M Pinzani

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi Liver fibrosis: from the bench to clinical targets
    M Pinzani
    Laboratory of Hepatology, Department of Internal Medicine, University of Florence, Viale G B Morgagni, 85, 50134 Florence, Italy
    Dig Liver Dis 36:231-42. 2004
  2. ncbi Fibrosis in chronic liver diseases: diagnosis and management
    Massimo Pinzani
    Dipartimento di Medicina Interna, Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Firenze, Italy
    J Hepatol 42:S22-36. 2005
  3. ncbi Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells
    Anja Schulze-Krebs
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    Gastroenterology 129:246-58. 2005
  4. pmc Pancreatic stellate cells: new kids become mature
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale GB Morgagni, 85, 50134 Firenze, Italy
    Gut 55:12-4. 2006
  5. pmc Non-invasive evaluation of hepatic fibrosis: don't count your chickens before they're hatched
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Firenze, Italy
    Gut 55:310-2. 2006
  6. pmc What is new in the liver sinusoids? meeting report, 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS)
    Krista Rombouts
    Department of Internal Medicine, DENOthe, University of Florence, Florence, Italy
    Fibrogenesis Tissue Repair 4:27. 2011
  7. ncbi Therapies for hepatic fibrosis: real hope or just academic exercise?
    M Pinzani
    Laboratory of Hepatology, Department of Internal Medicine, University of Florence, Viale G B Morgagni, 85, I 50134 Florence, Italy
    Dig Liver Dis 36:714-6. 2004
  8. ncbi PDGF and signal transduction in hepatic stellate cells
    Massimo Pinzani
    Dipartimento di Medicina Interna, Universit degli Studi di Firenze, Firenze, Italy
    Front Biosci 7:d1720-6. 2002
  9. doi Fibrosis and cirrhosis reversibility: clinical features and implications
    Massimo Pinzani
    Dipartimento di Medicina Interna, Center for Research, High Education and Transfer, Universita degli Studi di Firenze, Florence, Italy
    Clin Liver Dis 12:901-13, x. 2008
  10. doi Epithelial-mesenchymal transition in chronic liver disease: fibrogenesis or escape from death?
    Massimo Pinzani
    Dipartimento di Medicina Interna, Center for Research, High Education and Transfer DENOThe, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Firenze, Italy
    J Hepatol 55:459-65. 2011

Collaborators

Detail Information

Publications66

  1. ncbi Liver fibrosis: from the bench to clinical targets
    M Pinzani
    Laboratory of Hepatology, Department of Internal Medicine, University of Florence, Viale G B Morgagni, 85, 50134 Florence, Italy
    Dig Liver Dis 36:231-42. 2004
    ....
  2. ncbi Fibrosis in chronic liver diseases: diagnosis and management
    Massimo Pinzani
    Dipartimento di Medicina Interna, Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Firenze, Italy
    J Hepatol 42:S22-36. 2005
  3. ncbi Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells
    Anja Schulze-Krebs
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    Gastroenterology 129:246-58. 2005
    ....
  4. pmc Pancreatic stellate cells: new kids become mature
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale GB Morgagni, 85, 50134 Firenze, Italy
    Gut 55:12-4. 2006
  5. pmc Non-invasive evaluation of hepatic fibrosis: don't count your chickens before they're hatched
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Firenze, Italy
    Gut 55:310-2. 2006
  6. pmc What is new in the liver sinusoids? meeting report, 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS)
    Krista Rombouts
    Department of Internal Medicine, DENOthe, University of Florence, Florence, Italy
    Fibrogenesis Tissue Repair 4:27. 2011
    ..This symposium is a multidisciplinary meeting where new and important findings on the biology of liver cells are presented and discussed...
  7. ncbi Therapies for hepatic fibrosis: real hope or just academic exercise?
    M Pinzani
    Laboratory of Hepatology, Department of Internal Medicine, University of Florence, Viale G B Morgagni, 85, I 50134 Florence, Italy
    Dig Liver Dis 36:714-6. 2004
  8. ncbi PDGF and signal transduction in hepatic stellate cells
    Massimo Pinzani
    Dipartimento di Medicina Interna, Universit degli Studi di Firenze, Firenze, Italy
    Front Biosci 7:d1720-6. 2002
    ..In addition, stimulation with PDGF increases the activity of the Na+/H+ exchanger in rat or human HSC with consequent sustained changes in intracellular pH...
