Research Topics
Genomes and GenesSpecies | M PinzaniSummaryAffiliation: University of Florence Country: Italy Publications
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Publications
Liver fibrosis: from the bench to clinical targetsM Pinzani
Laboratory of Hepatology, Department of Internal Medicine, University of Florence, Viale G B Morgagni, 85, 50134 Florence, Italy
Dig Liver Dis 36:231-42. 2004....- Fibrosis in chronic liver diseases: diagnosis and managementMassimo Pinzani
Dipartimento di Medicina Interna, Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, , Viale G.B. Morgagni, 85, 50134 Firenze, Italy
J Hepatol 42:S22-36. 2005 - Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cellsAnja Schulze-Krebs
Department of Medicine I, University of Erlangen-Nuremberg, Germany
Gastroenterology 129:246-58. 2005.... - Pancreatic stellate cells: new kids become matureM Pinzani
Dipartimento di Medicina Interna, , Viale GB Morgagni, 85, 50134 Firenze, Italy
Gut 55:12-4. 2006 - Non-invasive evaluation of hepatic fibrosis: don't count your chickens before they're hatchedM Pinzani
Dipartimento di Medicina Interna, , Viale G B Morgagni, 85, 50134 Firenze, Italy
Gut 55:310-2. 2006 - What is new in the liver sinusoids? meeting report, 16th International Symposium on Cells of the Hepatic Sinusoid (ISCHS)Krista Rombouts
Department of Internal Medicine, DENOthe, University of Florence, Florence, Italy
Fibrogenesis Tissue Repair 4:27. 2011..This symposium is a multidisciplinary meeting where new and important findings on the biology of liver cells are presented and discussed... - Fibrosis and cirrhosis reversibility: clinical features and implicationsMassimo Pinzani
Dipartimento di Medicina Interna, Center for Research, High Education and Transfer, Universita degli Studi di Firenze, Florence, Italy
Clin Liver Dis 12:901-13, x. 2008..This article outlines differences between fibrosis and cirrhosis and discusses the reversibility of CLD and the regression of fibrosis and cirrhosis. The end-points of anti-fibrotic therapy are detailed... - PDGF and signal transduction in hepatic stellate cellsMassimo Pinzani
Dipartimento di Medicina Interna, Universit degli Studi di Firenze, Firenze, Italy
Front Biosci 7:d1720-6. 2002..In addition, stimulation with PDGF increases the activity of the Na+/H+ exchanger in rat or human HSC with consequent sustained changes in intracellular pH... - Update on the pathophysiology of liver fibrosisMassimo Pinzani
Universita degli Studi di Firenze, Florence, Italy Dipartimento di Medicina Interna, Viale GB Morgagni, 85, 50134 Firenze, Italy
Expert Rev Gastroenterol Hepatol 4:459-72. 2010..The aim of this article is to provide an update on these mechanisms with an attempt to integrate classic and novel pathways responsible for the evolution of the fibrogenic process and, potentially, for its regression... - Epithelial-mesenchymal transition in chronic liver disease: fibrogenesis or escape from death?Massimo Pinzani
Dipartimento di Medicina Interna, Center for Research, High Education and Transfer DENOThe, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Firenze, Italy
J Hepatol 55:459-65. 2011..The aim of this article is to analyze and discuss the evidence supporting or confuting this possibility in order to reach reasonable and useful conclusions... - Technology Insight: noninvasive assessment of liver fibrosis by biochemical scores and elastographyMassimo Pinzani
Unit 6 Hepatology, Center for Research, High Education and Transfer DENOThe, Universita degli Studi di Firenze, Florence, Italy
Nat Clin Pract Gastroenterol Hepatol 5:95-106. 2008..In particular, the Review focuses on the methods easily available as part of daily clinical practice in hepatology--biochemical markers and transient elastography (i.e. liver stiffness measurement)... - Liver cirrhosisMassimo Pinzani
Dipartimento di Medicina Interna, Viale G B Morgagni, 85, 50134 Firenze, Italy
Best Pract Res Clin Gastroenterol 25:281-90. 2011..Accordingly, the primary end-point of antifibrotic therapy in cirrhotic patients should be the reduction of fibrosis in the context of cirrhosis with a beneficial impact on portal hypertension and the emergence of HCC... - Pathophysiology of non-alcoholic steatohepatitis and basis for treatmentMassimo Pinzani
Department of Internal Medicine, Center for Research, High Education and Transfer DENOThe, University of Florence, Florence, Italy
