Research Topics
Species | Stefano A PileriSummaryAffiliation: University of Bologna Country: Italy Publications
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Publications
New molecular insights into peripheral T cell lymphomasStefano A Pileri
Hematopathology Section, Department of Hematology and Oncology L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
J Clin Invest 122:3448-55. 2012....
Lymphoma classification: the quiet after the stormStefano A Pileri
Department of Haematology and Oncological Sciences L and A Seragnoli, Bologna University School of Medicine, Bologna, Italy
Semin Diagn Pathol 28:113-23. 2011..The present review aims to analyse future perspectives after the fourth edition of the WHO Classification released in 2008...
Immunophenotype and intermediate-high international prognostic index score are prognostic factors for therapy in diffuse large B-cell lymphoma patientsPier Luigi Zinzani
Institute of Hematology and Medical Oncology L e A Seràgnoli, Policlinico Sant Orsola Malpighi, University of Bologna, Bologna, Italy
Cancer 116:5667-75. 2010..This study investigated the role of immunohistochemical discrimination between GCB and ABC&NC-DLBCL subtypes in identifying those high-risk patients who may benefit from a more aggressive first-line therapeutic approach...- Marker expression in peripheral T-cell lymphoma: a proposed clinical-pathologic prognostic scorePhilip Went
, Hematology and Hematopathology Units, St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
J Clin Oncol 24:2472-9. 2006..The latter represents one of the first examples of mixed score (including patient- and tumor-specific factors) applied to malignant lymphomas and may be the basis for future prospective therapeutic trials... - CDKN1B/p27 expression in peripheral T cell lymphoma not otherwise specifiedAnna Gazzola
Department of Haematology and Oncological Sciences L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
J Clin Pathol 64:83-7. 2011..CDKN1B/p27, a critical regulator of cell cycle and proliferation, has been suggested to be involved in T cell lymphomagenesis. This study aimed to evaluate the possible occurrence of CDKN1B/p27 aberrations in PTCL/NOS... - Pathobiology of primary mediastinal B-cell lymphomaStefano A Pileri
Institute of Haematology Seragnoli, Bologna University, Policinico S Orsola, Via Massarenti 9, 40138, Bologna, Italy
Leuk Lymphoma 44:S21-6. 2003..However, it differs from other aggressive B-cell lymphomas in that it shows defective Ig production despite the expression of Oct-2, BOB.1, and PU.1 transcription factors, and a lack of IgV(H) gene crippling mutations... - Gene expression analysis provides a potential rationale for revising the histological grading of follicular lymphomasPier Paolo Piccaluga
Molecular Pathology Laboratory, Unit of Hematopathology, Department of Hematology and Oncology, L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
Haematologica 93:1033-8. 2008..Follicular lymphomas are currently subdivided into grades I, II, IIIa and IIIb. This distinction is, however, questioned... - Cyclophosphamide, doxorubicin, vincristine, methotrexate, bleomicin and prednisone plus rituximab in untreated young patients with low-risk (age-adjusted international prognostic index 0-1) diffuse large B-cell lymphomaEnrico Derenzini
Institute of Haematology and Medical Oncology L and A Seragnoli, University of Bologna, Bologna, Italy
Leuk Lymphoma 50:1824-9. 2009..R-MACOP-B regimen followed by involved-field radiation on bulky presentation is safe and very effective in the treatment of young patients with low-risk DLBCL... - Gene expression analysis of angioimmunoblastic lymphoma indicates derivation from T follicular helper cells and vascular endothelial growth factor deregulationPier Paolo Piccaluga
Institute of Hematology and Medical Oncology L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Cancer Res 67:10703-10. 2007..Our study provides new relevant information on AILT biology and new candidates for possible therapeutic targets such as PDGFRA (platelet-derived growth factor alpha) and VEGF... - BCL10 down-regulation in peripheral T-cell lymphomasMaura Rossi
Molecular Pathology Laboratory, Hematopathology Section, Department of Hematology and Oncological Sciences L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Italy
Hum Pathol 43:2266-73. 2012..In conclusion, BCL10 was commonly down-regulated in peripheral T cell lymphomas, suggest the T-cell receptor signaling cascade for future characterization... - Pathobiology of hodgkin lymphomaPier Paolo Piccaluga
Hematopathology Section, Department of Hematology and Oncological Sciences L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, 40126 Bologna, Italy
