Antonello Pietrangelo

Summary

Affiliation: University of Modena and Reggio Emilia
Country: Italy

Publications

  1. pmc Molecular insights into the pathogenesis of hereditary haemochromatosis
    A Pietrangelo
    Centre for Haemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena Italy
    Gut 55:564-8. 2006
  2. pmc Haemochromatosis
    A Pietrangelo
    Department of Internal Medicine, University of Modena and Reggio Emilia, Italy
    Gut 52:ii23-30. 2003
  3. ncbi request reprint Non-HFE hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Semin Liver Dis 25:450-60. 2005
  4. ncbi request reprint Hereditary hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Biochim Biophys Acta 1763:700-10. 2006
  5. ncbi request reprint Hereditary hemochromatosis
    Antonello Pietrangelo
    Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, 41100 Modena, Italy
    Annu Rev Nutr 26:251-70. 2006
  6. ncbi request reprint The ferroportin disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena 41100, Italy
    Blood Cells Mol Dis 32:131-8. 2004
  7. ncbi request reprint Hereditary hemochromatosis--a new look at an old disease
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia Policlinico, Modena, Italy
    N Engl J Med 350:2383-97. 2004
  8. ncbi request reprint Non-invasive assessment of hepatic iron overload: are we finally there?
    Antonello Pietrangelo
    Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    J Hepatol 42:153-4. 2005
  9. ncbi request reprint Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes
    Antonello Pietrangelo
    Department of Internal Medicine, University of Modena and Regio Emilia, Policlinico, Modena, Italy
    Gastroenterology 128:470-9. 2005
  10. ncbi request reprint Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Disease, University Hospital of Modena, Italy
    Nat Clin Pract Gastroenterol Hepatol 1:39-45. 2004

