Research Topics
| Paola PizzoSummaryAffiliation: University of Padova Country: Italy Publications
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Detail Information
Publications
Lipid rafts in lymphocyte activationPaola Pizzo
Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I 35121, Italy
Microbes Infect 6:686-92. 2004..In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions...
Ca(2+) signalling in the Golgi apparatusPaola Pizzo
Department of Biomedical Sciences, University of Padova, Italy
Cell Calcium 50:184-92. 2011....- Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamicsPaola Pizzo
Department Biomedical Sciences, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
Trends Cell Biol 17:511-7. 2007.... - Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementiaMarta Giacomello
Department of Biomedical Sciences, University of Padova, Via G Colombo, 3, 35121 Padova, Italy
Neurobiol Dis 18:638-48. 2005..A similar Ca2+ alteration occurred in HeLa and HEK293 cells transiently expressing PS2-T122R. Based on these data, the "Ca2+ overload" hypothesis in AD pathogenesis is here discussed and reformulated... - Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levelsGiancarlo Zatti
Department of Biomedical Sciences, University of Padua, Italy
Cell Calcium 39:539-50. 2006..Taken as a whole, our findings, while confirming the capability of presenilins to modify Ca(2+) homeostasis, suggest a re-evaluation of the "Ca(2+) overload" hypothesis in AD and a new working hypothesis is presented... - Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channelsMarta Giacomello
Department of Biomedical Sciences, University of Padova, Padova, Italy
Mol Cell 38:280-90. 2010..These results demonstrate that mitochondria are exposed to Ca(2+) hot spots close to the ER but are excluded from the regions where capacitative Ca(2+) influx occurs... - Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptakeLucia Brunello
Department of Biomedical Sciences, University of Padova, Padova, Italy
J Cell Mol Med 13:3358-69. 2009..To exert this newly described function, PS2 needs to be in its full-length form, even if it can subsequently be cleaved... 
Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talkEnrico Zampese
Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy
Proc Natl Acad Sci U S A 108:2777-82. 2011..We also discuss the importance of this additional effect of FAD-linked PS2 mutants for the understanding of FAD pathogenesis...- Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartmentValentina Lissandron
Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy
Proc Natl Acad Sci U S A 107:9198-203. 2010.... - Physiological T cell activation starts and propagates in lipid raftsPaola Pizzo
Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
Immunol Lett 91:3-9. 2004..Moreover, T cell stimulation by pulsed EBV-B cells, but not by anti-CD3 antibodies, induced recruitment of active Lck in detergent-resistant membranes, where the signal transduction is organized and amplified... - Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificitiesPaola Pizzo
Department of Biomedical Sciences, University of Padua, Padua, Italy
Pflugers Arch 464:3-17. 2012..In this review, we summarize the processes involved in mitochondrial Ca²⁺ handling and its integration in cell physiology, highlighting the main common characteristics as well as key differences, in different tissues... - Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cellsPaola Pizzo
Department of Biomedical Sciences, University of Padova, Padova, Italy
J Cell Mol Med 14:970-81. 2010..Therefore, a brief exposure to curcumin induces a delayed cytoprotection against oxidative stress in myogenic cells by increasing Grp94 protein level, which acts as a regulator of calcium homeostasis... - After half a century mitochondrial calcium in- and efflux machineries reveal themselvesIlaria Drago
Department of Biomedical Sciences, University of Padova, Padova, Italy
EMBO J 30:4119-25. 2011.... - Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis productsMichela Rigoni
Department of Biomedical Sciences and Consiglio Nazionale Ricerche Institute of Neuroscience, University of Padova, 35121 Padova, Italy
J Biol Chem 282:11238-45. 2007..These results complete the picture of events occurring at nerve terminals intoxicated by SPANs and define the LysoPC+FA lipid mixture as a novel and effective agonist of synaptic vesicle release... - The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular storesGiancarlo Zatti
Department of Biomedical Sciences, University of Padova, Italy
Neurobiol Dis 15:269-78. 2004..No significant difference was however found in CCE between FAD and control fibroblasts. Similar results were obtained in two cell lines (HEK293 and HeLa) stably or transiently expressing the PS2 M239I mutation... - Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?Enrico Zampese
Department of Biomedical Sciences, University of Padova, Italy
Cell Mol Life Sci 69:1077-104. 2012.... - Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2Maulilio J Kipanyula
Department of Biomedical Sciences, University of Padua, Padua, Italy
Aging Cell 11:885-93. 2012..A model is described that integrates into a unifying hypothesis the contradictory effects on Ca2+ homeostasis of different PS mutations and points to the relevance of these findings in neurodegeneration and aging... - Lymphocyte lipid rafts: structure and functionPaola Pizzo
Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
Curr Opin Immunol 15:255-60. 2003.... - H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging systemAlex Costa
Dipartimento di Biologia, Universita degli Studi di Padova, Via U Bassi 58 B, 35131 Padova, Italy
Plant J 62:760-72. 2010..These analyses allowed us to demonstrate that an intraperoxisomal Ca2+ rise in vivo stimulates catalase activity, increasing peroxisomal H2O2 scavenging efficiency... - Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damageGiovanna Pontarin
Department of Biology, University of Padova, 35131 Padova, Italy
Proc Natl Acad Sci U S A 105:17801-6. 2008.... - Lipid rafts and T cell receptor signaling: a critical re-evaluationPaola Pizzo
Department of Biomedical Sciences, University of Padova, Padova, Italy
Eur J Immunol 32:3082-91. 2002..These results indicate that, while signaling through GPI-anchored proteins requires lipid raft integrity, CD3-dependent TCR activation occurs independently of cholesterol extraction... - High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's diseaseCristina Florean
Department Biomedical Sciences and CNR Institute of Neuroscience, University of Padua, Via G Colombo, 3, 35121 Padua, Italy
Biochim Biophys Acta 1783:1551-60. 2008.... - Paradoxical Ca2+ rises induced by low external Ca2+ in rat hippocampal neuronesAndrea Burgo
Department of Biomedical Sciences, University of Padua, Via G. Colombo 3, 35121 Padua, Italy
J Physiol 549:537-52. 2003..A model is presented to explain how this response is elicited by contemporaneous reduction of the [Ca2+]o and metabotropic receptor stimulation; implications for the pathophysiology of the CNS are also discussed... - Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene productsAlessandra Gamberucci
Dipartimento di Fisiopatologia e Medicina Sperimentale, Universita di Siena, Viale A Moro no 1, 53100 Siena, Italy
Biochem J 364:245-54. 2002..We conclude that T-cells express a diacylglycerol-activated cation channel, unrelated to the channel involved in capacitative Ca(2+) entry, and associated with the expression of TRP6 protein...