F Polticelli

Summary

Affiliation: University Roma Tre
Country: Italy

Publications

  1. pmc Cupricyclins, novel redox-active metallopeptides based on conotoxins scaffold
    Marco Barba
    Department of Biology, University Roma Tre, Rome, Italy
    PLoS ONE 7:e30739. 2012
  2. pmc Molecular evolution of the polyamine oxidase gene family in Metazoa
    Fabio Polticelli
    Dipartimento di Biologia, Universita Roma Tre, I 00146, Rome, Italy
    BMC Evol Biol 12:90. 2012
  3. doi request reprint GA/GB fold switching may modulate fatty acid transfer from human serum albumin to bacteria
    Fabio Polticelli
    Dipartimento di Biologia, Universita Roma Tre, Roma, Italy Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, Roma, Italy
    IUBMB Life 64:scope. 2012
  4. doi request reprint GA/GB fold switching may modulate fatty acid transfer from human serum albumin to bacteria
    Fabio Polticelli
    Dipartimento di Biologia, Universita Roma Tre, Roma, Italy
    IUBMB Life 64:885-8. 2012
  5. pmc Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm
    Manuela Cervelli
    Dipartimento di Biologia, Universita Roma Tre, Rome, Italy
    BMC Cancer 10:555. 2010
  6. pmc Massive non-natural proteins structure prediction using grid technologies
    Giovanni Minervini
    Department of Biology, University Roma Tre, Viale G, Marconi 446, Rome, I 00146, Italy
    BMC Bioinformatics 10:S22. 2009
  7. doi request reprint Human haptoglobin structure and function--a molecular modelling study
    F Polticelli
    Department of Biology and Interdepartmental Laboratory for Electron Microscopy, University Roma Tre, Italy
    FEBS J 275:5648-56. 2008
  8. ncbi request reprint Probing the cruzain S2 recognition subsite: a kinetic and binding energy calculation study
    Fabio Polticelli
    Dipartimento di Biologia and Laboratorio Interdipartimentale per la Microscopia Elettronica, Universita Roma Tre, Viale Guglielmo Marconi 446, I 00146 Roma, Italy
    Biochemistry 44:2781-9. 2005
  9. ncbi request reprint Modulation of the catalytic activity of cruzipain, the major cysteine proteinase from Trypanosoma cruzi, by temperature and pH
    L Salvati
    Dipartimento di Biologia, , Roma, Italy
    Eur J Biochem 268:3253-8. 2001
  10. ncbi request reprint Serine proteinase inhibition by the active site titrant N alpha-(N, N-dimethylcarbamoyl)-alpha-azaornithine p-nitrophenyl ester. A comparative study
    P Ascenzi
    Department of Biology, University of Rome Tre, Italy
    Eur J Biochem 267:1239-46. 2000

