Research Topics
Genomes and GenesSpecies | Lorenzo PinessiSummaryAffiliation: University of Turin Country: Italy Publications
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Publications
Abnormal 5-HT1D receptor function in cluster headache: a neuroendocrine study with sumatriptanL Pinessi
Neurology III, Headache Centre, Department of Neuroscience, Division of Endocrinology, Department of Internal Medicine and Division of Medicine, Department of Internal Medicine, University of Turin, Turin, Italy
Cephalalgia 23:354-60. 2003..05) reduced in patients with cluster headache, both in the active and in the remission period. Our results suggest that cerebral serotonergic functions mediated by 5-HT(1D) receptors are altered in patients with episodic cluster headache...- Hypnic headache syndrome: association of the attacks with REM sleepL Pinessi
Neurology III Headache Centre, Department of Neuroscience, University of Turin Medical School, Torino, Italy
Cephalalgia 23:150-4. 2003..Four nocturnal headache attacks were captured, all emerging from the REM phase of sleep. Our findings suggest a close relationship between the REM phase of sleep and the appearance of hypnic headache attacks... 
Genetics of cluster headache: an updateLorenzo Pinessi
Neurology III, Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126, Turin, Italy
J Headache Pain 6:234-6. 2005..Recently, we have reported a significant association between the HCRTR2 gene and the disease. The purpose of this review is to describe recent advances in the genetics of CH...- The 1246G-->A polymorphism of the HCRTR2 gene is not associated with migraineL Pinessi
Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy
Cephalalgia 27:945-9. 2007..Comparison of the clinical features of the disease with the 1246G-->A genotypes showed no significant difference. Our data suggest that the HCRTR2 gene is not a genetic risk factor in migraine... 
Pro-inflammatory cytokine genes influence the clinical features of frontotemporal lobar degenerationInnocenzo Rainero
Neurology II, Department of Neuroscience, University of Turin, IT 10126 Turin, Italy
Dement Geriatr Cogn Disord 27:543-7. 2009..The objective of this study was to evaluate the association of functionally active polymorphisms in pro-inflammatory cytokine genes with the occurrence and the clinical features of the disease...- Interleukin-1 cluster gene polymorphisms and aneurysmal subarachnoid hemorrhageMarco Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Torino, Torino, Italy
Neurosurgery 66:1058-62; discussion 1062-3. 2010..Interleukin (IL)-1 is a proinflammatory cytokine that plays a pivotal role in both acute and chronic central nervous system injuries... - Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysisInnocenzo Rainero
Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126 Turin, Italy
J Headache Pain 8:152-6. 2007..75, CI 95% 1.37-2.25; RE OR 1.69, CI 95% 1.11-2.58). Our data confirm that the G1246A polymorphism of the HCRTR2 gene may modulate the genetic risk for CH... - Brain arteriovenous malformations are associated with interleukin-1 cluster gene polymorphismsMarco Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Torino, Torino, Italy
Neurosurgery 70:12-7. 2012..Functional polymorphisms in proinflammatory cytokines have been associated with various cerebrovascular phenotypes, including ischemic stroke, aneurysmal subarachnoid hemorrhage, and BAVM... - Association between major mood disorders and the hypocretin receptor 1 geneInnocenzo Rainero
Neurology II, Department of Neuroscience, University of Turin, Italy
J Affect Disord 130:487-91. 2011.... - Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) geneInnocenzo Rainero
Neurology II Headache Center, Department of Neuroscience, University of Torino, Torino, Italy
Headache 50:92-8. 2010..The purpose of this study was to investigate the association of genetic variants within the ADH4 gene with cluster headache susceptibility and phenotype... - Lack of association between the apolipoprotein E gene and aneurysmal subarachnoid hemorrhage in an Italian populationMarco Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Turin, Italy
J Neurosurg 106:245-9. 2007..The purpose of this study was to evaluate whether a particular allele or genotype of the APOE gene would modify the occurrence or the clinical features of SAH... - Association between migraine and HLA-DRB1 gene polymorphismsInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126, Turin, Italy
J Headache Pain 6:185-7. 2005..We conclude that, in Italian patients, migraine is associated with different alleles of the HLA-DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region... - Tumor necrosis factor-alpha gene and cerebral aneurysmsMarco Fontanella
Department of Neuroscience, Division of Neurosurgery, University of Turin, Turin, Italy
