Roberta Piva

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. ncbi request reprint Modulation of estrogen receptor gene transcription in breast cancer cells by liposome delivered decoy molecules
    R Piva
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Ferrara, Via Luigi Borsari, 46 44100 Ferrara, Italy
    J Steroid Biochem Mol Biol 75:121-8. 2000
  2. pmc Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells
    Elisabetta Lambertini
    Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 44121, Italy
    BMC Cancer 12:445. 2012
  3. ncbi request reprint Methylation analysis of the promoter F of estrogen receptor alpha gene: effects on the level of transcription on human osteoblastic cells
    Letizia Penolazzi
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via L Borsari, 46 44100, Italy
    J Steroid Biochem Mol Biol 91:1-9. 2004
  4. doi request reprint Transcription factor decoy against NFATc1 in human primary osteoblasts
    Letizia Penolazzi
    Dipartimento di Biochimica e Biologia Molecolare, Sezione di Biologia Molecolare, Universita degli Studi di Ferrara, Ferrara, Italy
    Int J Mol Med 28:199-206. 2011
  5. ncbi request reprint Expression of estrogen receptor alpha gene in breast cancer cells treated with transcription factor decoy is modulated by Bangladeshi natural plant extracts
    Elizabeth Lambertini
    ER GenTech, Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
    Oncol Res 15:69-79. 2005
  6. doi request reprint Slug contributes to the regulation of CXCL12 expression in human osteoblasts
    Roberta Piva
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via Fossato di Mortara, Ferrara, Italy
    Exp Cell Res 317:1159-68. 2011
  7. doi request reprint Role of Slug transcription factor in human mesenchymal stem cells
    Elena Torreggiani
    Dipartimento di Biochimica e Biologia Molecolare, Sezione di Biologia Molecolare, Universita degli Studi di Ferrara, Ferrara, Italy
    J Cell Mol Med 16:740-51. 2012
  8. pmc Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis
    Letizia Penolazzi
    BioPharmaNet, ER GenTech, Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
    BMC Complement Altern Med 8:59. 2008
  9. doi request reprint ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts
    Elisabetta Lambertini
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Ferrara, Italy
    J Cell Physiol 216:101-10. 2008
  10. doi request reprint Slug gene expression supports human osteoblast maturation
    Elisabetta Lambertini
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Via Fossato di Mortara, 74, 44100, Ferrara, Italy
    Cell Mol Life Sci 66:3641-53. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Modulation of estrogen receptor gene transcription in breast cancer cells by liposome delivered decoy molecules
    R Piva
    Dipartimento di Biochimica e Biologia Molecolare, Universita di Ferrara, Via Luigi Borsari, 46 44100 Ferrara, Italy
    J Steroid Biochem Mol Biol 75:121-8. 2000
    ..This information may be useful for a series of in vitro transfections and also for in vivo application of the decoy strategy that is a potential therapeutic tool to control disease-related genes such as ER gene in breast cancer...
  2. pmc Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells
    Elisabetta Lambertini
    Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 44121, Italy
    BMC Cancer 12:445. 2012
    ..Breast cancer and its metastatic progression is mainly directed by epithelial to mesenchymal transition (EMT), a phenomenon supported by specific transcription factors and miRNAs...
  3. ncbi request reprint Methylation analysis of the promoter F of estrogen receptor alpha gene: effects on the level of transcription on human osteoblastic cells
    Letizia Penolazzi
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via L Borsari, 46 44100, Italy
    J Steroid Biochem Mol Biol 91:1-9. 2004
    ..The overall results suggest that methylation of the CpG sites inside ERalpha gene promoter F here analyzed may contribute to ERalpha transcriptional control, directly or indirectly, influencing the tissue specific expression of the gene...
  4. doi request reprint Transcription factor decoy against NFATc1 in human primary osteoblasts
    Letizia Penolazzi
    Dipartimento di Biochimica e Biologia Molecolare, Sezione di Biologia Molecolare, Universita degli Studi di Ferrara, Ferrara, Italy
    Int J Mol Med 28:199-206. 2011
    ..At the same time, our data add important information on the regulation of the expression of ColXV, which only recently has been proposed as an osteoblastic marker...
  5. ncbi request reprint Expression of estrogen receptor alpha gene in breast cancer cells treated with transcription factor decoy is modulated by Bangladeshi natural plant extracts
    Elizabeth Lambertini
    ER GenTech, Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
    Oncol Res 15:69-79. 2005
    ....
  6. doi request reprint Slug contributes to the regulation of CXCL12 expression in human osteoblasts
    Roberta Piva
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via Fossato di Mortara, Ferrara, Italy
    Exp Cell Res 317:1159-68. 2011
    ....
  7. doi request reprint Role of Slug transcription factor in human mesenchymal stem cells
    Elena Torreggiani
    Dipartimento di Biochimica e Biologia Molecolare, Sezione di Biologia Molecolare, Universita degli Studi di Ferrara, Ferrara, Italy
    J Cell Mol Med 16:740-51. 2012
    ....
  8. pmc Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis
    Letizia Penolazzi
    BioPharmaNet, ER GenTech, Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
    BMC Complement Altern Med 8:59. 2008
    ..In this study we determined whether extracts of Emblica officinalis fruits display activity of possible interest for the treatment of rheumatoid arthritis and osteoporosis by activating programmed cell death of human primary osteoclasts...
  9. doi request reprint ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts
    Elisabetta Lambertini
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Ferrara, Italy
    J Cell Physiol 216:101-10. 2008
    ..Taken together, our findings support a model in which ERalpha/AP-1 complexes modulate F promoter activity under conditions of 17-beta-estradiol stimulation...
  10. doi request reprint Slug gene expression supports human osteoblast maturation
    Elisabetta Lambertini
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Via Fossato di Mortara, 74, 44100, Ferrara, Italy
    Cell Mol Life Sci 66:3641-53. 2009
    ..In summary, our results support the hypothesis that Slug functions as a novel regulator of osteoblast activity and may be considered a new factor required for osteoblast maturation...
  11. ncbi request reprint Peptide nucleic acid-DNA decoy chimeras targeting NF-kappaB transcription factors: Induction of apoptosis in human primary osteoclasts
    Letizia Penolazzi
    Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
    Int J Mol Med 14:145-52. 2004
    ..Our data suggest that PDP-based induction of osteoclast apoptosis could be a therapeutic approach for disorders in which bone resorption is inappropriately excessive...
  12. doi request reprint Human mesenchymal stem cells seeded on extracellular matrix-scaffold: viability and osteogenic potential
    Letizia Penolazzi
    Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
    J Cell Physiol 227:857-66. 2012
    ..Finally, we have also demonstrated that pUBM-scaffolds positively affect the expression of typical osteoblastic markers in hWJMSCs...
  13. pmc Influence of obstetric factors on osteogenic potential of umbilical cord-derived mesenchymal stem cells
    Letizia Penolazzi
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Italy
    Reprod Biol Endocrinol 7:106. 2009
    ..Even if further evaluation is required, our hypothesis is that our findings may help in selecting the optimal umbilical cord donors and in collecting high potential Wharton's jelly-derived osteoprogenitors efficiently...
  14. doi request reprint Human osteoclasts differentiated from umbilical cord blood precursors are less prone to apoptotic stimuli than osteoclasts from peripheral blood
    Letizia Penolazzi
    Molecular Biology Section, Department of Biochemistry and Molecular Biology, Ferrara University, Via Fossato di Mortara, 74, Ferrara, 44100, Italy
    Apoptosis 13:553-61. 2008
    ..Therefore, our evidences are to be taken in consideration when both the effects of biological modifiers are tested and OCs apoptosis molecular mechanisms are investigated...
