A Pinchera

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. pmc Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouse
    Gino Giannaccini
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
    BMC Neurosci 12:18. 2011
  2. pmc The obesity and inflammatory marker haptoglobin attracts monocytes via interaction with chemokine (C-C motif) receptor 2 (CCR2)
    Margherita Maffei
    Dulbecco Telethon Institute, CNR, Area della Ricerca di Pisa, Pisa, Italy
    BMC Biol 7:87. 2009
  3. ncbi request reprint Research and academic education in medical sexology
    A Pinchera
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:13-4. 2003
  4. ncbi request reprint Thyroid and lipid metabolism
    E Pucci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Italy
    Int J Obes Relat Metab Disord 24:S109-12. 2000
  5. doi request reprint Thyroid incidentalomas
    Aldo Pinchera
    Department of Endocrinology, University of Pisa, Pisa, Italy
    Horm Res 68:199-201. 2007
  6. doi request reprint Thyroid autoantibodies and thyroid function in subjects exposed to Chernobyl fallout during childhood: evidence for a transient radiation-induced elevation of serum thyroid antibodies without an increase in thyroid autoimmune disease
    Laura Agate
    Department of Endocrinology, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 93:2729-36. 2008
  7. doi request reprint Male sex, single nodularity, and young age are associated with the risk of finding a papillary thyroid cancer on fine-needle aspiration cytology in a large series of patients with nodular thyroid disease
    T Rago
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 162:763-70. 2010
  8. ncbi request reprint Soluble interleukin-1 receptor antagonist concentration in patients with Graves' ophthalmopathy is neither related to cigarette smoking nor predictive of subsequent response to glucocorticoids
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 52:647-51. 2000
  9. ncbi request reprint Mutations in the SLC26A4 (pendrin) gene in patients with sensorineural deafness and enlarged vestibular aqueduct
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:430-5. 2004
  10. ncbi request reprint Retinoic acid receptor beta2 re-expression and growth inhibition in thyroid carcinoma cell lines after 5-aza-2'-deoxycytidine treatment
    F Y Miasaki
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Endocrinol Invest 31:724-30. 2008

Detail Information

Publications151 found, 100 shown here

  1. pmc Serotonin transporter (SERT) and translocator protein (TSPO) expression in the obese ob/ob mouse
    Gino Giannaccini
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
    BMC Neurosci 12:18. 2011
    ....
  2. pmc The obesity and inflammatory marker haptoglobin attracts monocytes via interaction with chemokine (C-C motif) receptor 2 (CCR2)
    Margherita Maffei
    Dulbecco Telethon Institute, CNR, Area della Ricerca di Pisa, Pisa, Italy
    BMC Biol 7:87. 2009
    ..In an effort to elucidate the biological significance of Hp presence in the WAT and of its upregulation in obesity we formulated the hypothesis that Hp may serve as a macrophage chemoattractant...
  3. ncbi request reprint Research and academic education in medical sexology
    A Pinchera
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:13-4. 2003
    ..The need for sexology--in this case, a new "medical" sexology--to utilize scientific tools and be taught in medical schools is therefore evident...
  4. ncbi request reprint Thyroid and lipid metabolism
    E Pucci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Italy
    Int J Obes Relat Metab Disord 24:S109-12. 2000
    ..Prudent substitution therapy with L-thyroxine is indicated in patients with both overt and subclinical hypothyroidism, with or without angina, to counteract the cardiovascular risk resulting from hyper-dyslipidemia...
  5. doi request reprint Thyroid incidentalomas
    Aldo Pinchera
    Department of Endocrinology, University of Pisa, Pisa, Italy
    Horm Res 68:199-201. 2007
    ....
  6. doi request reprint Thyroid autoantibodies and thyroid function in subjects exposed to Chernobyl fallout during childhood: evidence for a transient radiation-induced elevation of serum thyroid antibodies without an increase in thyroid autoimmune disease
    Laura Agate
    Department of Endocrinology, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 93:2729-36. 2008
    ..An increase in the prevalence of thyroid autoantibodies (ATAs) was reported 6-8 yr after the Chernobyl accident in radiation-exposed children and adolescents...
  7. doi request reprint Male sex, single nodularity, and young age are associated with the risk of finding a papillary thyroid cancer on fine-needle aspiration cytology in a large series of patients with nodular thyroid disease
    T Rago
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 162:763-70. 2010
    ..To evaluate the risk of papillary thyroid carcinoma (PTC) at fine-needle aspiration (FNA) cytology in 34 120 patients...
