A Pisani

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi Chronic cocaine prevents depotentiation at corticostriatal synapses
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 60:436-43. 2006
  2. ncbi Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease
    Valerio Pisani
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    J Neuroinflammation 9:188. 2012
  3. ncbi Neuroacanthocytosis associated with a defect of the 4.1R membrane protein
    Antonio Orlacchio
    Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, Rome, Italy
    BMC Neurol 7:4. 2007
  4. ncbi Re-emergence of striatal cholinergic interneurons in movement disorders
    Antonio Pisani
    Fondazione Santa Lucia IRCCS, and Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00135, Rome, Italy
    Trends Neurosci 30:545-53. 2007
  5. ncbi Role of tonically-active neurons in the control of striatal function: cellular mechanisms and behavioral correlates
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 25:211-30. 2001
  6. ncbi Metabotropic glutamate 2 receptors modulate synaptic inputs and calcium signals in striatal cholinergic interneurons
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 22:6176-85. 2002
  7. ncbi Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 45:45-56. 2003
  8. ncbi Activation of beta1-adrenoceptors excites striatal cholinergic interneurons through a cAMP-dependent, protein kinase-independent pathway
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    J Neurosci 23:5272-82. 2003
  9. ncbi Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Epilepsia 45:719-28. 2004
  10. ncbi Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy, and Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Neurobiol Dis 24:318-25. 2006

Collaborators

Detail Information

Publications85

  1. ncbi Chronic cocaine prevents depotentiation at corticostriatal synapses
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 60:436-43. 2006
    ..A pathology of habit forming systems might underlie these features of addiction...
  2. ncbi Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease
    Valerio Pisani
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    J Neuroinflammation 9:188. 2012
    ..Alterations in blood-brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson's disease progression. However, few studies have addressed this issue in patients at different stages of disease...
  3. ncbi Neuroacanthocytosis associated with a defect of the 4.1R membrane protein
    Antonio Orlacchio
    Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, Rome, Italy
    BMC Neurol 7:4. 2007
    ..We report clinical, biochemical, and genetic features in four patients from four unrelated families with NA in order to explain the cause of morphological abnormalities and the relationship with neurodegenerative processes...
  4. ncbi Re-emergence of striatal cholinergic interneurons in movement disorders
    Antonio Pisani
    Fondazione Santa Lucia IRCCS, and Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00135, Rome, Italy
    Trends Neurosci 30:545-53. 2007
    ..This review gives an overview of these recent experimental and clinical studies, placing them within the context of the pathogenesis of movement disorders...
  5. ncbi Role of tonically-active neurons in the control of striatal function: cellular mechanisms and behavioral correlates
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 25:211-30. 2001
    ..This evidence supports the hypothesis that cholinergic interneurons, or TANs, play a key role in the modulation of striatal function...
  6. ncbi Metabotropic glutamate 2 receptors modulate synaptic inputs and calcium signals in striatal cholinergic interneurons
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 22:6176-85. 2002
    ..These results suggest that the mGlu2 receptor-mediated modulatory action on cell excitability would tune striatal ACh release, representing an interesting target for pharmacological intervention in basal ganglia disorders...
  7. ncbi Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 45:45-56. 2003
    ..The potential relevance of these findings in the control of motor function and in the treatment of PD will be discussed...
  8. ncbi Activation of beta1-adrenoceptors excites striatal cholinergic interneurons through a cAMP-dependent, protein kinase-independent pathway
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    J Neurosci 23:5272-82. 2003
    ..We conclude that NA depolarizes striatal cholinergic interneurons via beta1-adrenoceptor activation, through a cAMP-dependent but PKA-independent mechanism...
  9. ncbi Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Epilepsia 45:719-28. 2004
    ..Levetiracetam (LEV) and lamotrigine (LTG), novel antiepileptic drugs (AEDs), were tested on epileptiform events and the corresponding elevations in intracellular Ca2+ concentration ([Ca2+]i) recorded from rat neocortical slices...
  10. ncbi Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy, and Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Neurobiol Dis 24:318-25. 2006
    ..Our data support the existence of an imbalance between striatal dopaminergic and cholinergic signaling in DYT1 dystonia...
  11. ncbi Acanthocytosis as a predisposing factor for non-ketotic hyperglycaemia induced chorea-ballism
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurol Neurosurg Psychiatry 76:1717-9. 2005
    ..Episodic non-ketotic hyperglycaemia in patients with diabetes may be responsible for a syndrome characterised by hemichorea-hemiballism associated with unique radiological features...
