidine administration
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Res 57:296-302. 2008
    ....
  2. pmc Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes
    Marco Milanese
    Department of Pharmacy, Unit of Pharmacology and Toxicology and Center of Excellence for Biomedical Research, Universita degli Studi di Genova, Genova, Italy
    BMC Neurosci 14:75. 2013
    ..Agomelatine, a new antidepressant endowed with MT1/MT2 agonist and 5-HT2C serotonergic antagonist properties, has shown efficacy at both preclinical and clinical levels...
  3. doi request reprint Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors
    Giorgio Racagni
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    World J Biol Psychiatry 12:574-87. 2011
    ..Animal studies showed that agomelatine resynchronizes disturbed circadian rhythms and reduces depression-like behaviour...
  4. pmc Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways
    Daniela Tardito
    Center of Neuropharmacology Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    BMC Neurosci 11:68. 2010
    ....
  5. ncbi request reprint Consensus on the use of substituted benzamides in psychiatric patients
    Giorgio Racagni
    Center of Neuropharmacology, University of Milan, Milan, Italy
    Neuropsychobiology 50:134-43. 2004
    ..Based on experimental data, amisulpride is a treatment of choice for dopaminergic transmission disorders, both in depression and in schizophrenia...
  6. doi request reprint Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression
    Laura Musazzi
    Center of Neuropharmacology, Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    J Psychiatr Res 44:511-20. 2010
    ..These results show that early gene-environment interaction may cause life-long synaptic changes affecting the course of depressive-like behavior and response to drugs...
  7. doi request reprint Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms
    Francesca Calabrese
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Mol Pharmacol 77:846-53. 2010
    ....
  8. doi request reprint Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan 20133, Italy
    Neuropsychopharmacology 34:1523-32. 2009
    ....
  9. doi request reprint Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Eur Neuropsychopharmacol 19:898-904. 2009
    ..These alterations may be associated to behavioral traits linked to SERT and may contribute to the neuroplastic and morphological changes observed in depression...
  10. doi request reprint Prenatal stress alters glutamatergic system responsiveness in adult rat prefrontal cortex
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 109:1733-44. 2009
    ..The inability to mount an homeostatic glutamatergic response to subsequent stress at adulthood may impair the normal responses of the cell to challenging situations...
  11. ncbi request reprint AMPA GluR-A receptor subunit mediates hippocampal responsiveness in mice exposed to stress
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Hippocampus 21:1028-35. 2011
    ....
  12. ncbi request reprint Chronic duloxetine treatment induces specific changes in the expression of BDNF transcripts and in the subcellular localization of the neurotrophin protein
    Francesca Calabrese
    Department of Pharmacological Sciences, Center of Neuropharmacology, University of Milan, Milan, Italy
    Neuropsychopharmacology 32:2351-9. 2007
    ..These changes might improve synaptic plasticity and cognitive function that are defective in depressed subjects...
  13. doi request reprint Basal and stress-induced modulation of activity-regulated cytoskeletal associated protein (Arc) in the rat brain following duloxetine treatment
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Psychopharmacology (Berl) 201:285-92. 2008
    ....
  14. ncbi request reprint Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases CEND, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neurobiol Dis 20:731-7. 2005
    ..The abnormal modulation of FGF-2 gene expression in specific brain regions in response to subsequent stress in adulthood may impair the normal adaptive responses of the cell to challenging situations...
  15. pmc Stress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatment
    Francesca Calabrese
    Center of Neuropharmacology, Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 7:e37916. 2012
    ..Our results provide support to the notion that antidepressants may exert their activity in the long-term also via modulation of the glutamatergic synapse...
  16. ncbi request reprint Fluoxetine and olanzapine have synergistic effects in the modulation of fibroblast growth factor 2 expression within the rat brain
    Maria Elisabetta Maragnoli
    Center of Neuropharmacology and Center of Excellence for Neurodegenerative Disorders, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Biol Psychiatry 55:1095-102. 2004
    ..We hypothesize that such combination may determine a specific modulation of neuroplastic genes, which could contribute to therapeutic activity...
