M Popoli

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc ErbB3 mRNA leukocyte levels as a biomarker for major depressive disorder
    Elena Milanesi
    Department of Biomedical Sciences and Biotechnologies Biology and Genetic Division, University of Brescia, Viale Europa 11, Brescia, 25123, Italy
    BMC Psychiatry 12:145. 2012
  2. pmc Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes
    Marco Milanese
    Department of Pharmacy, Unit of Pharmacology and Toxicology and Center of Excellence for Biomedical Research, Universita degli Studi di Genova, Genova, Italy
    BMC Neurosci 14:75. 2013
  3. doi request reprint Lost in translation. New unexplored avenues for neuropsychopharmacology: epigenetics and microRNAs
    Daniela Tardito
    Laboratory of Neuropsychopharmacology and Functional Neurogenomics, Dipartimento di Scienze Farmacologiche e Biomolecolari and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9 20133 Milano, Italy
    Expert Opin Investig Drugs 22:217-33. 2013
  4. pmc Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways
    Daniela Tardito
    Center of Neuropharmacology Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    BMC Neurosci 11:68. 2010
  5. pmc Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells
    Lorena Donnici
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    BMC Neurosci 9:61. 2008
  6. pmc Early raise of BDNF in hippocampus suggests induction of posttranscriptional mechanisms by antidepressants
    Laura Musazzi
    Center of Neuropharmacology Department of Pharmacological Sciences, University of Milan, Milan, Italy
    BMC Neurosci 10:48. 2009
  7. doi request reprint Agomelatine: innovative pharmacological approach in depression
    Maurizio Popoli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    CNS Drugs 23:27-34. 2009
  8. ncbi request reprint Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs
    M Popoli
    Center of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Italy
    J Neurochem 74:21-33. 2000
  9. ncbi request reprint Serine/threonine kinases as molecular targets of antidepressants: implications for pharmacological treatment and pathophysiology of affective disorders
    M Popoli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Pharmacol Ther 89:149-70. 2001
  10. ncbi request reprint Modulation of synaptic plasticity by stress and antidepressants
    Maurizio Popoli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Bipolar Disord 4:166-82. 2002