Neurosurgery 60:668-72; discussion 672-3. 2007..The purpose of this study is to evaluate the association of a functionally active polymorphism (-308 G<A) in the TNF-alpha gene with the risk and the clinical features of aneurysmal subarachnoid hemorrhage... - Absence of linkage between the interleukin-6 gene (-174 G/C) polymorphism and migraineInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15 10126, Turin, Italy
Neurosci Lett 343:155-8. 2003..In conclusion, we found no significant association between the -174 G/C IL-6 polymorphism and the occurrence or the clinical features of migraine... - Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study versus rizatriptanLidia Savi
Neurologia II, Department of Neurology, Centro Cefalee, University of Torino, Via Cherasco 15, 10126, Turin, Italy
J Headache Pain 12:609-15. 2011..These results need to be confirmed by randomized, double-blind, prospective, large clinical trials... - Prevalence of HFE (hemochromatosis) gene mutations in patients with cluster headacheInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Turin, Turin, Italy
Headache 45:1219-23. 2005..To evaluate whether polymorphisms of the HFE gene would modify the occurrence and the clinical features of cluster headache (CH)... - A polymorphism in the interleukin-1alpha gene influences the clinical features of migraineInnocenzo Rainero
Neurology III, Headache Center, Department of Neuroscience, University of Torino, Italy
Headache 42:337-40. 2002..To evaluate whether a particular genotype of the interleukin-1alpha (IL1A) gene affects the clinical features of migraine... - HLA-DRB1 genotyping in Italian migraine patientsInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy
Neurosci Lett 393:90-3. 2006..Our data suggest the presence of a genetic susceptibility factor for migraine without aura within the HLA region... - Haplotype analysis confirms the association between the HCRTR2 gene and cluster headacheInnocenzo Rainero
Neurology II Headache Center, Department of Neuroscience, Turin, Italy
Headache 48:1108-14. 2008..This association was confirmed in a large study from Germany but was not replicated in a dataset of CH patients from Northern Europe... - Proinflammatory cytokine gene polymorphisms and susceptibility to Paget's disease of bone: an association studySalvatore Gallone
Neurology II, Department of Neuroscience, University of Torino, Italy
Cytokine 56:560-3. 2011.... - Evidence for an association between migraine and the hypocretin receptor 1 geneInnocenzo Rainero
Neurology II, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126 Turin, Italy
J Headache Pain 12:193-9. 2011..In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine... - Absence of TARDBP gene mutations in an italian series of patients with frontotemporal lobar degenerationSalvatore Gallone
Neurology II, Department of Neuroscience, University of Turin, Turin, Italy
Dement Geriatr Cogn Disord 28:239-43. 2009..The aim of this study was to search for mutations of the TARDBP gene in the disease... - A polymorphism of the hypocretin receptor 2 gene is associated with cluster headacheI Rainero
Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15 10126 Turin, Italy
Neurology 63:1286-8. 2004..Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache... - SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosisElisa Rubino
Neurology II, Department of Internal Medicine, University of Torino, Torino, Italy
Neurology 79:1556-62. 2012..The purpose of our study was to evaluate the frequency of SQSTM1 mutations in a dataset of unrelated patients with FTLD or ALS, in comparison with healthy controls and patients with Paget disease of bone (PDB)... - Anger and emotional distress in patients with migraine and tension-type headachePaolo Perozzo
Fondazione Carlo Molo, CE.R.NE, Turin, Italy
J Headache Pain 6:392-9. 2005.... - Investigating the genetic role of aquaporin4 gene in migraineElisa Rubino
Neurology II, Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy
J Headache Pain 10:111-4. 2009..Our data do not support the hypothesis that the AQP4 gene could represent a genetic susceptibility factor for migraine... - Genetic variants in the NOTCH4 gene influence the clinical features of migraineElisa Rubino
Neurology II, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino, 10126, Italy
J Headache Pain 14:28. 2013..The aim of this study was to test the hypothesis that polymorphisms of the NOTCH4 gene would modify the occurrence and the clinical features of migraine... - Endocrine function is altered in chronic migraine patients with medication-overuseInnocenzo Rainero
Department of Neuroscience, Neurology III--Headache Center, University of Turin, Via Cherasco 15, 10126 Torino, Italy
Headache 46:597-603. 2006..CONCLUSIONS: Our study shows that both corticotropic and somatotropic functions are significantly impaired in CM-MOH patients and suggests a role for hormones in the development of chronic migraine... - A comparison of familial and sporadic migraine in a headache clinic populationInnocenzo Rainero
Neurology III, Headache Center, Department of Neuroscience, University of Turin, Italy