  8. ncbi request reprint Soluble interleukin-1 receptor antagonist concentration in patients with Graves' ophthalmopathy is neither related to cigarette smoking nor predictive of subsequent response to glucocorticoids
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 52:647-51. 2000
    ..The aim of the present study was to evaluate serum soluble interleukin-1 receptor antagonist (sIL-1RA) concentration and its relationship with the degree of cigarette smoking in patients with Graves' ophthalmopathy (GO)...
  9. ncbi request reprint Mutations in the SLC26A4 (pendrin) gene in patients with sensorineural deafness and enlarged vestibular aqueduct
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:430-5. 2004
    ..09) than patients without mutations. The results of the present study lend support to the concept that all patients with mutated SLC26A4 gene have abnormalities of thyroid function tests...
  10. ncbi request reprint Retinoic acid receptor beta2 re-expression and growth inhibition in thyroid carcinoma cell lines after 5-aza-2'-deoxycytidine treatment
    F Y Miasaki
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Endocrinol Invest 31:724-30. 2008
    ..A significant reduction of cell growth, but not cell re-differentiation, was also observed after 5-Aza-CdR treatment...
  11. doi request reprint L-thyroxine-treated patients with nodular goiter have lower serum TSH and lower frequency of papillary thyroid cancer: results of a cross-sectional study on 27 914 patients
    E Fiore
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    Endocr Relat Cancer 17:231-9. 2010
    ..In conclusion, patients with nodular goiter, treatment with L-T(4) is responsible for the reduction of serum TSH and is associated with a decreased frequency of PTC...
  12. doi request reprint Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role
    E Fiore
    Department of Endocrinology, University of Pisa, Pisa, Italy
    Endocr Relat Cancer 16:1251-60. 2009
    ..Thyroid autonomy conceivably protects against the risk of PTC, while thyroid autoimmunity does not play a significant role...
  13. ncbi request reprint RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults
    R Elisei
    Departments of Endocrinology and Metabolism, University of Pisa, Pisa 56124, Italy
    J Clin Endocrinol Metab 86:3211-6. 2001
    ..Other factors, probably influenced by ethnic or genetic background, may act independently from or in cooperation with radiation, to trigger the DNA damage leading to RET proto-oncogene activation...
  14. ncbi request reprint Prediction of disease status by recombinant human TSH-stimulated serum Tg in the postsurgical follow-up of differentiated thyroid carcinoma
    F Pacini
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:5686-90. 2001
    ....
  15. ncbi request reprint Autoantibodies from patients with autoimmune thyroid disease do not interfere with the activity of the human iodide symporter gene stably transfected in CHO cells
    M Tonacchera
    Dipartimento di Endocrinologia e Metabolismo, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
    Eur J Endocrinol 144:611-8. 2001
    ..To investigate the possible existence of autoantibodies able to interfere with the biological activity of hNIS, an assay was developed using a cell line stably expressing hNIS...
  16. ncbi request reprint Papillary thyroid cancer, although strongly associated with lymphocytic infiltration on histology, is only weakly predicted by serum thyroid auto-antibodies in patients with nodular thyroid diseases
    E Fiore
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Endocrinol Invest 32:344-51. 2009
    ..We evaluated the association between thyroid autoimmunity and thyroid cancer in a retrospective series of unselected thyroid nodules submitted to fine-needle aspiration (FNA) cytology...
  17. ncbi request reprint Radioiodine treatment of metastatic differentiated thyroid cancer in patients on L-thyroxine, using recombinant human TSH
    F Lippi
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 144:5-11. 2001
    ....
  18. ncbi request reprint Increased prevalence of primary hyperparathyroidism in treated breast cancer
    P Fierabracci
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 24:315-20. 2001
    ..We suggest that serum PTH should be determined in all BC patients with increased serum calcium concentration, especially in those with no evidence of metastatic disease...
  19. doi request reprint Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 17:1-6. 2010
    ..Our results suggest that the Wnt/beta-catenin signaling pathway is not involved in the development of parathyroid carcinomas and adenomas...
  20. ncbi request reprint Thyroid color flow doppler sonography and radioiodine uptake in 55 consecutive patients with amiodarone-induced thyrotoxicosis
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:635-40. 2003
    ....