Dig Dis 29:243-8. 2011..Current treatment relies on weight loss and exercise, although various insulin-sensitizing agents, antioxidants and anti-inflammatory and antifibrogenic agents are under evaluation... - Therapies for hepatic fibrosis: real hope or just academic exercise?M Pinzani
Laboratory of Hepatology, Department of Internal Medicine, University of Florence, Viale G.B. Morgagni, 85, I-50134 Florence, Italy
Dig Liver Dis 36:714-6. 2004 - Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cellsF Marra
Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
Gastroenterology 119:466-78. 2000..We explored the effects of PPAR-gamma agonists on the biological actions of cultured human HSCs... - Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cellsF Marra
Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
Hepatology 29:140-8. 1999..MCP-1-dependent signals in these cells are not transduced by CCR2 and may be mediated by alternative chemokine receptors. (HEPATOLOGY 1999;29:140-148.).. - Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the ratF Marra
Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
Hepatology 30:951-8. 1999..The results of this study indicate that ERK activation regulates proliferation and chemotaxis of HSC, and modulates nuclear signaling. Acute liver damage in vivo leads to activation of ERK in HSC... - Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltrationF Marra
Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
Am J Pathol 152:423-30. 1998..These data expand previous in vitro studies showing that secretion of MCP-1 may contribute to the formation and maintenance of the inflammatory infiltrate observed during chronic liver disease... - Liver failure complicating segmental hepatic ischaemia induced by a PTFE-coated TIPS stentF Vizzutti
Department of Internal Medicine, University of Florence, Florence, Italy
Gut 58:582-4. 2009..Moreover, we discuss the possible involvement of additional pathogenetic mechanisms other than out-flow obstruction in the onset of coated-stent induced congestive liver ischaemia... - Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis CU Arena
Department of Internal Medicine, University of Firenze, Firenze, Italy
Gut 57:1288-93. 2008..Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in patients with chronic liver disease... - Transient elastography for the assessment of liver fibrosis in patients with chronic viral hepatitis: the missing tool?C Stasi
Dipartimento di Medicina Interna, Università degli Studi di Firenze Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Dig Liver Dis 41:863-6. 2009..This review article will focus on the clinical utility of this novel methodology for the assessment of liver fibrosis in chronic viral hepatitis and will highlight potential further advantages... - Integrin-mediated stimulation of monocyte chemotactic protein-1 expressionF Marra
Istituto di Medicina Interna, Universita di Firenze, Florence, Italy
FEBS Lett 414:221-5. 1997..These findings indicate a novel mechanism of MCP-1 regulation possibly relevant in those conditions where HSC interact with an altered extracellular matrix... - Cell adhesion regulates platelet-derived growth factor-induced MAP kinase and PI-3 kinase activation in stellate cellsVinicio Carloni
, , Florence, Italy
Hepatology 36:582-91. 2002..In conclusion, these results suggest that cell adhesion differentially regulates major signaling pathways activated by PDGF in HSC... - Tyrosine phosphorylation of focal adhesion kinase by PDGF is dependent on ras in human hepatic stellate cellsV Carloni
Dipartimento di Medicina Interna, Universita di Firenze, Florence, Italy
Hepatology 31:131-40. 2000..Taken together, these results establish that Ras operates as a protein-linking PDGF-beta receptor to FAK in human HSCs, and that signaling molecules requiring geranylgeranylation may also be involved in this process... - Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cellsAlessandra Caligiuri
Dipartimento di Medicina Interna, Universita di Firenze, Italy
Gastroenterology 124:504-20. 2003..The aim of this study was to evaluate the possible direct antifibrogenic effects of canrenone, the active metabolite of spironolactone, in activated human hepatic stellate cells... - Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cellsE Efsen