Funct Neurol 17:193-7. 2002..01) earlier age at onset of the disease. No significant difference in all the remaining features examined was found. Our data suggest that famM and spoM represent a single disease entity... - Anger, depression and personality dimensions in patients with migraine without auraGiovanni Abbate Daga
Psychiatry Section, Department of Neuroscience, Ospedale San Giovanni Battista, Psichiatria Universitaria CPR DCA, Turin, Italy
Psychother Psychosom 76:122-8. 2007..The aim of this study was to identify whether migraine patients and controls share distinctive personality traits... - Resolution of cluster headache after closure of an anterior communicating artery aneurysm: the role of pericarotid sympathetic fibresSalvatore Gentile
Neurology III Headache Centre, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126 Torino, Italy
Clin Neurol Neurosurg 108:195-8. 2006..We suggest that the surgical dissection of the pericarotid sympathetic fibres could prevent the onset of the cluster headache attacks by cutting part of the circuit underlying it... - Lack of association between the 3092 T-->C Clock gene polymorphism and cluster headacheI Rainero
Neurology III, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy
Cephalalgia 25:1078-81. 2005..In conclusion, our study suggests that the 3092 T-->C polymorphism of the Clock gene is unlikely to play an important role in cluster headache... - Hypocretins and primary headaches: neurobiology and clinical implicationsInnocenzo Rainero
Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15 10126, Torino, Italy
Expert Rev Neurother 8:409-16. 2008..The aim of this review is to describe and discuss recent studies in humans suggesting a role for the hypocretin neuronal system in cluster headache and chronic migraine... - Voxel-based morphometry reveals gray matter abnormalities in migraineWalter Valfrè
Neurology II, Headache Center, The Department of Neuroscience, University of Torino, Italy
Headache 48:109-17. 2008..Migraine is generally considered a functional brain disorder lacking structural abnormalities. Recent magnetic resonance imaging (MRI) studies, however, suggested that migraine may be associated with subtle brain lesions... - Cluster headache attacks and multiple sclerosisSalvatore Gentile
Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15, I 10126, Torino, Italy
J Headache Pain 8:245-7. 2007..The association between cluster headache and MS has been rarely described before. This case suggests that in patients with cluster headache neuroimaging is often useful in order to exclude structural lesions... - Attachment styles and headacheLidia Savi
Primary Headache Centre, Neurology III, Department of Neurosciences, University of Turin, Molinette Hospital, Via Chiabrera 34, I 10126, Turin, Italy
J Headache Pain 6:254-7. 2005..Headache sufferers seem to be characterised by attachment styles of the "insecure" type. In particular they seem to feel extremely ill at ease if there is an expectation of reduction of interpersonal distance... - Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraineI Rainero
Neurology III Headache Center, Department of Neuroscience, University of Torino, Italy
Neurology 62:141-3. 2004..30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine... - Interleukin 6 gene polymorphisms are not associated with aneurysmal subarachnoid haemorrhage in an Italian populationM Fontanella
Division of Neurosurgery, Department of Neuroscience, University of Turin, Via Cherasco 15 10126 Torino, Italy
J Neurol Neurosurg Psychiatry 79:471-3. 2008.... - Brain metastasis from pheochromocytoma in a patient with multiple endocrine neoplasia type 2AS Gentile
Department of Neurology III, Headache Center Department of Neuroscience, University of Turin, Turin, Italy
Panminerva Med 43:305-6. 2001..The authors report the unusual case of a MEN 2A patient with a brain metastasis from a pheochromocytoma... - Effects of subcutaneous sumatriptan on plasma growth hormone concentrations in migraine patientsL Pinessi
Neurology III Headache Centre, Department of Neuroscience, University of Turin, Italy
Cephalalgia 20:223-7. 2000..Our results suggest that cerebral serotonergic functions mediated by 5-HT1D receptors are not altered in migraine. Sumatriptan overuse could lead to adverse effects mediated by its neuroendocrine activity... - Pain threshold and tolerance in Alzheimer's diseaseF Benedetti
Department of Neuroscience, CIND Center for the Neurophysiology of Pain, University of Torino Medical School, Italy
Pain 80:377-82. 1999..Thus, pain tolerance is tightly related to the severity of the disease according to the rule, 'the more severe the MMSE and EEG changes, the higher the tolerance to pain'... - A double-blind, randomized, multicenter, Italian study of frovatriptan versus rizatriptan for the acute treatment of migraineLidia Savi
Neurology II, Headache Center, Department of Neuroscience, University of Turin, Via Cherasco, 15, 10126 Turin, Italy