  21. ncbi request reprint Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hupsilonrthle cell thyroid lesions: results from a series of 505 consecutive patients
    T Rago
    Department of Endocrinology, University of Pisa, Italy
    Clin Endocrinol (Oxf) 66:13-20. 2007
    ..The diagnostic value of atypia at cytology, clinical parameters and echographic patterns were examined to establish the risk of malignancy in 505 patients with follicular and Hupsilonrthle cell thyroid nodules at cytology...
  22. ncbi request reprint The course of Graves' ophthalmopathy is not influenced by near total thyroidectomy: a case-control study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Pisa, Italy
    Clin Endocrinol (Oxf) 51:503-8. 1999
    ..Although controversial, radioiodine may be followed by progression of eye disease, preventable by glucocorticoid administration. Whether thyroidectomy affects the course of ophthalmopathy is uncertain...
  23. ncbi request reprint Prevalence of thyroid autoantibodies in children and adolescents from Belarus exposed to the Chernobyl radioactive fallout
    F Pacini
    Institute of Endocrinology, University of Pisa, Italy
    Lancet 352:763-6. 1998
    ..We compared thyroid immunity and function in two groups of children from Belarus, one of whom was exposed to the radioactive fallout of Chernobyl...
  24. doi request reprint The effect of voluntary iodine prophylaxis in a small rural community: the pescopagano survey 15 years later
    F Aghini Lombardi
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 98:1031-9. 2013
    ....
  25. doi request reprint Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein
    P Agretti
    Department of Endocrinology and Metabolism, Centro Eccellenza AmbiSEN, University of Pisa, Pisa, Italy
    J Endocrinol Invest 34:170-4. 2011
    ..Beyond to perchlorate and thyocianate ions a few other inhibitors of iodide uptake have been described...
  26. ncbi request reprint Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms
    M Tonacchera
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Italy
    J Clin Endocrinol Metab 84:4155-8. 1999
    ..Oncogenes other than the TShR and Gs alpha genes are probably involved in nonfunctioning follicular adenomas...
  27. doi request reprint Hashimoto's thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine
    E Fiore
    Department of Endocrinology, Department of Surgery, University of Pisa, Italy
    Endocr Relat Cancer 18:429-37. 2011
    ..Treatment with l-T(4) reduces TSH levels and decreases the occurrence of clinically detectable PTC...
  28. ncbi request reprint Failure to use measurement of megalin secretory components complexed with serum thyroglobulin as a tool to identify metastases after surgery in papillary thyroid cancer
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:636-42. 2004
    ..Thus, we concluded that measurement of megalin secretory components is unlikely to be useful to identify the origin of serum Tg in PTC patients after thyroidectomy...
  29. ncbi request reprint Favorable predictive value of thyroid autoimmunity in high aggressive breast cancer
    E Fiore
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Endocrinol Invest 30:734-8. 2007
    ..Patients with ER+ and TAb+ have a better prognosis and the absence of a significant relationship between these two parameters suggests an independent prognostic role in high malignancy degree BC women...
  30. ncbi request reprint Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 25:614-9. 2002
    ..The A986S polymorphism does not correlate with serum calcium levels in normal Italian subjects...
  31. doi request reprint Follow-up of low-risk differentiated thyroid cancer patients who underwent radioiodine ablation of postsurgical thyroid remnants after either recombinant human thyrotropin or thyroid hormone withdrawal
    R Elisei
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 94:4171-9. 2009
    ..7GBq (131)I (100 mCi) after recombinant human (rh) TSH during T(4) (L-T4) therapy vs. withholding L-T4 (euthyroid vs. hypothyroid groups). We now compared the outcomes of these patients 3.7 yr later...
  32. ncbi request reprint Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women
    F Cetani
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
    Eur J Endocrinol 148:603-7. 2003
    ..We investigated whether the presence of 986S allele was associated with bone mineral density (BMD) and osteoporotic fractures...
  33. ncbi request reprint Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells
    P Agretti
    Department of Endocrinology and Metabolism, Centro Eccellenza AmbiSEN University of Pisa, Pisa, Italy
    J Endocrinol Invest 30:279-84. 2007
    ..This interference is not specific and due to the co-expression of two membrane proteins...
  34. ncbi request reprint Thyroid consequences of the Chernobyl nuclear accident
    F Pacini
    Department of Endocrinology, University of Pisa, Italy
    Acta Paediatr Suppl 88:23-7. 1999
    ..Therefore, screening programmes for this at-risk population should focus, not only on the detection of thyroid nodules and cancer, but also on the development of thyroid autoimmune diseases...