  17. pmc Early raise of BDNF in hippocampus suggests induction of posttranscriptional mechanisms by antidepressants
    Laura Musazzi
    Center of Neuropharmacology Department of Pharmacological Sciences, University of Milan, Milan, Italy
    BMC Neurosci 10:48. 2009
    ..Total BDNF mRNA was measured by Real Time PCR, pro- and mature BDNF proteins were measured by Western blot...
  18. doi request reprint Repeated stress prevents cocaine-induced activation of BDNF signaling in rat prefrontal cortex
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur Neuropsychopharmacol 19:402-8. 2009
    ....
  19. doi request reprint Antipsychotic drug actions on gene modulation and signaling mechanisms
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Pharmacol Ther 124:74-85. 2009
    ....
  20. ncbi request reprint Long-term soluble Abeta1-40 activates CaM kinase II in organotypic hippocampal cultures
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy
    Neurobiol Aging 28:1388-95. 2007
    ..The marked effect of Abeta(1-40) on the kinase suggests that semi-physiological and slowly raising peptide concentrations may have a significant impact on synaptic plasticity in the absence of synaptic loss or neuronal cell death...
  21. doi request reprint Stress and cocaine interact to modulate Arc/Arg3.1 expression in rat brain
    Lucia Caffino
    Department of Pharmacological Sciences, Center of Neuropharmacology, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Psychopharmacology (Berl) 218:241-8. 2011
    ..Arc/Arg3.1 is an effector immediate early gene that may represent a bridge connecting short- and long-term neuronal modifications associated with exposure to stress and drugs of abuse...
  22. ncbi request reprint Reduced CREB phosphorylation after chronic lithium treatment is associated with down-regulation of CaM kinase IV in rat hippocampus
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milano, Italy
    Int J Neuropsychopharmacol 10:491-6. 2007
    ..These data suggest for the first time the involvement of CaMKIV in the mechanism of action of lithium...
  23. doi request reprint Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Neurobiol Dis 37:747-55. 2010
    ....
  24. ncbi request reprint Chronic antidepressants induce redistribution and differential activation of alphaCaM kinase II between presynaptic compartments
    Valentina S Barbiero
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, Center of Neuropharmacology, University of Milano, Milano, Italy
    Neuropsychopharmacology 32:2511-9. 2007
    ..Overall, antidepressants induce a complex pattern of modifications in distinct subcellular compartments; at presynaptic level, these changes are in line with a dampening of glutamate release...
  25. doi request reprint Modulation of neuroplastic molecules in selected brain regions after chronic administration of the novel antidepressant agomelatine
    Francesca Calabrese
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Psychopharmacology (Berl) 215:267-75. 2011
    ..It is therefore important to establish if and how antidepressant drugs may be able to regulate these mechanisms in order to achieve relevant clinical effects...
  26. doi request reprint Behavioural and neuroplastic properties of chronic lurasidone treatment in serotonin transporter knockout rats
    Alessia Luoni
    Center of Neuropharmacology, Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    Int J Neuropsychopharmacol 16:1319-30. 2013
    ....
  27. doi request reprint Lack of serotonin transporter alters BDNF expression in the rat brain during early postnatal development
    Francesca Calabrese
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy
    Mol Neurobiol 48:244-56. 2013
    ....
  28. doi request reprint The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, Milan, Italy
    Pharmacol Res 65:176-81. 2012
    ..Given that these mechanisms are critical for neuronal plasticity, we hypothesized that such changes may facilitate learning/coping mechanisms associated with a mild stressful experience...
  29. ncbi request reprint Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Rev 58:115-34. 2006
    ....
  30. ncbi request reprint Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades
    Ettore Tiraboschi
    Department of Pharmacological Sciences, Center of Neuropharmacology, University of Milano and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy
    Neuropsychopharmacology 29:1831-40. 2004
    ..Our results show that FLX exerts a more marked effect on CREB phosphorylation and suggest that CaMKIV and MAP kinase cascades are involved in this effect...
  31. pmc Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells
    Lorena Donnici
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    BMC Neurosci 9:61. 2008
    ..However, no data are available for the human BDNF gene. We studied the effect of different antidepressants on BDNF mRNA expression in human neuroblastoma SH-SY5Y cells...
