A Pisani


Affiliation: University of Rome Tor Vergata
Country: Italy


  1. Meringolo M, Tassone A, Imbriani P, Ponterio G, Pisani A. Dystonia: Are animal models relevant in therapeutics?. Rev Neurol (Paris). 2018;174:608-614 pubmed publisher
    ..Thus, our brief survey aims to review the state of the art as regards most of the commonly used animal models available for dystonia research. ..
  2. Eskow Jaunarajs K, Bonsi P, Chesselet M, Standaert D, Pisani A. Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia. Prog Neurobiol. 2015;127-128:91-107 pubmed publisher
  3. Madeo G, Schirinzi T, Maltese M, Martella G, Rapino C, Fezza F, et al. Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice. Neuropharmacology. 2016;101:460-70 pubmed publisher
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    Pisani A, Bonsi P, Centonze D, Bernardi G, Calabresi P. Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons. Neuropharmacology. 2001;40:460-3 pubmed
    ..The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons. ..
  5. Madeo G, Schirinzi T, Natoli S, Pierantozzi M, Stefani A, Dauri M, et al. Efficacy and safety profile of prolonged release oxycodone in combination with naloxone (OXN PR) in Parkinson's disease patients with chronic pain. J Neurol. 2015;262:2164-70 pubmed publisher
    ..More importantly, patients did not experience significant side effects, such as constipation or sedation. Our study provides evidence that opioids can be used to treat pain symptoms in PD patients. ..
  6. Martella G, Madeo G, Maltese M, Vanni V, Puglisi F, Ferraro E, et al. Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice. Neurobiol Dis. 2016;91:21-36 pubmed publisher
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    Pisani A, Gubellini P, Bonsi P, Conquet F, Picconi B, Centonze D, et al. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience. 2001;106:579-87 pubmed
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    Pisani A, Bonsi P, Centonze D, Martorana A, Fusco F, Sancesario G, et al. Activation of beta1-adrenoceptors excites striatal cholinergic interneurons through a cAMP-dependent, protein kinase-independent pathway. J Neurosci. 2003;23:5272-82 pubmed
    ..We conclude that NA depolarizes striatal cholinergic interneurons via beta1-adrenoceptor activation, through a cAMP-dependent but PKA-independent mechanism. ..
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    Pisani A, Martella G, Tscherter A, Costa C, Mercuri N, Bernardi G, et al. Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol Dis. 2006;23:54-60 pubmed
    ..These findings suggest that DJ-1 loss-of-function enhances vulnerability to energy metabolism alterations, and that nigral neurons are particularly sensitive to Na+/K+ ATPase impairment. ..

More Information


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    Pisani A, Martella G, Tscherter A, Bonsi P, Sharma N, Bernardi G, et al. Altered responses to dopaminergic D2 receptor activation and N-type calcium currents in striatal cholinergic interneurons in a mouse model of DYT1 dystonia. Neurobiol Dis. 2006;24:318-25 pubmed
    ..Our data support the existence of an imbalance between striatal dopaminergic and cholinergic signaling in DYT1 dystonia...
  2. Martella G, Maltese M, Nistico R, Schirinzi T, Madeo G, Sciamanna G, et al. Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia. Neurobiol Dis. 2014;65:124-32 pubmed publisher
    ..These results provide evidence for a regional specificity of the electrophysiological abnormalities observed and demonstrate the reproducibility of such alterations in distinct models of DYT1 dystonia. ..
  3. Sciamanna G, Napolitano F, Pelosi B, Bonsi P, Vitucci D, Nuzzo T, et al. Rhes regulates dopamine D2 receptor transmission in striatal cholinergic interneurons. Neurobiol Dis. 2015;78:146-61 pubmed publisher
    ..Our findings reveal that, besides its expression in MSNs, Rhes is localized also in striatal ChIs and, most importantly, lack of this G-protein, significantly alters D2R modulation of striatal cholinergic excitability. ..
  4. Vanni V, Puglisi F, Bonsi P, Ponterio G, Maltese M, Pisani A, et al. Cerebellar synaptogenesis is compromised in mouse models of DYT1 dystonia. Exp Neurol. 2015;271:457-67 pubmed publisher
  5. Imbriani P, Sciamanna G, Santoro M, Schirinzi T, Pisani A. Promising rodent models in Parkinson's disease. Parkinsonism Relat Disord. 2018;46 Suppl 1:S10-S14 pubmed publisher
    ..The development and characterization of new models is crucial for a better understanding of PD related-synaptopathy, and hold promise for the identification of novel therapeutics. ..
  6. Maltese M, Martella G, Imbriani P, Schuermans J, Billion K, Sciamanna G, et al. Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition. Neurobiol Dis. 2017;108:128-139 pubmed publisher
    ..Further, the positive effect of A2AR antagonists indicates that this drug class be tested in DYT11/SGCE dystonia. ..