  12. ncbi Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Roma, Italy
    Neurobiol Dis 23:54-60. 2006
    ..These findings suggest that DJ-1 loss-of-function enhances vulnerability to energy metabolism alterations, and that nigral neurons are particularly sensitive to Na+/K+ ATPase impairment...
  13. ncbi Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 40:460-3. 2001
    ..The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons...
  14. ncbi Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    A Pisani
    Clinica Neurologica, Dipartmento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 106:579-87. 2001
    ....
  15. ncbi Early sodium elevations induced by combined oxygen and glucose deprivation in pyramidal cortical neurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Eur J Neurosci 10:3572-4. 1998
    ..The present results demonstrate that, in cortical neurons, O2/glucose deprivation induces an early rise in [Na+]i which cannot be ascribed to the activity of voltage gated Na+-channels, glutamate receptors or of the Na+/Ca2+-exchanger...
  16. ncbi Activation of D2-like dopamine receptors reduces synaptic inputs to striatal cholinergic interneurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 20:RC69. 2000
    ....
  17. ncbi Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome 00133, Italy
    J Neurosci 21:5110-20. 2001
    ..Thus 3-NP-LTP might play a key role in the regional and cell type-specific neuronal death observed in HD...
  18. ncbi Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin
    G Martella
    Department of Neuroscience, University Tor Vergata, Rome, Italy
    Exp Neurol 215:388-96. 2009
    ..Together, these results suggest that the selective increase in sensitivity of striatal group II mGlu receptors represents an adaptive change in mice in which an altered dopamine metabolism has been documented...
  19. ncbi L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons
    A Pisani
    Clinica Neurologica, Dipartimento di Sanita, Universita Tor Vergata, and Ospedale S Lucia, IRCCS, Rome, Italy
    Stroke 29:196-201; discussion 202. 1998
    ..To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of oxygen (O2)/glucose deprivation...
  20. ncbi Stimulation of nitric oxide-cGMP pathway excites striatal cholinergic interneurons via protein kinase G activation
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , 00133 Rome, Italy
    J Neurosci 21:1393-400. 2001
    ..The characterization of the cellular mechanisms involved in the regulation of striatal interneuron activity is a key step for the understanding of the role of these cells in striatal microcircuitry...
  21. ncbi Selective involvement of mGlu1 receptors in corticostriatal LTD
    P Gubellini
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via di Tor Vergata 135, 00133, Rome, Italy
    Neuropharmacology 40:839-46. 2001
    ..mGluR1-mediated control of this form of synaptic plasticity may play a role in the modulatory effect exerted by mGluRs in the basal ganglia-related motor activity...
  22. ncbi Endogenous ACh enhances striatal NMDA-responses via M1-like muscarinic receptors and PKC activation
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Eur J Neurosci 10:2887-95. 1998
    ..Our data show that endogenous striatal ACh exerts a positive modulatory action on NMDA responses via M1-like muscarinic receptors and PKC activation...
  23. ncbi An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons
    P Calabresi
    Dip Sanità, Universita di Roma Tor Vergata, Rome, Italy
    Br J Pharmacol 126:689-96. 1999
    ....
  24. ncbi Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
    P Bonsi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, C.E.R.C, Rome, Italy
    Neuropharmacology 49:104-13. 2005
    ..Together, these data suggest that mGluR5 modulates mGluR1 activity to shape cell excitability...
  25. ncbi Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease
    G Martella
    Department of Neuroscience, University Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 177:240-51. 2011
    ..These results demonstrate that both dopamine depletion and DJ-1 deletion induce a rearrangement in the HVA Ca2+ channel profile, specifically involving those channels that are selectively modulated by D2 receptors...
  26. ncbi Early ionic and membrane potential changes caused by the pesticide rotenone in striatal cholinergic interneurons
    P Bonsi
    Clinica Neurologica, Dipartimento di Neuroscienze, , Fondazione Santa Lucia, IRCCS, 00133 Rome, Italy
    Exp Neurol 185:169-81. 2004
    ..In turn, the hyperpolarizing response might be generated both by the opening of ATP-sensitive K+ channels and by Na+-activated K+ conductances. The increase in [Ca2+]i occurs lately and does not seem to influence the early events...
  27. ncbi Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 129:157-66. 2004
    ..Understanding the physiological roles of DA D2 receptors in the striatum is essential for the treatment of several neuropsychiatric conditions, such as Parkinson's disease, Tourette's syndrome, schizophrenia, and drug addiction...
  28. ncbi Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson's disease
    P Bonsi
    Laboratorio di Neurofisiologia, I R C C S Fondazione Santa Lucia C E R C, European Brain Research Institute, Rome, Italy
    Amino Acids 32:189-95. 2007
    ..Thus, targeting mGluRs located onto cholinergic interneurons might result in a beneficial pharmacological effect in the parkinsonian state...
  29. ncbi Muscarinic IPSPs in rat striatal cholinergic interneurones
    P Calabresi
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    J Physiol 510:421-7. 1998
    ..6. The findings demonstrate that muscarinic IPSPs occur in the central nervous system. The IPSP may mediate an 'autoinhibition' of striatal cholinergic neurone activity...
  30. ncbi Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 133:831-40. 2005
    ..Since neither l-DOPA treatment nor STN lesion affected sEPSCs kinetic properties, the reversal of these abnormalities in striatal excitatory synaptic transmission can be attributable to the normalization of glutamate release...
  31. ncbi Blockade of M2-like muscarinic receptors enhances long-term potentiation at corticostriatal synapses
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Eur J Neurosci 10:3020-3. 1998
    ....
  32. ncbi Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome, Italy
    Brain 124:1855-65. 2001
    ..The early depression of GABA-mediated synaptic transmission might play a role in the development of irreversible neuronal injury in the course of brain ischaemia...
  33. ncbi Cell-type specificity of mGluR activation in striatal neuronal subtypes
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Amino Acids 19:119-29. 2000
    ....
  34. ncbi Aberrant striatal synaptic plasticity in monogenic parkinsonisms
    G Madeo
    Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Neuroscience 211:126-35. 2012
    ....
  35. ncbi Antiepileptic drugs on calcium currents recorded from cortical and PAG neurons: therapeutic implications for migraine
    G Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata Rome, Italy
    Cephalalgia 28:1315-26. 2008
    ..The negative modulation of specific subtypes of HVA Ca(2+) channels by various AEDs can restore normal electrical activity in target brain areas such as cortex and PAG, providing interesting therapeutic approaches in migraine prevention...
  36. ncbi Pharmacological inhibition of the Na(+)/Ca(2+) exchanger enhances depolarizations induced by oxygen/glucose deprivation but not responses to excitatory amino acids in rat striatal neurons
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome
    Stroke 30:1687-94. 1999
    ..However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes...
  37. ncbi Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors
    P Calabresi
    Clinica Neurologica, Universita di Roma Tor Vergata, Dipartimento Sanita, 00173 Rome, Italy
    J Neurosci 17:4536-44. 1997
    ..It also shows that an imbalance between D2R and NMDA receptor activity induces altered synaptic plasticity at corticostriatal synapses. This abnormal synaptic plasticity might cause the movement disorders observed in Parkinson's disease...
  38. ncbi Age-related functional changes of high-voltage-activated calcium channels in different neuronal subtypes of mouse striatum
    G Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 152:469-76. 2008
    ..Such changes might have profound implications for physiological and pathophysiological processes of the striatum...
  39. ncbi Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro
    Giuseppina Martella
    Department of Neuroscience, University of Rome Tor Vergata, and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Epilepsia 50:702-10. 2009
    ..We analyzed the effects of seletracetam (ucb 44212; SEL), a new antiepileptic drug candidate, in an in vitro model of epileptic activity. The activity of SEL was compared to the effects of levetiracetam (LEV; Keppra), in the same assays...
  40. ncbi Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors
    Diego Centonze
    Dipartimento di Neuroscienze, Clinica Neurologica, , IRCCS, Rome, Italy
    Neuropsychopharmacology 26:164-75. 2002
    ..The modulation of GABAergic synaptic transmission in the striatum might underlie some motor and cognitive effects of psychostimulants in mammalians...
  41. ncbi Synaptic transmission in the striatum: from plasticity to neurodegeneration
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata 135, 00133, Rome, Italy
    Prog Neurobiol 61:231-65. 2000
    ..These ionic mechanisms might partially explain the selective neuronal vulnerability observed in the striatum during global ischemia and Huntington's disease...
  42. ncbi Impairment of mitochondrial metabolism differentially affects striatal neuronal subtypes
    A Pisani
    Clinica Neurologica, , Via di Tor Vergata 135, 00133 Rome, Italy
    Neuroreport 13:641-4. 2002
    ..The present results indicate that mitochondrial Ca2+ released into the cytosol may contribute to the selective vulnerability to metabolic impairment in striatal neuronal subtypes...