Collaborators

Detail Information

Publications35

  1. pmc Cupricyclins, novel redox-active metallopeptides based on conotoxins scaffold
    Marco Barba
    Department of Biology, University Roma Tre, Rome, Italy
    PLoS ONE 7:e30739. 2012
    ..We thus propose knottins as a novel scaffold for the design of catalytically-active mini metalloproteins...
  2. pmc Molecular evolution of the polyamine oxidase gene family in Metazoa
    Fabio Polticelli
    Dipartimento di Biologia, Universita Roma Tre, I 00146, Rome, Italy
    BMC Evol Biol 12:90. 2012
    ....
  3. doi request reprint GA/GB fold switching may modulate fatty acid transfer from human serum albumin to bacteria
    Fabio Polticelli
    Dipartimento di Biologia, Universita Roma Tre, Roma, Italy Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tre, Roma, Italy
    IUBMB Life 64:scope. 2012
    ..2012 IUBMB. IUBMB Life, 64(11): 885-888, 2012...
  4. doi request reprint GA/GB fold switching may modulate fatty acid transfer from human serum albumin to bacteria
    Fabio Polticelli
    Dipartimento di Biologia, Universita Roma Tre, Roma, Italy
    IUBMB Life 64:885-8. 2012
    ....
  5. pmc Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm
    Manuela Cervelli
    Dipartimento di Biologia, Universita Roma Tre, Rome, Italy
    BMC Cancer 10:555. 2010
    ..Biochemical analysis of Spm analogues BENSpm and CPENSpm, utilized in anticancer therapy, was also carried out to test their property in silico and in vitro on the recombinant SMO enzyme...
  6. pmc Massive non-natural proteins structure prediction using grid technologies
    Giovanni Minervini
    Department of Biology, University Roma Tre, Viale G, Marconi 446, Rome, I 00146, Italy
    BMC Bioinformatics 10:S22. 2009
    ..Thus, the structural study of NBPs can help to understand if natural protein sequences were selected for their peculiar properties or if they are just one of the possible stable and functional ensembles...
  7. doi request reprint Human haptoglobin structure and function--a molecular modelling study
    F Polticelli
    Department of Biology and Interdepartmental Laboratory for Electron Microscopy, University Roma Tre, Italy
    FEBS J 275:5648-56. 2008
    ..The structural details of the models, which represent the first complete view of the molecular details of human haptoglobin variants, are discussed in relation to the known haptoglobin function(s)...
  8. ncbi request reprint Probing the cruzain S2 recognition subsite: a kinetic and binding energy calculation study
    Fabio Polticelli
    Dipartimento di Biologia and Laboratorio Interdipartimentale per la Microscopia Elettronica, Universita Roma Tre, Viale Guglielmo Marconi 446, I 00146 Roma, Italy
    Biochemistry 44:2781-9. 2005
    ..These results appear of general significance for a deeper understanding of (macro)molecular recognition and for the rational design of novel inhibitors of parasitic cysteine proteases...
  9. ncbi request reprint Modulation of the catalytic activity of cruzipain, the major cysteine proteinase from Trypanosoma cruzi, by temperature and pH
    L Salvati
    Dipartimento di Biologia, , Roma, Italy
    Eur J Biochem 268:3253-8. 2001
    ..However, allosteric effect(s) cannot be excluded...
  10. ncbi request reprint Serine proteinase inhibition by the active site titrant N alpha-(N, N-dimethylcarbamoyl)-alpha-azaornithine p-nitrophenyl ester. A comparative study
    P Ascenzi
    Department of Biology, University of Rome Tre, Italy
    Eur J Biochem 267:1239-46. 2000
    ..e. to P1-S1 recognition). These data represent the first detailed comparative investigation on the catalytic properties of serine proteinases towards an ornithine derivative (i. e. Dmc-azaOrn-ONp)...
  11. ncbi request reprint A barley polyamine oxidase isoform with distinct structural features and subcellular localization
    M Cervelli
    Dipartimento di Biologia, , Rome, Italy
    Eur J Biochem 268:3816-30. 2001
    ..We conclude that BPAO2 is a symplastic PAO in barley mesophyll cells. Production of BPAO2 mRNA and the corresponding protein is induced by light, and has a different pattern of accumulation in leaves and coleoptiles...
  12. ncbi request reprint Spermine metabolism and anticancer therapy
    R Amendola
    ENEA, CR Casaccia, BAS BIOTEC MED, Rome, Italy
    Curr Cancer Drug Targets 9:118-30. 2009
    ....
  13. ncbi request reprint Inhibition of Saccharomyces cerevisiae phosphomannose isomerase by the NO-donor S-nitroso-acetyl-penicillamine
    L Salvati
    Dipartimento di Biologia, , Viale Guglielmo Marconi 446, I-00146 Roma, Italy