  9. doi Fibrosis and cirrhosis reversibility: clinical features and implications
    Massimo Pinzani
    Dipartimento di Medicina Interna, Center for Research, High Education and Transfer, Universita degli Studi di Firenze, Florence, Italy
    Clin Liver Dis 12:901-13, x. 2008
    ..This article outlines differences between fibrosis and cirrhosis and discusses the reversibility of CLD and the regression of fibrosis and cirrhosis. The end-points of anti-fibrotic therapy are detailed...
  10. doi Epithelial-mesenchymal transition in chronic liver disease: fibrogenesis or escape from death?
    Massimo Pinzani
    Dipartimento di Medicina Interna, Center for Research, High Education and Transfer DENOThe, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Firenze, Italy
    J Hepatol 55:459-65. 2011
    ..The aim of this article is to analyze and discuss the evidence supporting or confuting this possibility in order to reach reasonable and useful conclusions...
  11. doi Liver cirrhosis
    Massimo Pinzani
    Dipartimento di Medicina Interna, Viale G B Morgagni, 85, 50134 Firenze, Italy
    Best Pract Res Clin Gastroenterol 25:281-90. 2011
    ..Accordingly, the primary end-point of antifibrotic therapy in cirrhotic patients should be the reduction of fibrosis in the context of cirrhosis with a beneficial impact on portal hypertension and the emergence of HCC...
  12. doi Pathophysiology of non-alcoholic steatohepatitis and basis for treatment
    Massimo Pinzani
    Department of Internal Medicine, Center for Research, High Education and Transfer DENOThe, University of Florence, Florence, Italy
    Dig Dis 29:243-8. 2011
    ..Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and anti-inflammatory and antifibrogenic agents are under evaluation...
  13. doi Technology Insight: noninvasive assessment of liver fibrosis by biochemical scores and elastography
    Massimo Pinzani
    Unit 6 Hepatology, Center for Research, High Education and Transfer DENOThe, Universita degli Studi di Firenze, Florence, Italy
    Nat Clin Pract Gastroenterol Hepatol 5:95-106. 2008
    ..In particular, the Review focuses on the methods easily available as part of daily clinical practice in hepatology--biochemical markers and transient elastography (i.e. liver stiffness measurement)...
  14. doi Update on the pathophysiology of liver fibrosis
    Massimo Pinzani
    Universita degli Studi di Firenze, Florence, Italy Dipartimento di Medicina Interna, Viale GB Morgagni, 85, 50134 Firenze, Italy
    Expert Rev Gastroenterol Hepatol 4:459-72. 2010
    ..The aim of this article is to provide an update on these mechanisms with an attempt to integrate classic and novel pathways responsible for the evolution of the fibrogenic process and, potentially, for its regression...
  15. ncbi Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Gastroenterology 119:466-78. 2000
    ..We explored the effects of PPAR-gamma agonists on the biological actions of cultured human HSCs...
  16. ncbi Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 29:140-8. 1999
    ..MCP-1-dependent signals in these cells are not transduced by CCR2 and may be mediated by alternative chemokine receptors. (HEPATOLOGY 1999;29:140-148.)..
  17. ncbi Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat
    F Marra
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 30:951-8. 1999
    ..The results of this study indicate that ERK activation regulates proliferation and chemotaxis of HSC, and modulates nuclear signaling. Acute liver damage in vivo leads to activation of ERK in HSC...
  18. pmc Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    Am J Pathol 152:423-30. 1998
    ..These data expand previous in vitro studies showing that secretion of MCP-1 may contribute to the formation and maintenance of the inflammatory infiltrate observed during chronic liver disease...
  19. doi Liver failure complicating segmental hepatic ischaemia induced by a PTFE-coated TIPS stent
    F Vizzutti
    Department of Internal Medicine, University of Florence, Florence, Italy
    Gut 58:582-4. 2009
    ..Moreover, we discuss the possible involvement of additional pathogenetic mechanisms other than out-flow obstruction in the onset of coated-stent induced congestive liver ischaemia...
  20. ncbi Integrin-mediated stimulation of monocyte chemotactic protein-1 expression
    F Marra
    Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
    FEBS Lett 414:221-5. 1997
    ..These findings indicate a novel mechanism of MCP-1 regulation possibly relevant in those conditions where HSC interact with an altered extracellular matrix...
  21. doi Transient elastography for the assessment of liver fibrosis in patients with chronic viral hepatitis: the missing tool?
    C Stasi
    Dipartimento di Medicina Interna, Università degli Studi di Firenze Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Dig Liver Dis 41:863-6. 2009
    ..This review article will focus on the clinical utility of this novel methodology for the assessment of liver fibrosis in chronic viral hepatitis and will highlight potential further advantages...