  15. pmc Expression of the human oestrogen receptor-alpha gene is regulated by promoter F in MG-63 osteoblastic cells
    Elisabetta Lambertini
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via L Borsari 46, Italy
    Biochem J 372:831-9. 2003
    ..These data provide evidence for different promoter usage of the ERalpha gene through the recruitment of tissue-specific transcription activators and co-regulators...
  16. doi request reprint Nuclear proteome analysis reveals a role of Vav1 in modulating RNA processing during maturation of tumoral promyelocytes
    Valeria Bertagnolo
    Signal Transduction Unit, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Italy
    J Proteomics 75:398-409. 2011
    ..Since defects in mRNA processing are common in tumor development, our data suggest that Vav1 is a potential target molecule for developing new anti-cancer strategies...
  17. doi request reprint Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation
    Federica Brugnoli
    Signal Transduction Unit Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, 44100 Ferrara, Italy
    Exp Cell Res 316:38-47. 2010
    ..1 to its consensus sequence on the CD11b promoter and, ultimately, in regulating CD11b expression during the late stages of neutrophil differentiation of APL-derived promyelocytes...
  18. doi request reprint Apoptosis of human primary osteoclasts treated with molecules targeting nuclear factor-kappaB
    Roberta Piva
    BioPharmaNet, Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
    Ann N Y Acad Sci 1171:448-56. 2009
    ..This might explain the observed effects of E. officinalis on the expression levels of IL-6, an NF-kappaB-specific target gene. We suggest the application of natural products as an alternative tool for therapy applied to bone diseases...
  19. ncbi request reprint Transcription Factor Decoy (TFD) as a novel approach for the control of osteoclastic resorption
    Mauro Cozzani
    Department of Orthodontics, School of Dentistry, University of Ferrara, Ferrara, Italy
    Prog Orthod 6:238-47. 2005
  20. ncbi request reprint Induction of estrogen receptor alpha expression with decoy oligonucleotide targeted to NFATc1 binding sites in osteoblasts
    Letizia Penolazzi
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, Ferrara, Italy
    Mol Pharmacol 71:1457-62. 2007
    ..Therefore, our data might be useful for proper manipulation of NFATc1- and ERalpha-mediated cellular reactions in different bone disorders, such as osteoporosis...
  21. pmc SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts
    Elisabetta Lambertini
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Via Fossato di Mortara, 74, 44100 Ferrara, Ferrara, Italy
    BMC Mol Biol 11:13. 2010
    ..In this study we investigated SLUG expression in normal human osteoblasts and their mesenchymal precursors, and its possible correlation with Lef-1 and Wnt/beta-catenin signalling...
  22. ncbi request reprint Local in vivo administration of a decoy oligonucleotide targeting NF-kappaB induces apoptosis of osteoclasts after application of orthodontic forces to rat teeth
    Letizia Penolazzi
    ER GenTech, Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Ferrara, Italy
    Int J Mol Med 18:807-11. 2006
    ....
  23. ncbi request reprint N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclasts
    Letizia Penolazzi
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, 44100, Ferrara, Italy
    J Biomed Sci 12:1013-20. 2005
    ....
  24. ncbi request reprint Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells
    Gianluca Aguiari
    Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
    FASEB J 18:884-6. 2004
    ..Therefore, PC2 and PC1 are functionally expressed in LCLs, which provide a model, easily obtainable from ADPKD patients, to study PKD gene expression and function...
  25. ncbi request reprint Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene
    Elisabetta Lambertini
    Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
    Int J Oncol 24:419-23. 2004
    ..Since activation of ERalpha gene expression could have clinical impact, our results suggest a possible use of extracts from medicinal plants to identify compounds of possible interest in the treatment of breast cancer...
  26. ncbi request reprint Evaluation of chemokine and cytokine profiles in osteoblast progenitors from umbilical cord blood stem cells by BIO-PLEX technology
    Letizia Penolazzi
    Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Via Fossato di Mortara, 74, Ferrara, Italy
    Cell Biol Int 32:320-5. 2008
    ..These findings should encourage the use of human umbilical cord blood as a potential stem cells source for bone regeneration...