  32. doi request reprint Neuronal plasticity: a link between stress and mood disorders
    Francesca Calabrese
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Psychoneuroendocrinology 34:S208-16. 2009
    ..Accordingly, effective treatments should not limit their effects to the control of neurotransmitter and hormonal dysfunctions, but should be able to normalize defective mechanisms that sustain the impairment of neuronal plasticity...
  33. ncbi request reprint Repeated exposure to cocaine differently modulates BDNF mRNA and protein levels in rat striatum and prefrontal cortex
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur J Neurosci 26:2756-63. 2007
    ....
  34. ncbi request reprint Stress and cocaine interact to modulate basic fibroblast growth factor (FGF-2) expression in rat brain
    Fabio Fumagalli
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Psychopharmacology (Berl) 196:357-64. 2008
    ..Brain Res Rev 37:249-258, 2001; Fumagalli et al., Neurobiol Dis 20:731-737, 2005) and cocaine (Fumagalli et al., J Neurochem 96:996-1004, 2006)...
  35. doi request reprint Abnormalities in α/β-CaMKII and related mechanisms suggest synaptic dysfunction in hippocampus of LPA1 receptor knockout mice
    Laura Musazzi
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Int J Neuropsychopharmacol 14:941-53. 2011
    ..This study shows that CaMKII and related synaptic mechanisms at glutamatergic synapses are strongly dysregulated in LPA1 KO mice...
  36. doi request reprint Synaptoproteomics of learned helpless rats involve energy metabolism and cellular remodeling pathways in depressive-like behavior and antidepressant response
    Alessandra Mallei
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Neuropharmacology 60:1243-53. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  37. doi request reprint Dynamic regulation of glutamatergic postsynaptic activity in rat prefrontal cortex by repeated administration of antipsychotic drugs
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 73:1484-90. 2008
    ..The global attenuation of glutamatergic function in prefrontal cortex might explain, at least in part, the cognitive deterioration observed in patients treated with haloperidol...
  38. ncbi request reprint Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases CEND, University of Milan, Milan, Italy
    Int J Neuropsychopharmacol 9:307-17. 2006
    ....
  39. ncbi request reprint Changes in signaling pathways regulating neuroplasticity induced by neurokinin 1 receptor knockout
    Laura Musazzi
    Center of Neuropharmacology Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9 20133 Milano, Italy
    Eur J Neurosci 21:1370-8. 2005
    ..These results show similarities between NK-1 knockouts and animals chronically treated with antidepressants and support the putative antidepressant activity of NK-1 receptor antagonists...
  40. doi request reprint Antipsychotic drugs modulate Arc expression in the rat brain
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur Neuropsychopharmacol 19:109-15. 2009
    ....
  41. doi request reprint Synergistic mechanisms in the modulation of the neurotrophin BDNF in the rat prefrontal cortex following acute agomelatine administration
    Raffaella Molteni
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    World J Biol Psychiatry 11:148-53. 2010
    ....
  42. ncbi request reprint Dynamic regulation of fibroblast growth factor 2 (FGF-2) gene expression in the rat brain following single and repeated cocaine administration
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 96:996-1004. 2006
    ....
  43. ncbi request reprint Long-term exposure to the atypical antipsychotic olanzapine differently up-regulates extracellular signal-regulated kinases 1 and 2 phosphorylation in subcellular compartments of rat prefrontal cortex
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 69:1366-72. 2006
    ....
  44. doi request reprint Reduced neuroplasticity in aged rats: a role for the neurotrophin brain-derived neurotrophic factor
    Francesca Calabrese
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    Neurobiol Aging 34:2768-76. 2013
    ..These modifications might contribute to the cognitive deficits associated with aging and suggest that pharmacological strategies aimed at restoring reduced neurotrophism might be useful to counteract age-related cognitive decline. ..
  45. doi request reprint Dynamic modulation of basic Fibroblast Growth Factor (FGF-2) expression in the rat brain following repeated exposure to cocaine during adolescence
    Giuseppe Giannotti
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Via Balzaretti 9, Milan, Italy
    Psychopharmacology (Berl) 225:553-60. 2013
    ....
  46. doi request reprint Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Int J Neuropsychopharmacol 15:235-46. 2012
    ..This effect may contribute to the amelioration of functions, such as cognition, closely associated with neuronal plasticity, which are deteriorated in schizophrenia patients...