J Headache Pain 12:219-26. 2011..The results suggest that frovatriptan has a similar efficacy to rizatriptan, but a more prolonged duration of action... - Haemochromatosis gene (HFE) polymorphisms and migraine: an association studyI Rainero
Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy
Cephalalgia 27:9-13. 2007..Our data suggest that the HFE gene is not a major disease gene for migraine. However, the H63D polymorphism of the HFE gene may be considered a modifying genetic factor in migraine... - Apolipoprotein E gene polymorphisms in patients with migraineInnocenzo Rainero
Neurology III Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126 Turin, Italy
Neurosci Lett 317:111-3. 2002..In conclusion, we observed no significant association between APOE polymorphisms and migraine. The association between the APOE varepsilon2-varepsilon4 genotype and the tension-type headache deserves further evaluation... - Decreased sensitivity of 5-HT1D receptors in chronic tension-type headacheI Rainero
Neurology III-Headache Center, Department of Neuroscience, University of Turin, Italy
Headache 42:709-14. 2002..01 and <0.05) altered in CTTH patients in comparison with controls. CONCLUSION: Our results suggest that cerebral serotonergic functions mediated by 5-HT1D receptors are altered in CTTH... - Quantitative EEG responses to ischaemic arm stress in migraineI Rainero
Neurology II Headache Center, Department of Neuroscience, University of Turin Medical School, Torino, Italy
Cephalalgia 21:224-9. 2001..The results of our study show that migraine sufferers display a lower threshold to physical stress and confirm previous studies indicating that migraine is a disease characterized by a state of altered neuronal excitability... - Differential diagnosis of headache in a neurological departmentS Gentile
Unit of Neurology III - Headache Center, Department of Neuroscience, University of Turin, Turin, Italy
Panminerva Med 45:203-9. 2003..Accurate anamnesis and accurate physical examination will help in diagnosing the aetiology of headache. In most cases, neurological and physical exams are normal. Anamnesis is therefore the key to a correct diagnosis... - Association between the interleukin-1alpha gene and Alzheimer's disease: a meta-analysisI Rainero
Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco, 15 10126 Torino, Italy
Neurobiol Aging 25:1293-8. 2004..Analysis of subgroups showed a significant association in patients with early-onset AD but not in late-onset AD. Our data support a significant but modest association between the T/T genotype of the IL-1alpha gene and AD... - Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysisE Rubino
Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy
Cephalalgia 29:818-25. 2009..32, 95% CI 1.10, 1.59; RE OR 1.63, 95% CI 1.10, 2.43). This study provides evidence for an association of the MTHFR gene only in migraine with aura... - Neuroendocrine effects of subcutaneous sumatriptan in patients with migraineI Rainero
Neurology III, Headache Center, Department of Neuroscience, University of Turin, Italy
J Endocrinol Invest 24:310-4. 2001..The neuroendocrine response was not significantly different in the two groups. Our results suggest that 5-HT1D receptor sensitivity is not altered in migraine... - Chronic Helicobacter pylori infection and migraine: a case-control studyL Pinessi
Neurology III-Headache Center, Department of Neuroscience, University of Turin, Italy
Headache 40:836-9. 2000..CONCLUSIONS: Our study suggests that chronic Helicobacter pylori infection is not more frequent in patients with migraine than in controls and that infection does not modify clinical features of the disease... - Autonomic dysfunction associated with multiple pelvic ganglioneuromasS Gentile
Neurology III--Headache Center, Department of Neuroscience, University of Turin, Neurology IV, San Giovanni Battista Hospital, Turin, Italy
Acta Neurol Scand 104:54-6. 2001..Patients with signs and symptoms of autonomic dysfunction need an extensive clinical and laboratory examination of all the autonomic functions in order to exclude secondary causes of the symptomatology... - Reversible MRI abnormalities in a patient with recurrent status migrainosusS Gentile
Neurology II Headache Centre, Department of Neuroscience, University of Turin, Via Cherasco 15 10126 Torino, Italy
Cephalalgia 29:687-90. 2009..These abnormalities, confirmed also by positron emission tomography, suggest that status migrainosus can be associated with a condition of vasogenic cerebral oedema... - Mutations in the lamin B1 gene are not present in multiple sclerosisA Brussino
Department of Genetics, Biology and Biochemistry, University of Torino, and S C D U Medical Genetics, A O U San Giovanni Battista, Torino, Italy
Eur J Neurol 16:544-6. 2009..Our aim was to test whether LMNB1 gene mutations were present amongst patients with a diagnosis of MS... - The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer diseaseEkaterina Rogaeva
Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
Nat Genet 39:168-77. 2007..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease...