Research Topics
| R PolosaSummaryAffiliation: University of Catania Country: Italy Publications
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Detail Information
Publications
Smoking and asthma: dangerous liaisonsRiccardo Polosa
Universita di Catania, Catania, Italy
Eur Respir J 41:716-26. 2013..Clinical trials assessing new therapies for asthma need to enroll smokers to identify treatments that are effective in the asthma smoking phenotype...- Monoclonal antibodies for chronic refractory asthma and pipeline developmentsRiccardo Polosa
Institute of Internal Medicine, G Rodolico, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Italy
Drug Discov Today 17:591-9. 2012..Future drug candidates directed at key targets and the specific role of monoclonal antibodies in distinctively targeted sub-populations of severe asthmatics will be also discussed... 
Successful smoking cessation with electronic cigarettes in smokers with a documented history of recurring relapses: a case seriesPasquale Caponnetto
Centro per la Prevenzione e Cura del Tabagismo CPCT, Dipartimento di Biomedicina Clinica e Molecolare, Azienda Ospedaliero Universitaria V, Emanuele Policlinico, Universita di Catania, Catania, Italy
J Med Case Rep 5:585. 2011..abstract:..- Greater severity of new onset asthma in allergic subjects who smoke: a 10-year longitudinal studyRiccardo Polosa
Dipartimento di biomedicina clinica e molecolare S, Marta Hospital, azienda ospedaliero universitaria O V E, Universita di Catania, Catania, Italy
Respir Res 12:16. 2011..Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma... - Treatment of nicotine addiction: present therapeutic options and pipeline developmentsRiccardo Polosa
Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
Trends Pharmacol Sci 32:281-9. 2011.... - Finding better therapeutic targets for patients with asthma: adenosine receptors?R Polosa
Dipartimento di Medicina Interna e Specialistica, Institute of Internal Medicine and Clinical Immunology, S Marta Hospital, University of Catania, Catania, Italy
Br J Pharmacol 155:441-3. 2008..Important conclusions can be drawn about the function of adenosine receptors in human asthma and approaches to these important targets with novel therapeutic agents... 
An overview of chronic severe asthmaR Polosa
Department of Internal Medicine, University of Catania, Catania, Italy
Intern Med J 38:190-8. 2008..In this review, a diagnostic and therapeutic overview of CSA is provided for the benefit of those who have a specific interest in this problematic condition...- Immunomodulatory and biologic therapies for severe refractory asthmaRiccardo Polosa
Ospedale Santa Marta, U O C di Medicina Interna e Medicina d Urgenza, Via Gesualdo Clementi 36, 95124 Catania, Italy
Respir Med 102:1499-510. 2008..This article reviews the current evidence for immunomodulating and biologic approaches in severe refractory asthma... - Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary diseaseRiccardo Polosa
Dipartimento di Medicina Interna e Specialistica, Institute of Internal Medicine and Clinical Immunology, University of Catania, Catania 95124, Italy
Trends Pharmacol Sci 30:528-35. 2009..Several adenosine receptor based pharmacologic agents have entered clinical development for the treatment of asthma and COPD; however, the studies have been limited and the efficacy of such approaches is not yet clear... - Managing patients with chronic severe asthma: rise to the challengeRiccardo Polosa
Dipartimento di Medicina Interna, Ospedale S Marta, Universita di Catania, Catania, Italy
Eur J Intern Med 20:114-24. 2009.... - Feasibility of using E-mail counseling as part of a smoking-cessation programRiccardo Polosa
Dipartimento di Medicina Interna e Specialistica, Centro Antifumo Universitario, Universita di Catania, Via Passo Gravina 187, 95125 Catania, Italy
Respir Care 54:1033-9. 2009..The aim of this pilot study was to assess the effectiveness of incorporating tailored e-mail consultation messages in a smoking-cessation program for smokers willing to quit... - Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammationRiccardo Polosa
Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
Curr Drug Targets 7:699-706. 2006.... - Cigarette smoking is associated with a greater risk of incident asthma in allergic rhinitisRiccardo Polosa
Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
J Allergy Clin Immunol 121:1428-34. 2008..Sensitization to allergen has been shown to be one of the strongest determinants of incident asthma, but little is known about the effects of cigarette smoking among individuals with allergic rhinitis... - Critical appraisal of antileukotriene use in asthma managementRiccardo Polosa
