Research Topics
Genomes and Genes | Antonello PietrangeloSummaryAffiliation: University of Modena and Reggio Emilia Country: Italy Publications
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Publications
HaemochromatosisA Pietrangelo
Department of Internal Medicine, University of Modena and Reggio Emilia, Italy
Gut 52:ii23-30. 2003....- Molecular insights into the pathogenesis of hereditary haemochromatosisA Pietrangelo
Centre for Haemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena Italy
Gut 55:564-8. 2006 
Hereditary hemochromatosisAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
Biochim Biophys Acta 1763:700-10. 2006..In vitro and in vivo studies will be needed to dissect the consequences of each hereditary hemochromatosis allele and increase our understanding of the precise contribution of each gene to the hereditary hemochromatosis phenotype...- Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disordersAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Disease, University Hospital of Modena, Italy
Nat Clin Pract Gastroenterol Hepatol 1:39-45. 2004..Given its role as the iron-regulatory hormone, the modulation of hepcidin activity using agonists or antagonists might offer new treatment opportunities in different human iron-dependent disorders... - Non-invasive assessment of hepatic iron overload: are we finally there?Antonello Pietrangelo
Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
J Hepatol 42:153-4. 2005 - The ferroportin diseaseAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena 41100, Italy
Blood Cells Mol Dis 32:131-8. 2004..Now, the disorder appears to be the most common cause of hereditary iron overload beyond HFE hemochromatosis... - Hereditary hemochromatosisAntonello Pietrangelo
Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, 41100 Modena, Italy
Annu Rev Nutr 26:251-70. 2006..Hepcidin, the iron hormone, seems to hold a central pathogenic place in hemochromatosis, similar to insulin in diabetes: Genetically determined lack of hepcidin synthesis or activity may cause the disease... - Non-HFE hemochromatosisAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
Semin Liver Dis 25:450-60. 2005.... - Genetics in liver diseasesAntonello Pietrangelo
Center for Hemochromatosis, University Hospital of Modena, Via del Pozza 71, 41100 Modena, Italy
J Hepatol 46:1143-8. 2007..This article reports the highlights of the conference and summarizes the main conclusions and implications for clinical and experimental hepatology... - Hemochromatosis: an endocrine liver diseaseAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
Hepatology 46:1291-301. 2007..The recognition of the endocrine nature of hemochromatosis suggests intriguing possibilities for new and more effective approaches to diagnosis and treatment... - Hereditary hemochromatosis--a new look at an old diseaseAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia Policlinico, Modena, Italy
N Engl J Med 350:2383-97. 2004 - Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genesAntonello Pietrangelo
Department of Internal Medicine, University of Modena and Regio Emilia, Policlinico, Modena, Italy
Gastroenterology 128:470-9. 2005..A milder adult-onset form is due to pathogenic mutations of HFE or, rarely, serum transferrin receptor 2... 
Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantationCinzia Garuti
Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
Gastroenterology 139:315-22.e1. 2010..However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regulatory hormone hepcidin-in pathogenesis in mice...- Altered hepatic BMP signaling pathway in human HFE hemochromatosisGiuliano Bolondi
Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
Blood Cells Mol Dis 45:308-12. 2010..These data indicate that in human HFE-HC a disrupted BMP/SMAD signaling in the liver is key in the pathogenesis of the disease... - Lack of enterocyte iron accumulation in the ferroportin diseaseElena Corradini
Center for Hemochromatosis, Department of Internal Medicine, University of Modena Policlinico Via del Pozzo 71 41100 Modena, Italy
Blood Cells Mol Dis 35:315-8. 2005..Not surprisingly, in the liver, iron excess was found mainly in Kupffer cells. These results indicate that FPN haploinsufficiency is not limiting for iron export from enterocytes... - Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overloadGiuliana Montosi
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
Hepatology 41:545-52. 2005..However, both Kupffer cells and human macrophages are dispensable for the regulatory activity exerted by iron on hepatic hepcidin... - Non-HFE hepatic iron overloadAntonello Pietrangelo
Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
Semin Liver Dis 31:302-18. 2011..e., chronic viral or metabolic liver diseases), regional or local iron accumulation may occur that aggravates the clinical course of the underlying disease or limits efficacy of therapy... - ER stress controls iron metabolism through induction of hepcidinChiara Vecchi
Center for Hemochromatosis, Department of Internal Medicine, University Hospital Policlinico di Modena, Modena, Italy