  47. ncbi request reprint Corticostriatal brain-derived neurotrophic factor dysregulation in adult rats following prenatal stress
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Italy
    Eur J Neurosci 20:1348-54. 2004
    ..The dysregulation of corticostriatal BDNF expression might thus contribute to permanent alterations in brain functions leading to heightened susceptibility to psychiatric disorders...
  48. ncbi request reprint Effect of antipsychotic drugs on brain-derived neurotrophic factor expression under reduced N-methyl-D-aspartate receptor activity
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurosci Res 72:622-8. 2003
    ....
  49. ncbi request reprint Early induction of CREB activation and CREB-regulating signalling by antidepressants
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Italy
    Int J Neuropsychopharmacol 12:1367-81. 2009
    ..The results also showed that, contrary to the activatory role of MAP-ERKs and CaM kinase IV, nuclear alphaCaM kinase II was inactivated in parallel with activation of CREB...
  50. ncbi request reprint Cognitive effects of second-generation antipsychotics: current insights into neurochemical mechanisms
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    CNS Drugs 23:603-14. 2009
    ....
  51. doi request reprint Olanzapine, but not haloperidol, enhances PSA-NCAM immunoreactivity in rat prefrontal cortex
    Angelisa Frasca
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Int J Neuropsychopharmacol 11:591-5. 2008
    ..Our findings reveal a possible role for PSA-NCAM in the mechanism of action of the SGA olanzapine adding complexity as well as specificity to the molecular changes set in motion by this drug...
  52. pmc Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants
    Laura Musazzi
    Department of Pharmacological Sciences, Center of Neuropharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy
    PLoS ONE 5:e8566. 2010
    ..Aim of this work was to investigate the mechanism whereby acute stress increases glutamate release, and if therapeutic drugs prevent the effect of stress on glutamate release...
  53. pmc Altered inflammatory responsiveness in serotonin transporter mutant rats
    Flavia Macchi
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy
    J Neuroinflammation 10:116. 2013
    ....
  54. pmc Cellular and molecular mechanisms in the long-term action of antidepressants
    Giorgio Racagni
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Dialogues Clin Neurosci 10:385-400. 2008
    ..In the final section, we also briefly review the main current novel strategies in the pharmacology of depression and the new putative targets for antidepressants, with particular emphasis on nonmonoaminergic mechanisms...
  55. ncbi request reprint Emerging role of the FGF system in psychiatric disorders
    Marco A Riva
    Center of Neuropharmacology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Trends Pharmacol Sci 26:228-31. 2005
    ..This provides further support to the notion that neurotrophic molecules might have a role in the etiology and treatment of mental disorders...
  56. ncbi request reprint Expression and phosphorylation of delta-CaM kinase II in cultured Alzheimer fibroblasts
    Chiara Cavazzin
    Center of Neuropharmacology, Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Neurobiol Aging 25:1187-96. 2004
    ..The observed abnormalities, if present in brain tissue, may be implicated either in dysfunction of neuroplasticity and cognitive functions or in dysregulation of cell cycle...
  57. ncbi request reprint Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions
    Mila Roceri
    Department of Pharmacological Sciences and Center of Excellence for Neurodegenerative Disorders, University of Milan, Milan, Italy
    Biol Psychiatry 55:708-14. 2004
    ..Identification of persistent changes associated with these events is crucial for the development of novel therapeutic strategies...
  58. ncbi request reprint Corticostriatal up-regulation of activity-regulated cytoskeletal-associated protein expression after repeated exposure to cocaine
    Fabio Fumagalli
    Department of Pharmacological Sciences, Center of Neuropharmacology, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 70:1726-34. 2006
    ..Our findings thus pinpoint this molecule as a neuropathological underpinning and molecular bridge that connects short- and long-term neuronal modifications associated with cocaine abuse...
  59. doi request reprint Single session of cocaine intravenous self-administration shapes goal-oriented behaviours and up-regulates Arc mRNA levels in rat medial prefrontal cortex
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Int J Neuropsychopharmacol 12:423-9. 2009
    ....
  60. pmc Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress: modulation by antidepressant treatment
    Gianluigi Guidotti
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Centro di Neurofarmacologia, Universita degli Studi di Milano, Milan, Italy
    Neuropsychopharmacology 38:616-27. 2013
    ....