Adv Hematol 2011:920898. 2011..Treatments adjusted to the pathobiological characteristics of the tumor in at-risk patients have been proposed and are on the way to being applied... - Primary cardiac non-Hodgkin lymphoma presenting with atrial flutter and pericardial effusionPier Paolo Piccaluga
, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
Br J Haematol 134:356. 2006 - Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypesPier Paolo Piccaluga
Department of Hematology and Oncological Sciences L and A Seràgnoli, Hematopathology Unit, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna, Italy
Blood 117:3596-608. 2011..In conclusion, our study provided substantial insights on the pathobiology of BLs, by offering novel evidences that may be relevant for its classification and possibly future treatment... - Peripheral T cell lymphomas with follicular T helper phenotype: a new basket or a distinct entity? Revising Karl Lennert's personal archiveClaudio Agostinelli
Haematopathology Section, Department of Haematology and Oncology L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Italy
Histopathology 59:679-91. 2011..To revise 25 cases selected from Karl Lennert's personal archive (21) and Bologna and Frankfurt Registries (four) because of cytological similarities... - Prognostic markers in peripheral T-cell lymphomaPier Paolo Piccaluga
Department of Hematology and Oncological Sciences L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Italy
Curr Hematol Malig Rep 5:222-8. 2010..The validation process for several models, including clinical-pathological and molecular models, is now ongoing... - Biology and treatment of follicular lymphomaPier Paolo Piccaluga
Molecular Pathology Laboratory, Hematopathology Unit, Department of Hematology and Oncological Sciences L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna, Italy
Expert Rev Hematol 2:533-47. 2009..Novel approaches, including stem cell transplantation, monoclonal antibodies and innovative agents, should be then considered for improving long-term results... - Peripheral T-cell lymphoma classification: the matter of cellular derivationPier Paolo Piccaluga
Hematopathology Section, Department of Hematology and Oncology L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Expert Rev Hematol 4:415-25. 2011.... - Characterization of a new monoclonal antibody against PAX5/BASP in 1525 paraffin-embedded human and animal tissue samplesClaudio Agostinelli
Departments of Haematology and Clinical Oncology L and A Seràgnoli, Pathology and Haematopathology Unit, St Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna, Italy
Appl Immunohistochem Mol Morphol 18:561-72. 2010..We describe the newly generated DAK-PAX5 monoclonal antibody raised against a fixation-resistant epitope of the human PAX5/BSAP molecule... - Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targetsPier Paolo Piccaluga
Institute of Hematology and Medical Oncology L and A Seragnoli, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
J Clin Invest 117:823-34. 2007..These results, which might be extended to other more rare PTCL categories, provide insight into tumor pathogenesis and clinical management of PTCL/U... - Detection of LIM domain only 2 (LMO2) in normal human tissues and haematopoietic and non-haematopoietic tumours using a newly developed rabbit monoclonal antibodyClaudio Agostinelli
Section of Haematopathology, Department of Haematology and Oncological Sciences Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Histopathology 61:33-46. 2012..We describe a new rabbit monoclonal antibody, raised against a fixation-resistant epitope of the transcription regulator LIM domain only 2 (LMO2)... - Systemic Epstein-Barr-virus-positive T cell lymphoproliferative childhood disease in a 22-year-old Caucasian man: A case report and review of the literatureValentina Tabanelli
Department of Hematology and Oncological Sciences L and A Seràgnoli, Hematopathology Section, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
J Med Case Reports 5:218. 2011..abstract:.. - Pathobiology of ALK-negative anaplastic large cell lymphomaStefano A Pileri
Hematopathology Section, Department of Hematology and Oncological Sciences L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Pediatr Rep 3:e5. 2011..The main histological findings are illustrated as well as the phenotypic, molecular and clinical characteristics. Finally, the biological rationale for possible innovative targeted therapies is presented... - Pathobiology of Epstein-Barr virus-driven peripheral T-cell lymphomasPier Paolo Piccaluga