  35. ncbi request reprint Identification of thyroglobulin in orbital tissues of patients with thyroid-associated ophthalmopathy
    M Marino
    Department of Endocrinology, University of Pisa, Italy
    Thyroid 11:177-85. 2001
    ..Tg-anti-Tg immune complexes were not found in orbital tissues, suggesting that if an autoimmune reaction to Tg occurs in TAO, it is likely to be cell mediated...
  36. doi request reprint Real-time elastosonography: useful tool for refining the presurgical diagnosis in thyroid nodules with indeterminate or nondiagnostic cytology
    T Rago
    Department of Endocrinology, University of Pisa, Via Paradisa, 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 95:5274-80. 2010
    ..The aim of this study was to get further insights into the role of USE in the presurgical diagnosis of nodules with indeterminate or nondiagnostic cytology...
  37. ncbi request reprint Non-palpable thyroid nodules in a borderline iodine-sufficient area: detection by ultrasonography and follow-up
    T Rago
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 24:770-6. 2001
    ..Incidentally discovered thyroid nodules are associated with goiter and are likely to progress in volume and number...
  38. ncbi request reprint Contralateral papillary thyroid cancer is frequent at completion thyroidectomy with no difference in low- and high-risk patients
    F Pacini
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Thyroid 11:877-81. 2001
    ..On these bases, we believe that PTC should be treated with TT when diagnosed before surgery and submitted to CT, if partial surgery was the initial intervention...
  39. ncbi request reprint Absence of interference of serum IgGs from patients with breast cancer and thyroid autoimmunity on the function of human iodide symporter gene stably transfected in CHO cells
    P Fierabracci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:862-5. 2004
    ..Our data showed no interference of autoantibodies on iodine uptake in patients with BC and thyroid autoimmunity and the very low percentage of inhibition of iodine uptake cannot explain the lower content of iodine in BC tissue...
  40. ncbi request reprint Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin
    S Lisi
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Endocrinol Invest 30:839-43. 2007
    ....
  41. ncbi request reprint Thyroid resistance to TSH complicated by autoimmune thyroiditis
    M Tonacchera
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, 56124 Cisanello, Pisa, Italy
    J Clin Endocrinol Metab 86:4543-6. 2001
    ..In conclusion, we describe the first case of compensated TSH resistance evolving to mild hypothyroidism due to the appearance of a chronic autoimmune thyroiditis...
  42. ncbi request reprint Increased frequency of euthyroid ophthalmopathy in patients with Graves' disease associated with myasthenia gravis
    M Marino
    Department of Endocrinology, University of Pisa, Italy
    Thyroid 10:799-802. 2000
    ....
  43. ncbi request reprint The newly developed three-dimensional (3D) and two-dimensional (2D) thyroid ultrasound are strongly correlated, but 2D overestimates thyroid volume in the presence of nodules
    T Rago
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 29:423-6. 2006
    ..This intrinsic defect of 2D US should be taken into account when evaluating TV in patients with nodular goiter...
  44. ncbi request reprint Serum concentrations of adiponectin and leptin in patients with thyroid dysfunctions
    F Santini
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:RC5-7. 2004
    ..We conclude that metabolic changes associated with thyroid dysfunction are not related to variations in serum levels of adiponectin or leptin...
  45. ncbi request reprint MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, Orthopedics and Traumatology, and Occupational Medicine, University of Pisa, Italy
    J Endocrinol Invest 25:508-12. 2002
    ..In conclusion, MEN1 gene alterations are rather common in sporadic PHPT and their presence does not correlate with the clinical manifestations of the disease...
  46. ncbi request reprint Effects of a mixture of polychlorinated biphenyls (Aroclor 1254) on the transcriptional activity of thyroid hormone receptor
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:972-8. 2003
    ..These results demonstrate that ARO interacts with TR, thereby affecting the transcription of TH-sensitive genes, and provide a molecular basis to further explain the complex effects of PCBs on TH disruption...
  47. ncbi request reprint New breakpoints in both the H4 and RET genes create a variant of PTC-1 in a post-Chernobyl papillary thyroid carcinoma
    R Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Clin Endocrinol (Oxf) 53:131-6. 2000
    ....
  48. ncbi request reprint Serum iodothyronines in the human fetus and the newborn: evidence for an important role of placenta in fetal thyroid hormone homeostasis
    F Santini
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Clin Endocrinol Metab 84:493-8. 1999
    ....
  49. ncbi request reprint Thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dsfunction in apparently healthy subjects
    T Rago
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 24:763-9. 2001
    ....
  50. doi request reprint Cinacalcet efficacy in patients with moderately severe primary hyperparathyroidism according to the European Medicine Agency prescription labeling
    F Cetani
    Department of Endocrinology and Metabolism, Section of Endocrinology and Bone Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Endocrinol Invest 35:655-60. 2012
    ..Patients with primary hyperparathyroidism (PHPT) with contraindications to parathyroidectomy (PTx) or persistent PHPT have few non surgical options...
  51. doi request reprint In silico and in vitro analysis of rare germline allelic variants of RET oncogene associated with medullary thyroid cancer
    B Cosci
    Department of Endocrinology and Metabolism, High Technology Center for the Study of the Environmental Damage of the Endocrine and Nervous Systems, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Endocr Relat Cancer 18:603-12. 2011
    ....
  52. doi request reprint Binding, uptake, and degradation of internalized thyroglobulin in cultured thyroid and non-thyroid cells
    R Botta
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 34:515-20. 2011
    ....
  53. ncbi request reprint RET proto-oncogene mutations in thyroid carcinomas: clinical relevance
    F Pacini
    Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Italy
    J Endocrinol Invest 23:328-38. 2000
    ..Those with the mutation may be treated at a pre-clinical stage of the disease or even before the disease is started. The present review is focused on the clinical implication of RET gene mutations in thyroid cancer patients...
  54. ncbi request reprint Thyroid hormone receptors in neonatal, prepubertal, and adult rat testis
    D Canale
    Department of Endocrinology, University of Pisa, Italy
    J Androl 22:284-8. 2001
    ..The presence of a TR alpha1 message indicates that the adult rat testis may be directly responsive to T3 and, therefore, suggests an action of TH on rat testis that is not only developmental, but also metabolic...
  55. ncbi request reprint The sodium-iodide symporter expression in placental tissue at different gestational age: an immunohistochemical study
    C Di Cosmo
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 65:544-8. 2006
    ..The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange. Low NIS expression has been reported in trophoblast cells from the first trimester and pregnancy at term...
  56. ncbi request reprint Long-term outcome of thyroid function after amiodarone-induced thyrotoxicosis, as compared to subacute thyroiditis
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Endocrinol Invest 29:694-9. 2006
    ..On the other hand, type 2 AIT is a form of destructive thyroiditis occurring in normal thyroids, the management of which usually consists in glucocorticoid treatment...
  57. doi request reprint Pattern of expression of adiponectin receptors in human liver and its relation to nonalcoholic steatohepatitis
    M Nannipieri
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Obes Surg 19:467-74. 2009
    ..Adiponectin has antisteatosis-anti-inflammatory properties and its circulating levels are reduced in nonalcoholic steatohepatitis (NASH)...
  58. ncbi request reprint Sporadic nonautoimmune congenital hyperthyroidism due to a strong activating mutation of the thyrotropin receptor gene
    M Tonacchera
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Medicina del Lavoro, Universita di Pisa, Italy
    Thyroid 10:859-63. 2000
    ..The sister and the parents of the propositus, all euthyroid, showed the wild-type TSHR gene. In conclusion, we describe a case of a de novo germinal mutation of the TSHR causing severe congenital hyperthyroidism...
  59. ncbi request reprint 131I therapy for differentiated thyroid cancer leads to an earlier onset of menopause: results of a retrospective study
    C Ceccarelli
    Department of Endocrinology, University of Pisa, 56122 Pisa, Italy
    J Clin Endocrinol Metab 86:3512-5. 2001
    ..Conceivably, the ovarian irradiation by 131I might contribute to the process of the follicular atresia, thus inducing earlier menopause...
  60. ncbi request reprint Outcome of differentiated thyroid cancer with detectable serum Tg and negative diagnostic (131)I whole body scan: comparison of patients treated with high (131)I activities versus untreated patients
    F Pacini
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:4092-7. 2001
    ..If positive in the lung, (131)I treatment should be continued up to total remission; surgical treatment should be preferred in patients with node metastases, and no treatment should be used in those with thyroid bed uptake or no uptake...
  61. ncbi request reprint TSH receptor and Gs(alpha) genetic analysis in children with Down's syndrome and subclinical hypothyroidism
    M Tonacchera
    Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Pisa, Italy
    J Endocrinol Invest 26:997-1000. 2003
    ..In conclusion, our results seem to exclude the role of TSHr or Gs(alpha) gene mutations in the pathogenesis of the non-autoimmune SH observed in some children with DS...
