Research Topics
Genomes and GenesSpecies | Pierluigi PolitiSummaryAffiliation: University of Pavia Country: Italy Publications
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Publications
Behavioral effects of omega-3 fatty acid supplementation in young adults with severe autism: an open label studyPierluigi Politi
Department of Health Applied Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Arch Med Res 39:682-5. 2008..However, data on the potential benefits of omega-3 supplements in young adults with severe autism are lacking. In the present study, we sought to explore this issue in an open label study...
Development of the "Playing-in-Touch" (PiT) questionnaire: a measure of musical intouchness in people with low-functioning autismPierluigi Politi
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Neuro Endocrinol Lett 33:552-8. 2012..There is accumulating evidence that people with autism have a particular affinity with music...
Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorderPierluigi Politi
Department of Applied Health and Behavioural Sciences, Section of Psychiatry, University of Pavia, via Bassi 21, I 27100, Pavia, Italy
Neurosci Lett 396:163-6. 2006..While our data suggest that this polymorphism is unlikely to have a major function in the pathogenesis of panic disorder, it could play a role in the subgroup of patients without agoraphobic avoidance...
[Depression and stroke: an up-to-date review]Pierluigi Politi
DSSAeP, Sezione di Psichiatria, Universittà di Pavia, Pavia
Epidemiol Psichiatr Soc 15:284-94. 2006..To define the epidemiological and clinical characteristics of Post Stroke Depression (PSD) and to evaluate treatment options...
Getting old with a new heart: impact of age on depression and quality of life in long-term heart transplant recipientsValentina Martinelli
DSSAeP, Section of Psychiatry, University of Pavia, Pavia, Italy
J Heart Lung Transplant 26:544-8. 2007..The aim of the present study was to investigate the role of age on depression and quality of life in a sample of long-term heart transplant recipients...
The T393C polymorphism of the GNAS1 gene is associated with deficit schizophrenia in an Italian population samplePiercarlo Minoretti
Interdepartmental Center for Research in Molecular Medicine CIRMC, University of Pavia, Viale Taramelli 24, I 27100 Pavia, Italy
Neurosci Lett 397:159-63. 2006..06 (95% confidence interval (CI): 1.21-3.47), p=0.007]. Altogether, our data suggest that the GNAS1 T393C status could influence susceptibility for deficit schizophrenia in Italian subjects...
Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophreniaEnzo Emanuele
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Neuro Endocrinol Lett 31:117-21. 2010..We also sought to assess whether urine concentrations of this molecule may be associated with the clinical characteristics of psychiatric patients...
QT interval duration in apparently healthy men is associated with depression-related personality trait neuroticismPiercarlo Minoretti
Interdepartmental Center for Research in Molecular Medicine (CIRMC, University of Pavia, Viale Taramelli, 24, I-27100 Pavia, Italy
J Psychosom Res 61:19-23. 2006..These findings highlight the possibility that higher arrhythmic risk could be present not only in patients with clinical depression but also in depression-prone, otherwise healthy individuals...
Chromosome 9p21.3 genotype is associated with vascular dementia and Alzheimer's diseaseEnzo Emanuele
Department of Health Sciences, Section of Psychiatry, University of Pavia, via Bassi 21, Pavia, Italy
Neurobiol Aging 32:1231-5. 2011..01). Altogether, our data indicate for the first time that the C allele of rs1333049 in the vascular disease susceptibility locus is associated with VaD and LOAD, independent of traditional risk factors and the APOE ε4 genotype...
A W148R mutation in the human FOXD4 gene segregating with dilated cardiomyopathy, obsessive-compulsive disorder, and suicidalityPiercarlo Minoretti
Interdepartmental Center for Research in Molecular Medicine CIRMC, University of Pavia, I 27100, Pavia, Italy
Int J Mol Med 19:369-72. 2007..Our present findings widen the spectrum of diseases associated with genetic aberrations in the forkhead gene family...