  43. ncbi Presynaptic modulation by group III metabotropic glutamate receptors (mGluRs) of the excitatory postsynaptic potential mediated by mGluR1 in rat cerebellar Purkinje cells
    M C Miniaci
    Fondazione Santa Lucia-IRCCS, Rome, Italy
    Neurosci Lett 310:61-5. 2001
    ..These data suggest that glutamate released by parallel fibres activates group III mGluR autoreceptors, depressing both iGluR- and mGluR1-mediated EPSPs...
  44. ncbi Behavioural learning-induced increase in spontaneous GABAA-dependent synaptic activity in rat striatal cholinergic interneurons
    Paola Bonsi
    Fondazione Santa Lucia IRCCS, Rome and Department of Neuroscience, Neurological Clinic, University 'Tor Vergata, Rome, Italy
    Eur J Neurosci 17:174-8. 2003
    ..This intrastriatal mechanism might be involved in the phasic suppression of discharge of TANs at the presentation of reward-related sensory stimuli...
  45. ncbi Distinct roles of group I mGlu receptors in striatal function
    P Bonsi
    Fondazione Santa Lucia I R C C S, Rome, Italy
    Neuropharmacology 55:392-5. 2008
    ..This review provides a brief survey of the cellular and synaptic actions of group I mGlu receptors, and discusses the potential relevance of these findings in neostriatal function and motor control...
  46. ncbi Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons
    D Centonze
    IRCCS Ospedale S. Lucia, Rome, Italy
    Prog Neurobiol 63:687-96. 2001
    ..The understanding of the ionic mechanisms underlying the differential membrane responses to ischemia represents the basis for the development of rational neuroprotective treatments during acute cerebrovascular insults...
  47. ncbi Morphological and functional study of dwarf neurons in the rat striatum
    G Sancesario
    Laboratorio di Neuroscienze, Universita di Roma Tor Vergata, Lucia, Rome
    Eur J Neurosci 10:3575-83. 1998
    ..9% of the recorded neurons). These data suggest that some neurogliaform cells in the striatum of young rat can be identified as dwarf interneurons, that may be dye-coupled with neurons of different classes...
  48. ncbi Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:8506-12. 2003
    ....
  49. ncbi Functional and ultrastructural analysis of group I mGluR in striatal fast-spiking interneurons
    Paola Bonsi
    Fondazione Santa Lucia I R C C S, Department of Neuroscience, Clinica Neurologica, University Tor Vergata, Via Montpellier, 00133 Rome, Italy
    Eur J Neurosci 25:1319-31. 2007
    ..Together, these results suggest that despite a common pattern of distribution, mGluR1 and mGluR5 exert distinct functions in the modulation of FS interneuron activity...
  50. ncbi Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:6245-54. 2003
    ....
  51. ncbi Dopamine, acetylcholine and nitric oxide systems interact to induce corticostriatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome, Italy
    Rev Neurosci 14:207-16. 2003
    ....
  52. ncbi Activation of dopamine D1-like receptors excites LTS interneurons of the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , Via di Tor Vergata, 135, 00133 Rome, Italy
    Eur J Neurosci 15:2049-52. 2002
    ..In addition, this pharmacological effect was mimicked by D1- but not D2-like DA receptor agonists, implying the selective involvement of D1-like receptors in this action...
  53. ncbi Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors
    Paola Bonsi
    Fondazione Santa Lucia I R C C S, European Brain Research Institute, Rome, Italy
    Neuropsychopharmacology 32:1840-54. 2007
    ..These results suggest that 5-HT released by serotonergic fibers originating in the raphe nuclei has a potent excitatory effect on striatal cholinergic interneurons...
  54. ncbi Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease
    Emilia Saulle
    Clinica Neurologica, Dipartimento di Medicina Clinica e Sperimentale, , Ferrara, Italy
    Mol Cell Neurosci 25:9-20. 2004
    ..Conversely, the hyperpolarization did not significantly differ from the one recorded in WT mice. The diverse membrane changes induced by SD inhibition may contribute to the cell-type-specific neuronal death in HD...
  55. ncbi Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity
    Giuseppina Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, , Italy
    Epilepsia 46:624-35. 2005
    ..These effects might cooperate with the opening of GABA-A-gated chloride channels, to achieve depression of cortical activity during both anesthesia and status epilepticus...