Department of Internal and Specialist Medicine, Ascoli Tomaselli Hospitals, University of Catania, Italy
Curr Opin Pulm Med 13:24-30. 2007..In the present article the clinical applications of this class of drugs have been critically reviewed based on recent evidence... - Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot studyRiccardo Polosa
Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
BMC Public Health 11:786. 2011..Efficacy and safety of these devices in long-term smoking cessation and/or smoking reduction studies have never been investigated... - A patient with antihistidyl-tRNA synthetase positive polymyositis presenting as acute respiratory distress syndromeRiccardo Polosa
Dipartimento di Medicina Interna e Specialistica, University of Catania, Az Ospedaliero Universitaria Vittorio Emanuele Ospedale S Marta, via G Clementi 36, Catania, Italy
J Clin Rheumatol 14:219-21. 2008..One year after onset, PM has been maintained in remission with oral prednisone and azathioprine. This is the first report of a patient in whom ARDS was the presenting feature of anti-Jo-1 positive PM... - Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitisR Polosa
Istituto di Malattie Apparato Respiratorio, University of Catania, Catania, Italy
Allergy 59:1224-8. 2004..Moreover, Parietaria-SIT appears to prevent the natural progression of allergic rhinitis to asthma, suggesting that SIT should be considered earlier in the management of subjects with allergic rhinitis... - Effect of salbutamol on nasal symptoms and mast cell degranulation induced by adenosine 5' monophosphate nasal challengeC Russo
Dipartimento di Medicina Interna e Specialistica, University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
Clin Exp Allergy 35:1192-6. 2005.... - The effect of inhaled furosemide and acetazolamide on bronchoconstriction induced by deep inspiration in asthmaL Spicuzza
Dipartimento di Medicina Interna e Medicina Specialistica, , 95125 Catania, Italy
Monaldi Arch Chest Dis 59:150-4. 2003..01) or acetazolamide (p < 0.05) compared to control. We interpret these results as due to a modulation of ionic fluxes across the smooth muscle cell membrane afforded by inhaled furosemide and acetazolamide... - [Smoking habits in health care workers: experience in two general hospitals of Eastern Sicily]L Proietti
Dipartimento di Medicina Interna e Patologie Sistemiche, Sezione di Medicina del Lavoro
Clin Ter 157:407-12. 2006..The aim of our study was to assess the smoking habits in health care workers... - Recurrent Hopkin's syndrome: a case report and review of the literaturePiero Pavone
Department of Pediatric and Pediatric Neurology, Azienda Ospedaliera Universitaria OVE Policlinico, Universita di Catania, Catania, Italy
J Neurol Sci 297:89-91. 2010..The present case is the first HS case demonstrating frequent recurrences and suggests a possible link between HS and atopic myelitis... - Cigarette smoke extract immobilizes human spermatozoa and induces sperm apoptosisAldo Calogero
Department of Biomedical Sciences, University of Catania, Catania, Italy
Reprod Biomed Online 19:564-71. 2009.... - Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary diseaseR Polosa
Dipartimento di Medicina Interna e Specialistica, Ospedale Tomaselli, Universita di Catania, 95125 Catania, Italy
Thorax 57:649-54. 2002.... - Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary diseaseR Polosa
Dept of Internal and Specialist Medicine, University of Catania, Ascoli Tomaselli Hospitals, Italy
Eur Respir J 20:488-96. 2002..The recent characterisation of the A2B receptors indicates the human lung mast cell as one of the most strategic cellular targets... - Non-occupational malignant pleural mesothelioma due to asbestos and non-asbestos fibresL Proietti
Dipartimento di Medicina Interna e Patologie Sistemiche Sezione di Medicina del Lavoro, Universita di Catania, Italy
Monaldi Arch Chest Dis 65:210-6. 2006..This paper reviews existing data related to non occupational MPM including its occurrence in the province of Catania (Sicily, Italy)... - Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthmaCristina Russo
Dipartimento di Medicina Interna e Specialistica, Ascoli-Tomaselli Hospitals, University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
Fundam Clin Pharmacol 20:9-19. 2006..In addition, because adenosine exerts its multiple biological activities by interacting with four adenosine receptor subtypes, selective activation or blockade of these receptors may lead to the development of novel therapies for asthma... - Research applications and implications of adenosine in diseased airwaysLucia Spicuzza
