Research Topics
Genomes and Genes | Marina PizziSummaryAffiliation: University of Brescia Country: Italy Publications
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Publications
Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerabilityMarina Pizzi
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Italy
FEBS J 276:27-35. 2009..We present, in this report, the latest findings and consider the therapeutic potential of targeting different NF-kappaB dimers to limit ischemia-associated neurodegeneration...
NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicityM Pizzi
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, 25123 Brescia, Italy
Cell Death Differ 12:761-72. 2005..These data demonstrate that mGlu5 receptor activation promotes a c-Rel-dependent antiapoptotic pathway responsible for neuroprotection against Abeta peptide...- Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slicesMarina Pizzi
Department of Biomedical Sciences and Biotechnologies, University of Brescia, 25123 Brescia, Italy
Mol Cell Neurosci 25:301-11. 2004..Our results suggest that IL-6 and IL6RIL6 may prove to be valuable in treating neurodegenerative and demyelinating diseases... - Inhibition of IkappaBalpha phosphorylation prevents glutamate-induced NF-kappaB activation and neuronal cell deathM Pizzi
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, Brescia, Italy
Acta Neurochir Suppl 93:59-63. 2005..Our results suggest that BAY 11-7082 preserves neuron viability from the glutamate-mediated injury... - Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell lineMarina Pizzi
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, 25123 Brescia, Italy
Eur J Neurosci 16:2342-50. 2002..These data suggest that SK-N-SH cells differentiated by brief treatment with RA may represent an unlimited source of neuron-like cells suitable for studying molecular events associated with activation of human NR1/NR2B receptors... - Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanismsMarina Pizzi
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, I 25123, Italy
Eur J Pharmacol 545:22-8. 2006..We here discuss the latest findings and consider the therapeutic potential of targeting distinct NF-kappaB complexes for the treatment of neurodegenerative disorders and memory dysfunctions... - Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1betaMarina Pizzi
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, 25123 Brescia, Italy
J Biol Chem 277:20717-23. 2002..These findings suggest that, within a single neuron, the balance between cell death and survival in response to external stimuli may rely on the activation of distinct NF-kappaB/Rel proteins... - Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult ratM Pizzi
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Brescia, Italy
Neuropharmacology 39:903-10. 2000..This was despite being localized differently and, possibly, activating different neuroprotective pathways... - Reversal of glutamate excitotoxicity by activation of PKC-associated metabotropic glutamate receptors in cerebellar granule cells relies on NR2C subunit expressionM Pizzi
Division of Pharmacology, Department of Biomedical Sciences, School of Medicine, University of Brescia, Italy
Eur J Neurosci 11:2489-96. 1999..Particularly, expression of the NR2C subunit is required to make the NMDA receptor sensitive to inhibitory modulation by mGluRs or PKC activation... - Neuroprotective effect of thyrotropin-releasing hormone against excitatory amino acid-induced cell death in hippocampal slicesM Pizzi
Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Italy
Eur J Pharmacol 370:133-7. 1999..TRH concentration dependently reduced NMDA toxicity by a mechanism that was highly sensitive to the protein kinase C blocker, bisindolilmaleimide. Delayed application of TRH, during NMDA exposure, still produced neuroprotection... - NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemiaIlenia Sarnico
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Viale Europa 11, Brescia, Italy
J Neurochem 108:475-85. 2009..Selective targeting of different dimers will unravel new approaches to limit ischaemia-associated apoptosis... - Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-kappaB/c-Rel-dependent transcriptionAlessandra Valerio
Department of Biomedical Sciences and Biotechnologies, Division of Pharmacology, University of Brescia, Brescia, Italy
Stroke 40:610-7. 2009..We tested the hypothesis that leptin might act as an endogenous mediator of recovery after ischemic stroke and investigated whether nuclear transcription factors kappaB activation is involved in leptin-mediated neuroprotection... - Soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro differentiation of purified rat oligodendroglial lineage cellsAlessandra Valerio
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, University of Brescia, 25123 Brescia, Italy
Mol Cell Neurosci 21:602-15. 2002.... - NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 productionAlessandra Valerio
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy
Eur J Neurosci 23:1711-20. 2006..These results open up interesting perspectives on the development of novel strategies targeting out NF-kappaB p50/p65 dimers for pharmacological intervention in AD... - NF-kappaB dimers in the regulation of neuronal survivalIlenia Sarnico
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Brescia 25123, Italy
Int Rev Neurobiol 85:351-62. 2009.... - Blockade of the tumor necrosis factor-related apoptosis inducing ligand death receptor DR5 prevents beta-amyloid neurotoxicityDaniela Uberti
Department of Biomedical Sciences and Biotechnologies, University of Brescia Medical School, Brescia, Italy
Neuropsychopharmacology 32:872-80. 2007..Thus, these findings may give intracellular TRAIL pathway a role in AD pathophysiology, making DR5 receptor a possible candidate as a pharmacological target... - Spinal cord mGlu1a receptors: possible target for amyotrophic lateral sclerosis therapyAlessandra Valerio
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, Brescia University School of Medicine, Via Valsabbina 19, Brescia, Italy
Pharmacol Biochem Behav 73:447-54. 2002..Surviving motor neurons from ALS spinal cord still revealed the presence of mGlu1a at levels comparable to that from controls. We suggest that mGlu1a receptors may act as suitable targets for ALS experimental therapies... 
