G Piccirillo

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
    Gianfranco Piccirillo
    Department of Cardiovascular, Respiratory, Nephrological and Geriatric Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
    Clin Interv Aging 8:293-300. 2013
  2. doi request reprint Indexes of temporal myocardial repolarization dispersion and sudden cardiac death in heart failure: any difference?
    Gianfranco Piccirillo
    Department of Cardiovascular, Respiratory, Nephrologic, and Geriatric Sciences, Sapienza University of Rome, 00185 Rome, Italy
    Ann Noninvasive Electrocardiol 18:130-9. 2013
  3. doi request reprint Autonomic nerve activity and the short-term variability of the Tpeak-Tend interval in dogs with pacing-induced heart failure
    Gianfranco Piccirillo
    Dipartimento di Scienze Cardiovascolari, respiratorie, Anestesiologiche, Nefrologiche e Geriatriche, Policlinico Umberto I, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Heart Rhythm 9:2044-50. 2012
  4. ncbi request reprint Factors influencing heart rate variability power spectral analysis during controlled breathing in patients with chronic heart failure or hypertension and in healthy normotensive subjects
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Clin Sci (Lond) 107:183-90. 2004
  5. ncbi request reprint Autonomic cardiovascular control and diastolic dysfunction in hypertensive subjects
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Int J Cardiol 110:160-6. 2006
  6. ncbi request reprint Power spectral analysis of heart rate variability as a predictive test in choosing the most effective length for tilt-training
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, 00161 Rome, Italy
    Int J Cardiol 111:59-66. 2006
  7. ncbi request reprint Influence of cardiac-resynchronization therapy on heart rate and blood pressure variability: 1-year follow-up
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, Universita La Sapienza, 00161 Rome, Italy
    Eur J Heart Fail 8:716-22. 2006
  8. ncbi request reprint Age and QT variability index during free breathing, controlled breathing and tilt in patients with chronic heart failure and healthy control subjects
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Transl Res 148:72-8. 2006
  9. ncbi request reprint QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular systolic dysfunction: a prospective study
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, Universita La Sapienza, Viale del Policlinico, 00161 Rome, Italy
    Eur Heart J 28:1344-50. 2007
  10. doi request reprint Increased QT variability in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    G Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Eur J Neurol 15:1216-21. 2008