  62. ncbi request reprint Binding of the low density lipoprotein receptor-associated protein (RAP) to thyroglobulin (Tg): putative role of RAP in the Tg secretory pathway
    M Marino
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    Mol Endocrinol 15:1829-37. 2001
    ..Chase experiments after inhibition of protein synthesis in FRTL-5 cells showed that thyroglobulin interacts with the receptor-associated protein shortly after the beginning of thyroglobulin biosynthesis...
  63. doi request reprint RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC)
    C Romei
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 74:241-7. 2011
    ..e. gene carriers) who are unaware of their condition...
  64. ncbi request reprint Comparison of the effectiveness and tolerability of intravenous or oral glucocorticoids associated with orbital radiotherapy in the management of severe Graves' ophthalmopathy: results of a prospective, single-blind, randomized study
    C Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:3562-7. 2001
    ....
  65. doi request reprint Quercetin decreases proliferation of orbital fibroblasts and their release of hyaluronic acid
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 34:521-7. 2011
    ..Inhibition of fibroblast (FB) proliferation and hyaluronic acid (HA) production may be a therapeutic approach to Graves' ophthalmopathy (GO). The flavonoid quercetin has a wide range of activities, including reduction of FB growth...
  66. doi request reprint Clinical aspects and therapeutic outcome in thyrotropin-secreting pituitary adenomas: a single center experience
    E Macchia
    Department of Endocrinology and Metabolism, University of Pisa, Pisa 56124, Italy
    J Endocrinol Invest 32:773-9. 2009
    ..The management of pituitary adenomas secreting TSH has evolved considerably over the last decades.We report the clinical features, management, and outcome of a large monocentric series...
  67. ncbi request reprint Free thyroxine and free triiodothyronine measurement in dried blood spots on filter paper by column adsorption chromatography followed by radioimmunoassay
    A Pacchiarotti
    Cattedra di Endocrinologia e Medicina Costituzionale, University of Pisa, Italy
    Horm Metab Res 20:293-7. 1988
    ....
  68. ncbi request reprint Effects of a thyroid-stimulating human monoclonal autoantibody (M22) on functional activity of LH and FSH receptors
    M Tonacchera
    Department of Endocrinology, Centre of Excellence for the Study of Damage to the Nervous and Endocrine Systems Produced by Environmental, Alimentary, and Pharmacological Agents, AmbiSEN, University of Pisa, Pisa, Italy, Via Paradisa 2, 56124 Pisa, Italy
    Thyroid 16:1085-9. 2006
    ..Consequently, we have studied the effects of high doses of the thyroid-stimulating human monoclonal autoantibody (M22) on the LHR and FSHR...
  69. ncbi request reprint Different somatic alterations of the HRPT2 gene in a patient with recurrent sporadic primary hyperparathyroidism carrying an HRPT2 germline mutation
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 14:493-9. 2007
    ....
  70. ncbi request reprint Video assisted prophylactic thyroidectomy and central compartment nodes clearance in two RET gene mutation adult carriers
    P Miccoli
    Department of Surgery, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:557-61. 2004
    ....
  71. ncbi request reprint Congenital hypothyroidism with impaired thyroid response to thyrotropin (TSH) and absent circulating thyroglobulin: evidence for a new inactivating mutation of the TSH receptor gene
    M Tonacchera
    Dipartimento di Endocrinologia, Universita di Pisa, Italy
    J Clin Endocrinol Metab 85:1001-8. 2000
    ....
  72. ncbi request reprint The aging thyroid in a mild to moderate iodine deficient area of Italy
    R Cavaliere
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 25:66-8. 2002
  73. ncbi request reprint Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 26:1105-10. 2003
    ..Therefore, we concluded that RAP is involved in Tg secretion by FRTL-5 cells suggesting that RAP may function as a Tg molecular chaperone...
  74. ncbi request reprint RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma
    F Basolo
    Dipartimento di Oncologia, Universita di Pisa, Via Paradisa, 56124 Pisa, Italy
    Eur J Endocrinol 145:599-604. 2001
    ..CONCLUSION: In conclusion, our analysis indicates that RET expression is frequently found in PTC, and has no influence on tumor outcome...
  75. ncbi request reprint Activating thyrotropin receptor mutations are present in nonadenomatous hyperfunctioning nodules of toxic or autonomous multinodular goiter
    M Tonacchera
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Italy
    J Clin Endocrinol Metab 85:2270-4. 2000
    ..In conclusion, activating TSHr mutations are present in the majority of nonadenomatous hyperfunctioning nodules scattered throughout the gland in patients with toxic or functionally autonomous multinodular goiter...