Seasonal fluctuations in problem behaviors among young adults with autism and intellectual disabilityMarianna Boso
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Med Sci Monit 16:CR213-6. 2010..Acute behavioral alterations have been frequently reported in patients with autism. However, the question as to whether behavioral problems undergo seasonal variations in autism remains to be addressed...
Increased dopamine DRD4 receptor mRNA expression in lymphocytes of musicians and autistic individuals: bridging the music-autism connectionEnzo Emanuele
Department of Applied and Psychobehavioural Sciences, University of Pavia, Pavia, Italy
Neuro Endocrinol Lett 31:122-5. 2010..Previous studies have suggested a pivotal role for the dopaminergic system in the psychobiology of reward, including the pleasure of music...
Decreased NT-3 plasma levels and platelet serotonin content in patients with hypochondriasisNatascia Brondino
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
J Psychosom Res 65:435-9. 2008..Although NTs have been associated to a variety of mental disorders, the potential role of NT alterations in hypochondriasis (HC) has never been investigated...
Alterations of circulating endogenous secretory RAGE and S100A9 levels indicating dysfunction of the AGE-RAGE axis in autismMarianna Boso
Department of Applied Health and Behavioural Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Neurosci Lett 410:169-73. 2006..34). Our results of a significantly reduced peripheral level of esRAGE coupled with elevated S100A9 point to a subtle but definite dysfunction of the AGEs/RAGE axis in autism that could play a role in the pathophysiology of this disorder...
Increased serum levels of high mobility group box 1 protein in patients with autistic disorderEnzo Emanuele
Department of Health Sciences, Section of Psychiatry, University of Pavia, via Bassi, 21, I 27100, Pavia, Italy
Prog Neuropsychopharmacol Biol Psychiatry 34:681-3. 2010..The objective of the present study was to measure serum levels of HMGB1 in patients with autistic disorder and to study their relationship with clinical characteristics...
Serum levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with different psychiatric disordersEnzo Emanuele
Department of Health Sciences, University of Pavia, Pavia, Italy
Neurosci Lett 487:99-102. 2011..Although subject to future confirmation, our findings suggest that the reduced serum sRAGE may contribute to increased cardiovascular risk in schizophrenia and major depression...
Lifestyles and cardiovascular risk in individuals with functional psychosesPaolo Fusar-Poli
Department of Psychobehavioural Health Sciences, University of Pavia, Pavia, Italy
Perspect Psychiatr Care 45:87-99. 2009..This study aims to examine known determinants of cardiovascular risk in Italian patients with functional psychoses...
Serum levels of vascular endothelial growth factor and its receptors in patients with severe autismEnzo Emanuele
Department of Health Sciences, Section of Psychiatry, University of Pavia, via Bassi, 21, I 27100, Pavia, Italy
Clin Biochem 43:317-9. 2010..To study vascular endothelial growth factor (VEGF) and its soluble receptors sVEGFR-1 and -2 in autism...
Determinants of quality of life in Marfan syndromePaolo Fusar-Poli
DSSAeP, Sezione di Psichiatria, Universita di Pavia, Pavia, Italy
Psychosomatics 49:243-8. 2008..Marfan syndrome (MFS) is a rare, heritable disorder that affects connective tissue. Men and women are equally affected. Clinical manifestations involve multiple sites, especially bones and ligaments and heart and blood vessels...
Effect of long-term interactive music therapy on behavior profile and musical skills in young adults with severe autismMarianna Boso
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
J Altern Complement Med 13:709-12. 2007..Data on the potential behavioral effects of music therapy in autism are scarce...
Reduced plasma apelin levels in patients with autistic spectrum disorderMarianna Boso
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Arch Med Res 38:70-4. 2007..Aims of the present study were to investigate circulating levels of apelin in patients with ASD and to assess their correlation with plasma AVP concentrations...
Italian translation, cultural adaptation and validation of KDQOL-SF, version 1.3, in patients with severe renal failureCatherine Klersy
Unit of Biometry and Clinical Epidemiology, IRCCS Policlinico San Matteo, Pavia, Italy
J Nephrol 20:43-51. 2007..This study aims to confirm the reliability and validity of the KDQOL-SF in its Italian version. Cultural adaptation of such an instrument to assess quality of life of patients with chronic kidney disease is a major challenge...