  22. doi Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C
    U Arena
    Department of Internal Medicine, University of Firenze, Firenze, Italy
    Gut 57:1288-93. 2008
    ..Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in patients with chronic liver disease...
  23. ncbi Cell adhesion regulates platelet-derived growth factor-induced MAP kinase and PI-3 kinase activation in stellate cells
    Vinicio Carloni
    Dipartimento di Medicina Interna and Dipartimento di Fisiopatologia Clinica Unità di Andrologia, Universita degli Studi di Firenze, Florence, Italy
    Hepatology 36:582-91. 2002
    ..In conclusion, these results suggest that cell adhesion differentially regulates major signaling pathways activated by PDGF in HSC...
  24. ncbi Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cells
    V Carloni
    Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
    Hepatology 31:131-40. 2000
    ..Taken together, these results establish that Ras operates as a protein-linking PDGF-beta receptor to FAK in human HSCs, and that signaling molecules requiring geranylgeranylation may also be involved in this process...
  25. ncbi Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells
    Alessandra Caligiuri
    Dipartimento di Medicina Interna, Universita di Firenze, Italy
    Gastroenterology 124:504-20. 2003
    ..The aim of this study was to evaluate the possible direct antifibrogenic effects of canrenone, the active metabolite of spironolactone, in activated human hepatic stellate cells...
  26. doi Non invasive diagnosis of portal hypertension in cirrhotic patients
    F Vizzutti
    Dipartimento di Medicina Interna, Universitá degli, Studi di Firenze Azienda Ospedaliero Universitaria Careggi, Firenze, Italy
    Gastroenterol Clin Biol 32:80-7. 2008
    ..On the other hand, the application of non-invasive methods for monitoring the response to vasoactive treatment for the reduction of portal pressure and the prevention of related complications seems at the moment not realistic...
  27. ncbi Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells
    E Efsen
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 33:713-21. 2001
    ..These findings indicate that cross-talk between cytokines and a prostaglandin-cAMP pathway differentially regulates the proinflammatory potential of HSC, contributing to the modulation of liver tissue inflammation...
  28. ncbi Performance of Doppler ultrasound in the prediction of severe portal hypertension in hepatitis C virus-related chronic liver disease
    Francesco Vizzutti
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale G B Morgagni, Firenze, Italy
    Liver Int 27:1379-88. 2007
    ..To evaluate the correlation between hepatic vein pressure gradient measurement and Doppler ultrasonography (DUS) in patients with chronic liver disease (CLD)...
  29. ncbi Role of hepatic stellate cells in the pathogenesis of portal hypertension
    F Marra
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Firenze, Italy
    Nefrologia 22:34-40. 2002
  30. pmc Intermittent fever in a patient with apparent fatty liver
    S Colagrande
    Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Italy
    Gut 55:774, 823. 2006
  31. ncbi Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis
    M Pinzani
    Dipartimento di Medicina Interna Università degli Studi di Firenze, Italy
    Semin Liver Dis 19:397-410. 1999
    ..Our aim is to establish a link between the available knowledge on the biology of hepatic stellate cells and their possible implication in the genesis and progression of portal hypertension...
  32. ncbi The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C
    Andrea Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Florence, Italy
    Gastroenterology 125:1060-76. 2003
    ..We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also studied...
  33. doi MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cells
    Krista Rombouts
    Department of Internal Medicine, University of Florence, Italy
    Exp Cell Res 314:1444-54. 2008
    ..In conclusion, the present study indicates that MARCKS play a major key role in PDGF-BB-induced chemotaxis in activated hHSC...
  34. ncbi Hemodynamic derangement and cardiac dysfunction in cirrhosis
    Paolo Gentilini
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze
    Ann Ital Med Int 19:90-7. 2004
    ....
  35. ncbi Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration
    Antonio Mazzocca
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, Florence, Italy
    J Hepatol 37:322-30. 2002
    ..We evaluated the expression and function of four TM4SF, namely CD9, CD81, CD63 and CD151, and their involvement in HSC migration, adhesion, and proliferation...
  36. ncbi Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells
    Fabio Marra
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50137 Florence, Italy
    Am J Physiol Gastrointest Liver Physiol 287:G18-26. 2004
    ..We conclude that members of the MAPK family differentially regulate cytokine-induced chemokine expression in human HSC...