  61. ncbi request reprint Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus
    Fabio Fumagalli
    Center of Neuropharmacology, Center of Excellence for Neurodegenerative Diseases, Department of Pharmacological Sciences University of Milan, Milan, Italy
    J Neurosci Res 74:74-80. 2003
    ..Our data highlight the complex modulation of FGF-2 expression in limbic areas pointing to this trophic molecule as a putative target of drugs used against acute and chronic neurodegenerative diseases such as Parkinson's disease...
  62. ncbi request reprint The interaction between the internal clock and antidepressant efficacy
    Giorgio Racagni
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Int Clin Psychopharmacol 22:S9-S14. 2007
    ....
  63. doi request reprint GABA synthesis in Schwann cells is induced by the neuroactive steroid allopregnanolone
    Valerio Magnaghi
    Department of Endocrinology, Physiopathology and Applied Biology, Universita degli Studi di Milano, Milan, Italy
    J Neurochem 112:980-90. 2010
    ....
  64. doi request reprint Repeated electroconvulsive shock (ECS) alters the phosphorylation of glutamate receptor subunits in the rat hippocampus
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Int J Neuropsychopharmacol 13:1255-60. 2010
    ..These effects functionally resemble the recently described antidepressant effects of ketamine...
  65. doi request reprint Sub-chronic exposure to atomoxetine up-regulates BDNF expression and signalling in the brain of adolescent spontaneously hypertensive rats: comparison with methylphenidate
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Res 62:523-9. 2010
    ....
  66. doi request reprint Neurotrophic factors in neurodegenerative disorders : potential for therapy
    Fabio Fumagalli
    Department of Pharmacological Sciences, Center of Neuropharmacology, University of Milan, Milan, Italy
    CNS Drugs 22:1005-19. 2008
    ..Although promising results have been seen in animal models, this approach still meets disparate and often insurmountable problems in clinical settings, presumably related to the unique nature of the human being...
  67. pmc Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment
    Gianluigi Guidotti
    Center of Neuropharmacology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Neuropsychopharmacology 37:746-58. 2012
    ..These changes lead to an impairment of the GABAergic system that may contribute to the anxious and depressive phenotype associated with inherited SERT downregulation...
  68. ncbi request reprint Protein kinase A activity in platelets from patients with bipolar disorder
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Affect Disord 76:249-53. 2003
    ..Since altered levels are generally accompanied by functional modifications, the purpose of this study was to investigate PKA activity in patients with BD...
  69. ncbi request reprint Stress during development: Impact on neuroplasticity and relevance to psychopathology
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Prog Neurobiol 81:197-217. 2007
    ..We believe these studies might prove useful for the identification of novel targets for more effective pharmacological treatments of mental illnesses...
  70. ncbi request reprint Long-term reduction of brain-derived neurotrophic factor levels and signaling impairment following prenatal treatment with the cannabinoid receptor 1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl) pyrrolo[1,2,3-de]-1,4-benzoxazin-
    Paola Francesca Maj
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur J Neurosci 25:3305-11. 2007
    ..In summary, the present data suggest that deficits of BDNF levels and signaling through ERK1/2 and alpha-CaMKII might contribute to cognitive and neuroplastic defects associated with prenatal exposure to cannabinoids...
  71. doi request reprint Stress, glucocorticoids and glutamate release: effects of antidepressant drugs
    Laura Musazzi
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milano, Italy
    Neurochem Int 59:138-49. 2011
    ..Understanding the action of traditional drugs on glutamate transmission could be of great help in developing drugs that may work directly at this level...
  72. doi request reprint The pharmacological properties of antidepressants
    Giorgio Racagni
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Int Clin Psychopharmacol 25:117-31. 2010
    ..The undesirable side effects of currently used antidepressants, which can often be a reason for lack of compliance, are also considered...
  73. ncbi request reprint Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801
    Fabio Fumagalli
    Center of Neuropharmacology and Center of Excellence for Neurodegenerative Diseases CEND, Department of Pharmacological Sciences University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neuroreport 15:2109-12. 2004
    ..These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed...