Dipartimento di Medicina Interna e Specialistica, Ospedale Tomaselli, , Via Passo Gravina, 187, 95125 Catania, Italy
Trends Pharmacol Sci 24:409-13. 2003.... - Effect of a nicotine-free inhalator as part of a smoking-cessation programmeP Caponnetto
Centro per la Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, Universita di Catania, Catania, Italy
Eur Respir J 38:1005-11. 2011.... - Making, disseminating and using clinical guidelinesR Polosa
Dipartimento di Medicina Interna e Specialistica, Universita di Catania, Via Passo Gravina, 187, 95125 Catania, Italy
Monaldi Arch Chest Dis 57:44-7. 2002..The critical approaches to making high-quality guidelines, the value of implementation strategies, and how healthcare organizations and individual physicians can use medical guidelines to enhance clinical effectiveness will be discussed... - The interaction between particulate air pollution and allergens in enhancing allergic and airway responsesR Polosa
Istituto Malattie Apparato Respiratorio, Universita di Catania, Ospedale Ascoli Tomaselli, 95125 Catania, Italy
Curr Allergy Asthma Rep 1:102-7. 2001..This article reviews the evidence that supports the causative link between particulate air pollution and the sharp increase in the prevalence of type I allergies in developed countries... - Monitoring of seasonal variability in bronchial hyper-responsiveness and sputum cell counts in non-asthmatic subjects with rhinitis and effect of specific immunotherapyR Polosa
Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
Clin Exp Allergy 33:873-81. 2003..The clinical efficacy of Parietaria SIT was exclusively associated with attenuation in seasonal worsening of PC15 AMP, suggesting that AMP may be useful in monitoring changes in allergic inflammation of the airways... - New and emerging infectious diseasesLucia Spicuzza
Dipartimento di Medicina Interna e Medicina Specialistica, Sezione Malattie Respiratorie, Universita di Catania, Italy
Allergy Asthma Proc 28:28-34. 2007..As for SARS, the World Health Organization has adopted a global action plan to control avian influenza among chickens and ducks and at the same time to limit the threat of a human flu pandemic... - Changes in airway hyperresponsiveness following smoking cessation: comparisons between Mch and AMPGiovita Piccillo
Smoking Cessation Research Centre, Department of Internal and Specialistic Medicine, University of Catania, Ascoli Tomaselli Hospitals, 95125 Catania, Italy
Respir Med 102:256-65. 2008.... - Common predictors of smoking cessation in clinical practicePasquale Caponnetto
Centro per la prevenzione e cura del tabagismo, Department of Internal and Specialistic Medicine, University of Catania, Azienda Ospedaliera Universitaria Vittorio Emanuele Ferrarotto Santo Bambino, 95124 Catania, Italy
Respir Med 102:1182-92. 2008..The purpose of the present article is to review those predictors of smoking cessation that can be of help in routine clinical consultation... - Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthmaGaetano Prosperini
Dipartimento di Medicina Interna e Specialistica, Sezione di Malattie Respiratorie, , Via Passo Gravina 187, 95125 Catania, Italy
Respir Med 100:1006-12. 2006..As a result of these findings, provocation with NKA is unlikely to provide additional useful information in the assessment of airway inflammation in asthma... - Adenosine signalling in airwaysMassimo Caruso
Dipartimento di Medicina Interna e Specialistica, Ascoli-Tomaselli Hospitals - University of Catania, Via Passo Gravina, 187, 95125 Catania, Italy
Curr Opin Pharmacol 6:251-6. 2006..It is likely that therapies interfering with adenosine signalling in the airways will offer a considerable advance in the management of asthma and COPD... - Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy: a retrospective cohort studyRiccardo Polosa
Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
Respir Res 6:153. 2005..Moreover, treatment with allergen immunotherapy lowers the risk of the development of new asthma cases in adults with allergic rhinitis... - TNF-alpha as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritisCristina Russo
Dipartimento di Medicina Interna e Specialistica, Ascoli-Tomaselli Hospitals, University of Catania, Italy
Clin Sci (Lond) 109:135-42. 2005.... - The role of adenosine as a novel bronchoprovocant in asthmaLucia Spicuzza
Department of Internal and Specialist Medicine, University of Catania, Italy