  56. ncbi Pathological synaptic plasticity in the striatum: implications for Parkinson's disease
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, , I.R.C.C.S, Via di Tor Vergata 135, Roma, Italy
    Neurotoxicology 26:779-83. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of Parkinson's disease and l-dopa-induced motor complications will be discussed...
  57. ncbi Tissue plasminogen activator is required for corticostriatal long-term potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Neurosci 16:713-21. 2002
    ....
  58. ncbi Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, , I.R.C.C.S. Fondazione Santa Lucia, Italy
    Brain 125:2635-45. 2002
    ..We suggest that an enhanced sensitivity of pre-synaptic inhibitory mGlu2/3 receptors might represent an adaptive change triggered by dopaminergic denervation, which can be reversed by L-DOPA treatment...
  59. ncbi Synaptic plasticity in the ischaemic brain
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and the IRCCS Fondazione Santa Lucia, Rome, Italy
    Lancet Neurol 2:622-9. 2003
    ..We discuss evidence that ischaemia could also induce protective and reparative forms of neuronal plasticity that may play a part in ischaemic tolerance and poststroke recovery...
  60. ncbi Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia
    Cinzia Costa
    Clinica Neurologica, , Ospedale Silvestrini, S. Andrea delle Fratte, Perugia, Italy
    Stroke 37:1319-26. 2006
    ..CONCLUSIONS: The concomitant inhibition of fast Na+ and HVA Ca2+ conductances is critically important for the neuroprotection, whereas the presynaptic inhibition on glutamate transmission does not seem to play a major role...
  61. ncbi Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine
    Giuseppina Martella
    Department of Neuroscience, University Tor Vergata, 00133 Rome, Italy
    Brain 132:2336-49. 2009
    ..More importantly, our results indicate that an unbalanced cholinergic transmission plays a pivotal role in these alterations, providing a clue to understand the ability of anticholinergic agents to restore motor deficits in dystonia...
  62. ncbi Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome, Italy
    Neuroreport 13:115-8. 2002
    ..The absence of striatal post-ischemic pote ntiat ion observed in tPA-lacking mice may account for the significant neuroprotection observed in these animals after the occlusion of middle cerebral artery...
  63. ncbi Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Brain 125:844-60. 2002
    ..We suggest that i-LTP represents a pathological form of synaptic plasticity that may account for the cell type-specific vulnerability observed in striatal spiny neurones following ischaemia and energy deprivation...
  64. ncbi Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia
    Giuseppe Sciamanna
    Department of Neuroscience, University Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurobiol Dis 34:133-45. 2009
    ..Our findings demonstrate a disinhibition of striatal GABAergic synaptic activity, that can be at least partially attributed to a D2 DA receptor dysfunction...
  65. ncbi Acute vs chronic effects of l-dopa on bladder function in patients with mild Parkinson disease
    L Brusa
    Clinica Neurologica, Università Tor Vergata Roma, Roma, Italy
    Neurology 68:1455-9. 2007
    ..To compare acute and chronic effects of l-dopa on bladder function in levodopa-naive Parkinson disease (PD) patients who had urinary urgency...
  66. ncbi Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice
    Tohru Kitada
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurochem 110:613-21. 2009
    ....
  67. ncbi Striatal synaptic plasticity: implications for motor learning and Parkinson's disease
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, , I.R.C.C.S, Roma, Italy
    Mov Disord 20:395-402. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of PD and L-dopa-induced motor complications will be discussed...
  68. ncbi NR2B subunit exerts a critical role in postischemic synaptic plasticity
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, Rome, Italy
    Stroke 37:1895-901. 2006
    ..We characterized the differential effect of the NR2B subunit antagonist ifenprodil in the induction of activity-dependent long-term potentiation (LTP) and of postischemic LTP as well as in the neuronal damage induced by focal ischemia...
  69. ncbi Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
    Matthew S Goldberg
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 45:489-96. 2005
    ..Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions...
  70. ncbi Calcium signaling and neuronal vulnerability to ischemia in the striatum
    Antonio Pisani
    Dipartimento di Neuroscienze, Clinica Neurologica, , Fondazione Santa Lucia, IRCCS, Rome, Italy
    Cell Calcium 36:277-84. 2004
    ..The potential relevance of these findings in the development of therapeutic strategies for acute stroke will be discussed...