Collaborators

Detail Information

Publications52

  1. pmc Molecular insights into the pathogenesis of hereditary haemochromatosis
    A Pietrangelo
    Centre for Haemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena Italy
    Gut 55:564-8. 2006
  2. pmc Haemochromatosis
    A Pietrangelo
    Department of Internal Medicine, University of Modena and Reggio Emilia, Italy
    Gut 52:ii23-30. 2003
    ....
  3. ncbi request reprint Non-HFE hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Semin Liver Dis 25:450-60. 2005
    ....
  4. ncbi request reprint Hereditary hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Biochim Biophys Acta 1763:700-10. 2006
    ..In vitro and in vivo studies will be needed to dissect the consequences of each hereditary hemochromatosis allele and increase our understanding of the precise contribution of each gene to the hereditary hemochromatosis phenotype...
  5. ncbi request reprint Hereditary hemochromatosis
    Antonello Pietrangelo
    Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, 41100 Modena, Italy
    Annu Rev Nutr 26:251-70. 2006
    ..Hepcidin, the iron hormone, seems to hold a central pathogenic place in hemochromatosis, similar to insulin in diabetes: Genetically determined lack of hepcidin synthesis or activity may cause the disease...
  6. ncbi request reprint The ferroportin disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena 41100, Italy
    Blood Cells Mol Dis 32:131-8. 2004
    ..Now, the disorder appears to be the most common cause of hereditary iron overload beyond HFE hemochromatosis...
  7. ncbi request reprint Hereditary hemochromatosis--a new look at an old disease
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia Policlinico, Modena, Italy
    N Engl J Med 350:2383-97. 2004
  8. ncbi request reprint Non-invasive assessment of hepatic iron overload: are we finally there?
    Antonello Pietrangelo
    Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    J Hepatol 42:153-4. 2005
  9. ncbi request reprint Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes
    Antonello Pietrangelo
    Department of Internal Medicine, University of Modena and Regio Emilia, Policlinico, Modena, Italy
    Gastroenterology 128:470-9. 2005
    ..A milder adult-onset form is due to pathogenic mutations of HFE or, rarely, serum transferrin receptor 2...
  10. ncbi request reprint Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Disease, University Hospital of Modena, Italy
    Nat Clin Pract Gastroenterol Hepatol 1:39-45. 2004
    ..Given its role as the iron-regulatory hormone, the modulation of hepcidin activity using agonists or antagonists might offer new treatment opportunities in different human iron-dependent disorders...
  11. ncbi request reprint Genetics in liver diseases
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena, Via del Pozza 71, 41100 Modena, Italy
    J Hepatol 46:1143-8. 2007
    ..This article reports the highlights of the conference and summarizes the main conclusions and implications for clinical and experimental hepatology...
  12. ncbi request reprint Hemochromatosis: an endocrine liver disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Hepatology 46:1291-301. 2007
    ..The recognition of the endocrine nature of hemochromatosis suggests intriguing possibilities for new and more effective approaches to diagnosis and treatment...
  13. doi request reprint Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation
    Cinzia Garuti
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Gastroenterology 139:315-22.e1. 2010
    ..However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regulatory hormone hepcidin-in pathogenesis in mice...
  14. pmc ER stress controls iron metabolism through induction of hepcidin
    Chiara Vecchi
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital Policlinico di Modena, Modena, Italy
    Science 325:877-80. 2009
    ..The regulation of hepcidin by ER stress links the intracellular response involved in protein quality control to innate immunity and iron homeostasis...
  15. ncbi request reprint Lack of enterocyte iron accumulation in the ferroportin disease
    Elena Corradini
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena Policlinico Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 35:315-8. 2005
    ..Not surprisingly, in the liver, iron excess was found mainly in Kupffer cells. These results indicate that FPN haploinsufficiency is not limiting for iron export from enterocytes...
  16. pmc Altered hepatic BMP signaling pathway in human HFE hemochromatosis
    Giuliano Bolondi
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Blood Cells Mol Dis 45:308-12. 2010
    ..These data indicate that in human HFE-HC a disrupted BMP/SMAD signaling in the liver is key in the pathogenesis of the disease...
  17. ncbi request reprint Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload
    Giuliana Montosi
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Hepatology 41:545-52. 2005
    ..However, both Kupffer cells and human macrophages are dispensable for the regulatory activity exerted by iron on hepatic hepcidin...
  18. doi request reprint Non-HFE hepatic iron overload
    Antonello Pietrangelo
    Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
    Semin Liver Dis 31:302-18. 2011
    ..e., chronic viral or metabolic liver diseases), regional or local iron accumulation may occur that aggravates the clinical course of the underlying disease or limits efficacy of therapy...
  19. ncbi request reprint Iron and the liver
    Elena Corradini
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Italy
    Pediatr Endocrinol Rev 2:245-8. 2004
