R Polosa

Summary

Affiliation: University of Catania
Country: Italy

Publications

  1. ncbi request reprint [Vaping: a new strategy to prevent smoking-related diseases?]
    Riccardo Polosa
    Dipartimento di Biomedicina Clinica e Molecolare, Universita di Catania
    Epidemiol Prev 38:264-7. 2014
  2. ncbi request reprint Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study
    Riccardo Polosa
    Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico V Emanuele, Universita di Catania, Catania, Italy
    Intern Emerg Med 9:537-46. 2014
  3. pmc Effect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversal
    Riccardo Polosa
    Department of Clinical and Molecular Biomedicine, University of Catania, Catania 95125, Italy
    Int J Environ Res Public Health 11:4965-77. 2014
  4. pmc EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study
    Pasquale Caponnetto
    Centro per la prevenzione e cura del tabagismo, Azienda Ospedaliero Universitaria Policlinico V Emanuele, Universita di Catania, Catania, Italy
    PLoS ONE 8:e66317. 2013
  5. pmc A fresh look at tobacco harm reduction: the case for the electronic cigarette
    Riccardo Polosa
    Presidio G, Rodolico Unità Operativa di Medicina Interna e Medicina d Urgenza, Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
    Harm Reduct J 10:19. 2013
  6. ncbi request reprint Effect of acute exacerbations on circulating endothelial, clotting and fibrinolytic markers in COPD patients
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, Universita di Catania, Catania, Italy
    Intern Emerg Med 8:567-74. 2013
  7. doi request reprint Adenosine signaling pathways as potential therapeutic targets in respiratory disease
    Massimo Caruso
    University of Catania AOU Policlinico V Emanuele, Institute of Internal Medicine and Clinical Immunology, Department of Clinical and Molecular Bio Medicine, Catania, Italy
    Expert Opin Ther Targets 17:761-72. 2013
  8. doi request reprint Smoking and asthma: dangerous liaisons
    Riccardo Polosa
    Universita di Catania, Catania, Italy
    Eur Respir J 41:716-26. 2013
  9. doi request reprint Monoclonal antibodies for chronic refractory asthma and pipeline developments
    Riccardo Polosa
    Institute of Internal Medicine, G Rodolico, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Italy
    Drug Discov Today 17:591-9. 2012
  10. pmc Successful smoking cessation with electronic cigarettes in smokers with a documented history of recurring relapses: a case series
    Pasquale Caponnetto
    Centro per la Prevenzione e Cura del Tabagismo CPCT, Dipartimento di Biomedicina Clinica e Molecolare, Azienda Ospedaliero Universitaria V, Emanuele Policlinico, Universita di Catania, Catania, Italy
    J Med Case Rep 5:585. 2011

Collaborators

Detail Information

Publications68

  1. ncbi request reprint [Vaping: a new strategy to prevent smoking-related diseases?]
    Riccardo Polosa
    Dipartimento di Biomedicina Clinica e Molecolare, Universita di Catania
    Epidemiol Prev 38:264-7. 2014
    ..In this article, the author suggests that the wide dissemination of vaping behaviour can become a successful strategy to reduce smoking and preventing smoking-related diseases, advancing on how to succeed with this matter. ..
  2. ncbi request reprint Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study
    Riccardo Polosa
    Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico V Emanuele, Universita di Catania, Catania, Italy
    Intern Emerg Med 9:537-46. 2014
    ..Withdrawal symptoms were uncommon. Long-term e-Cigarette use can substantially decrease cigarette consumption in smokers not willing to quit and is well tolerated. ( http://ClinicalTrials.govnumberNCT01195597 ). ..
  3. pmc Effect of smoking abstinence and reduction in asthmatic smokers switching to electronic cigarettes: evidence for harm reversal
    Riccardo Polosa
    Department of Clinical and Molecular Biomedicine, University of Catania, Catania 95125, Italy
    Int J Environ Res Public Health 11:4965-77. 2014
    ....