  27. doi request reprint Optimised production of multifunctional microfibres by microfluidic chip technology for tissue engineering applications
    Stefania Mazzitelli
    Department of Biochemistry and Molecular Biology, University of Ferrara, Via F Mortara 74, Ferrara, 44121, Italy
    Lab Chip 11:1776-85. 2011
    ..We provide an approach for the production of alginate microfibres with controlled shape and content, which could be further developed for scaling up and working towards FDA approval...
  28. doi request reprint Encapsulation of mesenchymal stem cells from Wharton's jelly in alginate microbeads
    Letizia Penolazzi
    Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
    Tissue Eng Part C Methods 16:141-55. 2010
    ..In conclusion, the described encapsulation procedure represents a promising strategy to utilize WJMSCs for possible in vivo applications in tissue engineering and biomedicine...
  29. doi request reprint Sex hormone receptor levels in laryngeal carcinoma: a comparison between protein and RNA evaluations
    Chiara Bianchini
    ORL Division, University of Ferrara, Ferrara, Italy
    Eur Arch Otorhinolaryngol 265:1089-94. 2008
    ..A strict correspondence between protein and mRNA hormone receptor levels was not found. This is in agreement with the transcriptional and protein synthesis mechanisms, and it is also compatible with the complex larynx tumorigenesis...
  30. ncbi request reprint Transcription factor decoy (TFD) in breast cancer research and treatment
    Roberta Piva
    Department of Biochemistry and Molecular Biology, Ferrara University, Via Luigi Borsari, 46, 44100 Ferrara, Italy
    Technol Cancer Res Treat 1:405-16. 2002
    ..In the future, transcription factors regulating cell cycle, hormone-dependent differentiation, tumor invasion and metastasis are expected to be suitable targets for transcription factor decoy...
  31. ncbi request reprint Osteoblastic differentiation induced by transcription factor decoy against estrogen receptor alpha gene
    Elisabetta Lambertini
    Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
    Biochem Biophys Res Commun 292:761-70. 2002
    ..The augmentation of ER alpha and ER beta expression by the decoy approach may offer a further possibility for patient response to estrogenic therapy in the treatment of diseases related to estrogen deficiency...
  32. ncbi request reprint Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: induction of apoptosis in human primary osteoclasts
    Letizia Penolazzi
    Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
    Biochem Pharmacol 66:1189-98. 2003
    ..We consider these data as the basis for setting up experimental conditions allowing nonviral gene therapy of several bone disorders...
  33. doi request reprint Targeted therapy in head and neck cancer
    Chiara Bianchini
    ENT Department, University Hospital of Ferrara, Ferrara, Italy
    Tumori 97:137-41. 2011
    ..e., non-Hodgkin's lymphomas) antibodies specifically designed to target tumor-specific cells have already been introduced, in solid tumors molecular targeted therapy is now entering clinical practice...
  34. ncbi request reprint Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells
    Gianluca Aguiari
    Department of Biochemistry and Molecular Biology, Section of General Pathology, University of Ferrara, Italy
    Biochem Biophys Res Commun 301:657-64. 2003
    ..These observations indicate that the C-terminal tail of PC1 in kidney and other epithelial cells upregulates a Ca(2+) channel activity also involved in the release of intracellular stores...
  35. doi request reprint From microRNA functions to microRNA therapeutics: Novel targets and novel drugs in breast cancer research and treatment (Review)
    Roberta Piva
    Department of Biomedical and Specialty Surgical Sciences, Ferrara University, Ferrara, Italy
    Int J Oncol 43:985-94. 2013
    ..Interference with this process can be achieved using antisense miRNA (antagomiR) molecules targeting miR-221, inducing the downregulation of Slug and the upregulation of p27Kip1. ..