Science 325:877-80. 2009..The regulation of hepcidin by ER stress links the intracellular response involved in protein quality control to innate immunity and iron homeostasis... - Iron and the liverElena Corradini
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Italy
Pediatr Endocrinol Rev 2:245-8. 2004.... - Iron and steatohepatitisElena Corradini
Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
J Gastroenterol Hepatol 27:42-6. 2012..The present study reviews the pathogenic mechanisms of iron accumulation in steatohepatitis during alcoholic and non-alcoholic liver disease and the role of excess iron in chronic disease progression... - Serum ferritin as a predictor of treatment outcome in patients with chronic hepatitis CFrancesca Ferrara
Department of Internal Medicine, Center for Hemochromatosis, University Hospital of Modena, Italy
Am J Gastroenterol 104:605-16. 2009..Antiviral treatment in chronic hepatitis C (CHC) involves ribavirin, a hemolytic agent. We planned a prospective study to evaluate whether drug-induced iron perturbation is clinically relevant as it relates to therapeutic outcome... - Hereditary hemochromatosis: pathogenesis, diagnosis, and treatmentAntonello Pietrangelo
2nd Division of Internal Medicine and Centre for Hemochromatosis, University Hospital of Modena, Modena, Italy
Gastroenterology 139:393-408, 408.e1-2. 2010..The role of hepcidin in the pathogenesis of hemochromatosis reveals its similarities to endocrine diseases such as diabetes and indicates new approaches to diagnosis and management of this common disorder in iron metabolism... - Magnetic resonance imaging to identify classic and nonclassic forms of ferroportin diseaseAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University Hospital of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71 41100 Modena, Italy
Blood Cells Mol Dis 37:192-6. 2006..In conclusion, MRI is a useful non-invasive diagnostic tool to categorize and diagnose the disorder, monitor the status of iron depletion and gain insights on its natural history and management... - STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivoAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico Via del Pozzo 71, 41100 Modena, Italy
Gastroenterology 132:294-300. 2007..To clarify the molecular pathways involved in hepcidin activation by IL-6, we used different mice strains in which the main IL-6/gp130 signaling pathways have been genetically disrupted... - Hepcidin in human iron disorders: therapeutic implicationsAntonello Pietrangelo
Centre for Hemochromatosis, Center for Advanced Research in Hepatology Mario Coppo, University Hospital of Modena, Modena, Via del Pozzo 71, 41100 Modena, Italy
J Hepatol 54:173-81. 2011.... - Solving hemochromatosis with knock-out miceAntonello Pietrangelo
Department of Internal Medicine, University of Modena and Reggio Emilia. Policlinico, Italy
J Hepatol 38:121-3. 2003 - Huh-7: a human "hemochromatotic" cell lineChiara Vecchi
Department of Internal Medicine, University Hospital of Modena, Center for Hemochromatosis, Policlinico, Modena, Italy
Hepatology 51:654-9. 2010..CONCLUSION: Huh-7 cells may represent a novel and valuable tool to investigate the role of altered HFE traffic in iron metabolism and pathogenesis of human HFE HC... - Physiology of iron transport and the hemochromatosis geneAntonello Pietrangelo
Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Am J Physiol Gastrointest Liver Physiol 282:G403-14. 2002..This review focuses on recent advances in iron research and presents a model of HFE function in iron metabolism... - Ferroportin is a monomer in vivo in miceElisa Pignatti
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Blood Cells Mol Dis 36:26-32. 2006..The latter finding may have important implications for understanding the pathogenesis of the disease due to ferroportin mutations... - Non-HFE hemochromatosisAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
Hepatology 39:21-9. 2004 - Iron chelation beyond transfusion iron overloadAntonello Pietrangelo
Center for Hemochromatosis, University Hospital of Modena and Reggio Emilia, Modena, Italy
Am J Hematol 82:1142-6. 2007..This article discusses the potential use of iron chelation therapy to treat iron overload from causes other than transfusion overload... - Iron-induced oxidant stress in alcoholic liver fibrogenesisAntonello Pietrangelo
Centre for the Study of Iron Disorders, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
Alcohol 30:121-9. 2003..A challenge for future research is to develop therapeutic tools able to block "redox-active" free iron in the cell... - Hemochromatosis gene modifies course of hepatitis C viral infectionAntonello Pietrangelo
Department of Internal Medicine, Centre for Hemochromatosis and Metabolic Liver Diseases, University of Modena and Reggio Emilia, Modeno, Italy
Gastroenterology 124:1509-23. 2003 - The porphyrias: pathophysiologyAntonello Pietrangelo
Division of Internal Medicine, Center for Hereditary Liver Diseases, Mario Coppo Liver Research Center, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy
Intern Emerg Med 5:S65-71. 2010..While genetics has a role in confirming clinical suspicion and in family screening, biochemical and clinical studies are still central in the diagnosis... - Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) geneG Montosi
Department of Internal Medicine, University of Modena, Modena, Italy
J Clin Invest 108:619-23. 2001..We propose that partial loss of ferroportin function leads to an imbalance in iron distribution and a consequent increase in tissue iron accumulation... - The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expressionAthina Lymboussaki
Center for Hemochromatosis and Metabolic Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
J Hepatol 39:710-5. 2003..However, the way this gene is regulated by iron is still unclear. The aim of this study was to investigate the functional role of genomic SLC40A1 elements in response to iron... - Mechanism of iron toxicityAntonello Pietrangelo
Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Adv Exp Med Biol 509:19-43. 2002 - Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis geneA Pietrangelo
Department of Internal Medicine, Universita di Modena, Italy
N Engl J Med 341:725-32. 1999..We performed biochemical, histologic, and genetic studies of 53 living members of the family, including microsatellite analysis of chromosome 6 and direct sequencing of the HFE gene... - Inherited metabolic disease of the liverAntonello Pietrangelo
Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
Curr Opin Gastroenterol 25:209-14. 2009..This advancement paves the way for development of new strategies to diagnose and cure metabolic liver diseases... - Frequency and biochemical expression of C282Y/H63D hemochromatosis (HFE) gene mutations in the healthy adult population in ItalyS Cassanelli
Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Italy
J Hepatol 34:523-8. 2001..The actual prevalence of the main hemochromatosis (HFE) mutations in the Italian adult population and their phenotypic expression have not yet been established. This information is key to advocate a mass-screening program... - Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcriptionSohji Nishina
Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
Gastroenterology 134:226-38. 2008..The aim of this study was to investigate how hepatic iron overload develops in the presence of HCV proteins... - Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) geneVictor R Gordeuk
Howard University College of Medicine, Washington, DC 20059, USA
Blood Cells Mol Dis 31:299-304. 2003..We conclude that the Q248H mutation is a common polymorphism in the ferroportin 1 gene in African populations that may be associated with mild anemia and a tendency to iron loading... - The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damageGaetano Cairo
Institute of General Pathology, Cell Pathology Centre CNR, Milano, Italy
Free Radic Biol Med 32:1237-43. 2002..Here we briefly review the role of IRP in iron-mediated damage induced by oxygen radicals, nitrogen-centered reactive species, and xenobiotics of pharmacological and clinical interest... - Molecular and clinical correlates in iron overload associated with mutations in ferroportinIvana De Domenico
Dipartimento di Scienze Microbiologiche Genetiche e Molecolari, Universita di Messina, 98166 Messina, Italia
Haematologica 91:1092-5. 2006..We suggest that FpnG80S represents a class of Fpn mutants whose behavior in vitro does not explain the patients' phenotype... - Haptoglobin modifies the hemochromatosis phenotype in miceEmanuela Tolosano
Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy emanuela
Blood 105:3353-5. 2005.... - The penetrance of hemochromatosis: mice to the rescueAntonello Pietrangelo
Gastroenterology 132:805-8. 2007 - Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282YDaniel F Wallace
Centre for Hepatology, Department of Medicine, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
J Hepatol 36:474-9. 2002..Some are compound heterozygotes for C282Y/H63D. A small proportion have neither of these genotypes. We have investigated the phenotype of compound heterozygotes for C282Y and another missense mutation S65C... - Disease progression and liver cancer in the ferroportin diseaseElena Corradini
Gut 56:1030-2. 2007 - Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybinAntonello Pietrangelo
Dipartimento di Medicina Interna e Sezione di Patologia Generale, Universita di Modena, Italy
J Bioenerg Biomembr 34:67-79. 2002..Iron-induced oxidant stress in nonparenchymal cells appeared to bring about irreversible mitochondrial derangement associated with the onset of hepatic fibrosis... - Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspectsBeatrice Dozin
Centro Biotecnologie Avanzate Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
Matrix Biol 21:449-59. 2002..Diacerein largely prevents the metabolic alterations caused by cytokine exposure in human chondrocytes, possibly through its ability to block early intracellular mediators after cytokine stimulation, such as oxygen radicals... - Strategies for liver support: from stem cells to xenotransplantationPatrizia Burra
Department of Surgical and Gastroenterological Sciences, University Hospital, Padova, Italy
J Hepatol 41:1050-9. 2004