  4. pmc EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as tobacco cigarettes substitute: a prospective 12-month randomized control design study
    Pasquale Caponnetto
    Centro per la prevenzione e cura del tabagismo, Azienda Ospedaliero Universitaria Policlinico V Emanuele, Universita di Catania, Catania, Italy
    PLoS ONE 8:e66317. 2013
    ..The study consisted of nine visits during which cig/day use and exhaled carbon monoxide (eCO) levels were measured. Smoking reduction and abstinence rates were calculated. Adverse events and product preferences were also reviewed...
  5. pmc A fresh look at tobacco harm reduction: the case for the electronic cigarette
    Riccardo Polosa
    Presidio G, Rodolico Unità Operativa di Medicina Interna e Medicina d Urgenza, Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
    Harm Reduct J 10:19. 2013
    ..The focus of this article is on the health effects of using an E-cig, with consideration given to the acceptability, safety and effectiveness of this product as a long-term substitute for smoking...
  6. ncbi request reprint Effect of acute exacerbations on circulating endothelial, clotting and fibrinolytic markers in COPD patients
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, Universita di Catania, Catania, Italy
    Intern Emerg Med 8:567-74. 2013
    ..The pro-thrombotic nature of COPD exacerbations sustained by enhanced clotting activation appears to be mitigated by excessive fibrinolysis. ..
  7. doi request reprint Adenosine signaling pathways as potential therapeutic targets in respiratory disease
    Massimo Caruso
    University of Catania AOU Policlinico V Emanuele, Institute of Internal Medicine and Clinical Immunology, Department of Clinical and Molecular Bio Medicine, Catania, Italy
    Expert Opin Ther Targets 17:761-72. 2013
    ....
  8. doi request reprint Smoking and asthma: dangerous liaisons
    Riccardo Polosa
    Universita di Catania, Catania, Italy
    Eur Respir J 41:716-26. 2013
    ..Clinical trials assessing new therapies for asthma need to enroll smokers to identify treatments that are effective in the asthma smoking phenotype...
  9. doi request reprint Monoclonal antibodies for chronic refractory asthma and pipeline developments
    Riccardo Polosa
    Institute of Internal Medicine, G Rodolico, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Italy
    Drug Discov Today 17:591-9. 2012
    ..Future drug candidates directed at key targets and the specific role of monoclonal antibodies in distinctively targeted sub-populations of severe asthmatics will be also discussed...
  10. pmc Successful smoking cessation with electronic cigarettes in smokers with a documented history of recurring relapses: a case series
    Pasquale Caponnetto
    Centro per la Prevenzione e Cura del Tabagismo CPCT, Dipartimento di Biomedicina Clinica e Molecolare, Azienda Ospedaliero Universitaria V, Emanuele Policlinico, Universita di Catania, Catania, Italy
    J Med Case Rep 5:585. 2011
    ..abstract:..
  11. doi request reprint Immunomodulatory and biologic therapies for severe refractory asthma
    Riccardo Polosa
    Ospedale Santa Marta, U O C di Medicina Interna e Medicina d Urgenza, Via Gesualdo Clementi 36, 95124 Catania, Italy
    Respir Med 102:1499-510. 2008
    ..This article reviews the current evidence for immunomodulating and biologic approaches in severe refractory asthma...
  12. doi request reprint Cigarette smoking is associated with a greater risk of incident asthma in allergic rhinitis
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    J Allergy Clin Immunol 121:1428-34. 2008
    ..Sensitization to allergen has been shown to be one of the strongest determinants of incident asthma, but little is known about the effects of cigarette smoking among individuals with allergic rhinitis...
  13. pmc Finding better therapeutic targets for patients with asthma: adenosine receptors?
    R Polosa
    Dipartimento di Medicina Interna e Specialistica, Institute of Internal Medicine and Clinical Immunology, S Marta Hospital, University of Catania, Catania, Italy
    Br J Pharmacol 155:441-3. 2008
    ..Important conclusions can be drawn about the function of adenosine receptors in human asthma and approaches to these important targets with novel therapeutic agents...
  14. ncbi request reprint A patient with antihistidyl-tRNA synthetase positive polymyositis presenting as acute respiratory distress syndrome
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Az Ospedaliero Universitaria Vittorio Emanuele Ospedale S Marta, via G Clementi 36, Catania, Italy
    J Clin Rheumatol 14:219-21. 2008
    ..One year after onset, PM has been maintained in remission with oral prednisone and azathioprine. This is the first report of a patient in whom ARDS was the presenting feature of anti-Jo-1 positive PM...
