A Pisani

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Chronic cocaine prevents depotentiation at corticostriatal synapses
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 60:436-43. 2006
  2. pmc Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia
    Giuseppe Sciamanna
    Department of Neuroscience, University Tor Vergata, Rome, Italy
    PLoS ONE 6:e24261. 2011
  3. pmc Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry
    Francesca Puglisi
    Department of Systems Medicine, University of Rome Tor Vergata Laboratory of Neurophysiology and Synaptic Plasticity, Fondazione Santa Lucia, Rome, Italy
    PLoS ONE 8:e68063. 2013
  4. pmc Centrality of striatal cholinergic transmission in Basal Ganglia function
    Paola Bonsi
    Laboratory of Neurophysiology and Plasticity, Fondazione Santa Lucia IRCCS Rome, Italy
    Front Neuroanat 5:6. 2011
  5. pmc Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease
    Valerio Pisani
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    J Neuroinflammation 9:188. 2012
  6. pmc Neuroacanthocytosis associated with a defect of the 4.1R membrane protein
    Antonio Orlacchio
    Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, Rome, Italy
    BMC Neurol 7:4. 2007
  7. pmc Acanthocytosis as a predisposing factor for non-ketotic hyperglycaemia induced chorea-ballism
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurol Neurosurg Psychiatry 76:1717-9. 2005
  8. ncbi request reprint Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    A Pisani
    Clinica Neurologica, Dipartmento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 106:579-87. 2001
  9. ncbi request reprint Metabotropic glutamate 2 receptors modulate synaptic inputs and calcium signals in striatal cholinergic interneurons
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 22:6176-85. 2002
  10. ncbi request reprint Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 45:45-56. 2003

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Chronic cocaine prevents depotentiation at corticostriatal synapses
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 60:436-43. 2006
    ..A pathology of habit forming systems might underlie these features of addiction...
  2. pmc Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia
    Giuseppe Sciamanna
    Department of Neuroscience, University Tor Vergata, Rome, Italy
    PLoS ONE 6:e24261. 2011
    ..DYT1 dystonia, a severe form of genetically determined human dystonia, exhibits reduced penetrance among carriers and begins usually during adolescence. The reasons for such age dependence and variability remain unclear...
  3. pmc Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry
    Francesca Puglisi
    Department of Systems Medicine, University of Rome Tor Vergata Laboratory of Neurophysiology and Synaptic Plasticity, Fondazione Santa Lucia, Rome, Italy
    PLoS ONE 8:e68063. 2013
    ..Finally, TA was observed also in glial cells, a cellular population little explored so far. These results extend our knowledge on TA synaptic localization providing a clue to its potential role in synaptic development...
  4. pmc Centrality of striatal cholinergic transmission in Basal Ganglia function
    Paola Bonsi
    Laboratory of Neurophysiology and Plasticity, Fondazione Santa Lucia IRCCS Rome, Italy
    Front Neuroanat 5:6. 2011
    ..Based on converging experimental and clinical evidence, we provide an overview of the role of striatal cholinergic transmission in physiological and pathological conditions, in the context of the pathogenesis of movement disorders...
  5. pmc Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease
    Valerio Pisani
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    J Neuroinflammation 9:188. 2012
    ..Alterations in blood-brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson's disease progression. However, few studies have addressed this issue in patients at different stages of disease...
  6. pmc Neuroacanthocytosis associated with a defect of the 4.1R membrane protein
    Antonio Orlacchio
    Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, Rome, Italy
    BMC Neurol 7:4. 2007
    ..We report clinical, biochemical, and genetic features in four patients from four unrelated families with NA in order to explain the cause of morphological abnormalities and the relationship with neurodegenerative processes...
  7. pmc Acanthocytosis as a predisposing factor for non-ketotic hyperglycaemia induced chorea-ballism
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurol Neurosurg Psychiatry 76:1717-9. 2005
    ..Episodic non-ketotic hyperglycaemia in patients with diabetes may be responsible for a syndrome characterised by hemichorea-hemiballism associated with unique radiological features...
  8. ncbi request reprint Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    A Pisani
    Clinica Neurologica, Dipartmento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 106:579-87. 2001
    ....