Molecular Pathology Laboratory, Hematopathology Section, Department of Hematology and Oncological Sciences L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Semin Diagn Pathol 28:234-44. 2011..For example, the nuclear factor-KB pathway and platelet-derived growth factor receptor inhibition may represent 2 options to be tested in clinical trials... - Primary cutaneous lymphomas: a reprisalAlessandro Pileri
Department of Internal Medicine, Geriatrics, and Nephrology, Division of Dermatology, University of Bologna, Bologna, Italy
Semin Diagn Pathol 28:214-33. 2011..Our aim is to evaluate the commonest types of PCL analysing the clinical characteristics, histology, phenotype, molecular biology, prognosis and therapy... - Erythrophagocytosis by neoplastic cells in a patient with myelodysplastic syndromeStefano Ascani
Unit of Hematopathology, , Bologna University, St. Orsola Hospital, Bologna, Italy
Haematologica 89:EIM07. 2004 - Identification of outcome predictors in diffuse large B-cell lymphoma. Immunohistochemical profiling of homogeneously treated de novo tumors with nodal presentation on tissue micro-arraysPier Luigi Zinzani
Pathologic Anatomy and Lymphoma Unit, Institute of Haematology and Medical Oncology L and A Seragnoli, Bologna University, Bologna, Italy
Haematologica 90:341-7. 2005..Patients with diffuse large B-cell lymphoma (DLBCL) could benefit from integration of well-established bioclinical prognostic factors with new tools - such as micro-arrays - exploring aberrant gene and/or protein expression... - Molecular profiling of aggressive lymphomasMaura Rossi
Molecular Pathology Laboratory, Haematopathology Unit, Department of Haematology and Oncology L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
Adv Hematol 2012:464680. 2012..In this paper, the authors based on their own experience and the most updated literature review, the main concept on molecular profiling of aggressive lymphomas... - Follicular lymphoma: still Six characters in search of an author?Pier Paolo Piccaluga
Hematopathology Section, Department of Hematology and Oncology L and A Seràgnoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Leuk Lymphoma 52:1655-67. 2011..This review was inspired by the reappraisal of Professor Lennert's personal archive that represents a unique legacy for the entire scientific community... - Simultaneous occurrence of peripheral T-cell lymphoma unspecified and B-cell small lymphocytic lymphoma. Report of 2 casesCristina Campidelli
Institute of Hematology and Clinical Oncology L and A Seràgnoli, Unit of Hematopathology, Bologna University School of Medicine, Bologna, Italy
Hum Pathol 38:787-92. 2007..To the best of our knowledge, the simultaneous occurrence of PTCL unspecified and B-cell small lymphocytic lymphoma is an exceptional event; the possible pathogenetic correlations between the 2 neoplasms are discussed... - Difficult diagnostic and therapeutic cases: CASE 1. true thymic hyperplasia in a patient treated for T-cell lymphomaStefano Ascani
Unit of Hematopathology, , Bologna University, Bologna, Italy
J Clin Oncol 22:953-4. 2004 - Poor outcome of adult acute lymphoblastic leukemia patients carrying the (1;19)(q23;p13) translocationPier Paolo Piccaluga
Institute of Haematology and Medical Oncology L and A Serànoli, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Leuk Lymphoma 47:469-72. 2006.... - Myeloid sarcoma: extramedullary manifestation of myeloid disordersCristina Campidelli
Unit of Haematopathology, Institute of Haematology and Oncological Sciences L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Am J Clin Pathol 132:426-37. 2009.... - Granulocytic sarcoma of main biliary ductsStefano Ascani
Unit of Haematopathology, , Bologna University, St. Orsola Hospital, Bologna, Italy
Br J Haematol 121:534. 2003 - Efficacy of hormonal manipulation in lymphangioleiomyomatosis. A 20-year-experience in 36 patientsMario Schiavina
Respiratory Pathophysiology Unit, S Orsola Malpighi Hospital, Via Massarenti 9 40138 Bologna, Italy
Sarcoidosis Vasc Diffuse Lung Dis 24:39-50. 2007..These observations suggested already in the past a treatment strategy based on hormonal manipulation: discontinuation of estrogens containing medications, avoiding pregnancy, inhibition of estrogens activity and induction of menopause... - The karma of Kikuchi's diseaseStefano A Pileri
, Bologna University School of Medicine, Bologna, Italy
Clin Immunol 114:27-9. 2005 - Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulinsStefano A Pileri
Istituto di Ematologia e Oncologia Medica, L e A Seràgnoli Unità Cliniche e di Anatomia Patologica, Universita di Bologna, Bologna, Italy
Am J Pathol 162:243-53. 2003..However, it differs from other aggressive B-cell lymphomas in that it shows defective immunoglobulin production despite the expression of OCT-2, BOB.1, and PU.1 transcription factors and the lack of IgV(H) gene crippling mutations...