  15. ncbi request reprint An overview of chronic severe asthma
    R Polosa
    Department of Internal Medicine, University of Catania, Catania, Italy
    Intern Med J 38:190-8. 2008
    ..In this review, a diagnostic and therapeutic overview of CSA is provided for the benefit of those who have a specific interest in this problematic condition...
  16. ncbi request reprint Critical appraisal of antileukotriene use in asthma management
    Riccardo Polosa
    Department of Internal and Specialist Medicine, Ascoli Tomaselli Hospitals, University of Catania, Italy
    Curr Opin Pulm Med 13:24-30. 2007
    ..In the present article the clinical applications of this class of drugs have been critically reviewed based on recent evidence...
  17. doi request reprint Managing patients with chronic severe asthma: rise to the challenge
    Riccardo Polosa
    Dipartimento di Medicina Interna, Ospedale S Marta, Universita di Catania, Catania, Italy
    Eur J Intern Med 20:114-24. 2009
    ....
  18. ncbi request reprint Feasibility of using E-mail counseling as part of a smoking-cessation program
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, Centro Antifumo Universitario, Universita di Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Respir Care 54:1033-9. 2009
    ..The aim of this pilot study was to assess the effectiveness of incorporating tailored e-mail consultation messages in a smoking-cessation program for smokers willing to quit...
  19. pmc Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, Institute of Internal Medicine and Clinical Immunology, University of Catania, Catania 95124, Italy
    Trends Pharmacol Sci 30:528-35. 2009
    ..Several adenosine receptor based pharmacologic agents have entered clinical development for the treatment of asthma and COPD; however, the studies have been limited and the efficacy of such approaches is not yet clear...
  20. pmc Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study
    Riccardo Polosa
    Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
    BMC Public Health 11:786. 2011
    ..Efficacy and safety of these devices in long-term smoking cessation and/or smoking reduction studies have never been investigated...
  21. pmc Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal study
    Riccardo Polosa
    Dipartimento di biomedicina clinica e molecolare S, Marta Hospital, azienda ospedaliero universitaria O V E, Universita di Catania, Catania, Italy
    Respir Res 12:16. 2011
    ..Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma...
  22. doi request reprint Treatment of nicotine addiction: present therapeutic options and pipeline developments
    Riccardo Polosa
    Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
    Trends Pharmacol Sci 32:281-9. 2011
    ....
  23. ncbi request reprint Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Curr Drug Targets 7:699-706. 2006
    ....
  24. ncbi request reprint Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis
    R Polosa
    Istituto di Malattie Apparato Respiratorio, University of Catania, Catania, Italy
    Allergy 59:1224-8. 2004
    ..Specific immunotherapy (SIT) reduces symptom in subjects with allergic rhinitis, but the mechanisms are not clear...
  25. ncbi request reprint Effect of salbutamol on nasal symptoms and mast cell degranulation induced by adenosine 5' monophosphate nasal challenge
    C Russo
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Clin Exp Allergy 35:1192-6. 2005
    ..In addition to its well-known functional agonism at the level of beta(2) adrenergic receptors on airways smooth muscle cells, salbutamol appears to have additional protective effects, possibly through an inhibition of mast cell activation...
  26. ncbi request reprint Electronic cigarette: a possible substitute for cigarette dependence
    P Caponnetto
    Centro per Ia Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico V Emanuele, Universita di Catania, Catania, Italy
    Monaldi Arch Chest Dis 79:12-9. 2013
    ....
  27. ncbi request reprint The effect of inhaled furosemide and acetazolamide on bronchoconstriction induced by deep inspiration in asthma
    L Spicuzza
    Dipartimento di Medicina Interna e Medicina Specialistica, Universita di Catania, 95125 Catania, Italy
    Monaldi Arch Chest Dis 59:150-4. 2003
    ..01) or acetazolamide (p < 0.05) compared to control. We interpret these results as due to a modulation of ionic fluxes across the smooth muscle cell membrane afforded by inhaled furosemide and acetazolamide...
  28. ncbi request reprint [Smoking habits in health care workers: experience in two general hospitals of Eastern Sicily]
    L Proietti
    Dipartimento di Medicina Interna e Patologie Sistemiche, Sezione di Medicina del Lavoro
    Clin Ter 157:407-12. 2006
    ..The aim of our study was to assess the smoking habits in health care workers...
  29. ncbi request reprint Cigarette smoke extract immobilizes human spermatozoa and induces sperm apoptosis
    Aldo Calogero
    Department of Biomedical Sciences, University of Catania, Catania, Italy
    Reprod Biomed Online 19:564-71. 2009
    ....
  30. ncbi request reprint Recurrent Hopkin's syndrome: a case report and review of the literature
    Piero Pavone
    Department of Pediatric and Pediatric Neurology, Azienda Ospedaliera Universitaria OVE Policlinico, Universita di Catania, Catania, Italy
    J Neurol Sci 297:89-91. 2010
    ..The present case is the first HS case demonstrating frequent recurrences and suggests a possible link between HS and atopic myelitis...
  31. ncbi request reprint Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease
    R Polosa
    Dept of Internal and Specialist Medicine, University of Catania, Ascoli Tomaselli Hospitals, Italy
    Eur Respir J 20:488-96. 2002
    ..The recent characterisation of the A2B receptors indicates the human lung mast cell as one of the most strategic cellular targets...
  32. pmc Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease
    R Polosa
    Dipartimento di Medicina Interna e Specialistica, Ospedale Tomaselli, Universita di Catania, 95125 Catania, Italy
    Thorax 57:649-54. 2002
    ....
  33. ncbi request reprint Non-occupational malignant pleural mesothelioma due to asbestos and non-asbestos fibres
    L Proietti
    Dipartimento di Medicina Interna e Patologie Sistemiche Sezione di Medicina del Lavoro, Universita di Catania, Italy
    Monaldi Arch Chest Dis 65:210-6. 2006
    ..This paper reviews existing data related to non occupational MPM including its occurrence in the province of Catania (Sicily, Italy)...
  34. ncbi request reprint Research applications and implications of adenosine in diseased airways
    Lucia Spicuzza
    Dipartimento di Medicina Interna e Specialistica, Ospedale Tomaselli, Universita di Catania, Via Passo Gravina, 187, 95125 Catania, Italy
    Trends Pharmacol Sci 24:409-13. 2003
    ....
  35. ncbi request reprint Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma
    Cristina Russo
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals, University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Fundam Clin Pharmacol 20:9-19. 2006
    ..In addition, because adenosine exerts its multiple biological activities by interacting with four adenosine receptor subtypes, selective activation or blockade of these receptors may lead to the development of novel therapies for asthma...
  36. doi request reprint Effect of a nicotine-free inhalator as part of a smoking-cessation programme
    P Caponnetto
    Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
    Eur Respir J 38:1005-11. 2011
    ....
  37. ncbi request reprint Monitoring of seasonal variability in bronchial hyper-responsiveness and sputum cell counts in non-asthmatic subjects with rhinitis and effect of specific immunotherapy
    R Polosa
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    Clin Exp Allergy 33:873-81. 2003
    ..The clinical efficacy of Parietaria SIT was exclusively associated with attenuation in seasonal worsening of PC15 AMP, suggesting that AMP may be useful in monitoring changes in allergic inflammation of the airways...
  38. ncbi request reprint The interaction between particulate air pollution and allergens in enhancing allergic and airway responses
    R Polosa
    Istituto Malattie Apparato Respiratorio, Universita di Catania, Ospedale Ascoli Tomaselli, 95125 Catania, Italy
    Curr Allergy Asthma Rep 1:102-7. 2001
    ..This article reviews the evidence that supports the causative link between particulate air pollution and the sharp increase in the prevalence of type I allergies in developed countries...
  39. ncbi request reprint Making, disseminating and using clinical guidelines
    R Polosa
    Dipartimento di Medicina Interna e Specialistica, Universita di Catania, Via Passo Gravina, 187, 95125 Catania, Italy
    Monaldi Arch Chest Dis 57:44-7. 2002
    ..The critical approaches to making high-quality guidelines, the value of implementation strategies, and how healthcare organizations and individual physicians can use medical guidelines to enhance clinical effectiveness will be discussed...
  40. ncbi request reprint Adenosine signalling in airways
    Massimo Caruso
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals University of Catania, Via Passo Gravina, 187, 95125 Catania, Italy
    Curr Opin Pharmacol 6:251-6. 2006
    ..It is likely that therapies interfering with adenosine signalling in the airways will offer a considerable advance in the management of asthma and COPD...
  41. ncbi request reprint TNF-alpha as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis
    Cristina Russo
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals, University of Catania, Italy
    Clin Sci (Lond) 109:135-42. 2005
    ....
  42. ncbi request reprint Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma
    Gaetano Prosperini
    Dipartimento di Medicina Interna e Specialistica, Sezione di Malattie Respiratorie, Universita di Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Respir Med 100:1006-12. 2006
    ..However, little is known about the possibility that treatment with ICS might cause additional protection on BHR to inhaled tachykinins such as neurokinin A (NKA)...
  43. doi request reprint Common predictors of smoking cessation in clinical practice
    Pasquale Caponnetto
    Centro per la prevenzione e cura del tabagismo, Department of Internal and Specialistic Medicine, University of Catania, Azienda Ospedaliera Universitaria Vittorio Emanuele Ferrarotto Santo Bambino, 95124 Catania, Italy
    Respir Med 102:1182-92. 2008
    ..The purpose of the present article is to review those predictors of smoking cessation that can be of help in routine clinical consultation...
  44. pmc Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy: a retrospective cohort study
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    Respir Res 6:153. 2005
    ..Moreover, treatment with allergen immunotherapy lowers the risk of the development of new asthma cases in adults with allergic rhinitis...
  45. ncbi request reprint Changes in airway hyperresponsiveness following smoking cessation: comparisons between Mch and AMP
    Giovita Piccillo
    Smoking Cessation Research Centre, Department of Internal and Specialistic Medicine, University of Catania, Ascoli Tomaselli Hospitals, 95125 Catania, Italy
    Respir Med 102:256-65. 2008
    ....
  46. ncbi request reprint New and emerging infectious diseases
    Lucia Spicuzza
    Dipartimento di Medicina Interna e Medicina Specialistica, Sezione Malattie Respiratorie, Universita di Catania, Italy
    Allergy Asthma Proc 28:28-34. 2007
    ..As for SARS, the World Health Organization has adopted a global action plan to control avian influenza among chickens and ducks and at the same time to limit the threat of a human flu pandemic...
  47. ncbi request reprint Changes in sputum counts and airway hyperresponsiveness after budesonide: monitoring anti-inflammatory response on the basis of surrogate markers of airway inflammation
    Gaetano Prosperini
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    J Allergy Clin Immunol 110:855-61. 2002
    ..In addition, detailed longitudinal assessment of changes in airway response with inhaled GCSs has never been carried out...
  48. ncbi request reprint Relevance of endothelial-haemostatic dysfunction in cigarette smoking
    Rossella R Cacciola
    Dipartimento di Scienze Biomediche Sez Ematologia, Ferrarotto Hospital University of Catania, via S Citelli 6, 95124 Catania, Italy
    Curr Med Chem 14:1887-92. 2007
    ....
  49. ncbi request reprint The role of adenosine as a novel bronchoprovocant in asthma
    Lucia Spicuzza
    Department of Internal and Specialist Medicine, University of Catania, Italy
    Curr Opin Allergy Clin Immunol 3:65-9. 2003
    ..Here the authors review the most recent development in this area of rapidly evolving clinical research, focusing on the putative role of adenosine as a useful bronchoprovocant in asthma...
  50. ncbi request reprint The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Pulmonology, University Hospital Groningen, The Netherlands
    J Allergy Clin Immunol 114:737-46. 2004
    ..The aim of this article was to review the literature assessing AMP's value in asthma and chronic obstructive pulmonary disease...
  51. ncbi request reprint Adenosine in the airways: implications and applications
    Lucia Spicuzza
    Dipartimento di Medicina Interna e Medicina Specialistica Sezione Malattie Respiratorie Università di Catania, Italy
    Eur J Pharmacol 533:77-88. 2006
    ....