  9. ncbi request reprint Metabotropic glutamate 2 receptors modulate synaptic inputs and calcium signals in striatal cholinergic interneurons
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 22:6176-85. 2002
    ..These results suggest that the mGlu2 receptor-mediated modulatory action on cell excitability would tune striatal ACh release, representing an interesting target for pharmacological intervention in basal ganglia disorders...
  10. ncbi request reprint Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 45:45-56. 2003
    ..The potential relevance of these findings in the control of motor function and in the treatment of PD will be discussed...
  11. ncbi request reprint Activation of beta1-adrenoceptors excites striatal cholinergic interneurons through a cAMP-dependent, protein kinase-independent pathway
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    J Neurosci 23:5272-82. 2003
    ..We conclude that NA depolarizes striatal cholinergic interneurons via beta1-adrenoceptor activation, through a cAMP-dependent but PKA-independent mechanism...
  12. ncbi request reprint Re-emergence of striatal cholinergic interneurons in movement disorders
    Antonio Pisani
    Fondazione Santa Lucia IRCCS, and Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00135, Rome, Italy
    Trends Neurosci 30:545-53. 2007
    ..This review gives an overview of these recent experimental and clinical studies, placing them within the context of the pathogenesis of movement disorders...
  13. ncbi request reprint Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy, and Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Neurobiol Dis 24:318-25. 2006
    ..Our data support the existence of an imbalance between striatal dopaminergic and cholinergic signaling in DYT1 dystonia...
  14. ncbi request reprint Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Roma, Italy
    Neurobiol Dis 23:54-60. 2006
    ..These findings suggest that DJ-1 loss-of-function enhances vulnerability to energy metabolism alterations, and that nigral neurons are particularly sensitive to Na+/K+ ATPase impairment...
  15. ncbi request reprint Role of tonically-active neurons in the control of striatal function: cellular mechanisms and behavioral correlates
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 25:211-30. 2001
    ..This evidence supports the hypothesis that cholinergic interneurons, or TANs, play a key role in the modulation of striatal function...
  16. ncbi request reprint Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 40:460-3. 2001
    ..The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons...
  17. ncbi request reprint Early sodium elevations induced by combined oxygen and glucose deprivation in pyramidal cortical neurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Eur J Neurosci 10:3572-4. 1998
    ..The present results demonstrate that, in cortical neurons, O2/glucose deprivation induces an early rise in [Na+]i which cannot be ascribed to the activity of voltage gated Na+-channels, glutamate receptors or of the Na+/Ca2+-exchanger...
  18. ncbi request reprint Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Epilepsia 45:719-28. 2004
    ..Levetiracetam (LEV) and lamotrigine (LTG), novel antiepileptic drugs (AEDs), were tested on epileptiform events and the corresponding elevations in intracellular Ca2+ concentration ([Ca2+]i) recorded from rat neocortical slices...
  19. ncbi request reprint Activation of D2-like dopamine receptors reduces synaptic inputs to striatal cholinergic interneurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 20:RC69. 2000
    ....
  20. ncbi request reprint Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome 00133, Italy
    J Neurosci 21:5110-20. 2001
    ..Thus 3-NP-LTP might play a key role in the regional and cell type-specific neuronal death observed in HD...
  21. pmc Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin
    G Martella
    Department of Neuroscience, University Tor Vergata, Rome, Italy
    Exp Neurol 215:388-96. 2009
    ..Together, these results suggest that the selective increase in sensitivity of striatal group II mGlu receptors represents an adaptive change in mice in which an altered dopamine metabolism has been documented...
  22. ncbi request reprint L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons
    A Pisani
    Clinica Neurologica, Dipartimento di Sanita, Universita Tor Vergata, and Ospedale S Lucia, IRCCS, Rome, Italy
    Stroke 29:196-201; discussion 202. 1998
    ..To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of oxygen (O2)/glucose deprivation...
  23. ncbi request reprint Stimulation of nitric oxide-cGMP pathway excites striatal cholinergic interneurons via protein kinase G activation
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , 00133 Rome, Italy
    J Neurosci 21:1393-400. 2001
    ..The characterization of the cellular mechanisms involved in the regulation of striatal interneuron activity is a key step for the understanding of the role of these cells in striatal microcircuitry...