    ....
  20. doi request reprint Iron and steatohepatitis
    Elena Corradini
    Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
    J Gastroenterol Hepatol 27:42-6. 2012
    ..The present study reviews the pathogenic mechanisms of iron accumulation in steatohepatitis during alcoholic and non-alcoholic liver disease and the role of excess iron in chronic disease progression...
  21. ncbi request reprint Magnetic resonance imaging to identify classic and nonclassic forms of ferroportin disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 37:192-6. 2006
    ..In conclusion, MRI is a useful non-invasive diagnostic tool to categorize and diagnose the disorder, monitor the status of iron depletion and gain insights on its natural history and management...
  22. doi request reprint Serum ferritin as a predictor of treatment outcome in patients with chronic hepatitis C
    Francesca Ferrara
    Department of Internal Medicine, Center for Hemochromatosis, University Hospital of Modena, Italy
    Am J Gastroenterol 104:605-16. 2009
    ..Antiviral treatment in chronic hepatitis C (CHC) involves ribavirin, a hemolytic agent. We planned a prospective study to evaluate whether drug-induced iron perturbation is clinically relevant as it relates to therapeutic outcome...
  23. doi request reprint Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment
    Antonello Pietrangelo
    2nd Division of Internal Medicine and Centre for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Gastroenterology 139:393-408, 408.e1-2. 2010
    ..The role of hepcidin in the pathogenesis of hemochromatosis reveals its similarities to endocrine diseases such as diabetes and indicates new approaches to diagnosis and management of this common disorder in iron metabolism...
  24. doi request reprint Hepcidin in human iron disorders: therapeutic implications
    Antonello Pietrangelo
    Centre for Hemochromatosis, Center for Advanced Research in Hepatology Mario Coppo, University Hospital of Modena, Modena, Via del Pozzo 71, 41100 Modena, Italy
    J Hepatol 54:173-81. 2011
    ....
  25. ncbi request reprint Solving hemochromatosis with knock-out mice
    Antonello Pietrangelo
    Department of Internal Medicine, University of Modena and Reggio Emilia Policlinico, Italy
    J Hepatol 38:121-3. 2003
  26. ncbi request reprint STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico Via del Pozzo 71, 41100 Modena, Italy
    Gastroenterology 132:294-300. 2007
    ..To clarify the molecular pathways involved in hepcidin activation by IL-6, we used different mice strains in which the main IL-6/gp130 signaling pathways have been genetically disrupted...
  27. doi request reprint Gluconeogenic Signals Regulate Iron Homeostasis via Hepcidin in Mice
    Chiara Vecchi
    Center for Hemochromatosis and Metabolic Liver Diseases, Department of Medical and Surgical Sciences, University Hospital of Modena, Modena, Italy
    Gastroenterology 146:1060-1069.e3. 2014
    ..We investigated whether gluconeogenic signals directly control Hepcidin, an important regulator of iron homeostasis, in starving mice (a model of persistently activated gluconeogenesis and insulin resistance)...
  28. ncbi request reprint Physiology of iron transport and the hemochromatosis gene
    Antonello Pietrangelo
    Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Am J Physiol Gastrointest Liver Physiol 282:G403-14. 2002
    ..This review focuses on recent advances in iron research and presents a model of HFE function in iron metabolism...
  29. ncbi request reprint Non-HFE hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Hepatology 39:21-9. 2004
  30. doi request reprint Huh-7: a human "hemochromatotic" cell line
    Chiara Vecchi
    Department of Internal Medicine, University Hospital of Modena, Center for Hemochromatosis, Policlinico, Modena, Italy
    Hepatology 51:654-9. 2010
    ..Interestingly, hepcidin messenger RNA levels increased significantly in Huh-7 cells stably expressing exogenous wild-type HFE at the plasma membrane...
  31. ncbi request reprint Ferroportin is a monomer in vivo in mice
    Elisa Pignatti
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Blood Cells Mol Dis 36:26-32. 2006
    ..The latter finding may have important implications for understanding the pathogenesis of the disease due to ferroportin mutations...
  32. ncbi request reprint Iron-induced oxidant stress in alcoholic liver fibrogenesis
    Antonello Pietrangelo
    Centre for the Study of Iron Disorders, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Alcohol 30:121-9. 2003
    ..A challenge for future research is to develop therapeutic tools able to block "redox-active" free iron in the cell...
  33. ncbi request reprint Iron chelation beyond transfusion iron overload
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena and Reggio Emilia, Modena, Italy
    Am J Hematol 82:1142-6. 2007
    ..This article discusses the potential use of iron chelation therapy to treat iron overload from causes other than transfusion overload...
  34. ncbi request reprint Hemochromatosis gene modifies course of hepatitis C viral infection
    Antonello Pietrangelo
    Department of Internal Medicine, Centre for Hemochromatosis and Metabolic Liver Diseases, University of Modena and Reggio Emilia, Modeno, Italy
    Gastroenterology 124:1509-23. 2003
  35. doi request reprint The porphyrias: pathophysiology
    Antonello Pietrangelo
    Division of Internal Medicine, Center for Hereditary Liver Diseases, Mario Coppo Liver Research Center, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy
    Intern Emerg Med 5:S65-71. 2010
