Antonello Pietrangelo

Summary

Affiliation: University of Modena and Reggio Emilia
Country: Italy

Publications

  1. ncbi request reprint Non-HFE hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Semin Liver Dis 25:450-60. 2005
  2. ncbi request reprint Diacerhein blocks iron regulatory protein activation in inflamed human monocytes
    A Pietrangelo
    Department of Internal Medicine, University of Modena, Italy
    Life Sci 63:PL213-9. 1998
  3. ncbi request reprint Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene
    A Pietrangelo
    Department of Internal Medicine, Universita di Modena, Italy
    N Engl J Med 341:725-32. 1999
  4. ncbi request reprint Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin
    Antonello Pietrangelo
    Dipartimento di Medicina Interna e Sezione di Patologia Generale, Universita di Modena, Italy
    J Bioenerg Biomembr 34:67-79. 2002
  5. ncbi request reprint Lack of enterocyte iron accumulation in the ferroportin disease
    Elena Corradini
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena Policlinico Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 35:315-8. 2005
  6. ncbi request reprint Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload
    Giuliana Montosi
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Hepatology 41:545-52. 2005
  7. pmc ER stress controls iron metabolism through induction of hepcidin
    Chiara Vecchi
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital Policlinico di Modena, Modena, Italy
    Science 325:877-80. 2009
  8. ncbi request reprint Iron and the liver
    Elena Corradini
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Italy
    Pediatr Endocrinol Rev 2:245-8. 2004
  9. doi request reprint Serum ferritin as a predictor of treatment outcome in patients with chronic hepatitis C
    Francesca Ferrara
    Department of Internal Medicine, Center for Hemochromatosis, University Hospital of Modena, Italy
    Am J Gastroenterol 104:605-16. 2009
  10. ncbi request reprint Magnetic resonance imaging to identify classic and nonclassic forms of ferroportin disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 37:192-6. 2006

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Non-HFE hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Semin Liver Dis 25:450-60. 2005
    ....
  2. ncbi request reprint Diacerhein blocks iron regulatory protein activation in inflamed human monocytes
    A Pietrangelo
    Department of Internal Medicine, University of Modena, Italy
    Life Sci 63:PL213-9. 1998
    ..Interestingly, NO-induced IRP activation was efficiently blocked by DAR. These data show for the first time that a clinically useful antiinflammatory compound, DAR, interferes with IRP activation by NO in inflammed human cells...
  3. ncbi request reprint Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene
    A Pietrangelo
    Department of Internal Medicine, Universita di Modena, Italy
    N Engl J Med 341:725-32. 1999
    ..We performed biochemical, histologic, and genetic studies of 53 living members of the family, including microsatellite analysis of chromosome 6 and direct sequencing of the HFE gene...
  4. ncbi request reprint Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin
    Antonello Pietrangelo
    Dipartimento di Medicina Interna e Sezione di Patologia Generale, Universita di Modena, Italy
    J Bioenerg Biomembr 34:67-79. 2002
    ..Iron-induced oxidant stress in nonparenchymal cells appeared to bring about irreversible mitochondrial derangement associated with the onset of hepatic fibrosis...
  5. ncbi request reprint Lack of enterocyte iron accumulation in the ferroportin disease
    Elena Corradini
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena Policlinico Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 35:315-8. 2005
    ..Not surprisingly, in the liver, iron excess was found mainly in Kupffer cells. These results indicate that FPN haploinsufficiency is not limiting for iron export from enterocytes...
  6. ncbi request reprint Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload
    Giuliana Montosi
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Hepatology 41:545-52. 2005
    ..However, both Kupffer cells and human macrophages are dispensable for the regulatory activity exerted by iron on hepatic hepcidin...
  7. pmc ER stress controls iron metabolism through induction of hepcidin
    Chiara Vecchi
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital Policlinico di Modena, Modena, Italy
    Science 325:877-80. 2009
    ..The regulation of hepcidin by ER stress links the intracellular response involved in protein quality control to innate immunity and iron homeostasis...
  8. ncbi request reprint Iron and the liver
    Elena Corradini
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Italy
    Pediatr Endocrinol Rev 2:245-8. 2004
    ....
  9. doi request reprint Serum ferritin as a predictor of treatment outcome in patients with chronic hepatitis C
    Francesca Ferrara
    Department of Internal Medicine, Center for Hemochromatosis, University Hospital of Modena, Italy
    Am J Gastroenterol 104:605-16. 2009
    ..Antiviral treatment in chronic hepatitis C (CHC) involves ribavirin, a hemolytic agent. We planned a prospective study to evaluate whether drug-induced iron perturbation is clinically relevant as it relates to therapeutic outcome...
  10. ncbi request reprint Magnetic resonance imaging to identify classic and nonclassic forms of ferroportin disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 37:192-6. 2006
    ..In conclusion, MRI is a useful non-invasive diagnostic tool to categorize and diagnose the disorder, monitor the status of iron depletion and gain insights on its natural history and management...
  11. ncbi request reprint Hereditary hemochromatosis--a new look at an old disease
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia Policlinico, Modena, Italy
    N Engl J Med 350:2383-97. 2004
  12. ncbi request reprint Hemochromatosis: an endocrine liver disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Hepatology 46:1291-301. 2007
    ..The recognition of the endocrine nature of hemochromatosis suggests intriguing possibilities for new and more effective approaches to diagnosis and treatment...
  13. ncbi request reprint STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico Via del Pozzo 71, 41100 Modena, Italy
    Gastroenterology 132:294-300. 2007
    ..To clarify the molecular pathways involved in hepcidin activation by IL-6, we used different mice strains in which the main IL-6/gp130 signaling pathways have been genetically disrupted...
  14. doi request reprint Huh-7: a human "hemochromatotic" cell line
    Chiara Vecchi
    Department of Internal Medicine, University Hospital of Modena, Center for Hemochromatosis, Policlinico, Modena, Italy
    Hepatology 51:654-9. 2010
    ..CONCLUSION: Huh-7 cells may represent a novel and valuable tool to investigate the role of altered HFE traffic in iron metabolism and pathogenesis of human HFE HC...
  15. ncbi request reprint Ferroportin is a monomer in vivo in mice
    Elisa Pignatti
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Blood Cells Mol Dis 36:26-32. 2006
    ..The latter finding may have important implications for understanding the pathogenesis of the disease due to ferroportin mutations...
  16. ncbi request reprint Hereditary hemochromatosis
    Antonello Pietrangelo
    Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, 41100 Modena, Italy
    Annu Rev Nutr 26:251-70. 2006
    ..Hepcidin, the iron hormone, seems to hold a central pathogenic place in hemochromatosis, similar to insulin in diabetes: Genetically determined lack of hepcidin synthesis or activity may cause the disease...
  17. ncbi request reprint Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes
    Antonello Pietrangelo
    Department of Internal Medicine, University of Modena and Regio Emilia, Policlinico, Modena, Italy
    Gastroenterology 128:470-9. 2005
    ..A milder adult-onset form is due to pathogenic mutations of HFE or, rarely, serum transferrin receptor 2...
  18. ncbi request reprint Solving hemochromatosis with knock-out mice
    Antonello Pietrangelo
    Department of Internal Medicine, University of Modena and Reggio Emilia Policlinico, Italy
    J Hepatol 38:121-3. 2003
  19. ncbi request reprint Iron chelation beyond transfusion iron overload
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena and Reggio Emilia, Modena, Italy
    Am J Hematol 82:1142-6. 2007
    ..This article discusses the potential use of iron chelation therapy to treat iron overload from causes other than transfusion overload...
  20. ncbi request reprint Physiology of iron transport and the hemochromatosis gene
    Antonello Pietrangelo
    Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Am J Physiol Gastrointest Liver Physiol 282:G403-14. 2002
    ..This review focuses on recent advances in iron research and presents a model of HFE function in iron metabolism...
  21. ncbi request reprint The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression
    Athina Lymboussaki
    Center for Hemochromatosis and Metabolic Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    J Hepatol 39:710-5. 2003
    ..However, the way this gene is regulated by iron is still unclear. The aim of this study was to investigate the functional role of genomic SLC40A1 elements in response to iron...
  22. ncbi request reprint Hemochromatosis gene modifies course of hepatitis C viral infection
    Antonello Pietrangelo
    Department of Internal Medicine, Centre for Hemochromatosis and Metabolic Liver Diseases, University of Modena and Reggio Emilia, Modeno, Italy
    Gastroenterology 124:1509-23. 2003
  23. ncbi request reprint Iron-induced oxidant stress in alcoholic liver fibrogenesis
    Antonello Pietrangelo
    Centre for the Study of Iron Disorders, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Alcohol 30:121-9. 2003
    ..A challenge for future research is to develop therapeutic tools able to block "redox-active" free iron in the cell...
  24. ncbi request reprint Non-HFE hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Hepatology 39:21-9. 2004
  25. ncbi request reprint Non-invasive assessment of hepatic iron overload: are we finally there?
    Antonello Pietrangelo
    Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    J Hepatol 42:153-4. 2005
  26. ncbi request reprint Hereditary hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Biochim Biophys Acta 1763:700-10. 2006
    ..In vitro and in vivo studies will be needed to dissect the consequences of each hereditary hemochromatosis allele and increase our understanding of the precise contribution of each gene to the hereditary hemochromatosis phenotype...
  27. ncbi request reprint The ferroportin disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena 41100, Italy
    Blood Cells Mol Dis 32:131-8. 2004
    ..Now, the disorder appears to be the most common cause of hereditary iron overload beyond HFE hemochromatosis...
  28. ncbi request reprint The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage
    Gaetano Cairo
    Institute of General Pathology, Cell Pathology Centre CNR, Milano, Italy
    Free Radic Biol Med 32:1237-43. 2002
    ..Here we briefly review the role of IRP in iron-mediated damage induced by oxygen radicals, nitrogen-centered reactive species, and xenobiotics of pharmacological and clinical interest...
  29. ncbi request reprint Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene
    Victor R Gordeuk
    Howard University College of Medicine, Washington, DC 20059, USA
    Blood Cells Mol Dis 31:299-304. 2003
    ..We conclude that the Q248H mutation is a common polymorphism in the ferroportin 1 gene in African populations that may be associated with mild anemia and a tendency to iron loading...
  30. ncbi request reprint Haptoglobin modifies the hemochromatosis phenotype in mice
    Emanuela Tolosano
    Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy emanuela
    Blood 105:3353-5. 2005
    ....
  31. ncbi request reprint The penetrance of hemochromatosis: mice to the rescue
    Antonello Pietrangelo
    Gastroenterology 132:805-8. 2007
  32. ncbi request reprint Mechanism of iron toxicity
    Antonello Pietrangelo
    Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Adv Exp Med Biol 509:19-43. 2002
  33. doi request reprint Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    Sohji Nishina
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Gastroenterology 134:226-38. 2008
    ..The aim of this study was to investigate how hepatic iron overload develops in the presence of HCV proteins...
  34. ncbi request reprint Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Disease, University Hospital of Modena, Italy
    Nat Clin Pract Gastroenterol Hepatol 1:39-45. 2004
    ..Given its role as the iron-regulatory hormone, the modulation of hepcidin activity using agonists or antagonists might offer new treatment opportunities in different human iron-dependent disorders...
  35. ncbi request reprint Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y
    Daniel F Wallace
    Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Hepatol 36:474-9. 2002
    ..Some are compound heterozygotes for C282Y/H63D. A small proportion have neither of these genotypes. We have investigated the phenotype of compound heterozygotes for C282Y and another missense mutation S65C...
  36. pmc Disease progression and liver cancer in the ferroportin disease
    Elena Corradini
    Gut 56:1030-2. 2007
  37. ncbi request reprint Genetics in liver diseases
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena, Via del Pozza 71, 41100 Modena, Italy
    J Hepatol 46:1143-8. 2007
    ..This article reports the highlights of the conference and summarizes the main conclusions and implications for clinical and experimental hepatology...
  38. ncbi request reprint Strategies for liver support: from stem cells to xenotransplantation
    Patrizia Burra
    Department of Surgical and Gastroenterological Sciences, University Hospital, Padova, Italy
    J Hepatol 41:1050-9. 2004
  39. pmc Molecular and clinical correlates in iron overload associated with mutations in ferroportin
    Ivana De Domenico
    Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Universita di Messina, 98166 Messina, Italia
    Haematologica 91:1092-5. 2006
    ..We suggest that FpnG80S represents a class of Fpn mutants whose behavior in vitro does not explain the patients' phenotype...