  24. ncbi request reprint Selective involvement of mGlu1 receptors in corticostriatal LTD
    P Gubellini
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via di Tor Vergata 135, 00133, Rome, Italy
    Neuropharmacology 40:839-46. 2001
    ..mGluR1-mediated control of this form of synaptic plasticity may play a role in the modulatory effect exerted by mGluRs in the basal ganglia-related motor activity...
  25. ncbi request reprint Endogenous ACh enhances striatal NMDA-responses via M1-like muscarinic receptors and PKC activation
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Eur J Neurosci 10:2887-95. 1998
    ..Our data show that endogenous striatal ACh exerts a positive modulatory action on NMDA responses via M1-like muscarinic receptors and PKC activation...
  26. ncbi request reprint Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
    P Bonsi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, C E R C, Rome, Italy
    Neuropharmacology 49:104-13. 2005
    ..Together, these data suggest that mGluR5 modulates mGluR1 activity to shape cell excitability...
  27. pmc An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons
    P Calabresi
    Dip Sanità, Universita di Roma Tor Vergata, Rome, Italy
    Br J Pharmacol 126:689-96. 1999
    ....
  28. doi request reprint Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease
    G Martella
    Department of Neuroscience, University Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 177:240-51. 2011
    ..These results demonstrate that both dopamine depletion and DJ-1 deletion induce a rearrangement in the HVA Ca2+ channel profile, specifically involving those channels that are selectively modulated by D2 receptors...
  29. ncbi request reprint Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson's disease
    P Bonsi
    Laboratorio di Neurofisiologia, I R C C S Fondazione Santa Lucia C E R C, European Brain Research Institute, Rome, Italy
    Amino Acids 32:189-95. 2007
    ..Thus, targeting mGluRs located onto cholinergic interneurons might result in a beneficial pharmacological effect in the parkinsonian state...
  30. ncbi request reprint Early ionic and membrane potential changes caused by the pesticide rotenone in striatal cholinergic interneurons
    P Bonsi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Fondazione Santa Lucia, IRCCS, 00133 Rome, Italy
    Exp Neurol 185:169-81. 2004
    ..In turn, the hyperpolarizing response might be generated both by the opening of ATP-sensitive K+ channels and by Na+-activated K+ conductances. The increase in [Ca2+]i occurs lately and does not seem to influence the early events...
  31. ncbi request reprint Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 129:157-66. 2004
    ..Understanding the physiological roles of DA D2 receptors in the striatum is essential for the treatment of several neuropsychiatric conditions, such as Parkinson's disease, Tourette's syndrome, schizophrenia, and drug addiction...
  32. pmc Muscarinic IPSPs in rat striatal cholinergic interneurones
    P Calabresi
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    J Physiol 510:421-7. 1998
    ..6. The findings demonstrate that muscarinic IPSPs occur in the central nervous system. The IPSP may mediate an 'autoinhibition' of striatal cholinergic neurone activity...
  33. ncbi request reprint Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors
    P Calabresi
    Clinica Neurologica, Universita di Roma Tor Vergata, Dipartimento Sanita, 00173 Rome, Italy
    J Neurosci 17:4536-44. 1997
    ..It also shows that an imbalance between D2R and NMDA receptor activity induces altered synaptic plasticity at corticostriatal synapses. This abnormal synaptic plasticity might cause the movement disorders observed in Parkinson's disease...
  34. ncbi request reprint Blockade of M2-like muscarinic receptors enhances long-term potentiation at corticostriatal synapses
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Eur J Neurosci 10:3020-3. 1998
    ....
  35. ncbi request reprint Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 133:831-40. 2005
    ..Since neither l-DOPA treatment nor STN lesion affected sEPSCs kinetic properties, the reversal of these abnormalities in striatal excitatory synaptic transmission can be attributable to the normalization of glutamate release...
  36. ncbi request reprint Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome, Italy
    Brain 124:1855-65. 2001
    ..The early depression of GABA-mediated synaptic transmission might play a role in the development of irreversible neuronal injury in the course of brain ischaemia...
  37. ncbi request reprint Cell-type specificity of mGluR activation in striatal neuronal subtypes
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Amino Acids 19:119-29. 2000
    ....
  38. doi request reprint Aberrant striatal synaptic plasticity in monogenic parkinsonisms
    G Madeo
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Neuroscience 211:126-35. 2012
    ....
  39. doi request reprint Age-related functional changes of high-voltage-activated calcium channels in different neuronal subtypes of mouse striatum
    G Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 152:469-76. 2008
    ..Such changes might have profound implications for physiological and pathophysiological processes of the striatum...
  40. ncbi request reprint Pharmacological inhibition of the Na(+)/Ca(2+) exchanger enhances depolarizations induced by oxygen/glucose deprivation but not responses to excitatory amino acids in rat striatal neurons
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome
    Stroke 30:1687-94. 1999
    ..However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes...
  41. doi request reprint Antiepileptic drugs on calcium currents recorded from cortical and PAG neurons: therapeutic implications for migraine
    G Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata Rome, Italy
    Cephalalgia 28:1315-26. 2008
    ..The negative modulation of specific subtypes of HVA Ca(2+) channels by various AEDs can restore normal electrical activity in target brain areas such as cortex and PAG, providing interesting therapeutic approaches in migraine prevention...
  42. doi request reprint Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro
    Giuseppina Martella
    Department of Neuroscience, University of Rome Tor Vergata, and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Epilepsia 50:702-10. 2009
    ..We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays...
  43. ncbi request reprint Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors
    Diego Centonze
    Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 26:164-75. 2002
    ..The modulation of GABAergic synaptic transmission in the striatum might underlie some motor and cognitive effects of psychostimulants in mammalians...
  44. ncbi request reprint Synaptic transmission in the striatum: from plasticity to neurodegeneration
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata 135, 00133, Rome, Italy
    Prog Neurobiol 61:231-65. 2000
    ..These ionic mechanisms might partially explain the selective neuronal vulnerability observed in the striatum during global ischemia and Huntington's disease...
  45. ncbi request reprint Impairment of mitochondrial metabolism differentially affects striatal neuronal subtypes
    A Pisani
    Clinica Neurologica, Universita di Roma Tor Vergata, Via di Tor Vergata 135, 00133 Rome, Italy
    Neuroreport 13:641-4. 2002
    ..The present results indicate that mitochondrial Ca2+ released into the cytosol may contribute to the selective vulnerability to metabolic impairment in striatal neuronal subtypes...
  46. ncbi request reprint Presynaptic modulation by group III metabotropic glutamate receptors (mGluRs) of the excitatory postsynaptic potential mediated by mGluR1 in rat cerebellar Purkinje cells
    M C Miniaci
    Fondazione Santa Lucia-IRCCS, Rome, Italy
    Neurosci Lett 310:61-5. 2001
    ..These data suggest that glutamate released by parallel fibres activates group III mGluR autoreceptors, depressing both iGluR- and mGluR1-mediated EPSPs...
  47. ncbi request reprint Behavioural learning-induced increase in spontaneous GABAA-dependent synaptic activity in rat striatal cholinergic interneurons
    Paola Bonsi
    Fondazione Santa Lucia IRCCS, Rome and Department of Neuroscience, Neurological Clinic, University Tor Vergata, Rome, Italy
    Eur J Neurosci 17:174-8. 2003
    ..This intrastriatal mechanism might be involved in the phasic suppression of discharge of TANs at the presentation of reward-related sensory stimuli...
  48. doi request reprint Distinct roles of group I mGlu receptors in striatal function
    P Bonsi
    Fondazione Santa Lucia I R C C S, Rome, Italy
    Neuropharmacology 55:392-5. 2008
    ..This review provides a brief survey of the cellular and synaptic actions of group I mGlu receptors, and discusses the potential relevance of these findings in neostriatal function and motor control...
  49. ncbi request reprint Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons
    D Centonze
    IRCCS Ospedale S. Lucia, Rome, Italy
    Prog Neurobiol 63:687-96. 2001
    ..The understanding of the ionic mechanisms underlying the differential membrane responses to ischemia represents the basis for the development of rational neuroprotective treatments during acute cerebrovascular insults...
  50. ncbi request reprint Morphological and functional study of dwarf neurons in the rat striatum
    G Sancesario
    Laboratorio di Neuroscienze, Universita di Roma Tor Vergata, Lucia, Rome
    Eur J Neurosci 10:3575-83. 1998
    ..9% of the recorded neurons). These data suggest that some neurogliaform cells in the striatum of young rat can be identified as dwarf interneurons, that may be dye-coupled with neurons of different classes...
  51. ncbi request reprint Functional and ultrastructural analysis of group I mGluR in striatal fast-spiking interneurons
    Paola Bonsi
    Fondazione Santa Lucia I R C C S, Department of Neuroscience, Clinica Neurologica, University Tor Vergata, Via Montpellier, 00133 Rome, Italy
    Eur J Neurosci 25:1319-31. 2007
    ..Together, these results suggest that despite a common pattern of distribution, mGluR1 and mGluR5 exert distinct functions in the modulation of FS interneuron activity...
  52. ncbi request reprint Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:8506-12. 2003
    ....
  53. ncbi request reprint Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:6245-54. 2003
    ....
  54. ncbi request reprint Activation of dopamine D1-like receptors excites LTS interneurons of the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via di Tor Vergata, 135, 00133 Rome, Italy
    Eur J Neurosci 15:2049-52. 2002
    ..In addition, this pharmacological effect was mimicked by D1- but not D2-like DA receptor agonists, implying the selective involvement of D1-like receptors in this action...
  55. ncbi request reprint Dopamine, acetylcholine and nitric oxide systems interact to induce corticostriatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Rev Neurosci 14:207-16. 2003
    ....
  56. doi request reprint Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia
    G Martella
    Department of System Medicine, University of Rome Tor Vergata, Italy Laboratory of Neurophysiology and Synaptic Plasticity, IRCCS Fondazione Santa Lucia, Rome, Italy
    Neurobiol Dis 65:124-32. 2014
    ..These results provide evidence for a regional specificity of the electrophysiological abnormalities observed and demonstrate the reproducibility of such alterations in distinct models of DYT1 dystonia. ..
  57. ncbi request reprint Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors
    Paola Bonsi
    Fondazione Santa Lucia I R C C S, European Brain Research Institute, Rome, Italy
    Neuropsychopharmacology 32:1840-54. 2007
    ..These results suggest that 5-HT released by serotonergic fibers originating in the raphe nuclei has a potent excitatory effect on striatal cholinergic interneurons...
  58. ncbi request reprint Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease
    Emilia Saulle
    Clinica Neurologica, Dipartimento di Medicina Clinica e Sperimentale, Universita di Ferrara, Ferrara, Italy
    Mol Cell Neurosci 25:9-20. 2004
    ..Conversely, the hyperpolarization did not significantly differ from the one recorded in WT mice. The diverse membrane changes induced by SD inhibition may contribute to the cell-type-specific neuronal death in HD...
  59. ncbi request reprint Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity
    Giuseppina Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Epilepsia 46:624-35. 2005
    ..We examined the electrophysiologic effects of propofol on an in vitro model of epileptic activity obtained from a slice preparation...
  60. doi request reprint Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum
    G Ponterio
    Department of System Medicine, University of Rome Tor Vergata, Via Montpellier, Rome 00133, Italy Laboratory of Neurophysiology and Plasticity, Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropharmacology 75:78-85. 2013
    ..Such opioidergic regulation of cholinergic transmission might contribute to shape information processing in basal ganglia circuits, and represent a potential target for pharmacological intervention. ..
  61. ncbi request reprint Tissue plasminogen activator is required for corticostriatal long-term potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Neurosci 16:713-21. 2002
    ....
  62. ncbi request reprint Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, I R C C S Fondazione Santa Lucia, Italy
    Brain 125:2635-45. 2002
    ..We suggest that an enhanced sensitivity of pre-synaptic inhibitory mGlu2/3 receptors might represent an adaptive change triggered by dopaminergic denervation, which can be reversed by L-DOPA treatment...
