Antonello Pietrangelo

Summary

Affiliation: University of Modena and Reggio Emilia
Country: Italy

Publications

  1. doi request reprint Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment
    Antonello Pietrangelo
    2nd Division of Internal Medicine and Centre for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Gastroenterology 139:393-408, 408.e1-2. 2010
  2. doi request reprint The porphyrias: pathophysiology
    Antonello Pietrangelo
    Division of Internal Medicine, Center for Hereditary Liver Diseases, Mario Coppo Liver Research Center, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy
    Intern Emerg Med 5:S65-71. 2010
  3. doi request reprint Non-HFE hepatic iron overload
    Antonello Pietrangelo
    Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
    Semin Liver Dis 31:302-18. 2011
  4. doi request reprint Inherited metabolic disease of the liver
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Curr Opin Gastroenterol 25:209-14. 2009
  5. doi request reprint Hepcidin in human iron disorders: therapeutic implications
    Antonello Pietrangelo
    Centre for Hemochromatosis, Center for Advanced Research in Hepatology Mario Coppo, University Hospital of Modena, Modena, Via del Pozzo 71, 41100 Modena, Italy
    J Hepatol 54:173-81. 2011
  6. doi request reprint Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation
    Cinzia Garuti
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Gastroenterology 139:315-22.e1. 2010
  7. pmc Altered hepatic BMP signaling pathway in human HFE hemochromatosis
    Giuliano Bolondi
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Blood Cells Mol Dis 45:308-12. 2010
  8. ncbi request reprint Lack of enterocyte iron accumulation in the ferroportin disease
    Elena Corradini
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena Policlinico Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 35:315-8. 2005
  9. pmc ER stress controls iron metabolism through induction of hepcidin
    Chiara Vecchi
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital Policlinico di Modena, Modena, Italy
    Science 325:877-80. 2009
  10. ncbi request reprint Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload
    Giuliana Montosi
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Hepatology 41:545-52. 2005

Collaborators

Detail Information

Publications33

  1. doi request reprint Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment
    Antonello Pietrangelo
    2nd Division of Internal Medicine and Centre for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Gastroenterology 139:393-408, 408.e1-2. 2010
    ..The role of hepcidin in the pathogenesis of hemochromatosis reveals its similarities to endocrine diseases such as diabetes and indicates new approaches to diagnosis and management of this common disorder in iron metabolism...
  2. doi request reprint The porphyrias: pathophysiology
    Antonello Pietrangelo
    Division of Internal Medicine, Center for Hereditary Liver Diseases, Mario Coppo Liver Research Center, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy
    Intern Emerg Med 5:S65-71. 2010
    ..While genetics has a role in confirming clinical suspicion and in family screening, biochemical and clinical studies are still central in the diagnosis...
  3. doi request reprint Non-HFE hepatic iron overload
    Antonello Pietrangelo
    Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
    Semin Liver Dis 31:302-18. 2011
    ..e., chronic viral or metabolic liver diseases), regional or local iron accumulation may occur that aggravates the clinical course of the underlying disease or limits efficacy of therapy...
  4. doi request reprint Inherited metabolic disease of the liver
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Curr Opin Gastroenterol 25:209-14. 2009
    ..This advancement paves the way for development of new strategies to diagnose and cure metabolic liver diseases...
  5. doi request reprint Hepcidin in human iron disorders: therapeutic implications
    Antonello Pietrangelo
    Centre for Hemochromatosis, Center for Advanced Research in Hepatology Mario Coppo, University Hospital of Modena, Modena, Via del Pozzo 71, 41100 Modena, Italy
    J Hepatol 54:173-81. 2011
    ....
  6. doi request reprint Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation
    Cinzia Garuti
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Gastroenterology 139:315-22.e1. 2010
    ..However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regulatory hormone hepcidin-in pathogenesis in mice...
  7. pmc Altered hepatic BMP signaling pathway in human HFE hemochromatosis
    Giuliano Bolondi
    Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
    Blood Cells Mol Dis 45:308-12. 2010
    ..These data indicate that in human HFE-HC a disrupted BMP/SMAD signaling in the liver is key in the pathogenesis of the disease...
  8. ncbi request reprint Lack of enterocyte iron accumulation in the ferroportin disease
    Elena Corradini
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena Policlinico Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 35:315-8. 2005
    ..Not surprisingly, in the liver, iron excess was found mainly in Kupffer cells. These results indicate that FPN haploinsufficiency is not limiting for iron export from enterocytes...
  9. pmc ER stress controls iron metabolism through induction of hepcidin
    Chiara Vecchi
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital Policlinico di Modena, Modena, Italy
    Science 325:877-80. 2009
    ..The regulation of hepcidin by ER stress links the intracellular response involved in protein quality control to innate immunity and iron homeostasis...
  10. ncbi request reprint Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload
    Giuliana Montosi
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Hepatology 41:545-52. 2005
    ..However, both Kupffer cells and human macrophages are dispensable for the regulatory activity exerted by iron on hepatic hepcidin...
  11. ncbi request reprint Hereditary hemochromatosis--a new look at an old disease
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia Policlinico, Modena, Italy
    N Engl J Med 350:2383-97. 2004
  12. ncbi request reprint Non-HFE hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Semin Liver Dis 25:450-60. 2005
    ....
  13. doi request reprint Iron and steatohepatitis
    Elena Corradini
    Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
    J Gastroenterol Hepatol 27:42-6. 2012
    ..The present study reviews the pathogenic mechanisms of iron accumulation in steatohepatitis during alcoholic and non-alcoholic liver disease and the role of excess iron in chronic disease progression...
  14. ncbi request reprint Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes
    Antonello Pietrangelo
    Department of Internal Medicine, University of Modena and Regio Emilia, Policlinico, Modena, Italy
    Gastroenterology 128:470-9. 2005
    ..A milder adult-onset form is due to pathogenic mutations of HFE or, rarely, serum transferrin receptor 2...
  15. ncbi request reprint Magnetic resonance imaging to identify classic and nonclassic forms of ferroportin disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University Hospital of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71 41100 Modena, Italy
    Blood Cells Mol Dis 37:192-6. 2006
    ..In conclusion, MRI is a useful non-invasive diagnostic tool to categorize and diagnose the disorder, monitor the status of iron depletion and gain insights on its natural history and management...
  16. doi request reprint Serum ferritin as a predictor of treatment outcome in patients with chronic hepatitis C
    Francesca Ferrara
    Department of Internal Medicine, Center for Hemochromatosis, University Hospital of Modena, Italy
    Am J Gastroenterol 104:605-16. 2009
    ..Antiviral treatment in chronic hepatitis C (CHC) involves ribavirin, a hemolytic agent. We planned a prospective study to evaluate whether drug-induced iron perturbation is clinically relevant as it relates to therapeutic outcome...
  17. ncbi request reprint Hemochromatosis: an endocrine liver disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
    Hepatology 46:1291-301. 2007
    ..The recognition of the endocrine nature of hemochromatosis suggests intriguing possibilities for new and more effective approaches to diagnosis and treatment...
  18. ncbi request reprint STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico Via del Pozzo 71, 41100 Modena, Italy
    Gastroenterology 132:294-300. 2007
    ..To clarify the molecular pathways involved in hepcidin activation by IL-6, we used different mice strains in which the main IL-6/gp130 signaling pathways have been genetically disrupted...
  19. doi request reprint Huh-7: a human "hemochromatotic" cell line
    Chiara Vecchi
    Department of Internal Medicine, University Hospital of Modena, Center for Hemochromatosis, Policlinico, Modena, Italy
    Hepatology 51:654-9. 2010
    ..CONCLUSION: Huh-7 cells may represent a novel and valuable tool to investigate the role of altered HFE traffic in iron metabolism and pathogenesis of human HFE HC...
  20. ncbi request reprint Genetics in liver diseases
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena, Via del Pozza 71, 41100 Modena, Italy
    J Hepatol 46:1143-8. 2007
    ..This article reports the highlights of the conference and summarizes the main conclusions and implications for clinical and experimental hepatology...
  21. ncbi request reprint Non-HFE hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Hepatology 39:21-9. 2004
  22. ncbi request reprint Hereditary hemochromatosis
    Antonello Pietrangelo
    Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, 41100 Modena, Italy
    Annu Rev Nutr 26:251-70. 2006
    ..Hepcidin, the iron hormone, seems to hold a central pathogenic place in hemochromatosis, similar to insulin in diabetes: Genetically determined lack of hepcidin synthesis or activity may cause the disease...
  23. ncbi request reprint Ferroportin is a monomer in vivo in mice
    Elisa Pignatti
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Blood Cells Mol Dis 36:26-32. 2006
    ..The latter finding may have important implications for understanding the pathogenesis of the disease due to ferroportin mutations...
  24. ncbi request reprint Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disorders
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Disease, University Hospital of Modena, Italy
    Nat Clin Pract Gastroenterol Hepatol 1:39-45. 2004
    ..Given its role as the iron-regulatory hormone, the modulation of hepcidin activity using agonists or antagonists might offer new treatment opportunities in different human iron-dependent disorders...
  25. ncbi request reprint Iron chelation beyond transfusion iron overload
    Antonello Pietrangelo
    Center for Hemochromatosis, University Hospital of Modena and Reggio Emilia, Modena, Italy
    Am J Hematol 82:1142-6. 2007
    ..This article discusses the potential use of iron chelation therapy to treat iron overload from causes other than transfusion overload...
  26. ncbi request reprint Iron-induced oxidant stress in alcoholic liver fibrogenesis
    Antonello Pietrangelo
    Centre for the Study of Iron Disorders, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Alcohol 30:121-9. 2003
    ..A challenge for future research is to develop therapeutic tools able to block "redox-active" free iron in the cell...
  27. ncbi request reprint Hemochromatosis gene modifies course of hepatitis C viral infection
    Antonello Pietrangelo
    Department of Internal Medicine, Centre for Hemochromatosis and Metabolic Liver Diseases, University of Modena and Reggio Emilia, Modeno, Italy
    Gastroenterology 124:1509-23. 2003
  28. ncbi request reprint Physiology of iron transport and the hemochromatosis gene
    Antonello Pietrangelo
    Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Am J Physiol Gastrointest Liver Physiol 282:G403-14. 2002
    ..This review focuses on recent advances in iron research and presents a model of HFE function in iron metabolism...
  29. ncbi request reprint The ferroportin disease
    Antonello Pietrangelo
    Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena 41100, Italy
    Blood Cells Mol Dis 32:131-8. 2004
    ..Now, the disorder appears to be the most common cause of hereditary iron overload beyond HFE hemochromatosis...
  30. ncbi request reprint Mechanism of iron toxicity
    Antonello Pietrangelo
    Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Adv Exp Med Biol 509:19-43. 2002
  31. ncbi request reprint Non-invasive assessment of hepatic iron overload: are we finally there?
    Antonello Pietrangelo
    Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    J Hepatol 42:153-4. 2005
  32. ncbi request reprint The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression
    Athina Lymboussaki
    Center for Hemochromatosis and Metabolic Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    J Hepatol 39:710-5. 2003
    ..However, the way this gene is regulated by iron is still unclear. The aim of this study was to investigate the functional role of genomic SLC40A1 elements in response to iron...
  33. ncbi request reprint Hereditary hemochromatosis
    Antonello Pietrangelo
    Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
    Biochim Biophys Acta 1763:700-10. 2006
    ..In vitro and in vivo studies will be needed to dissect the consequences of each hereditary hemochromatosis allele and increase our understanding of the precise contribution of each gene to the hereditary hemochromatosis phenotype...