  37. ncbi Small diameter H-graft porta-caval shunt performed at different stages of liver disease
    Giacomo Batignani
    Dipartimento di Fisiopatologia Clinica Unità di Chirurgia, Viale Morgagni, Universita degli Studi di Firenze, 85 50134 Firenze, Italy
    Hepatobiliary Pancreat Dis Int 3:516-21. 2004
    ..To further investigate these assumptions, we retrospectively reviewed the results of partial porta-caval shunts performed at different stages of liver disease...
  38. ncbi Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells
    Antonio Mazzocca
    Dipartimento di Medicina Interna, Centro di Ricerca, Trasferimento e Alta Formazione MCIDNENT Università di Firenze, I 50134 Firenze, Italy
    J Biol Chem 280:11329-39. 2005
    ..Increased degradation of the normal hepatic extracellular matrix in areas where HCV is concentrated may favor inflammatory infiltration and further parenchymal damage...
  39. ncbi Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    Sara Aleffi
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 42:1339-48. 2005
    ..In conclusion, ObR activation in HSCs leads to increased expression of proinflammatory and proangiogenic cytokines, indicating a complex role for leptin in the regulation of the liver wound-healing response...
  40. ncbi Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis
    Fabio Marra
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, Florence I 50134, Italy
    World J Gastroenterol 11:4931-8. 2005
    ....
  41. ncbi Ordered array of dendritic cells and CD8+ lymphocytes in portal infiltrates in chronic hepatitis C
    M B Gallè
    Departments of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    Histopathology 39:373-81. 2001
    ..Therefore, we addressed the ultrastructure, immunophenotype, distribution and relationships to lymphatics of dendritic cells in portal infiltrates of this disease...
  42. ncbi Cytokine receptors and signaling in hepatic stellate cells
    M Pinzani
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, I 50134 Florence, Italy
    Semin Liver Dis 21:397-416. 2001
    ..In the past decade the major intracellular signaling pathways elicited by these factors in HSCs have been greatly elucidated...
  43. ncbi ADMA correlates with portal pressure in patients with compensated cirrhosis
    F Vizzutti
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Florence, Italy
    Eur J Clin Invest 37:509-15. 2007
    ..We therefore investigated the possible implication of ADMA in chronic liver diseases-induced portal hypertension...
  44. ncbi Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes
    A Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Italy
    J Biol Chem 276:9945-54. 2001
    ..These data characterize CXCR3 signaling in pericytes and clarify the relevance of downstream pathways in the modulation of different biologic responses...
  45. doi Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells
    Marco Trappoliere
    Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Florence, Italy
    J Hepatol 50:1102-11. 2009
    ..However, scant information is available on the fine cellular and molecular events responsible for this effect. The aim of this study was to assess the mechanisms regulating the anti-fibrogenic and anti-inflammatory activity of Silybin...
  46. ncbi Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis
    Francesco Vizzutti
    Dipartimento di Medicina Interna, Center for Research, Higher Education and Transfer DENOThe, Firenze, Italy
    Hepatology 45:1290-7. 2007
    ....
  47. ncbi Nuclear localization of TRK-A in liver cells
    Andrea Bonacchi
    Department of Medicina Interna, University of Florence, Italy
    Histol Histopathol 23:327-40. 2008
    ..We conclude that nuclear localization of the intracellular domain of Trk-A is observed constitutively in liver cells such as HSC, while in other cell types it could be induced in response to soluble factors...
  48. ncbi Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans
    Eva Efsen
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
    J Hepatol 37:39-47. 2002
    ..Little is known about the role of fractalkine (CX3CL1) in the liver. The aim of this study was to investigate the expression patterns of fractalkine and its receptor CX3CR1 in normal human liver and in conditions of injury...
  49. ncbi Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells
    Alessandra Caligiuri
    Dipartimento di Medicina Interna, University of Florence, Italy
    Hepatology 47:668-76. 2008
    ..The ability of interleukin-a (IL-1) to activate nuclear factor kappa B (NF-kappaB) was also reduced by AICAR...
  50. doi Curcumin limits the fibrogenic evolution of experimental steatohepatitis
    Francesco Vizzutti
    Dipartimento di Medicina Interna, University of Florence, Florence, Italy
    Lab Invest 90:104-15. 2010
    ..In conclusion, curcumin administration effectively limits the development and progression of fibrosis in mice with experimental steatohepatitis, and reduces TIMP-1 secretion and oxidative stress in cultured stellate cells...
  51. ncbi Non-invasive assessment of fibrosis in non-alcoholic fatty liver disease
    Francesco Vizzutti
    Department of Internal Medicine, University of Florence, Firenze, Italy
    Ann Hepatol 8:89-94. 2009
    ....