    J Enzyme Inhib 16:287-92. 2001
    ..The analysis of the X-ray crystal structure of C. albicans PMI and of the molecular model of S. cerevisiae PMI provides a rationale for the low reactivity of Cys150 towards alkylating and nitrosylating agents...
  14. doi request reprint Cytochromes: Reactivity of the "dark side" of the heme
    Paolo Ascenzi
    Department of Biology, University Roma Tre, Viale Guglielmo Marconi 446, I 00146 Roma, Italy
    Biophys Chem 152:21-7. 2010
    ..Here, structural and functional aspects of NO binding to ferrous Axcyt c' and (CL-)hhcyt c are reviewed...
  15. ncbi request reprint May monomeric proteins be allosterically controlled?
    Paolo Ascenzi
    IUBMB Life 54:223-4. 2002
  16. ncbi request reprint The Rhodococcus sp. cocaine esterase: a bacterial candidate for novel pharmacokinetic-based therapies for cocaine abuse
    Paolo Ascenzi
    Department of Biology, University Roma Tre, Viale G Marconi 446, I 00146 Roma, Italy
    IUBMB Life 55:397-402. 2003
    ..The discovery of the cocaine esterase from the strain MBI of the bacterium Rhodococcus sp. (cocE) could be a major breakthrough in this field; cocE hydrolyzes cocaine faster than any known cocaine esterase and catalytic antibody...
  17. doi request reprint Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana
    Valentina Spedaletti
    Department of Biology, University Roma Tre, 00146 Rome, Italy
    Biochemistry 47:4936-47. 2008
    ..This observation, together with AtLSD1 peculiar surface electrostatic potential distribution, suggests that the molecular partners of AtLSD1 are probably different from those of the human orthologue...
  18. pmc Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion
    Paraskevi Tavladoraki
    Department of Biology, University Roma Tre, 00146 Rome, Italy
    Plant Physiol 141:1519-32. 2006
    ..To our knowledge, AtPAO1 is the first plant PAO reported to be involved in a polyamine back-conversion pathway...
  19. ncbi request reprint Contryphan-Vn: a novel peptide from the venom of the Mediterranean snail Conus ventricosus
    G R Massilia
    Department of Biology, University Roma Tre, Viale G. Marconi 446, Rome, 00146, Italy
    Biochem Biophys Res Commun 288:908-13. 2001
    ..Although the biological function(s) of contryphans is still unknown, these characteristics suggest distinct molecular target(s) and/or function(s) for Contryphan-Vn...
  20. ncbi request reprint Inhibition of cysteine protease activity by NO-donors
    P Ascenzi
    Dipartimento di Biologia, Universita Roma Tre, Viale G. Marconi 446, Italy
    Curr Protein Pept Sci 2:137-53. 2001
    ..Here, inhibition of representative cysteine proteases by NO(-donors) is reviewed...
  21. ncbi request reprint Inhibition of polyamine and spermine oxidases by polyamine analogues
    Marzia Bianchi
    Dipartimento di Biologia, Universita Roma Tre, Italy
    FEBS J 273:1115-23. 2006
    ..Thus, the data reported here provide the basis for the development of novel and selective inhibitors able to discriminate between mammalian SMO and PAO activities...
  22. ncbi request reprint Molecular basis for the binding of competitive inhibitors of maize polyamine oxidase
    Alessandra Cona
    Dipartimento di Biologia, Universita Roma Tre, Viale Guglielmo Marconi 446, I 00146 Roma, Italy
    Biochemistry 43:3426-35. 2004
    ..Finally, docking simulations performed with the charged and uncharged forms of MPAO inhibitors indicate that the stereoelectronic properties of the MPAO active site are consistent with the binding of inhibitors in the protonated form...
  23. ncbi request reprint Heterologous expression and characterization of mouse spermine oxidase
    Manuela Cervelli
    Dipartimento di Biologia, Universita Roma Tre, I 00146 Roma, Italy
    J Biol Chem 278:5271-6. 2003
    ..0. Molecular modeling of mSMO protein based on maize polyamine oxidase three-dimensional structure suggests that the general features of maize polyamine oxidase active site are conserved in mSMO...
  24. ncbi request reprint Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase mu isoform
    Marzia Bianchi
    Dipartimento di Biologia, Universita Roma Tre, Roma, Italy
    FEBS J 272:3052-9. 2005
    ..A deletion mutant enzyme of this region was constructed to demonstrate its role in protein nuclear targeting by means of transient expression in the murine neuroblastoma cell line, N18TG2...
  25. pmc Cupryphans, metal-binding, redox-active, redesigned conopeptides
    Marco Barba
