M Pinzani

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis
    M Pinzani
    Dipartimento di Medicina Interna Università degli Studi di Firenze, Italy
    Semin Liver Dis 19:397-410. 1999
  2. ncbi Cytokine receptors and signaling in hepatic stellate cells
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, I 50134 Florence, Italy
    Semin Liver Dis 21:397-416. 2001
  3. ncbi Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Gastroenterology 119:466-78. 2000
  4. ncbi Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 30:951-8. 1999
  5. ncbi Transient elastography for the assessment of liver fibrosis in patients with chronic viral hepatitis: the missing tool?
    C Stasi
    Dipartimento di Medicina Interna, Università degli Studi di Firenze Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Dig Liver Dis 41:863-6. 2009
  6. ncbi Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells
    V Carloni
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 31:131-40. 2000
  7. ncbi Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells
    E Efsen
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 33:713-21. 2001
  8. ncbi Non invasive diagnosis of portal hypertension in cirrhotic patients
    F Vizzutti
    Dipartimento di Medicina Interna, Universitá degli, Studi di Firenze Azienda Ospedaliero Universitaria Careggi, Firenze, Italy
    Gastroenterol Clin Biol 32:80-7. 2008
  9. ncbi Non-invasive evaluation of hepatic fibrosis: don't count your chickens before they're hatched
    M Pinzani
    Dipartimento di Medicina Interna, , Viale G B Morgagni, 85, 50134 Firenze, Italy
    Gut 55:310-2. 2006
  10. ncbi Role of hepatic stellate cells in the pathogenesis of portal hypertension
    F Marra
    Dipartimento di Medicina Interna, , Firenze, Italy
    Nefrologia 22:34-40. 2002

Collaborators

Detail Information

Publications20

  1. ncbi Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis
    M Pinzani
    Dipartimento di Medicina Interna Università degli Studi di Firenze, Italy
    Semin Liver Dis 19:397-410. 1999
    ..Our aim is to establish a link between the available knowledge on the biology of hepatic stellate cells and their possible implication in the genesis and progression of portal hypertension...
  2. ncbi Cytokine receptors and signaling in hepatic stellate cells
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, I 50134 Florence, Italy
    Semin Liver Dis 21:397-416. 2001
    ..In the past decade the major intracellular signaling pathways elicited by these factors in HSCs have been greatly elucidated...
  3. ncbi Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Gastroenterology 119:466-78. 2000
    ..We explored the effects of PPAR-gamma agonists on the biological actions of cultured human HSCs...
  4. ncbi Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 30:951-8. 1999
    ..The results of this study indicate that ERK activation regulates proliferation and chemotaxis of HSC, and modulates nuclear signaling. Acute liver damage in vivo leads to activation of ERK in HSC...
  5. ncbi Transient elastography for the assessment of liver fibrosis in patients with chronic viral hepatitis: the missing tool?
    C Stasi
    Dipartimento di Medicina Interna, Università degli Studi di Firenze Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Dig Liver Dis 41:863-6. 2009
    ..This review article will focus on the clinical utility of this novel methodology for the assessment of liver fibrosis in chronic viral hepatitis and will highlight potential further advantages...
  6. ncbi Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells
    V Carloni
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 31:131-40. 2000
    ..Taken together, these results establish that Ras operates as a protein-linking PDGF-beta receptor to FAK in human HSCs, and that signaling molecules requiring geranylgeranylation may also be involved in this process...
  7. ncbi Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells
    E Efsen
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 33:713-21. 2001
    ..These findings indicate that cross-talk between cytokines and a prostaglandin-cAMP pathway differentially regulates the proinflammatory potential of HSC, contributing to the modulation of liver tissue inflammation...
  8. ncbi Non invasive diagnosis of portal hypertension in cirrhotic patients
    F Vizzutti
    Dipartimento di Medicina Interna, Universitá degli, Studi di Firenze Azienda Ospedaliero Universitaria Careggi, Firenze, Italy
    Gastroenterol Clin Biol 32:80-7. 2008
    ..On the other hand, the application of non-invasive methods for monitoring the response to vasoactive treatment for the reduction of portal pressure and the prevention of related complications seems at the moment not realistic...
  9. ncbi Non-invasive evaluation of hepatic fibrosis: don't count your chickens before they're hatched
    M Pinzani
    Dipartimento di Medicina Interna, , Viale G B Morgagni, 85, 50134 Firenze, Italy
    Gut 55:310-2. 2006
  10. ncbi Role of hepatic stellate cells in the pathogenesis of portal hypertension
    F Marra
    Dipartimento di Medicina Interna, , Firenze, Italy
    Nefrologia 22:34-40. 2002
  11. ncbi Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes
    A Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Italy
    J Biol Chem 276:9945-54. 2001
    ..These data characterize CXCR3 signaling in pericytes and clarify the relevance of downstream pathways in the modulation of different biologic responses...
  12. ncbi Liver fibrosis: from the bench to clinical targets
    M Pinzani
    Laboratory of Hepatology, Department of Internal Medicine, University of Florence, Viale G B Morgagni, 85, 50134 Florence, Italy
    Dig Liver Dis 36:231-42. 2004
    ....
  13. ncbi Therapies for hepatic fibrosis: real hope or just academic exercise?
    M Pinzani
    Laboratory of Hepatology, Department of Internal Medicine, University of Florence, Viale G B Morgagni, 85, I 50134 Florence, Italy
    Dig Liver Dis 36:714-6. 2004
  14. ncbi ADMA correlates with portal pressure in patients with compensated cirrhosis
    F Vizzutti
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Florence, Italy
    Eur J Clin Invest 37:509-15. 2007
    ..We therefore investigated the possible implication of ADMA in chronic liver diseases-induced portal hypertension...
  15. ncbi Pancreatic stellate cells: new kids become mature
    M Pinzani
    Dipartimento di Medicina Interna, , Viale GB Morgagni, 85, 50134 Firenze, Italy
    Gut 55:12-4. 2006
  16. ncbi Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C
    U Arena
    Department of Internal Medicine, University of Firenze, Firenze, Italy
    Gut 57:1288-93. 2008
    ..Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in patients with chronic liver disease...
  17. ncbi Intermittent fever in a patient with apparent fatty liver
    S Colagrande
    Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Italy
    Gut 55:774, 823. 2006
  18. ncbi Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans
    E Novo
    Dip Medicina e Oncologia Sperimentale, University of Torino, Italy
    Gut 55:1174-82. 2006
    ..CONCLUSIONS: Human activated HSC/MFs are resistant to most proapoptotic stimuli due to Bcl-2 overexpression and this feature may play a key role in the progression of fibrosis in chronic liver diseases...
  19. ncbi Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma
    H Reynaert
    Laboratory for Molecular Liver Cell Biology, Free University of Brussels VUB, Belgium
    Gut 53:1180-9. 2004
    ....
  20. ncbi Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis
    M Pinzani
    Istituto di Medicina Interna Centro Interuniversitario di Fisiopatologia Epatica, Universita di Firenze, Italy
    Am J Pathol 148:785-800. 1996
    ....