Biochemical markers of impending psychosisEnzo Emanuele
Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Curr Pharm Des 18:505-9. 2012..We will also examine the practical issues that seem to be limiting the effective integration of biomarkers into clinical development...
Exploring musical taste in severely autistic subjects: preliminary dataMarianna Boso
Department of Applied Health and Behavioral Sciences, Section of Psychiatry, University of Pavia, via Bassi 21, 27100 Pavia, Italy
Ann N Y Acad Sci 1169:332-5. 2009..Both groups significantly preferred the musical task and the pleasant music condition. No difference between groups was detected. Results demonstrate that severely autistic subjects share with healthy people the same musical preferences...
Low-grade endotoxemia in patients with severe autismEnzo Emanuele
Department of Health Sciences, Section of Psychiatry, University of Pavia, via Bassi, 21, I 27100, Pavia, Italy
Neurosci Lett 471:162-5. 2010..Whether increased endotoxin may contribute to the pathophysiology of inflammation and impaired reciprocal social interaction in autism should be further explored in future studies...
Anti-depressive therapies after heart transplantationPaolo Fusar-Poli
Department of Applied and Psychobehavioural Sciences, University of Pavia, Pavia, Italy
J Heart Lung Transplant 25:785-93. 2006..To date, no review has explored the efficacy and safety of pharmacologic or psychologic interventions in this patient group...
Circulating levels of soluble CD26 are associated with phobic anxiety in womenEnzo Emanuele
Interdepartmental Center for Research in Molecular Medicine CIRMC, University of Pavia, Viale Taramelli, 24, I 27100, Pavia, Italy
Prog Neuropsychopharmacol Biol Psychiatry 30:1334-6. 2006..31 (95% CI: 0.18-0.74) for the second and 0.47 (95% CI: 0.34-0.63) for the third tertile. Altogether, our data suggest that reduced plasma sCD26 concentrations could be a marker of high levels of phobic anxiety in women...
Elevated plasma N-terminal ProBNP levels in unmedicated patients with major depressive disorderPierluigi Politi
Department of Applied Health and Behavioural Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Neurosci Lett 417:322-5. 2007..422, P=0.008) between plasma NT-proBNP and HAMD scores. Altogether, our results indicate that elevated NT-proBNP levels may play a role in linking MDD with increased cardiovascular risk...
Neurophysiology and neurobiology of the musical experienceMarianna Boso
Department of Applied and Psychobehavioural Health Sciences, Section of Psychiatry, University of Pavia, Italy
Funct Neurol 21:187-91. 2006..This need should be addressed through prospective, randomized, controlled, single-blinded investigations of the short- and long-term effects of music therapy in diverse clinical conditions...
Effect of omega-3 fatty acids supplementation on depressive symptoms and on health-related quality of life in the treatment of elderly women with depression: a double-blind, placebo-controlled, randomized clinical trialMariangela Rondanelli
Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, University of Pavia, Pavia, Italy or
J Am Coll Nutr 29:55-64. 2010..The authors investigated whether a supplement containing long-chain omega-3 polyunsaturated fatty acids (n-3 LCPUFA) improves depressive symptoms and health-related quality of life (HRQoL) in depressed elderly patients...
Paul Eugen Bleuler and the birth of schizophrenia (1908)Paolo Fusar-Poli
Department of Applied and Psychobehavioral Health Sciences, University of Pavia, Pavia, Italy
Am J Psychiatry 165:1407. 2008
Depression and quality of life in patients living 10 to 18 years beyond heart transplantationPaolo Fusar-Poli
DSSAeP, Sezione di Psichiatria, Università di Pavia and Servizio Psichiatrico di Diagnosi e Cura San Matteo, Pavia, Italy
J Heart Lung Transplant 24:2269-78. 2005..The purpose of this study was to advance current understanding of factors that influence long-term quality-of-life (QoL) outcomes after heart transplantation, by addressing the influence of depression on perceived health status...