Curr Opin Allergy Clin Immunol 3:65-9. 2003.... - Changes in sputum counts and airway hyperresponsiveness after budesonide: monitoring anti-inflammatory response on the basis of surrogate markers of airway inflammationGaetano Prosperini
Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
J Allergy Clin Immunol 110:855-61. 2002..When compared with that to the other markers, AHR to inhaled AMP is an early and sensitive indicator of the beneficial anti-inflammatory effects of topical GCSs... - Relevance of endothelial-haemostatic dysfunction in cigarette smokingRossella R Cacciola
Dipartimento di Scienze Biomediche Sez Ematologia, Ferrarotto Hospital University of Catania, via S Citelli 6, 95124 Catania, Italy
Curr Med Chem 14:1887-92. 2007.... - The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary diseaseMaarten van den Berge
Department of Pulmonology, University Hospital Groningen, The Netherlands
J Allergy Clin Immunol 114:737-46. 2004..The aim of this article was to review the literature assessing AMP's value in asthma and chronic obstructive pulmonary disease... - Adenosine in the airways: implications and applicationsLucia Spicuzza
Dipartimento di Medicina Interna e Medicina Specialistica Sezione Malattie Respiratorie Università di Catania, Italy
Eur J Pharmacol 533:77-88. 2006.... - The mechanisms, diagnosis, and management of severe asthma in adultsStephen T Holgate
AIR Division, Level D Centre Block, Southampton General Hospital, Southampton, UK
Lancet 368:780-93. 2006.... - Can immunotherapy prevent progression to asthma in allergic individuals?Riccardo Polosa
J Allergy Clin Immunol 110:672-3; author reply 273. 2002 - Endothelial-coagulative activation during chronic obstructive pulmonary disease exacerbationsRiccardo Polosa
Haematologica 93:1275-6. 2008 - Adenosine monophosphate challenge and monitoring of airway response to antiinflammatory therapyRiccardo Polosa
Am J Respir Crit Care Med 165:1336; author reply 1336. 2002 - Exercise-induced asthma and plasma adenosine: Is there a causative link?Lucia Spicuzza
J Allergy Clin Immunol 110:537; author reply 537-8. 2002 - Rapid effect of inhaled fluticasone on airway responsiveness to AMP: research implicationsGaetano Prosperini
J Allergy Clin Immunol 111:1416; author reply 1416-7. 2003 - A randomized, controlled study of specific immunotherapy in monosensitized subjects with seasonal rhinitis: effect on bronchial hyperresponsiveness, sputum inflammatory markers and development of asthma symptomsNunzio Crimi
Istituto di Malattie dell'Apparato Respiratorio,
Ann Ital Med Int 19:98-108. 2004..Moreover, Parietaria-SIT appears to prevent the natural progression of allergic rhinitis to asthma, suggesting that SIT should be considered earlier in the management of this condition... - Monitoring the adjustment of antiasthma medications with adenosine monophosphate bronchoprovocationLidia Proietti
Chest 126:1384-5; author reply 1385. 2004 - Mast cell degranulation after endobronchial adenosine challengeDaniela Lauretta
J Allergy Clin Immunol 115:1097-8; author reply 1098-9. 2005 - Poor quality of life in young smokers with smoking history of short durationMarco Raciti
Chest 127:1862; author reply 1862-3. 2005 - Study of infliximab treatment in smokers with COPD: what next?Cristina Russo
Am J Respir Crit Care Med 172:1607-8; author reply 1608. 2005 - Anti-TNF-alpha and Th1 cytokine-directed therapies for the treatment of asthmaMario Cazzola
Department of Respiratory Medicine, Unit of Pneumology and Allergology and Centre of Respiratory Clinical Pharmacology, Antonio Cardarelli Hospital, Napoli, Italy
Curr Opin Allergy Clin Immunol 6:43-50. 2006..SUMMARY: It is likely that therapies blocking TNF-alpha and interfering with Th1-derived cytokines may be a considerable advance in the management of those asthma patients who are particularly resistant to typical treatment modalities... - Tumor necrosis factor alpha in refractory asthmaChiara Oliveri
N Engl J Med 354:2074-5; author reply 2074-5. 2006 - Study of infliximab treatment in asthmaChristopher J Edwards
Am J Respir Crit Care Med 175:196; author reply 196-7. 2007 - The puzzling relationship between cigarette smoking, reduced respiratory function, and systemic inflammationValeria Asero
Chest 128:3772-3; author reply 3773. 2005 - Treatment strategies for allergy and asthmaStephen T Holgate
IIR Division, F Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
Nat Rev Immunol 8:218-30. 2008.... - Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjectsRiccardo Polosa
School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
J Allergy Clin Immunol 109:75-81. 2002....