  76. ncbi request reprint Iopanoic acid rapidly controls type I amiodarone-induced thyrotoxicosis prior to thyroidectomy
    F Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 25:176-80. 2002
    ..We suggest that IOP is the drug of choice in the rapid restoration of euthyroidism prior to definitive thyroidectomy in patients with drug resistant Type I AIT...
  77. ncbi request reprint Elastography: new developments in ultrasound for predicting malignancy in thyroid nodules
    T Rago
    Department of Endocrinology, University of Pisa, Via Paradisa, 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 92:2917-22. 2007
    ..US elastography has been applied to differentiate malignant from benign lesions...
  78. ncbi request reprint Role of thyroglobulin in the pathogenesis of Graves' ophthalmopathy: the hypothesis of Kriss revisited
    M Marino
    Department of Endocrinology, University of Pisa, Italy
    J Endocrinol Invest 27:230-6. 2004
    ..Our current view is that, provided that Tg plays a role, it is unlikely the only factor involved and Tg in orbital tissues may rather reinforce or worsen a damage initiated by other mechanisms...
  79. ncbi request reprint Insulin-like growth factor II (IGF-II) immunohistochemistry in breast cancer: relationship with the most important morphological and biochemical prognostic parameters
    C Giani
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Int J Biol Markers 17:90-5. 2002
    ..These preliminary results indicate that IGF-II expression in breast cancer is connected with two important regulators of breast cancer growth and differentiation...
  80. ncbi request reprint Recombinant human thyrotropin-stimulated serum thyroglobulin combined with neck ultrasonography has the highest sensitivity in monitoring differentiated thyroid carcinoma
    F Pacini
    Section of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:3668-73. 2003
    ....
  81. ncbi request reprint Ultrasonographic evaluation of liver volume and the metabolic syndrome in obese women
    F Santini
    Department of Endocrinology and Metabolic Diseases, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Endocrinol Invest 30:104-10. 2007
    ....
  82. ncbi request reprint Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study
    F Pacini
    Section of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 91:926-32. 2006
    ..Quality of life was determined at the time of randomization and ablation. After the administration of the 131-I dose, the rate of radiation clearance from blood, thyroid remnant, and whole body was measured...
  83. ncbi request reprint Cigarette smoking and treatment outcomes in Graves ophthalmopathy
    L Bartalena
    University of Pisa, Italy
    Ann Intern Med 129:632-5. 1998
    ..It is unclear whether smoking affects the course of Graves ophthalmopathy and therapeutic outcomes...
  84. ncbi request reprint Toxic multinodular goiter in the elderly
    P Vitti
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 25:16-8. 2002
    ..The treatment with antithyroid drug does not allow a permanent remission of hyperthyroidism, but its use is indicated to achieve euthyroidism before the definitive treatment. The definitive treatment is radioiodine or thyroidectomy...
  85. ncbi request reprint Relationship between preclinical abnormalities of global and regional left ventricular function and insulin resistance in severe obesity: a Color Doppler Imaging Study
    V Di Bello
    Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    Int J Obes (Lond) 30:948-56. 2006
    ..09+/-1.6) than those determined in the control group (0.92+/-0.5) (P<0.0001). The HOMA-IR values, in the obese group, were significantly related to systolic strain and SR values sampled at the septum level (P<0.0001)...
  86. ncbi request reprint Cyclin D1 overexpression in thyroid carcinomas: relation with clinico-pathological parameters, retinoblastoma gene product, and Ki67 labeling index
    F Basolo
    Department of Oncology, University of Pisa, Italy
    Thyroid 10:741-6. 2000
    ..03), while the protein product was higher in tumors from patients less than 40 than patients over 40 years of age. Inversely, there was no significant correlation with gender and tumor status, pRB and with proliferative activity...
  87. ncbi request reprint Serum haptoglobin: a novel marker of adiposity in humans
    C Chiellini
    Dulbecco Telethon Institute, University of Pisa, 56126 Pisa, Italy
    J Clin Endocrinol Metab 89:2678-83. 2004
    ..In conclusion, serum Hp constitutes a novel marker of adiposity in humans, and the adipose tissue likely contributes to determine its levels...