    Department of Biology, University Roma Tre, Rome, Italy
    Protein Sci 18:559-68. 2009
    ..We conclude that the Contryphan motif represents a natural robust scaffold which can be engineered to perform different functions, providing additional means for the design of catalytically active mini metalloproteins...
  26. ncbi request reprint Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform
    Manuela Cervelli
    Dipartimento di Biologia, Universita Roma Tre, Rome, Italy
    Eur J Biochem 271:760-70. 2004
    ..In addition, the relative transcription levels of the gene splicing variants were evaluated by RT-PCR analysis to verify a relationship with the SMO enzyme activity in various murine organs...
  27. doi request reprint The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients
    Alessandra di Masi
    Department of Biology, University Roma Tre, Viale Guglielmo Marconi 446, I 00146 Roma, Italy
    Biochem Biophys Res Commun 369:835-40. 2008
    ..Present data represent the first evidence for the role of NBS1 tandem BRCT domains in gamma-H2AX recognition, and could explain the severe phenotype observed in 657del5/R215W NBS patients...
  28. ncbi request reprint Lys300 plays a major role in the catalytic mechanism of maize polyamine oxidase
    Fabio Polticelli
    Department of Biology, University Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
    Biochemistry 44:16108-20. 2005
    ..Our studies indicate the importance of Lys300 and probable importance of HOH309 to the mechanism of flavin reduction in MPAO. Possible roles for Lys300 and water in the mechanism of flavin reduction are discussed...
  29. ncbi request reprint Mitochondrial type I nitric oxide synthase physically interacts with cytochrome c oxidase
    Tiziana Persichini
    Department of Biology LIME, University Roma Tre, Viale Guglielmo Marconi 446, 00146 Rome, Italy
    Neurosci Lett 384:254-9. 2005
    ..The molecular details of the interaction have been analyzed by means of molecular modeling and molecular dynamics simulations. This is the first evidence of a protein-protein interaction mediated by PDZ domains involving CcOX...
  30. ncbi request reprint The production of de novo folded proteins by a stepwise chain elongation: a model for prebiotic chemical evolution of macromolecular sequences
    Salvatore Chessari
    Department of Materials, Swiss Federal Institute of Technology, ETHZ, CH 8093 Zurich
    Chem Biodivers 3:1202-10. 2006
    ..The implication of this procedure as a general mechanism for the etiology of de novo macromolecular sequences and globular proteins in the origin of life is briefly discussed...
  31. ncbi request reprint AtCYS1, a cystatin from Arabidopsis thaliana, suppresses hypersensitive cell death
    Beatrice Belenghi
    Dipartimento Scientifico e Tecnologico, Universita degli Studi di Verona, Verona, Italy
    Eur J Biochem 270:2593-604. 2003
    ....
  32. ncbi request reprint Investigation of de novo totally random biosequences, Part II: On the folding frequency in a totally random library of de novo proteins obtained by phage display
    Cristiano Chiarabelli
    Centro Studi e Ricerche E Fermi, Via Panisperna 89A, IT 00184 Rome
    Chem Biodivers 3:840-59. 2006
    ..The consequences of this finding within a library of 'Never Born Proteins' are discussed in terms of molecular evolution...
  33. pmc ATP specifically drives refolding of non-native conformations of cytochrome c
    Federica Sinibaldi
    Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Protein Sci 14:1049-58. 2005
    ..The finding that ATP and dATP are unique among the nucleotides in being able to turn non-native states of cyt c back to native conformation is discussed in the light of cyt c involvement in cell apoptosis...
  34. ncbi request reprint 1H NMR relaxometric characterization of bovine lactoferrin
    Mauro Fasano
    Dipartimento di Biologia Strutturale e Funzionale, Universita dell Insubria, Via Alberto da Giussano 12, I 21052 Busto Arsizio VA, Italy
    J Inorg Biochem 98:1421-6. 2004
    ..By increasing the pH from 6.5 to 12 two distinct titrations are observed, consistent with sequential removal of both water molecules...
  35. doi request reprint Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in the intraspecific variation
    Cristina Romeo
    Consorzio Interuniversitario Istituto Nazionale Biostrutture e Biosistemi, Rome, Italy
    J Sep Sci 31:488-98. 2008
    ..Similarly, molecular modeling data suggest that -Conotoxin-Vn should represent a competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs)...