  71. ncbi Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
    Tohru Kitada
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:11441-6. 2007
    ..These results reveal a critical role for PINK1 in DA release and striatal synaptic plasticity in the nigrostriatal circuit and suggest that altered dopaminergic physiology may be a pathogenic precursor to nigrostriatal degeneration...
  72. ncbi R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
    Youren Tong
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:14622-7. 2009
    ..Together, our data suggest that the R1441C mutation in LRRK2 impairs stimulated dopamine neurotransmission and D2 receptor function, which may represent pathogenic precursors preceding dopaminergic degeneration in PD brains...
  73. ncbi Acetyl-L-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropharmacology 50:917-23. 2006
    ..These findings show that ALC exert a neuroprotective action against in vitro ischemia. This neuroprotective effect requires the activity of choline uptake system and the activation of M2 muscarinic receptors...
  74. ncbi Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 27:723-6. 2002
    ..Thus, pharmacological compounds able to interfere selectively with presynaptic D2S receptors might constitute effective therapeutic strategies in neuropsychiatric disorders, by causing negligible side-effects...
  75. ncbi Biochemical and electrophysiological changes of substantia nigra pars reticulata driven by subthalamic stimulation in patients with Parkinson's disease
    Salvatore Galati
    I.R.C.C.S. Fondazione S, Via Ardeatina 306-00133, Rome, Italy
    Eur J Neurosci 23:2923-8. 2006
    ..Our findings suggest that, during STN-DBS, a critical change towards a high-frequency oscillatory discharge occurs...
  76. ncbi Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum
    Paola Bonsi
    Fondazione Santa Lucia Instituto di Ricovero e Cura a Carattere Scientifico, Rome 00146, Italy
    J Neurosci 28:6258-63. 2008
    ..These results demonstrate that M(2)/M(4) muscarinic autoreceptors regulate ACh release from striatal ChIs. As a consequence, endogenous ACh drives the polarity of bidirectional synaptic plasticity...
  77. ncbi Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 65, 00143 Rome, Italy
    Neurobiol Dis 22:143-52. 2006
    ....
  78. ncbi Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases
    Paolo Gubellini
    Interactions Cellulaires, Neurodégénérescence et Neuroplasticité IC2N UMR6186, Centre National de la Recherche Scientifique CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Prog Neurobiol 74:271-300. 2004
    ....
  79. ncbi Stimulus frequency, calcium levels and striatal synaptic plasticity
    Paola Bonsi
    Fondazione Santa Lucia, IRCCS Rome
    Neuroreport 14:419-22. 2003
    ..These results suggest that the induction of long-term depression required large, transient increases in intracellular calcium concentration...
  80. ncbi Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons
    Paola Bonsi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia I.R.C.C.S, 00179 Roma, Italy
    Learn Mem 11:755-60. 2004
    ..In conclusion, the expression of LTP in striatal cholinergic interneurons is a selective response to a precise stimulation pattern of induction requiring a critical rise in [Ca2+]i...
  81. ncbi High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients
    Antonio Pisani
    Ann Neurol 57:777-9. 2005
  82. ncbi Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson's disease patients
    Mariangela Pierantozzi
    Department of Neuroscience, Tor Vergata University, Rome, Italy
    J Neural Transm 115:731-5. 2008
    ....
  83. ncbi Inhibition of Ras/ERK1/2 signaling protects against postischemic renal injury
    Massimo Sabbatini
    University Magna Graecia of Catanzaro, Italy
    Am J Physiol Renal Physiol 290:F1408-15. 2006
    ..These data demonstrate that inhibition of farnesylation and consequently of Ras/ERK1/2 signaling significantly reduces acute postischemic renal injury...
  84. ncbi Arginase inhibition slows the progression of renal failure in rats with renal ablation
    Massimo Sabbatini
    Departments of Nephrology and Experimental Medicine, University Federico II, 80131 Naples, Italy
    Am J Physiol Renal Physiol 284:F680-7. 2003
    ..Inhibition of arginase slows the progression of CRF in remnant rats similarly to arginine-treated rats; the better histological protection in MNF rats, however, suggests that additional factors are involved in these modifications...
  85. ncbi Central acute D2 stimulation worsens bladder function in patients with mild Parkinson's disease
    Livia Brusa
    Department of Neurology, University of Rome Tor Vergata, Rome, Italy
    J Urol 175:202-6; discussion 206-7. 2006
    ..CONCLUSIONS: According to our results, a central acute D2 stimulation seems to be responsible of a reduction of bladder capacity with worsening of detrusor overactivity in patients with mild PD...