1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310Rosaria Ingrassia
Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Brescia, Italy
PLoS ONE 7:e38019. 2012....- The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's diseaseAnnamaria Lanzillotta
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia and Istituto Nazionale di Neuroscienze Brescia, Italy
J Mol Neurosci 45:22-31. 2011..Our data show that the novel γ-secretase modulator CHF5074 can fully reverse β-amyloid-associated tau pathology, thus representing a promising therapeutic agent for AD... - Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3betaAlessandra Valerio
Center for Study and Research on Obesity, School of Medicine, University of Milan, 20129 Milan, Italy
J Biol Chem 281:12950-8. 2006..We concluded that the leptin-mediated regulation of growth cone morphogenesis in cortical neurons relies on upstream regulators of GSK3beta activity... - NF-κB and epigenetic mechanisms as integrative regulators of brain resilience to anoxic stressIlenia Sarnico
Department of Biomedical Sciences and Biotechnologies, University of Brescia and Istituto Nazionale di Neuroscienze, Italy
Brain Res 1476:203-10. 2012..This article is part of a Special Issue entitled: Brain Integration... - Activation of NF-kappaB p65/c-Rel dimer is associated with neuroprotection elicited by mGlu5 receptor agonists against MPP(+) toxicity in SK-N-SH cellsI Sarnico
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Brescia, Italy
J Neural Transm 115:669-76. 2008..It is suggested that mGlu5 receptor agonists through activation of a c-Rel-dependent anti-apoptotic pathway can rescue dopaminergic cell from mitochondrial toxicity... - Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic windowAnnamaria Lanzillotta
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies and National Institute of Neuroscience, School of Medicine, University of Brescia, Italy
Neurobiol Dis 49:177-189. 2012..CONCLUSION: Our study reveals that epigenetic therapy shaping acetylation of both RelA and histones may be a promising strategy to limit post-ischemic injury with an extended therapeutic window... - Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytesI Sarnico
Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Brescia, Italy
J Neural Transm 115:693-701. 2008..Our results suggest that AS602868 may prove to be a valuable approach in treating neurodegeneration and demyelination associated with cerebral trauma and ischemia... - Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activationM Grilli
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, University of Brescia Medical School, Brescia, I 25123 Italy
Science 274:1383-5. 1996..These results may contribute to the emerging theme of anti-inflammatory drugs and neurodegeneration... - Late-onset Parkinsonism in NFκB/c-Rel-deficient miceCristina Baiguera
Department of Biomedical Sciences and Biotechnologies, University of Brescia and National Institute of Neuroscience, 25123 Brescia, Italy
Brain 135:2750-65. 2012..These data suggest that c-Rel may act as a regulator of the substantia nigra pars compacta resilience to ageing and that aged c-rel(-/-) mice may be a suitable model of Parkinson's disease... - Glutamatergic reinnervation through peripheral nerve graft dictates assembly of glutamatergic synapses at rat skeletal muscleGiorgio Brunelli
Foundation for Experimental Spinal Cord Research, School of Medicine, University of Brescia, 25123 Brescia, Italy
Proc Natl Acad Sci U S A 102:8752-7. 2005..Our data suggest that supraspinal neurons can target skeletal muscle, which retains the plasticity to generate functional glutamatergic NMJ... - The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slicesF Goffi
Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, Viale Europa, 11, 25123 Brescia, Italy
Neurosci Lett 377:147-51. 2005.... - Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemiaIoana Inta
Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany
J Neurosci 26:12896-903. 2006..Thus, the deleterious function in cerebral ischemia is specific for the NF-kappaB subunit RelA and may be mediated through Bim and Noxa... - A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-relJonathan M Levenson
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 24:3933-43. 2004..Using a knock-out mouse, we found that c-rel, one of the transcription factors identified in our bioinformatics study, is necessary for hippocampus-dependent long-term memory formation... - Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptorsKenneth J O'Riordan
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 26:4870-9. 2006.... - Glutamatergic innervation of rat skeletal muscle by supraspinal neurons: a new paradigm in spinal cord injury repairMarina Pizzi
Divisions of Pharmacology and Experimental Therapeutics, Italy
Curr Opin Neurobiol 16:323-8. 2006..These data demonstrate that under appropriate surgical manipulation supraspinal neurons can directly target muscle fibres and specify the postsynaptic receptors to achieve a functional glutamatergic NMJ...