  52. doi Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B
    Ilaria Petrai
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
    Int J Biochem Cell Biol 40:1764-74. 2008
    ..In conclusion, the p38(MAPK) pathway is a downstream effector of CXCR3-B implicated in the angiostatic action of this chemokine receptor...
  53. pmc Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells
    Cristiana Bertolani
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I 50134 Florence, Italy, and the Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Am J Pathol 169:2042-53. 2006
    ....
  54. ncbi Acute viral hepatitis increases liver stiffness values measured by transient elastography
    Umberto Arena
    Dipartimento di Medicina Interna, Università degli Studi di Firenze Azienda Ospedaliero Universitaria Careggi Firenze, Italy
    Hepatology 47:380-4. 2008
    ..LSM does not represent a reliable instrument to detect the presence of advanced fibrosis and cirrhosis in patients presenting with a clinical picture of acute hepatitis...
  55. ncbi 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cells
    Elena Zamara
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Corso Raffaello 30, 10125 Turin, Italy
    J Hepatol 40:60-8. 2004
    ..This study has been performed to evaluate its 'in vivo' levels in injured liver and whether HNE may induce apoptosis and/or affect selected phenotypic responses in activated human hepatic stellate cells (HSC/MF)...
  56. ncbi Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells
    Paola Brun
    Department of Histology, University of Padua, Padua, Italy
    Am J Physiol Gastrointest Liver Physiol 289:G571-8. 2005
    ..We speculate that high levels of bacterial endotoxins in the portal vein may directly induce a proinflammatory phenotype in HSCs that contributes to liver damage...
  57. ncbi Myofibroblast - like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario
    Maurizio Parola
    Dipartimento di Medicina e Oncologia Sperimentale, University of Torino, Corso Raffaello 30, 10125 Torino, Italy
    Mol Aspects Med 29:58-66. 2008
    ..In this short review emerging concepts in hepatic fibrogenesis and related molecular mechanisms, as provided by recent experimental and clinical studies, are presented...
  58. pmc Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells
    Erica Novo
    Universita degli Studi di Torino, Dipartimento Medicina e Oncologia Sperimentale, Corso Raffaello 30, 10125 Turin, Italy
    Am J Pathol 170:1942-53. 2007
    ..Moreover, HSC/MFs, in addition to their established profibrogenic role, may also contribute to neoangiogenesis during chronic hepatic wound healing...
  59. ncbi A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions
    Antonio Mazzocca
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 65:4728-38. 2005
    ..These results emphasize the importance of tumor-stromal interactions in invasion and suggest that ADAM9-S can be an important determinant in the ability of cancer cells to invade and colonize the liver...
  60. ncbi Serum markers detect the presence of liver fibrosis: a cohort study
    William M C Rosenberg
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, England SO16 6YD
    Gastroenterology 127:1704-13. 2004
    ..We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis...
  61. ncbi Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice
    Elena Zamara
    Dipartimento di Medicina e Oncologia Sperimentale, University of Turin, Italy
    J Hepatol 46:230-8. 2007
    ..In this study, we investigated the development of acute toxic damage in mice lacking monocyte chemoattractant protein-1 (MCP-1), a chemokine which recruits monocytes and activated lymphocytes...
  62. pmc Increased risk of hepatocellular carcinoma and liver cirrhosis in vinyl chloride workers: synergistic effect of occupational exposure with alcohol intake
    Giuseppe Mastrangelo
    Department of Environmental Medicine and Public Health, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Environ Health Perspect 112:1188-92. 2004
    ..In conclusion, according to our findings, VCM exposure appears to be an independent risk factor for HCC and LC interacting synergistically with alcohol consumption and additively with viral hepatitis infection...
  63. ncbi Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins
    Willem Boers
    AMC Liver Center, Academic Medical Center, University of Amsterdam, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    J Biol Chem 281:16289-95. 2006
    ..In conclusion, the comparison of the three transcriptomes of (activated) stellate cells reveals novel genes involved in fibrogenesis and provides an appreciation of the sequence and timing of the fibrotic process in liver...
  64. ncbi Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis
    Paola Brun
    Department of Histology, Univ of Padua, Via Gabelli 63, Padova, Italy
    Am J Physiol Gastrointest Liver Physiol 292:G518-25. 2007
    ..We suggest that in metabolic syndrome, patients may likewise have a greater intestinal mucosa permeability and increased lipopolysaccharide levels in portal blood that can contribute to the liver inflammatory damage...
  65. doi Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Hepatology 48:442-8. 2008
    ..In patients in which likelihood ratios are not optimal to provide a reliable indication of the disease stage, liver biopsy should be considered when clinically indicated...