  88. ncbi request reprint Multidetector CT in diagnostic work-up of patients with primary hyperparathyroidism
    S Mazzeo
    Divisione di Radiologia Diagnostica e Interventistica, Dipartimento di Oncologia, Trapianti e Nuove Tecnologie in Medicina, Pisa, Italy
    Radiol Med 112:763-75. 2007
    ..This study was performed to evaluate the accuracy of multidetector computed tomography (MDCT) in detecting parathyroid lesions in patients with primary hyperparathyroidism...
  89. ncbi request reprint Diagnostic 131-iodine whole-body scan may be avoided in thyroid cancer patients who have undetectable stimulated serum Tg levels after initial treatment
    F Pacini
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:1499-501. 2002
    ..These patients may be monitored with clinical examination, neck ultrasound, and serum Tg measurements on L-T(4)...
  90. ncbi request reprint Spontaneous short-term remission of primary hyperparathyroidism from infarction of a parathyroid adenoma
    F Cetani
    J Endocrinol Invest 27:687-90. 2004
    ..0 x 1.2 cm parathyroid adenoma with areas of necrosis with hemosiderinladen macrophages. In conclusion, we describe a case of spontaneous short-term remission of PHPT due to infarction of parathyroid adenoma...
  91. ncbi request reprint Management of Graves' ophthalmopathy: reality and perspectives
    L Bartalena
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, University of Pisa, Italy
    Endocr Rev 21:168-99. 2000
    ..In addition, thyroid ablation may prove beneficial for the ophthalmopathy in view of the pathogenetic model relating eye disease to autoimmune reactions directed against antigens shared by the thyroid and the orbit...
  92. ncbi request reprint Novel aspects of immunosuppressive and radiotherapy management of Graves' ophthalmopathy
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:272-80. 2004
    ..New data on recently performed placebo-controlled studies on orbital radiotherapy are discussed, together with studies on long-term safety of orbital radiotherapy...
  93. ncbi request reprint Analysis of cancer/testis antigens in sporadic medullary thyroid carcinoma: expression and humoral response to NY-ESO-1
    Michele Maio
    Cancer Bioimmunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy
    J Clin Endocrinol Metab 88:748-54. 2003
    ..Serological survey may be useful as a way to identify patients with humoral immune response to NY-ESO-1 that provide a new attractive target for vaccine-based immunotherapy of MTC...
  94. ncbi request reprint Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:682-7. 2008
    ..The aim of this study was to verify the prognostic value of somatic RET mutations in a large series of MTCs with a long follow up...
  95. ncbi request reprint Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies
    Francesco Latrofa
    Department of Endocrinology, University Hospital of Pisa, Via Cisanello 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:591-6. 2008
    ....
  96. ncbi request reprint Treatment of type II amiodarone-induced thyrotoxicosis by either iopanoic acid or glucocorticoids: a prospective, randomized study
    Fausto Bogazzi
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Clin Endocrinol Metab 88:1999-2002. 2003
    ..221 +/- 111 d, respectively, P < 0.002). This study shows that, albeit both drugs are effective, glucocorticoids are probably the drug of choice for more rapidly curing type II AIT...
  97. ncbi request reprint Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutation
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 58:199-206. 2003
    ..Description of two unrelated Italian kindreds with familial hypocalciuric hypercalcaemia (FHH), an autosomal dominant disease mostly caused by heterozygous inactivating mutations of the Ca2+ sensing receptor (CaR)...
  98. ncbi request reprint RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:4725-9. 2007
    ....
  99. ncbi request reprint Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis
    Yaron Tomer
    Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Autoimmun 29:69-77. 2007
    ..In view of the significant genetic heterogeneity observed in AITD, analyzing subsets is an efficient way to resolve heterogeneity and identify novel genes...
  100. ncbi request reprint Effects of bariatric surgery on early myocardial alterations in adult severely obese subjects
    Vitantonio Di Bello
    Cardiac Thoracic and Vascular Department, University of Pisa, Pisa, Italy
    Cardiology 109:241-8. 2008
    ..Aim of this study was to investigate the effect of weight loss on structural and functional myocardial alterations in severely obese subjects treated with bariatric surgery...
  101. ncbi request reprint Identification of TSH receptor mutations in three families with resistance to TSH
    Massimo Tonacchera
    Dipartimento di Endocrinologia e Metabolismo, Centro Eccellenza AmbiSEN, Universita di Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 67:712-8. 2007
    ..Genetic analysis of the TSH receptor gene in seven subjects with subclinical hypothyroidism (SH), in whom the diagnosis of autoimmune thyroid disease had been excluded by laboratory and instrumental techniques currently available...