Research Topics
Genomes and Genes | Antonello PietrangeloSummaryAffiliation: University of Modena and Reggio Emilia Country: Italy Publications
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Publications
Hereditary hemochromatosis: pathogenesis, diagnosis, and treatmentAntonello Pietrangelo
2nd Division of Internal Medicine and Centre for Hemochromatosis, University Hospital of Modena, Modena, Italy
Gastroenterology 139:393-408, 408.e1-2. 2010..The role of hepcidin in the pathogenesis of hemochromatosis reveals its similarities to endocrine diseases such as diabetes and indicates new approaches to diagnosis and management of this common disorder in iron metabolism...- The porphyrias: pathophysiologyAntonello Pietrangelo
Division of Internal Medicine, Center for Hereditary Liver Diseases, Mario Coppo Liver Research Center, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy
Intern Emerg Med 5:S65-71. 2010..While genetics has a role in confirming clinical suspicion and in family screening, biochemical and clinical studies are still central in the diagnosis... - Non-HFE hepatic iron overloadAntonello Pietrangelo
Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
Semin Liver Dis 31:302-18. 2011..e., chronic viral or metabolic liver diseases), regional or local iron accumulation may occur that aggravates the clinical course of the underlying disease or limits efficacy of therapy... - Inherited metabolic disease of the liverAntonello Pietrangelo
Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
Curr Opin Gastroenterol 25:209-14. 2009..This advancement paves the way for development of new strategies to diagnose and cure metabolic liver diseases... - Hepcidin in human iron disorders: therapeutic implicationsAntonello Pietrangelo
Centre for Hemochromatosis, Center for Advanced Research in Hepatology Mario Coppo, University Hospital of Modena, Modena, Via del Pozzo 71, 41100 Modena, Italy
J Hepatol 54:173-81. 2011.... - Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantationCinzia Garuti
Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
Gastroenterology 139:315-22.e1. 2010..However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regulatory hormone hepcidin-in pathogenesis in mice... 
Altered hepatic BMP signaling pathway in human HFE hemochromatosisGiuliano Bolondi
Center for Hemochromatosis, University Hospital of Modena, Modena, Italy
Blood Cells Mol Dis 45:308-12. 2010..These data indicate that in human HFE-HC a disrupted BMP/SMAD signaling in the liver is key in the pathogenesis of the disease...
Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overloadGiuliana Montosi
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
Hepatology 41:545-52. 2005..However, both Kupffer cells and human macrophages are dispensable for the regulatory activity exerted by iron on hepatic hepcidin...- Lack of enterocyte iron accumulation in the ferroportin diseaseElena Corradini
Center for Hemochromatosis, Department of Internal Medicine, University of Modena Policlinico Via del Pozzo 71 41100 Modena, Italy
Blood Cells Mol Dis 35:315-8. 2005..Not surprisingly, in the liver, iron excess was found mainly in Kupffer cells. These results indicate that FPN haploinsufficiency is not limiting for iron export from enterocytes... - ER stress controls iron metabolism through induction of hepcidinChiara Vecchi
Center for Hemochromatosis, Department of Internal Medicine, University Hospital Policlinico di Modena, Modena, Italy
Science 325:877-80. 2009..The regulation of hepcidin by ER stress links the intracellular response involved in protein quality control to innate immunity and iron homeostasis... - Hereditary hemochromatosis--a new look at an old diseaseAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia Policlinico, Modena, Italy
N Engl J Med 350:2383-97. 2004 - Non-HFE hemochromatosisAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
Semin Liver Dis 25:450-60. 2005.... - Iron and steatohepatitisElena Corradini
Division of Internal Medicine 2 and Center for Hemochromatosis, Mario Coppo Liver Research Center, University Hospital of Modena, Modena, Italy
J Gastroenterol Hepatol 27:42-6. 2012..The present study reviews the pathogenic mechanisms of iron accumulation in steatohepatitis during alcoholic and non-alcoholic liver disease and the role of excess iron in chronic disease progression... - Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genesAntonello Pietrangelo
Department of Internal Medicine, University of Modena and Regio Emilia, Policlinico, Modena, Italy
Gastroenterology 128:470-9. 2005..A milder adult-onset form is due to pathogenic mutations of HFE or, rarely, serum transferrin receptor 2... - Magnetic resonance imaging to identify classic and nonclassic forms of ferroportin diseaseAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University Hospital of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71 41100 Modena, Italy
Blood Cells Mol Dis 37:192-6. 2006..In conclusion, MRI is a useful non-invasive diagnostic tool to categorize and diagnose the disorder, monitor the status of iron depletion and gain insights on its natural history and management... - Serum ferritin as a predictor of treatment outcome in patients with chronic hepatitis CFrancesca Ferrara
Department of Internal Medicine, Center for Hemochromatosis, University Hospital of Modena, Italy
Am J Gastroenterol 104:605-16. 2009..Antiviral treatment in chronic hepatitis C (CHC) involves ribavirin, a hemolytic agent. We planned a prospective study to evaluate whether drug-induced iron perturbation is clinically relevant as it relates to therapeutic outcome... - Hemochromatosis: an endocrine liver diseaseAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Modena, Italy
Hepatology 46:1291-301. 2007..The recognition of the endocrine nature of hemochromatosis suggests intriguing possibilities for new and more effective approaches to diagnosis and treatment... - STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivoAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico Via del Pozzo 71, 41100 Modena, Italy
Gastroenterology 132:294-300. 2007..To clarify the molecular pathways involved in hepcidin activation by IL-6, we used different mice strains in which the main IL-6/gp130 signaling pathways have been genetically disrupted... - Huh-7: a human "hemochromatotic" cell lineChiara Vecchi
Department of Internal Medicine, University Hospital of Modena, Center for Hemochromatosis, Policlinico, Modena, Italy
Hepatology 51:654-9. 2010..CONCLUSION: Huh-7 cells may represent a novel and valuable tool to investigate the role of altered HFE traffic in iron metabolism and pathogenesis of human HFE HC... - Genetics in liver diseasesAntonello Pietrangelo
Center for Hemochromatosis, University Hospital of Modena, Via del Pozza 71, 41100 Modena, Italy
J Hepatol 46:1143-8. 2007..This article reports the highlights of the conference and summarizes the main conclusions and implications for clinical and experimental hepatology... - Non-HFE hemochromatosisAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
Hepatology 39:21-9. 2004 - Hereditary hemochromatosisAntonello Pietrangelo
Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, 41100 Modena, Italy
Annu Rev Nutr 26:251-70. 2006..Hepcidin, the iron hormone, seems to hold a central pathogenic place in hemochromatosis, similar to insulin in diabetes: Genetically determined lack of hepcidin synthesis or activity may cause the disease... - Ferroportin is a monomer in vivo in miceElisa Pignatti
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Blood Cells Mol Dis 36:26-32. 2006..The latter finding may have important implications for understanding the pathogenesis of the disease due to ferroportin mutations... - Mechanisms of disease: The role of hepcidin in iron homeostasis--implications for hemochromatosis and other disordersAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Disease, University Hospital of Modena, Italy
Nat Clin Pract Gastroenterol Hepatol 1:39-45. 2004..Given its role as the iron-regulatory hormone, the modulation of hepcidin activity using agonists or antagonists might offer new treatment opportunities in different human iron-dependent disorders... - Iron chelation beyond transfusion iron overloadAntonello Pietrangelo
Center for Hemochromatosis, University Hospital of Modena and Reggio Emilia, Modena, Italy
Am J Hematol 82:1142-6. 2007..This article discusses the potential use of iron chelation therapy to treat iron overload from causes other than transfusion overload... - Iron-induced oxidant stress in alcoholic liver fibrogenesisAntonello Pietrangelo
Centre for the Study of Iron Disorders, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
Alcohol 30:121-9. 2003..A challenge for future research is to develop therapeutic tools able to block "redox-active" free iron in the cell... - Hemochromatosis gene modifies course of hepatitis C viral infectionAntonello Pietrangelo
Department of Internal Medicine, Centre for Hemochromatosis and Metabolic Liver Diseases, University of Modena and Reggio Emilia, Modeno, Italy
Gastroenterology 124:1509-23. 2003 - Physiology of iron transport and the hemochromatosis geneAntonello Pietrangelo
Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Am J Physiol Gastrointest Liver Physiol 282:G403-14. 2002..This review focuses on recent advances in iron research and presents a model of HFE function in iron metabolism... - The ferroportin diseaseAntonello Pietrangelo
Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena 41100, Italy
Blood Cells Mol Dis 32:131-8. 2004..Now, the disorder appears to be the most common cause of hereditary iron overload beyond HFE hemochromatosis... - Mechanism of iron toxicityAntonello Pietrangelo
Unit for the Study of Iron Metabolism, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Adv Exp Med Biol 509:19-43. 2002 - Non-invasive assessment of hepatic iron overload: are we finally there?Antonello Pietrangelo
Department of Internal Medicine, Center for Hemochromatosis, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
J Hepatol 42:153-4. 2005 - The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expressionAthina Lymboussaki
Center for Hemochromatosis and Metabolic Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
J Hepatol 39:710-5. 2003..However, the way this gene is regulated by iron is still unclear. The aim of this study was to investigate the functional role of genomic SLC40A1 elements in response to iron... - Hereditary hemochromatosisAntonello Pietrangelo
Center for Hemochromatosis and Hereditary Liver Diseases, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, Italy
Biochim Biophys Acta 1763:700-10. 2006..In vitro and in vivo studies will be needed to dissect the consequences of each hereditary hemochromatosis allele and increase our understanding of the precise contribution of each gene to the hereditary hemochromatosis phenotype...