Research Topics
Genomes and GenesSpecies | Roberta PivaSummaryAffiliation: University of Ferrara Country: Italy Publications
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Detail Information
Publications
Modulation of estrogen receptor gene transcription in breast cancer cells by liposome delivered decoy moleculesR Piva
Dipartimento di Biochimica e Biologia Molecolare, Universita di Ferrara, Via Luigi Borsari, 46 44100 Ferrara, Italy
J Steroid Biochem Mol Biol 75:121-8. 2000..This information may be useful for a series of in vitro transfections and also for in vivo application of the decoy strategy that is a potential therapeutic tool to control disease-related genes such as ER gene in breast cancer...
Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cellsElisabetta Lambertini
Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara, 44121, Italy
BMC Cancer 12:445. 2012..Breast cancer and its metastatic progression is mainly directed by epithelial to mesenchymal transition (EMT), a phenomenon supported by specific transcription factors and miRNAs...- Methylation analysis of the promoter F of estrogen receptor alpha gene: effects on the level of transcription on human osteoblastic cellsLetizia Penolazzi
Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via L Borsari, 46 44100, Italy
J Steroid Biochem Mol Biol 91:1-9. 2004..The overall results suggest that methylation of the CpG sites inside ERalpha gene promoter F here analyzed may contribute to ERalpha transcriptional control, directly or indirectly, influencing the tissue specific expression of the gene... 
Transcription factor decoy against NFATc1 in human primary osteoblastsLetizia Penolazzi
Dipartimento di Biochimica e Biologia Molecolare, Sezione di Biologia Molecolare, Universita degli Studi di Ferrara, Ferrara, Italy
Int J Mol Med 28:199-206. 2011..At the same time, our data add important information on the regulation of the expression of ColXV, which only recently has been proposed as an osteoblastic marker...- Expression of estrogen receptor alpha gene in breast cancer cells treated with transcription factor decoy is modulated by Bangladeshi natural plant extractsElizabeth Lambertini
ER GenTech, Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
Oncol Res 15:69-79. 2005.... - ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblastsElisabetta Lambertini
Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Ferrara, Italy
J Cell Physiol 216:101-10. 2008..Taken together, our findings support a model in which ERalpha/AP-1 complexes modulate F promoter activity under conditions of 17-beta-estradiol stimulation... - Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalisLetizia Penolazzi
BioPharmaNet, ER GenTech, Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
BMC Complement Altern Med 8:59. 2008..In this study we determined whether extracts of Emblica officinalis fruits display activity of possible interest for the treatment of rheumatoid arthritis and osteoporosis by activating programmed cell death of human primary osteoclasts... - Slug gene expression supports human osteoblast maturationElisabetta Lambertini
Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Via Fossato di Mortara, 74, 44100, Ferrara, Italy
Cell Mol Life Sci 66:3641-53. 2009..In summary, our results support the hypothesis that Slug functions as a novel regulator of osteoblast activity and may be considered a new factor required for osteoblast maturation... - Peptide nucleic acid-DNA decoy chimeras targeting NF-kappaB transcription factors: Induction of apoptosis in human primary osteoclastsLetizia Penolazzi
Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
Int J Mol Med 14:145-52. 2004..Our data suggest that PDP-based induction of osteoclast apoptosis could be a therapeutic approach for disorders in which bone resorption is inappropriately excessive... - Slug contributes to the regulation of CXCL12 expression in human osteoblastsRoberta Piva
Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via Fossato di Mortara, Ferrara, Italy
Exp Cell Res 317:1159-68. 2011.... - Role of Slug transcription factor in human mesenchymal stem cellsElena Torreggiani
Dipartimento di Biochimica e Biologia Molecolare, Sezione di Biologia Molecolare, Universita degli Studi di Ferrara, Ferrara, Italy
J Cell Mol Med 16:740-51. 2012.... - Influence of obstetric factors on osteogenic potential of umbilical cord-derived mesenchymal stem cellsLetizia Penolazzi
Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Italy
Reprod Biol Endocrinol 7:106. 2009..Even if further evaluation is required, our hypothesis is that our findings may help in selecting the optimal umbilical cord donors and in collecting high potential Wharton's jelly-derived osteoprogenitors efficiently... - Human mesenchymal stem cells seeded on extracellular matrix-scaffold: viability and osteogenic potentialLetizia Penolazzi
Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
J Cell Physiol 227:857-66. 2012..Finally, we have also demonstrated that pUBM-scaffolds positively affect the expression of typical osteoblastic markers in hWJMSCs... - Human osteoclasts differentiated from umbilical cord blood precursors are less prone to apoptotic stimuli than osteoclasts from peripheral bloodLetizia Penolazzi
Molecular Biology Section, Department of Biochemistry and Molecular Biology, Ferrara University, Via Fossato di Mortara, 74, Ferrara, 44100, Italy
Apoptosis 13:553-61. 2008..Therefore, our evidences are to be taken in consideration when both the effects of biological modifiers are tested and OCs apoptosis molecular mechanisms are investigated... - Transcription Factor Decoy (TFD) as a novel approach for the control of osteoclastic resorptionMauro Cozzani
Department of Orthodontics, School of Dentistry, University of Ferrara, Ferrara, Italy
Prog Orthod 6:238-47. 2005 - Nuclear proteome analysis reveals a role of Vav1 in modulating RNA processing during maturation of tumoral promyelocytesValeria Bertagnolo
Signal Transduction Unit, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, Italy
J Proteomics 75:398-409. 2011..Since defects in mRNA processing are common in tumor development, our data suggest that Vav1 is a potential target molecule for developing new anti-cancer strategies... - Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiationFederica Brugnoli
Signal Transduction Unit Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, 44100 Ferrara, Italy
Exp Cell Res 316:38-47. 2010..1 to its consensus sequence on the CD11b promoter and, ultimately, in regulating CD11b expression during the late stages of neutrophil differentiation of APL-derived promyelocytes... - Apoptosis of human primary osteoclasts treated with molecules targeting nuclear factor-kappaBRoberta Piva
BioPharmaNet, Department of Biochemistry and Molecular Biology, Ferrara University, Ferrara, Italy
Ann N Y Acad Sci 1171:448-56. 2009..This might explain the observed effects of E. officinalis on the expression levels of IL-6, an NF-kappaB-specific target gene. We suggest the application of natural products as an alternative tool for therapy applied to bone diseases... - Induction of estrogen receptor alpha expression with decoy oligonucleotide targeted to NFATc1 binding sites in osteoblastsLetizia Penolazzi
Department of Biochemistry and Molecular Biology, Molecular Biology Section, Ferrara, Italy
Mol Pharmacol 71:1457-62. 2007..Therefore, our data might be useful for proper manipulation of NFATc1- and ERalpha-mediated cellular reactions in different bone disorders, such as osteoporosis... - Expression of the human oestrogen receptor-alpha gene is regulated by promoter F in MG-63 osteoblastic cellsElisabetta Lambertini
Dipartimento di Biochimica e Biologia Molecolare, , Via L. Borsari 46, Italy
Biochem J 372:831-9. 2003..These data provide evidence for different promoter usage of the ERalpha gene through the recruitment of tissue-specific transcription activators and co-regulators... - Local in vivo administration of a decoy oligonucleotide targeting NF-kappaB induces apoptosis of osteoclasts after application of orthodontic forces to rat teethLetizia Penolazzi
ER-GenTech, Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Ferrara, Italy
Int J Mol Med 18:807-11. 2006.... - N-Arylpiperazine modified analogues of the P2X7 receptor KN-62 antagonist are potent inducers of apoptosis of human primary osteoclastsLetizia Penolazzi
Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, 44100, Ferrara, Italy
J Biomed Sci 12:1013-20. 2005.... - SLUG: a new target of lymphoid enhancer factor-1 in human osteoblastsElisabetta Lambertini
Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Via Fossato di Mortara, 74, 44100 Ferrara, Ferrara, Italy
BMC Mol Biol 11:13. 2010..In this study we investigated SLUG expression in normal human osteoblasts and their mesenchymal precursors, and its possible correlation with Lef-1 and Wnt/beta-catenin signalling... - Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha geneElisabetta Lambertini
Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
Int J Oncol 24:419-23. 2004..Since activation of ERalpha gene expression could have clinical impact, our results suggest a possible use of extracts from medicinal plants to identify compounds of possible interest in the treatment of breast cancer... - Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cellsGianluca Aguiari
Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
FASEB J 18:884-6. 2004..Therefore, PC2 and PC1 are functionally expressed in LCLs, which provide a model, easily obtainable from ADPKD patients, to study PKD gene expression and function... - Encapsulation of mesenchymal stem cells from Wharton's jelly in alginate microbeadsLetizia Penolazzi
Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
Tissue Eng Part C Methods 16:141-55. 2010..In conclusion, the described encapsulation procedure represents a promising strategy to utilize WJMSCs for possible in vivo applications in tissue engineering and biomedicine... - Optimised production of multifunctional microfibres by microfluidic chip technology for tissue engineering applicationsStefania Mazzitelli
Department of Biochemistry and Molecular Biology, University of Ferrara, Via F Mortara 74, Ferrara, 44121, Italy
Lab Chip 11:1776-85. 2011..We provide an approach for the production of alginate microfibres with controlled shape and content, which could be further developed for scaling up and working towards FDA approval... - Evaluation of chemokine and cytokine profiles in osteoblast progenitors from umbilical cord blood stem cells by BIO-PLEX technologyLetizia Penolazzi
Department of Biochemistry and Molecular Biology, Molecular Biology Section, University of Ferrara, Via Fossato di Mortara, 74, Ferrara, Italy
Cell Biol Int 32:320-5. 2008..These findings should encourage the use of human umbilical cord blood as a potential stem cells source for bone regeneration... - Osteoblastic differentiation induced by transcription factor decoy against estrogen receptor alpha geneElisabetta Lambertini
Dipartimento di Biochimica e Biologia Molecolare, Universita degli Studi di Ferrara, Via L Borsari 46, 44100 Ferrara, Italy
Biochem Biophys Res Commun 292:761-70. 2002..The augmentation of ER alpha and ER beta expression by the decoy approach may offer a further possibility for patient response to estrogenic therapy in the treatment of diseases related to estrogen deficiency... - Sex hormone receptor levels in laryngeal carcinoma: a comparison between protein and RNA evaluationsChiara Bianchini
ORL Division, University of Ferrara, Ferrara, Italy
Eur Arch Otorhinolaryngol 265:1089-94. 2008..A strict correspondence between protein and mRNA hormone receptor levels was not found. This is in agreement with the transcriptional and protein synthesis mechanisms, and it is also compatible with the complex larynx tumorigenesis... - Transcription factor decoy (TFD) in breast cancer research and treatmentRoberta Piva
Department of Biochemistry and Molecular Biology, Ferrara University, Via Luigi Borsari, 46, 44100 Ferrara, Italy
Technol Cancer Res Treat 1:405-16. 2002..In the future, transcription factors regulating cell cycle, hormone-dependent differentiation, tumor invasion and metastasis are expected to be suitable targets for transcription factor decoy... - Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: induction of apoptosis in human primary osteoclastsLetizia Penolazzi
Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy
Biochem Pharmacol 66:1189-98. 2003..We consider these data as the basis for setting up experimental conditions allowing nonviral gene therapy of several bone disorders... - Targeted therapy in head and neck cancerChiara Bianchini
ENT Department, University Hospital of Ferrara, Ferrara, Italy
Tumori 97:137-41. 2011..e., non-Hodgkin's lymphomas) antibodies specifically designed to target tumor-specific cells have already been introduced, in solid tumors molecular targeted therapy is now entering clinical practice... - Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cellsGianluca Aguiari
Department of Biochemistry and Molecular Biology, Section of General Pathology, University of Ferrara, Italy
Biochem Biophys Res Commun 301:657-64. 2003..These observations indicate that the C-terminal tail of PC1 in kidney and other epithelial cells upregulates a Ca(2+) channel activity also involved in the release of intracellular stores...