  63. ncbi request reprint Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neuroreport 13:115-8. 2002
    ..The absence of striatal post-ischemic pote ntiat ion observed in tPA-lacking mice may account for the significant neuroprotection observed in these animals after the occlusion of middle cerebral artery...
  64. ncbi request reprint Synaptic plasticity in the ischaemic brain
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and the IRCCS Fondazione Santa Lucia, Rome, Italy
    Lancet Neurol 2:622-9. 2003
    ..We discuss evidence that ischaemia could also induce protective and reparative forms of neuronal plasticity that may play a part in ischaemic tolerance and poststroke recovery...
  65. ncbi request reprint Pathological synaptic plasticity in the striatum: implications for Parkinson's disease
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I R C C S, Via di Tor Vergata 135, Roma, Italy
    Neurotoxicology 26:779-83. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of Parkinson's disease and l-dopa-induced motor complications will be discussed...
  66. ncbi request reprint Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia
    Cinzia Costa
    Clinica Neurologica, Universita di Perugia, Ospedale Silvestrini, S Andrea delle Fratte, Perugia, Italy
    Stroke 37:1319-26. 2006
    ..In particular, the aim of the study was to correlate the putative neuroprotective effects with the action of these drugs on fast sodium (Na+) and high-voltage-activated (HVA) calcium (Ca2+) currents...
  67. pmc Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine
    Giuseppina Martella
    Department of Neuroscience, University Tor Vergata, 00133 Rome, Italy
    Brain 132:2336-49. 2009
    ..More importantly, our results indicate that an unbalanced cholinergic transmission plays a pivotal role in these alterations, providing a clue to understand the ability of anticholinergic agents to restore motor deficits in dystonia...
  68. ncbi request reprint Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Brain 125:844-60. 2002
    ..We suggest that i-LTP represents a pathological form of synaptic plasticity that may account for the cell type-specific vulnerability observed in striatal spiny neurones following ischaemia and energy deprivation...
  69. pmc Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia
    Giuseppe Sciamanna
    Department of Neuroscience, University Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurobiol Dis 34:133-45. 2009
    ..Our findings demonstrate a disinhibition of striatal GABAergic synaptic activity, that can be at least partially attributed to a D2 DA receptor dysfunction...
  70. ncbi request reprint Acute vs chronic effects of l-dopa on bladder function in patients with mild Parkinson disease
    L Brusa
    Clinica Neurologica, Università Tor Vergata Roma, Roma, Italy
    Neurology 68:1455-9. 2007
    ..To compare acute and chronic effects of l-dopa on bladder function in levodopa-naive Parkinson disease (PD) patients who had urinary urgency...
  71. doi request reprint Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice
    Tohru Kitada
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurochem 110:613-21. 2009
    ....
  72. ncbi request reprint Striatal synaptic plasticity: implications for motor learning and Parkinson's disease
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I R C C S, Roma, Italy
    Mov Disord 20:395-402. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of PD and L-dopa-induced motor complications will be discussed...
  73. ncbi request reprint Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
    Matthew S Goldberg
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 45:489-96. 2005
    ..Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions...
  74. ncbi request reprint NR2B subunit exerts a critical role in postischemic synaptic plasticity
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, Rome, Italy
    Stroke 37:1895-901. 2006
    ..We characterized the differential effect of the NR2B subunit antagonist ifenprodil in the induction of activity-dependent long-term potentiation (LTP) and of postischemic LTP as well as in the neuronal damage induced by focal ischemia...
  75. ncbi request reprint Acetyl-L-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropharmacology 50:917-23. 2006
    ..These findings show that ALC exert a neuroprotective action against in vitro ischemia. This neuroprotective effect requires the activity of choline uptake system and the activation of M2 muscarinic receptors...
  76. pmc R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:14622-7. 2009
    ..Together, our data suggest that the R1441C mutation in LRRK2 impairs stimulated dopamine neurotransmission and D2 receptor function, which may represent pathogenic precursors preceding dopaminergic degeneration in PD brains...
  77. pmc Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
    Tohru Kitada
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:11441-6. 2007
    ..These results reveal a critical role for PINK1 in DA release and striatal synaptic plasticity in the nigrostriatal circuit and suggest that altered dopaminergic physiology may be a pathogenic precursor to nigrostriatal degeneration...