Dipartimento di Medicina Interna, University of Florence, Italy
Hepatology 33:713-21. 2001..These findings indicate that cross-talk between cytokines and a prostaglandin-cAMP pathway differentially regulates the proinflammatory potential of HSC, contributing to the modulation of liver tissue inflammation... - Non invasive diagnosis of portal hypertension in cirrhotic patientsF Vizzutti
Dipartimento di Medicina Interna, Universitá degli, Studi di Firenze Azienda Ospedaliero Universitaria Careggi, Firenze, Italy
Gastroenterol Clin Biol 32:80-7. 2008..On the other hand, the application of non-invasive methods for monitoring the response to vasoactive treatment for the reduction of portal pressure and the prevention of related complications seems at the moment not realistic... - Performance of Doppler ultrasound in the prediction of severe portal hypertension in hepatitis C virus-related chronic liver diseaseFrancesco Vizzutti
Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale G B Morgagni, Firenze, Italy
Liver Int 27:1379-88. 2007..To evaluate the correlation between hepatic vein pressure gradient measurement and Doppler ultrasonography (DUS) in patients with chronic liver disease (CLD)... - Role of hepatic stellate cells in the pathogenesis of portal hypertensionF Marra
Dipartimento di Medicina Interna, , Firenze, Italy
Nefrologia 22:34-40. 2002 - Intermittent fever in a patient with apparent fatty liverS Colagrande
Sezione di Radiodiagnostica, Dipartimento di Fisiopatologia Clinica, Italy
Gut 55:774, 823. 2006 - Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosisM Pinzani
Dipartimento di Medicina Interna Università degli Studi di Firenze, Italy
Semin Liver Dis 19:397-410. 1999..Our aim is to establish a link between the available knowledge on the biology of hepatic stellate cells and their possible implication in the genesis and progression of portal hypertension... - MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cellsKrista Rombouts
Department of Internal Medicine, University of Florence, Italy
Exp Cell Res 314:1444-54. 2008..In conclusion, the present study indicates that MARCKS play a major key role in PDGF-BB-induced chemotaxis in activated hHSC... - Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cellsSara Aleffi
Dipartimento di Medicina Interna, University of Florence, Italy
Hepatology 42:1339-48. 2005..In conclusion, ObR activation in HSCs leads to increased expression of proinflammatory and proangiogenic cytokines, indicating a complex role for leptin in the regulation of the liver wound-healing response... - Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migrationAntonio Mazzocca
Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, Florence, Italy
J Hepatol 37:322-30. 2002..We evaluated the expression and function of four TM4SF, namely CD9, CD81, CD63 and CD151, and their involvement in HSC migration, adhesion, and proliferation... - The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis CAndrea Bonacchi
Dipartimento di Medicina Interna, University of Florence, Florence, Italy
Gastroenterology 125:1060-76. 2003..We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also studied... - Small diameter H-graft porta-caval shunt performed at different stages of liver diseaseGiacomo Batignani
Dipartimento di Fisiopatologia Clinica Unità di Chirurgia, Viale Morgagni, Universita degli Studi di Firenze, 85 50134 Firenze, Italy
Hepatobiliary Pancreat Dis Int 3:516-21. 2004..To further investigate these assumptions, we retrospectively reviewed the results of partial porta-caval shunts performed at different stages of liver disease... - Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cellsAntonio Mazzocca
Dipartimento di Medicina Interna, Centro di Ricerca, Trasferimento e Alta Formazione MCIDNENT Università di Firenze, I 50134 Firenze, Italy
J Biol Chem 280:11329-39. 2005..Increased degradation of the normal hepatic extracellular matrix in areas where HCV is concentrated may favor inflammatory infiltration and further parenchymal damage... - Hemodynamic derangement and cardiac dysfunction in cirrhosisPaolo Gentilini
Dipartimento di Medicina Interna, Universita degli Studi di Firenze
Ann Ital Med Int 19:90-7. 2004.... - Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cellsFabio Marra
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50137 Florence, Italy
Am J Physiol Gastrointest Liver Physiol 287:G18-26. 2004..We conclude that members of the MAPK family differentially regulate cytokine-induced chemokine expression in human HSC... - Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasisFabio Marra
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, Florence I 50134, Italy
World J Gastroenterol 11:4931-8. 2005.... - Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytesA Bonacchi
Dipartimento di Medicina Interna, University of Florence, Italy
J Biol Chem 276:9945-54. 2001..These data characterize CXCR3 signaling in pericytes and clarify the relevance of downstream pathways in the modulation of different biologic responses... - Cytokine receptors and signaling in hepatic stellate cellsM Pinzani
Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale Morgagni, 85, I 50134 Florence, Italy
Semin Liver Dis 21:397-416. 2001..In the past decade the major intracellular signaling pathways elicited by these factors in HSCs have been greatly elucidated... - ADMA correlates with portal pressure in patients with compensated cirrhosisF Vizzutti
Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Florence, Italy
Eur J Clin Invest 37:509-15. 2007..We therefore investigated the possible implication of ADMA in chronic liver diseases-induced portal hypertension... - Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosisFrancesco Vizzutti
Dipartimento di Medicina Interna, Center for Research, Higher Education and Transfer DENOThe, Firenze, Italy
Hepatology 45:1290-7. 2007.... - Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cellsMarco Trappoliere
Dipartimento di Medicina Interna, Universita degli Studi di Firenze, Viale G B Morgagni, 85, 50134 Florence, Italy
J Hepatol 50:1102-11. 2009..However, scant information is available on the fine cellular and molecular events responsible for this effect. The aim of this study was to assess the mechanisms regulating the anti-fibrogenic and anti-inflammatory activity of Silybin... - Curcumin limits the fibrogenic evolution of experimental steatohepatitisFrancesco Vizzutti
Dipartimento di Medicina Interna, University of Florence, Florence, Italy
Lab Invest 90:104-15. 2010..In conclusion, curcumin administration effectively limits the development and progression of fibrosis in mice with experimental steatohepatitis, and reduces TIMP-1 secretion and oxidative stress in cultured stellate cells... - Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cellsAlessandra Caligiuri
Dipartimento di Medicina Interna, University of Florence, Italy
Hepatology 47:668-76. 2008..The ability of interleukin-a (IL-1) to activate nuclear factor kappa B (NF-kappaB) was also reduced by AICAR. CONCLUSION: Activation of AMPK negatively modulates the activated phenotype of HSCs... - Nuclear localization of TRK-A in liver cellsAndrea Bonacchi
Department of Medicina Interna, University of Florence, Italy
Histol Histopathol 23:327-40. 2008..We conclude that nuclear localization of the intracellular domain of Trk-A is observed constitutively in liver cells such as HSC, while in other cell types it could be induced in response to soluble factors... - Non-invasive assessment of fibrosis in non-alcoholic fatty liver diseaseFrancesco Vizzutti
Department of Internal Medicine, University of Florence, Firenze, Italy
Ann Hepatol 8:89-94. 2009.... - Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humansEva Efsen
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
J Hepatol 37:39-47. 2002..Little is known about the role of fractalkine (CX3CL1) in the liver. The aim of this study was to investigate the expression patterns of fractalkine and its receptor CX3CR1 in normal human liver and in conditions of injury... - Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-BIlaria Petrai
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
Int J Biochem Cell Biol 40:1764-74. 2008..In conclusion, the p38(MAPK) pathway is a downstream effector of CXCR3-B implicated in the angiostatic action of this chemokine receptor... - Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cellsCristiana Bertolani
Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I 50134 Florence, Italy, and the Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
Am J Pathol 169:2042-53. 2006.... - Acute viral hepatitis increases liver stiffness values measured by transient elastographyUmberto Arena