Collaborators

Detail Information

Publications29

  1. pmc ErbB3 mRNA leukocyte levels as a biomarker for major depressive disorder
    Elena Milanesi
    Department of Biomedical Sciences and Biotechnologies Biology and Genetic Division, University of Brescia, Viale Europa 11, Brescia, 25123, Italy
    BMC Psychiatry 12:145. 2012
    ..On this basis, the aim of the study was to determine if ErbB3 and Fgfr1 mRNA levels could be a biomarkers of MDD...
  2. pmc Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes
    Marco Milanese
    Department of Pharmacy, Unit of Pharmacology and Toxicology and Center of Excellence for Biomedical Research, Universita degli Studi di Genova, Genova, Italy
    BMC Neurosci 14:75. 2013
    ..Agomelatine, a new antidepressant endowed with MT1/MT2 agonist and 5-HT2C serotonergic antagonist properties, has shown efficacy at both preclinical and clinical levels...
  3. doi request reprint Lost in translation. New unexplored avenues for neuropsychopharmacology: epigenetics and microRNAs
    Daniela Tardito
    Laboratory of Neuropsychopharmacology and Functional Neurogenomics, Dipartimento di Scienze Farmacologiche e Biomolecolari and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9 20133 Milano, Italy
    Expert Opin Investig Drugs 22:217-33. 2013
    ..Here focus is on epigenetics mechanisms, including microRNAs, which seem particularly promising for the identification of new targets for alternative pharmacological approaches...
  4. pmc Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways
    Daniela Tardito
    Center of Neuropharmacology Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    BMC Neurosci 11:68. 2010
    ....
  5. pmc Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells
    Lorena Donnici
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    BMC Neurosci 9:61. 2008
    ..However, no data are available for the human BDNF gene. We studied the effect of different antidepressants on BDNF mRNA expression in human neuroblastoma SH-SY5Y cells...
  6. pmc Early raise of BDNF in hippocampus suggests induction of posttranscriptional mechanisms by antidepressants
    Laura Musazzi
    Center of Neuropharmacology Department of Pharmacological Sciences, University of Milan, Milan, Italy
    BMC Neurosci 10:48. 2009
    ..Total BDNF mRNA was measured by Real Time PCR, pro- and mature BDNF proteins were measured by Western blot...
  7. doi request reprint Agomelatine: innovative pharmacological approach in depression
    Maurizio Popoli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    CNS Drugs 23:27-34. 2009
    ..Likewise, it has been shown to improve disturbed sleep-wake rhythms in depressed patients. Moreover, current pharmacological and clinical data strongly support the use of agomelatine in the management of MDD...
  8. ncbi request reprint Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs
    M Popoli
    Center of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Italy
    J Neurochem 74:21-33. 2000
    ..The changes in protein phosphorylation induced by long-term antidepressant treatment may contribute to explain the therapeutic action of antidepressants and suggest new strategies of pharmacological intervention...
  9. ncbi request reprint Serine/threonine kinases as molecular targets of antidepressants: implications for pharmacological treatment and pathophysiology of affective disorders
    M Popoli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Pharmacol Ther 89:149-70. 2001
    ..The molecular consequences of protein kinase activation may account for some of the alterations in neural function induced by antidepressants, and may suggest novel possible strategies of pharmacological intervention...
  10. ncbi request reprint Modulation of synaptic plasticity by stress and antidepressants
    Maurizio Popoli
    Center of Neuropharmacology, Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Bipolar Disord 4:166-82. 2002
    ..The role of these molecular effectors in synaptic plasticity is discussed in relation to the action of antidepressants and the search for new molecular targets of drug action in the therapy of mood disorders...
  11. ncbi request reprint Effect of reboxetine treatment on brain cAMP- and calcium/calmodulin-dependent protein kinases
    S Mori
    Center of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Milan, Italy
    Neuropharmacology 40:448-56. 2001
    ..An increase in the calcium/calmodulin-dependent phosphorylation of presynaptic substrates was also detected. These findings showed that reboxetine modulates post-receptor signal transduction systems in rat brain...
  12. ncbi request reprint Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades
    Ettore Tiraboschi
    Department of Pharmacological Sciences, Center of Neuropharmacology, University of Milano and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy
    Neuropsychopharmacology 29:1831-40. 2004
    ..Our results show that FLX exerts a more marked effect on CREB phosphorylation and suggest that CaMKIV and MAP kinase cascades are involved in this effect...
  13. ncbi request reprint Antidepressants activate CaMKII in neuron cell body by Thr286 phosphorylation
    Ettore Tiraboschi
    Center of Neuropharmacology Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Neuroreport 15:2393-6. 2004
    ..The short-term inhibitory effect of reboxetine suggests that kinase up-regulation during antidepressant drug treatment is an adaptive response compensating for initial functional down-regulation...
  14. ncbi request reprint Reduced CREB phosphorylation after chronic lithium treatment is associated with down-regulation of CaM kinase IV in rat hippocampus
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milano, Italy
    Int J Neuropsychopharmacol 10:491-6. 2007