Elevated plasma levels of lipoprotein(a) in psychiatric patients: a possible contribution to increased vascular riskEnzo Emanuele
Molecular Medicine Laboratory, Clinica Medica 2, IRCCS Policlinico San Matteo, University of Pavia, Piazzale Golgi, 2, 27100 Pavia, Italy
Eur Psychiatry 21:129-33. 2006..On the other hand, no differences were found among personality disorder and controls. Our findings suggest that the elevation of plasma Lp(a) may contribute to increased cardiovascular risk in several patients with psychiatric disorders...
Increased proapoptotic serum activity in patients with chronic mood disordersPierluigi Politi
Department of Applied Health and Behavioural Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
Arch Med Res 39:242-5. 2008..In this study, we sought to determine whether serum of patients with chronic mood disorders could directly induce apoptosis in human endothelial cells...
A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trialMirella Ruggeri
Section of Psychiatry, Department of Public Health and Community Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy
Trials 13:73. 2012....
Raised plasma nerve growth factor levels associated with early-stage romantic loveEnzo Emanuele
Interdepartmental Center for Research in Molecular Medicine, CIRMC, University of Pavia, Viale Taramelli 24, I 27100 Pavia, Italy
Psychoneuroendocrinology 31:288-94. 2006..Taken together, these findings suggest that some behavioural and/or psychological features associated with falling in love could be related to raised NGF levels in the bloodstream...
Socioeconomic provisions for specialist training in Italy and the UK: integrating the differencesPaolo Fusar-Poli
Department of Applied and Psychobehavioural Sciences, University of Pavia, via Bassi 21, 27100 Pavia, Italy
Postgrad Med J 82:810-2. 2006....
Franco Basaglia, 1924-1980Giovanni de Girolamo
Department of Applied and Psychobehavioral Health Sciences, University of Pavia, via Bassi 21, 27100 Pavia, Italy
Am J Psychiatry 165:968. 2008
Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementiaEnzo Emanuele
Molecular Medicine Laboratory, University of Pavia, IRCCS San Matteo Hospital, Pavia, Italy
Arch Neurol 62:1734-6. 2005..In addition, administration of sRAGE has been shown to reduce development of cerebral beta-amyloidosis in an Alzheimer disease mouse model...
Increased plasma aldosterone in patients with clinical depressionEnzo Emanuele
Molecular Medicine Laboratory, University of Pavia, Italy
Arch Med Res 36:544-8. 2005....
Employment status, aspirations and perceptions of support amongst psychiatric service users in Pavia, ItalyIrene Cirillo
School of Specialisation in Psychiatry, University of Pavia, Pavia
Epidemiol Psichiatr Soc 18:40-7. 2009....
Ten years of "extended" life: quality of life among heart transplantation survivorsPierluigi Politi
DSSAeP, Sezione di Psichiatria, Università di Pavia and Servizio Psichiatrico di Diagnosi e Cura, IRCCS Policlinico San Matteo Pavia, 27100 Pavia, Italy
Transplantation 78:257-63. 2004..Long-term quality of life (QOL) outcome in heart transplant recipients still remains uncertain. This study evaluates the health status and QOL of survivors with associated predictors 10 years after heart transplantation...
Potential usefulness of N1,N11-diethylnorspermine to prevent suicidal behaviourEnzo Emanuele
Med Hypotheses 67:192. 2006
Burnout in health care providers of dialysis service in Northern Italy--a multicentre studyCatherine Klersy
Service of Biometry and Clinical Epidemiology, IRCCS Fondazione Policlinico San Matteo, Italy
Nephrol Dial Transplant 22:2283-90. 2007..Aims of the present study were to assess and compare burnout levels in a sample of nurses and physicians working in dialysis units, and to investigate their relationships with quality of life, in a cross-sectional observational study...
Focus on psychiatry in ItalyMarco Piccinelli
, Azienda Ospedaliera Universitaria Ospedale di Circolo e Fondazione Macchi di Varese, Presidio Ospedaliero del Verbano-sede di Cittiglio, Via Marconi 40, Italy
Br J Psychiatry 181:538-44. 2002