    ..While genetics has a role in confirming clinical suspicion and in family screening, biochemical and clinical studies are still central in the diagnosis...
  36. pmc Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene
    G Montosi
    Department of Internal Medicine, University of Modena, Modena, Italy
    J Clin Invest 108:619-23. 2001
    ..We propose that partial loss of ferroportin function leads to an imbalance in iron distribution and a consequent increase in tissue iron accumulation...
  37. ncbi request reprint Mechanism of iron toxicity
    Antonello Pietrangelo
    Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Adv Exp Med Biol 509:19-43. 2002
  38. ncbi request reprint The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression
    Athina Lymboussaki
    Center for Hemochromatosis and Metabolic Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    J Hepatol 39:710-5. 2003
    ..However, the way this gene is regulated by iron is still unclear. The aim of this study was to investigate the functional role of genomic SLC40A1 elements in response to iron...
  39. ncbi request reprint Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene
    A Pietrangelo
    Department of Internal Medicine, Universita di Modena, Italy
    N Engl J Med 341:725-32. 1999
    ..We performed biochemical, histologic, and genetic studies of 53 living members of the family, including microsatellite analysis of chromosome 6 and direct sequencing of the HFE gene...
  40. doi request reprint Inherited metabolic disease of the liver
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Curr Opin Gastroenterol 25:209-14. 2009
    ..This advancement paves the way for development of new strategies to diagnose and cure metabolic liver diseases...
  41. ncbi request reprint Frequency and biochemical expression of C282Y/H63D hemochromatosis (HFE) gene mutations in the healthy adult population in Italy
    S Cassanelli
    Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Italy
    J Hepatol 34:523-8. 2001
    ..The actual prevalence of the main hemochromatosis (HFE) mutations in the Italian adult population and their phenotypic expression have not yet been established. This information is key to advocate a mass-screening program...
  42. ncbi request reprint Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin
    Antonello Pietrangelo
    Dipartimento di Medicina Interna e Sezione di Patologia Generale, Universita di Modena, Italy
    J Bioenerg Biomembr 34:67-79. 2002
    ..Iron-induced oxidant stress in nonparenchymal cells appeared to bring about irreversible mitochondrial derangement associated with the onset of hepatic fibrosis...
  43. ncbi request reprint Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y
    Daniel F Wallace
    Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    J Hepatol 36:474-9. 2002
    ..Some are compound heterozygotes for C282Y/H63D. A small proportion have neither of these genotypes. We have investigated the phenotype of compound heterozygotes for C282Y and another missense mutation S65C...
  44. ncbi request reprint Haptoglobin modifies the hemochromatosis phenotype in mice
    Emanuela Tolosano
    Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy emanuela
    Blood 105:3353-5. 2005
    ....
  45. pmc Disease progression and liver cancer in the ferroportin disease
    Elena Corradini
    Gut 56:1030-2. 2007
  46. ncbi request reprint The penetrance of hemochromatosis: mice to the rescue
    Antonello Pietrangelo
    Gastroenterology 132:805-8. 2007
  47. ncbi request reprint The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage
    Gaetano Cairo
    Institute of General Pathology, Cell Pathology Centre CNR, Milano, Italy
    Free Radic Biol Med 32:1237-43. 2002
    ..Here we briefly review the role of IRP in iron-mediated damage induced by oxygen radicals, nitrogen-centered reactive species, and xenobiotics of pharmacological and clinical interest...
  48. pmc Molecular and clinical correlates in iron overload associated with mutations in ferroportin
    Ivana De Domenico
    Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Universita di Messina, 98166 Messina, Italia
    Haematologica 91:1092-5. 2006
    ..We suggest that FpnG80S represents a class of Fpn mutants whose behavior in vitro does not explain the patients' phenotype...
  49. ncbi request reprint Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene
    Victor R Gordeuk
    Howard University College of Medicine, Washington, DC 20059, USA
    Blood Cells Mol Dis 31:299-304. 2003
    ..We conclude that the Q248H mutation is a common polymorphism in the ferroportin 1 gene in African populations that may be associated with mild anemia and a tendency to iron loading...
  50. doi request reprint Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    Sohji Nishina
    Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Gastroenterology 134:226-38. 2008
    ..The aim of this study was to investigate how hepatic iron overload develops in the presence of HCV proteins...
  51. ncbi request reprint Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects
    Beatrice Dozin
    Centro Biotecnologie Avanzate Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Matrix Biol 21:449-59. 2002
    ..Diacerein largely prevents the metabolic alterations caused by cytokine exposure in human chondrocytes, possibly through its ability to block early intracellular mediators after cytokine stimulation, such as oxygen radicals...
  52. ncbi request reprint Strategies for liver support: from stem cells to xenotransplantation
    Patrizia Burra
    Department of Surgical and Gastroenterological Sciences, University Hospital, Padova, Italy
    J Hepatol 41:1050-9. 2004