Daniela Pietrobon

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. pmc Modal gating of human CaV2.1 (P/Q-type) calcium channels: II. the b mode and reversible uncoupling of inactivation
    Tommaso Fellin
    Dept of Biomedical Sciences, University of Padova, Viale G Colombo, 3 35121 Padova, Italy
    J Gen Physiol 124:463-74. 2004
  2. pmc Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits
    Siro Luvisetto
    Dept of Biomedical Sciences, University of Padova, Viale G Colombo 3, 35121 Padova, Italy
    J Gen Physiol 124:445-61. 2004
  3. doi Calcium channels and migraine
    Daniela Pietrobon
    Dept of Biomedical Sciences, University of Padova, Italy
    Biochim Biophys Acta 1828:1655-65. 2013
  4. doi Pathophysiology of migraine
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Annu Rev Physiol 75:365-91. 2013
  5. pmc Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine
    B Fioretti
    Department of Biomedical Sciences, University of Padova and CNR Institute of Neuroscience, 35121 Padova, Italy
    J Physiol 589:5879-95. 2011
  6. doi CaV2.1 channelopathies
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, 35121, Padua, Italy
    Pflugers Arch 460:375-93. 2010
  7. pmc Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    J Physiol 588:1871-8. 2010
  8. ncbi Familial hemiplegic migraine
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    Neurotherapeutics 4:274-84. 2007
  9. ncbi Migraine: new molecular mechanisms
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Neuroscientist 11:373-86. 2005
  10. ncbi Function and dysfunction of synaptic calcium channels: insights from mouse models
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, Viale le G Colombo 3, 35121 Padova, Italy
    Curr Opin Neurobiol 15:257-65. 2005

Collaborators

  • Rossella Conti
  • Tommaso Fellin
  • Jorg Striessnig
  • Tommaso Pizzorusso
  • Gerald J Obermair
  • Alexandra Koschak
  • Angelita Tottene
  • Dania Vecchia
  • Arn M J M van den Maagdenberg
  • B Fioretti
  • Siro Luvisetto
  • Michel D Ferrari
  • Tiziana Cesetti
  • Andrea Urbani
  • L Sforna
  • L Catacuzzeno
  • M B Gerke-Duncan
  • F Franciolini
  • M Connor
  • A M J M van den Maagdenberg
  • Maryna Shapovalova
  • Mirko Santello
  • Alessandra Fabbro
  • Francesca Pivotto
  • Bruno Hivert
  • Rob C G van de Ven
  • Ludo A M Broos
  • Jaap J Plomp
  • Simon Kaja
  • Kenneth A Stauderman
  • Rune R Frants
  • Michael M Harpold
  • Paul F Brust
  • Michele Spagnolo
  • Mark E Williams
  • Jos van der Kaa
  • Stefano Pagnutti
  • Colin Fletcher