Dipartimento di Medicina Interna, Università degli Studi di Firenze Azienda Ospedaliero Universitaria Careggi Firenze, Italy
Hepatology 47:380-4. 2008..LSM does not represent a reliable instrument to detect the presence of advanced fibrosis and cirrhosis in patients presenting with a clinical picture of acute hepatitis... - Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cellsErica Novo
Universita degli Studi di Torino, Dipartimento Medicina e Oncologia Sperimentale, Corso Raffaello 30, 10125 Turin, Italy
Am J Pathol 170:1942-53. 2007..Moreover, HSC/MFs, in addition to their established profibrogenic role, may also contribute to neoangiogenesis during chronic hepatic wound healing... - Myofibroblast - like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenarioMaurizio Parola
Dipartimento di Medicina e Oncologia Sperimentale, University of Torino, Corso Raffaello 30, 10125 Torino, Italy
Mol Aspects Med 29:58-66. 2008..In this short review emerging concepts in hepatic fibrogenesis and related molecular mechanisms, as provided by recent experimental and clinical studies, are presented... - Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cellsPaola Brun
Department of Histology, University of Padua, Padua, Italy
Am J Physiol Gastrointest Liver Physiol 289:G571-8. 2005..We speculate that high levels of bacterial endotoxins in the portal vein may directly induce a proinflammatory phenotype in HSCs that contributes to liver damage... - 4-Hydroxynonenal as a selective pro-fibrogenic stimulus for activated human hepatic stellate cellsElena Zamara
Dipartimento di Medicina e Oncologia Sperimentale, , Corso Raffaello 30, 10125 Turin, Italy
J Hepatol 40:60-8. 2004.... - Increased risk of hepatocellular carcinoma and liver cirrhosis in vinyl chloride workers: synergistic effect of occupational exposure with alcohol intakeGiuseppe Mastrangelo
Department of Environmental Medicine and Public Health, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
Environ Health Perspect 112:1188-92. 2004..In conclusion, according to our findings, VCM exposure appears to be an independent risk factor for HCC and LC interacting synergistically with alcohol consumption and additively with viral hepatitis infection... - A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactionsAntonio Mazzocca
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 65:4728-38. 2005..These results emphasize the importance of tumor-stromal interactions in invasion and suggest that ADAM9-S can be an important determinant in the ability of cancer cells to invade and colonize the liver... - Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteinsWillem Boers
AMC Liver Center, Academic Medical Center, University of Amsterdam, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
J Biol Chem 281:16289-95. 2006..In conclusion, the comparison of the three transcriptomes of (activated) stellate cells reveals novel genes involved in fibrogenesis and provides an appreciation of the sequence and timing of the fibrotic process in liver... - Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitisPaola Brun
Department of Histology, Univ of Padua, Via Gabelli 63, Padova, Italy
Am J Physiol Gastrointest Liver Physiol 292:G518-25. 2007..We suggest that in metabolic syndrome, patients may likewise have a greater intestinal mucosa permeability and increased lipopolysaccharide levels in portal blood that can contribute to the liver inflammatory damage... - Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient miceElena Zamara
Dipartimento di Medicina e Oncologia Sperimentale, University of Turin, Italy
J Hepatol 46:230-8. 2007..In this study, we investigated the development of acute toxic damage in mice lacking monocyte chemoattractant protein-1 (MCP-1), a chemokine which recruits monocytes and activated lymphocytes... - Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitisValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Hepatology 48:442-8. 2008..In patients in which likelihood ratios are not optimal to provide a reliable indication of the disease stage, liver biopsy should be considered when clinically indicated... - Serum markers detect the presence of liver fibrosis: a cohort studyWilliam M C Rosenberg
Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, England SO16 6YD
Gastroenterology 127:1704-13. 2004..We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis...