Paola Pizzo

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Lipid rafts in lymphocyte activation
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I 35121, Italy
    Microbes Infect 6:686-92. 2004
  2. doi request reprint Ca(2+) signalling in the Golgi apparatus
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Italy
    Cell Calcium 50:184-92. 2011
  3. ncbi request reprint Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics
    Paola Pizzo
    Department Biomedical Sciences, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
    Trends Cell Biol 17:511-7. 2007
  4. ncbi request reprint Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia
    Marta Giacomello
    Department of Biomedical Sciences, University of Padova, Via G Colombo, 3, 35121 Padova, Italy
    Neurobiol Dis 18:638-48. 2005
  5. ncbi request reprint Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels
    Giancarlo Zatti
    Department of Biomedical Sciences, University of Padua, Italy
    Cell Calcium 39:539-50. 2006
  6. doi request reprint Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels
    Marta Giacomello
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Mol Cell 38:280-90. 2010
  7. doi request reprint Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
    Lucia Brunello
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    J Cell Mol Med 13:3358-69. 2009
  8. pmc Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk
    Enrico Zampese
    Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy
    Proc Natl Acad Sci U S A 108:2777-82. 2011
  9. doi request reprint Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2
    Maulilio J Kipanyula
    Department of Biomedical Sciences, University of Padua, Padua, Italy
    Aging Cell 11:885-93. 2012
  10. pmc Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment
    Valentina Lissandron
    Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy
    Proc Natl Acad Sci U S A 107:9198-203. 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Lipid rafts in lymphocyte activation
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I 35121, Italy
    Microbes Infect 6:686-92. 2004
    ..In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions...
  2. doi request reprint Ca(2+) signalling in the Golgi apparatus
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Italy
    Cell Calcium 50:184-92. 2011
    ....
  3. ncbi request reprint Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics
    Paola Pizzo
    Department Biomedical Sciences, University of Padua, Viale G Colombo 3, 35121 Padua, Italy
    Trends Cell Biol 17:511-7. 2007
    ....
  4. ncbi request reprint Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia
    Marta Giacomello
    Department of Biomedical Sciences, University of Padova, Via G Colombo, 3, 35121 Padova, Italy
    Neurobiol Dis 18:638-48. 2005
    ..A similar Ca2+ alteration occurred in HeLa and HEK293 cells transiently expressing PS2-T122R. Based on these data, the "Ca2+ overload" hypothesis in AD pathogenesis is here discussed and reformulated...
  5. ncbi request reprint Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels
    Giancarlo Zatti
    Department of Biomedical Sciences, University of Padua, Italy
    Cell Calcium 39:539-50. 2006
    ..Taken as a whole, our findings, while confirming the capability of presenilins to modify Ca(2+) homeostasis, suggest a re-evaluation of the "Ca(2+) overload" hypothesis in AD and a new working hypothesis is presented...
  6. doi request reprint Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels
    Marta Giacomello
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Mol Cell 38:280-90. 2010
    ..These results demonstrate that mitochondria are exposed to Ca(2+) hot spots close to the ER but are excluded from the regions where capacitative Ca(2+) influx occurs...
  7. doi request reprint Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake
    Lucia Brunello
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    J Cell Mol Med 13:3358-69. 2009
    ..To exert this newly described function, PS2 needs to be in its full-length form, even if it can subsequently be cleaved...
  8. pmc Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk
    Enrico Zampese
    Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy
    Proc Natl Acad Sci U S A 108:2777-82. 2011
    ..We also discuss the importance of this additional effect of FAD-linked PS2 mutants for the understanding of FAD pathogenesis...
  9. doi request reprint Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2
    Maulilio J Kipanyula
    Department of Biomedical Sciences, University of Padua, Padua, Italy
    Aging Cell 11:885-93. 2012
    ..A model is described that integrates into a unifying hypothesis the contradictory effects on Ca2+ homeostasis of different PS mutations and points to the relevance of these findings in neurodegeneration and aging...
  10. pmc Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment
    Valentina Lissandron
    Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy
    Proc Natl Acad Sci U S A 107:9198-203. 2010
    ....
  11. ncbi request reprint Physiological T cell activation starts and propagates in lipid rafts
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
    Immunol Lett 91:3-9. 2004
    ..Moreover, T cell stimulation by pulsed EBV-B cells, but not by anti-CD3 antibodies, induced recruitment of active Lck in detergent-resistant membranes, where the signal transduction is organized and amplified...
  12. doi request reprint Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificities
    Paola Pizzo
    Department of Biomedical Sciences, University of Padua, Padua, Italy
    Pflugers Arch 464:3-17. 2012
    ..In this review, we summarize the processes involved in mitochondrial Ca²⁺ handling and its integration in cell physiology, highlighting the main common characteristics as well as key differences, in different tissues...
  13. doi request reprint Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cells
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    J Cell Mol Med 14:970-81. 2010
    ..Therefore, a brief exposure to curcumin induces a delayed cytoprotection against oxidative stress in myogenic cells by increasing Grp94 protein level, which acts as a regulator of calcium homeostasis...
  14. ncbi request reprint Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products
    Michela Rigoni
    Department of Biomedical Sciences and Consiglio Nazionale Ricerche Institute of Neuroscience, University of Padova, 35121 Padova, Italy
    J Biol Chem 282:11238-45. 2007
    ..These results complete the picture of events occurring at nerve terminals intoxicated by SPANs and define the LysoPC+FA lipid mixture as a novel and effective agonist of synaptic vesicle release...
  15. pmc After half a century mitochondrial calcium in- and efflux machineries reveal themselves
    Ilaria Drago
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    EMBO J 30:4119-25. 2011
    ....
  16. ncbi request reprint The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores
    Giancarlo Zatti
    Department of Biomedical Sciences, University of Padova, Italy
    Neurobiol Dis 15:269-78. 2004
    ..No significant difference was however found in CCE between FAD and control fibroblasts. Similar results were obtained in two cell lines (HEK293 and HeLa) stably or transiently expressing the PS2 M239I mutation...
  17. doi request reprint Heterogeneity of Ca2+ handling among and within Golgi compartments
    Andrea K C Wong
    Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy
    J Mol Cell Biol 5:266-76. 2013
    ..The functional role of such micro-heterogeneity in GA Ca(2+) handling is discussed. ..
  18. doi request reprint Intracellular organelles in the saga of Ca2+ homeostasis: different molecules for different purposes?
    Enrico Zampese
    Department of Biomedical Sciences, University of Padova, Italy
    Cell Mol Life Sci 69:1077-104. 2012
    ....
  19. ncbi request reprint Lymphocyte lipid rafts: structure and function
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
    Curr Opin Immunol 15:255-60. 2003
    ....
  20. pmc H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system
    Alex Costa
    Dipartimento di Biologia, Universita degli Studi di Padova, Via U Bassi 58 B, 35131 Padova, Italy
    Plant J 62:760-72. 2010
    ..These analyses allowed us to demonstrate that an intraperoxisomal Ca2+ rise in vivo stimulates catalase activity, increasing peroxisomal H2O2 scavenging efficiency...
  21. pmc Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage
    Giovanna Pontarin
    Department of Biology, University of Padova, 35131 Padova, Italy
    Proc Natl Acad Sci U S A 105:17801-6. 2008
    ....
  22. ncbi request reprint Lipid rafts and T cell receptor signaling: a critical re-evaluation
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Eur J Immunol 32:3082-91. 2002
    ..These results indicate that, while signaling through GPI-anchored proteins requires lipid raft integrity, CD3-dependent TCR activation occurs independently of cholesterol extraction...
  23. doi request reprint High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease
    Cristina Florean
    Department Biomedical Sciences and CNR Institute of Neuroscience, University of Padua, Via G Colombo, 3, 35121 Padua, Italy
    Biochim Biophys Acta 1783:1551-60. 2008
    ....
  24. pmc Paradoxical Ca2+ rises induced by low external Ca2+ in rat hippocampal neurones
    Andrea Burgo
    Department of Biomedical Sciences, University of Padua, Via G Colombo 3, 35121 Padua, Italy
    J Physiol 549:537-52. 2003
    ..A model is presented to explain how this response is elicited by contemporaneous reduction of the [Ca2+]o and metabotropic receptor stimulation; implications for the pathophysiology of the CNS are also discussed...
  25. pmc Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products
    Alessandra Gamberucci
    Dipartimento di Fisiopatologia e Medicina Sperimentale, Universita di Siena, Viale A Moro no 1, 53100 Siena, Italy
    Biochem J 364:245-54. 2002
    ..We conclude that T-cells express a diacylglycerol-activated cation channel, unrelated to the channel involved in capacitative Ca(2+) entry, and associated with the expression of TRP6 protein...