Detail Information

Publications19

  1. pmc Modal gating of human CaV2.1 (P/Q-type) calcium channels: II. the b mode and reversible uncoupling of inactivation
    Tommaso Fellin
    Dept of Biomedical Sciences, University of Padova, Viale G Colombo, 3 35121 Padova, Italy
    J Gen Physiol 124:463-74. 2004
    ..1 channels could be a potent and versatile mechanism for the modulation of synaptic strength and plasticity as well as of neuronal excitability and other postsynaptic Ca2+-dependent processes...
  2. pmc Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits
    Siro Luvisetto
    Dept of Biomedical Sciences, University of Padova, Viale G Colombo 3, 35121 Padova, Italy
    J Gen Physiol 124:445-61. 2004
    ....
  3. doi Calcium channels and migraine
    Daniela Pietrobon
    Dept of Biomedical Sciences, University of Padova, Italy
    Biochim Biophys Acta 1828:1655-65. 2013
    ..This article is part of a Special Issue entitled: Calcium channels...
  4. doi Pathophysiology of migraine
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Annu Rev Physiol 75:365-91. 2013
    ..This review focuses on emerging concepts that drive the science of migraine in both a mechanistic direction and a therapeutic direction...
  5. pmc Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine
    B Fioretti
    Department of Biomedical Sciences, University of Padova and CNR Institute of Neuroscience, 35121 Padova, Italy
    J Physiol 589:5879-95. 2011
    ..Our findings suggest that the facilitation of peripheral mechanisms of CGRP action, such as dural vasodilatation and nociceptor sensitization at the meninges, does not contribute to the generation of headache in FHM1...
  6. doi CaV2.1 channelopathies
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, 35121, Padua, Italy
    Pflugers Arch 460:375-93. 2010
    ..1 channels that were obtained from their functional characterization...
  7. pmc Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    J Physiol 588:1871-8. 2010
    ....
  8. ncbi Familial hemiplegic migraine
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    Neurotherapeutics 4:274-84. 2007
    ..Hence, they support novel therapeutic strategies that consider CSD and cortical hyperexcitability as key targets for preventive migraine treatment...
  9. ncbi Migraine: new molecular mechanisms
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Neuroscientist 11:373-86. 2005
    ....
  10. ncbi Function and dysfunction of synaptic calcium channels: insights from mouse models
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, Viale le G Colombo 3, 35121 Padova, Italy
    Curr Opin Neurobiol 15:257-65. 2005
    ..The different disorders probably arise from disruption of neurotransmission in specific brain regions: the cortex in the case of migraine, the thalamus in the case of absence epilepsy and the cerebellum in the case of ataxia...
  11. ncbi Neurobiology of migraine
    Daniela Pietrobon
    Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
    Nat Rev Neurosci 4:386-98. 2003
  12. doi Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice
    Angelita Tottene
    Department of Biomedical Sciences, University of Padova and CNR Institute of Neuroscience, Viale G Colombo 3, Padua, Italy
    Neuron 61:762-73. 2009
    ..The synapse-specific effect of FHM1 mutations points to disruption of excitation-inhibition balance and neuronal hyperactivity as the basis for episodic vulnerability to CSD ignition in migraine...
  13. ncbi A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression
    Arn M J M van den Maagdenberg
    Department of Biomedical Sciences, University of Padova, CNR Institute of Neuroscience, Viale G Colombo 3, 35121 Padova, Italy
    Neuron 41:701-10. 2004
    ..Our data show that the increased susceptibility for CSD and aura in migraine may be due to cortical hyperexcitability. The R192Q FHM-1 mouse is a promising animal model to study migraine mechanisms and treatments...
  14. ncbi Specific kinetic alterations of human CaV2.1 calcium channels produced by mutation S218L causing familial hemiplegic migraine and delayed cerebral edema and coma after minor head trauma
    Angelita Tottene
    Department of Biomedical Sciences, University of Padova, CNR Institute of Neuroscience, Viale G Colombo 3, 35121 Padova, Italy
    J Biol Chem 280:17678-86. 2005
    ....
  15. ncbi Role of different voltage-gated Ca2+ channels in cortical spreading depression: specific requirement of P/Q-type Ca2+ channels
    Angelita Tottene
    Department of Biomedical Sciences, University of Padova, Padua, Italy
    Channels (Austin) 5:110-4. 2011
    ....
  16. ncbi Calcium channels and channelopathies of the central nervous system
    Daniela Pietrobon
    Dept of Biomedical Sciences, Univ of Padova, Italy
    Mol Neurobiol 25:31-50. 2002
    ....
  17. pmc Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons
    Angelita Tottene
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    Proc Natl Acad Sci U S A 99:13284-9. 2002
    ..1 current density in neurons. We discuss the relevance of these findings for the pathogenesis of migraine with aura...
  18. ncbi Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells
    Alexandra Koschak
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, 35121 Padova, Italy
    J Neurosci 27:3855-63. 2007
    ..2005), we discuss the hypothesis that anomalous rather than cardiac-type Ca(v)1.2 channels are specifically involved in LTCC-dependent and gene transcription-dependent LTP...
  19. doi Migraine: a disorder of brain excitatory-inhibitory balance?
    Dania Vecchia
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    Trends Neurosci 35:507-20. 2012
    ..We also discuss insights obtained from the functional analysis of familial hemiplegic migraine mouse models...