  52. ncbi request reprint The mechanisms, diagnosis, and management of severe asthma in adults
    Stephen T Holgate
    AIR Division, Level D Centre Block, Southampton General Hospital, Southampton, UK
    Lancet 368:780-93. 2006
    ....
  53. ncbi request reprint Exercise-induced asthma and plasma adenosine: Is there a causative link?
    Lucia Spicuzza
    J Allergy Clin Immunol 110:537; author reply 537-8. 2002
  54. ncbi request reprint Rapid effect of inhaled fluticasone on airway responsiveness to AMP: research implications
    Gaetano Prosperini
    J Allergy Clin Immunol 111:1416; author reply 1416-7. 2003
  55. ncbi request reprint Can immunotherapy prevent progression to asthma in allergic individuals?
    Riccardo Polosa
    J Allergy Clin Immunol 110:672-3; author reply 273. 2002
  56. ncbi request reprint Adenosine monophosphate challenge and monitoring of airway response to antiinflammatory therapy
    Riccardo Polosa
    Am J Respir Crit Care Med 165:1336; author reply 1336. 2002
  57. ncbi request reprint A randomized, controlled study of specific immunotherapy in monosensitized subjects with seasonal rhinitis: effect on bronchial hyperresponsiveness, sputum inflammatory markers and development of asthma symptoms
    Nunzio Crimi
    Istituto di Malattie dell Apparato Respiratorio, Universita degli Studi di Catania
    Ann Ital Med Int 19:98-108. 2004
    ..Moreover, Parietaria-SIT appears to prevent the natural progression of allergic rhinitis to asthma, suggesting that SIT should be considered earlier in the management of this condition...
  58. ncbi request reprint Tumor necrosis factor alpha in refractory asthma
    Chiara Oliveri
    N Engl J Med 354:2074-5; author reply 2074-5. 2006
  59. ncbi request reprint Study of infliximab treatment in smokers with COPD: what next?
    Cristina Russo
    Am J Respir Crit Care Med 172:1607-8; author reply 1608. 2005
  60. ncbi request reprint Study of infliximab treatment in asthma
    Christopher J Edwards
    Am J Respir Crit Care Med 175:196; author reply 196-7. 2007
  61. ncbi request reprint The puzzling relationship between cigarette smoking, reduced respiratory function, and systemic inflammation
    Valeria Asero
    Chest 128:3772-3; author reply 3773. 2005
  62. ncbi request reprint Treatment strategies for allergy and asthma
    Stephen T Holgate
    IIR Division, F Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Nat Rev Immunol 8:218-30. 2008
    ....
  63. doi request reprint Endothelial-coagulative activation during chronic obstructive pulmonary disease exacerbations
    Riccardo Polosa
    Haematologica 93:1275-6. 2008
  64. ncbi request reprint Poor quality of life in young smokers with smoking history of short duration
    Marco Raciti
    Chest 127:1862; author reply 1862-3. 2005
  65. ncbi request reprint Mast cell degranulation after endobronchial adenosine challenge
    Daniela Lauretta
    J Allergy Clin Immunol 115:1097-8; author reply 1098-9. 2005
  66. ncbi request reprint Monitoring the adjustment of antiasthma medications with adenosine monophosphate bronchoprovocation
    Lidia Proietti
    Chest 126:1384-5; author reply 1385. 2004
  67. ncbi request reprint Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects
    Riccardo Polosa
    School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 109:75-81. 2002
    ..The c-erbB family of receptor tyrosine kinases act in a combinatorial fashion to regulate cell behavior. Disturbances in this system have been associated with neoplastic and inflammatory diseases...
  68. ncbi request reprint Anti-TNF-alpha and Th1 cytokine-directed therapies for the treatment of asthma
    Mario Cazzola
    Department of Respiratory Medicine, Unit of Pneumology and Allergology and Centre of Respiratory Clinical Pharmacology, Antonio Cardarelli Hospital, Napoli, Italy
    Curr Opin Allergy Clin Immunol 6:43-50. 2006
    ..This article examines recent work about the role of TNF-alpha and of selected Th1-related cytokines in asthma with particular emphasis on the therapeutic potential of blocking the biological activity of these mediators...