    ..These data suggest for the first time the involvement of CaMKIV in the mechanism of action of lithium...
  15. doi request reprint Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression
    Laura Musazzi
    Center of Neuropharmacology, Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    J Psychiatr Res 44:511-20. 2010
    ..These results show that early gene-environment interaction may cause life-long synaptic changes affecting the course of depressive-like behavior and response to drugs...
  16. pmc Cellular and molecular mechanisms in the long-term action of antidepressants
    Giorgio Racagni
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Dialogues Clin Neurosci 10:385-400. 2008
    ..In the final section, we also briefly review the main current novel strategies in the pharmacology of depression and the new putative targets for antidepressants, with particular emphasis on nonmonoaminergic mechanisms...
  17. ncbi request reprint Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Rev 58:115-34. 2006
    ....
  18. doi request reprint The pharmacological properties of antidepressants
    Giorgio Racagni
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Italy
    Int Clin Psychopharmacol 25:117-31. 2010
    ..The undesirable side effects of currently used antidepressants, which can often be a reason for lack of compliance, are also considered...
  19. ncbi request reprint The interaction between the internal clock and antidepressant efficacy
    Giorgio Racagni
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Int Clin Psychopharmacol 22:S9-S14. 2007
    ....
  20. pmc Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants
    Laura Musazzi
    Department of Pharmacological Sciences, Center of Neuropharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy
    PLoS ONE 5:e8566. 2010
    ..Aim of this work was to investigate the mechanism whereby acute stress increases glutamate release, and if therapeutic drugs prevent the effect of stress on glutamate release...
  21. ncbi request reprint Selective regulation of presynaptic calcium/calmodulin-dependent protein kinase II by psychotropic drugs
    Elisa Celano
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Italy
    Biol Psychiatry 53:442-9. 2003
    ....
  22. doi request reprint Early induction of CREB activation and CREB-regulating signalling by antidepressants
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Italy
    Int J Neuropsychopharmacol 12:1367-81. 2009
    ..The results also showed that, contrary to the activatory role of MAP-ERKs and CaM kinase IV, nuclear alphaCaM kinase II was inactivated in parallel with activation of CREB...
  23. ncbi request reprint Chronic antidepressants induce redistribution and differential activation of alphaCaM kinase II between presynaptic compartments
    Valentina S Barbiero
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, Center of Neuropharmacology, University of Milano, Milano, Italy
    Neuropsychopharmacology 32:2511-9. 2007
    ..Overall, antidepressants induce a complex pattern of modifications in distinct subcellular compartments; at presynaptic level, these changes are in line with a dampening of glutamate release...
  24. ncbi request reprint Expression and phosphorylation of delta-CaM kinase II in cultured Alzheimer fibroblasts
    Chiara Cavazzin
    Center of Neuropharmacology, Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Neurobiol Aging 25:1187-96. 2004
    ..The observed abnormalities, if present in brain tissue, may be implicated either in dysfunction of neuroplasticity and cognitive functions or in dysregulation of cell cycle...
  25. ncbi request reprint Long-term soluble Abeta1-40 activates CaM kinase II in organotypic hippocampal cultures
    Daniela Tardito
    Center of Neuropharmacology, Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy
    Neurobiol Aging 28:1388-95. 2007
    ..The marked effect of Abeta(1-40) on the kinase suggests that semi-physiological and slowly raising peptide concentrations may have a significant impact on synaptic plasticity in the absence of synaptic loss or neuronal cell death...
  26. ncbi request reprint Changes in signaling pathways regulating neuroplasticity induced by neurokinin 1 receptor knockout
    Laura Musazzi
    Center of Neuropharmacology Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9 20133 Milano, Italy
    Eur J Neurosci 21:1370-8. 2005
    ..These results show similarities between NK-1 knockouts and animals chronically treated with antidepressants and support the putative antidepressant activity of NK-1 receptor antagonists...
  27. ncbi request reprint Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus
    Giambattista Bonanno
    Section of Pharmacology and Toxicology, Department of Experimental Medicine, and Center of Excellence for Biomedical Research, University of Genoa, 16148 Genoa, Italy
    J Neurosci 25:3270-9. 2005
    ....
  28. ncbi request reprint Antidepressant treatments and function of glutamate ionotropic receptors mediating amine release in hippocampus
    Anna Pittaluga
    Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genoa, 16148 Genoa, Italy
    Neuropharmacology 53:27-36. 2007
    ..The results obtained support the view that glutamate plays a major role in AD activity...
  29. ncbi request reprint Regulation of editing and expression of glutamate alpha-amino-propionic-acid (AMPA)/kainate receptors by antidepressant drugs
    Alessandro Barbon
    Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy
    Biol Psychiatry 59:713-20. 2006
    ..In particular, antidepressant treatment was shown to modulate expression and function of ionotropic glutamate receptors, to inhibit glutamate release and to restore synaptic plasticity impaired by stress...