  74. ncbi request reprint Modulation of synaptic plasticity by stress and antidepressants
    Maurizio Popoli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Bipolar Disord 4:166-82. 2002
    ..The role of these molecular effectors in synaptic plasticity is discussed in relation to the action of antidepressants and the search for new molecular targets of drug action in the therapy of mood disorders...
  75. ncbi request reprint Single exposure to erythropoietin modulates Nerve Growth Factor expression in the spinal cord following traumatic injury: comparison with methylprednisolone
    Fabio Fumagalli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Eur J Pharmacol 578:19-27. 2008
    ....
  76. ncbi request reprint Selective regulation of presynaptic calcium/calmodulin-dependent protein kinase II by psychotropic drugs
    Elisa Celano
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Italy
    Biol Psychiatry 53:442-9. 2003
    ....
  77. ncbi request reprint Noradrenaline in mood and anxiety disorders: basic and clinical studies
    Nicoletta Brunello
    Center of Neuropharmacology, Intsitute of Pharmacological Science, University of Milan, Italy
    Int Clin Psychopharmacol 18:191-202. 2003
    ....
  78. ncbi request reprint Chronic phencyclidine administration reduces the expression and editing of specific glutamate receptors in rat prefrontal cortex
    Alessandro Barbon
    Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Exp Neurol 208:54-62. 2007
    ..Combining all the data, it can be inferred that the PCP treatment induced a specific and site-selective reduction of glutamatergic neurotransmission in the prefrontal cortex but not in the hippocampus...
  79. ncbi request reprint Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation
    Ettore Tiraboschi
    Center of Neuropharmacology Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Neuroreport 15:2393-6. 2004
    ..The short-term inhibitory effect of reboxetine suggests that kinase up-regulation during antidepressant drug treatment is an adaptive response compensating for initial functional down-regulation...
  80. ncbi request reprint Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus
    Giambattista Bonanno
    Section of Pharmacology and Toxicology, Department of Experimental Medicine, and Center of Excellence for Biomedical Research, University of Genoa, 16148 Genoa, Italy
    J Neurosci 25:3270-9. 2005
    ....
  81. ncbi request reprint Antidepressant treatments and function of glutamate ionotropic receptors mediating amine release in hippocampus
    Anna Pittaluga
    Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genoa, 16148 Genoa, Italy
    Neuropharmacology 53:27-36. 2007
    ..The results obtained support the view that glutamate plays a major role in AD activity...
  82. ncbi request reprint Association study of -1727 A/T, -50 C/T and (CAA)n repeat GSK-3beta gene polymorphisms with schizophrenia
    Catia Scassellati
    Genetic Unit, IRCCS San Giovanni di Dio, Fatebenefratelli, Brescia, Italy
    Neuropsychobiology 50:16-20. 2004
    ..In conclusion, we would speculate that this gene may be linked to some features of psychotic disorders rather than to schizophrenia itself...
  83. doi request reprint World Psychiatric Association Pharmacopsychiatry Section statement on comparative effectiveness of antipsychotics in the treatment of schizophrenia
    Rajiv Tandon
    University of Florida, Tallahassee, USA
    Schizophr Res 100:20-38. 2008
    ....
  84. doi request reprint Do SSRIs or antidepressants in general increase suicidality? WPA Section on Pharmacopsychiatry: consensus statement
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University Munchen, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:3-23. 2008
    ..It is the major problem facing efforts to identify the possible 'suicidal effects' of antidepressants...
  85. ncbi request reprint Regulation of editing and expression of glutamate alpha-amino-propionic-acid (AMPA)/kainate receptors by antidepressant drugs
    Alessandro Barbon
    Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy
    Biol Psychiatry 59:713-20. 2006
    ..In particular, antidepressant treatment was shown to modulate expression and function of ionotropic glutamate receptors, to inhibit glutamate release and to restore synaptic plasticity impaired by stress...
  86. ncbi request reprint Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission
    Paola Fadda
    Department of Neuroscience B B Brodie, Center for Excellence in Neurobiology of Dependence, University of Cagliari, Cittadella Universitaria, Monserrato, Italy
    Biol Psychiatry 62:235-42. 2007
    ..Basic fibroblast growth factor (FGF2) plays a crucial role during the development of the cerebral cortex. Mice with a knockout of the FGF2 gene have a reduced number of glutamatergic neurons within the deep layers of the cerebral cortex...