  78. ncbi request reprint Calcium signaling and neuronal vulnerability to ischemia in the striatum
    Antonio Pisani
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma Tor Vergata, Fondazione Santa Lucia, IRCCS, Rome, Italy
    Cell Calcium 36:277-84. 2004
    ..The potential relevance of these findings in the development of therapeutic strategies for acute stroke will be discussed...
  79. ncbi request reprint Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 27:723-6. 2002
    ..Thus, pharmacological compounds able to interfere selectively with presynaptic D2S receptors might constitute effective therapeutic strategies in neuropsychiatric disorders, by causing negligible side-effects...
  80. ncbi request reprint Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease
    Salvatore Galati
    I R C C S Fondazione S, Via Ardeatina 306 00133, Rome, Italy
    Eur J Neurosci 23:2923-8. 2006
    ..Our findings suggest that, during STN-DBS, a critical change towards a high-frequency oscillatory discharge occurs...
  81. ncbi request reprint Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases
    Paolo Gubellini
    Interactions Cellulaires, Neurodégénérescence et Neuroplasticité IC2N UMR6186, Centre National de la Recherche Scientifique CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Prog Neurobiol 74:271-300. 2004
    ....
  82. ncbi request reprint Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 65, 00143 Rome, Italy
    Neurobiol Dis 22:143-52. 2006
    ....
  83. pmc Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons
    Paola Bonsi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia I R C C S, 00179 Roma, Italy
    Learn Mem 11:755-60. 2004
    ..In conclusion, the expression of LTP in striatal cholinergic interneurons is a selective response to a precise stimulation pattern of induction requiring a critical rise in [Ca2+]i...
  84. pmc Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum
    Paola Bonsi
    Fondazione Santa Lucia Instituto di Ricovero e Cura a Carattere Scientifico, Rome 00146, Italy
    J Neurosci 28:6258-63. 2008
    ..These results demonstrate that M(2)/M(4) muscarinic autoreceptors regulate ACh release from striatal ChIs. As a consequence, endogenous ACh drives the polarity of bidirectional synaptic plasticity...
  85. ncbi request reprint Stimulus frequency, calcium levels and striatal synaptic plasticity
    Paola Bonsi
    Fondazione Santa Lucia, IRCCS Rome
    Neuroreport 14:419-22. 2003
    ..These results suggest that the induction of long-term depression required large, transient increases in intracellular calcium concentration...
  86. ncbi request reprint Arginase inhibition slows the progression of renal failure in rats with renal ablation
    Massimo Sabbatini
    Departments of Nephrology and Experimental Medicine, University Federico II, 80131 Naples, Italy
    Am J Physiol Renal Physiol 284:F680-7. 2003
    ..Inhibition of arginase slows the progression of CRF in remnant rats similarly to arginine-treated rats; the better histological protection in MNF rats, however, suggests that additional factors are involved in these modifications...
  87. ncbi request reprint High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients
    Antonio Pisani
    Ann Neurol 57:777-9. 2005
  88. ncbi request reprint Inhibition of Ras/ERK1/2 signaling protects against postischemic renal injury
    Massimo Sabbatini
    University Magna Graecia of Catanzaro, Italy
    Am J Physiol Renal Physiol 290:F1408-15. 2006
    ..These data demonstrate that inhibition of farnesylation and consequently of Ras/ERK1/2 signaling significantly reduces acute postischemic renal injury...
  89. ncbi request reprint Central acute D2 stimulation worsens bladder function in patients with mild Parkinson's disease
    Livia Brusa
    Department of Neurology, University of Rome Tor Vergata, Rome, Italy
    J Urol 175:202-6; discussion 206-7. 2006
    ..This finding has never been confirmed in human studies. Thus, in this study we investigated the role of D1 and D2 agonists/antagonists on LUT behavior in patients with PD...
  90. doi request reprint Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients
    Mariangela Pierantozzi
    Department of Neuroscience, Tor Vergata University, Rome, Italy
    J Neural Transm 115:731-5. 2008
    ....