Detail Information

Publications34

  1. pmc Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization
    Gianfranco Piccirillo
    Department of Cardiovascular, Respiratory, Nephrological and Geriatric Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
    Clin Interv Aging 8:293-300. 2013
    ..We studied age-dependent influence on short-term temporal dispersion of these two variables in patients with postischemic CHF...
  2. doi request reprint Indexes of temporal myocardial repolarization dispersion and sudden cardiac death in heart failure: any difference?
    Gianfranco Piccirillo
    Department of Cardiovascular, Respiratory, Nephrologic, and Geriatric Sciences, Sapienza University of Rome, 00185 Rome, Italy
    Ann Noninvasive Electrocardiol 18:130-9. 2013
    ..We therefore investigated differences between these indexes in patients with CHF who died suddenly and in those who survived with a left ventricular ejection fraction (LVEF) ≤35% or >35%...
  3. doi request reprint Autonomic nerve activity and the short-term variability of the Tpeak-Tend interval in dogs with pacing-induced heart failure
    Gianfranco Piccirillo
    Dipartimento di Scienze Cardiovascolari, respiratorie, Anestesiologiche, Nefrologiche e Geriatriche, Policlinico Umberto I, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Heart Rhythm 9:2044-50. 2012
    ..An increased interval between the peak and the end of the T wave (T(peak)-T(end)) has been reported to increase the incidence of sudden cardiac death. However, the ANS influence on the T(peak)-T(end) interval remains unclear...
  4. ncbi request reprint Factors influencing heart rate variability power spectral analysis during controlled breathing in patients with chronic heart failure or hypertension and in healthy normotensive subjects
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Clin Sci (Lond) 107:183-90. 2004
    ..LFP might therefore increase the sensitivity of factors already used in stratifying the risk of sudden death in patients with CHF...
  5. ncbi request reprint Autonomic cardiovascular control and diastolic dysfunction in hypertensive subjects
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Int J Cardiol 110:160-6. 2006
    ..Early hypertension is associated with left ventricular diastolic dysfunction due to increased end-diastolic pressure. This increase, through the cardiopulmonary reflexes, can influence autonomic cardiovascular control...
  6. ncbi request reprint Power spectral analysis of heart rate variability as a predictive test in choosing the most effective length for tilt-training
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, 00161 Rome, Italy
    Int J Cardiol 111:59-66. 2006
    ..We designed dual retrospective and prospective studies to assess cardiovascular autonomic function in subjects with recurrent syncope and identify the most effective length of tilt training between one and three months...
  7. ncbi request reprint Influence of cardiac-resynchronization therapy on heart rate and blood pressure variability: 1-year follow-up
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, Universita La Sapienza, 00161 Rome, Italy
    Eur J Heart Fail 8:716-22. 2006
    ..In subjects with CHF, power spectral values for the low-frequency (LF) component of RR variability < or =13 ms2, are associated with an increased risk of sudden death...
  8. ncbi request reprint Age and QT variability index during free breathing, controlled breathing and tilt in patients with chronic heart failure and healthy control subjects
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Transl Res 148:72-8. 2006
    ..Further studies should assess the usefulness of the QTVI as a marker predicting sudden cardiac death under the various conditions of risk...
  9. ncbi request reprint QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular systolic dysfunction: a prospective study
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, Universita La Sapienza, Viale del Policlinico, 00161 Rome, Italy
    Eur Heart J 28:1344-50. 2007
    ..We assessed whether the indices of QT variability from a short-term electrocardiographic (ECG) recording predict sudden death...
  10. doi request reprint Increased QT variability in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    G Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Eur J Neurol 15:1216-21. 2008
    ....
  11. pmc Power spectral analysis of heart rate variability and autonomic nervous system activity measured directly in healthy dogs and dogs with tachycardia-induced heart failure
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Heart Rhythm 6:546-52. 2009
    ..In HRV power spectral analysis, the low-frequency (LF) component diminishes in patients with CHF and the decrease is related to an increased risk of sudden death...
  12. pmc Autonomic nervous system activity measured directly and QT interval variability in normal and pacing-induced tachycardia heart failure dogs
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Universita degli Studi di Roma La Sapienza, Rome, Italy
    J Am Coll Cardiol 54:840-50. 2009
    ..This study sought to find out more about the relationship between sympathetic and vagal nerve activity and the cardiac repolarization in a canine model of pacing-induced tachycardia congestive heart failure (CHF)...
  13. ncbi request reprint Influence of L-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic cardiomyopathy
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Am J Cardiol 93:650-4. 2004
    ..We found that healthy subjects have a substantial ability to modulate sympathetic-mediated peripheral vascular resistance through endothelial synthesis of nitric oxide. Patients with chronic heart failure lose this ability...
  14. ncbi request reprint Heart rate and blood pressure variability in subjects with vasovagal syncope
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Policlinico Umberto I, Universita La Sapienza, 00161 Rome, Italy
    Clin Sci (Lond) 107:55-61. 2004
    ..Spectral analysis of RR variability during controlled breathing, a procedure that predicts tilt-test responses, could be a useful guide in choosing the method of tilt testing...
  15. ncbi request reprint Influence of vitamin C on baroreflex sensitivity in chronic heart failure
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, Universita La Sapienza, 00161 Rome, Italy
    Hypertension 41:1240-5. 2003
    ..This finding could have notable clinical and therapeutic implications. Key issues to understand are whether the beneficial effect persists during chronic administration and whether it helps to improve survival...
  16. ncbi request reprint Effects of long-term beta-blocker (metoprolol or carvedilol) therapy on QT variability in subjects with chronic heart failure secondary to ischemic cardiomyopathy
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Istituto del Cuore, Policlinico Umberto I, Universita La Sapienza, 00161 Rome, Italy
    Am J Cardiol 90:1113-7. 2002
    ..05). Although both beta-blocker treatments helped to normalize the QTVI measured in normal subjects at rest, they each differentially altered the index after tilt. Carvedilol seemed to improve the QTVI more than metoprolol...
  17. ncbi request reprint Effects of carvedilol on heart rate and blood pressure variability in subjects with chronic heart failure
    G Piccirillo
    Dipartimento di Scienze dell Invecchiamenti, Universita La Sapienza, Rome, Italy
    Am J Cardiol 86:1392-5, A6. 2000
    ..These findings contribute to improvement in survival in such patients...
  18. ncbi request reprint Influence of age, the autonomic nervous system and anxiety on QT-interval variability
    G Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, 00161 Rome, Italy
    Clin Sci (Lond) 101:429-38. 2001
    ..Because a negative trend in QTVI induced by sympathetic stress increases only in younger subjects, it could represent a protective mechanism that is lost with aging...
  19. ncbi request reprint Influence of aging on cardiac baroreflex sensitivity determined non-invasively by power spectral analysis
    G Piccirillo
    Isituto di Prima Clinica Medica, Universita La Sapienza, Roma, Italy
    Clin Sci (Lond) 100:267-74. 2001
    ..The elderly subjects we selected for this study probably had greater resistance to cardiovascular disease that is manifested clinically, with preserved cardiac baroreceptor sensitivity...
  20. ncbi request reprint Power spectral analysis of heart rate in subjects over a hundred years old
    G Piccirillo
    I Clinica Medica, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Int J Cardiol 63:53-61. 1998
    ..Parasympathetic predominance may be the neuroautonomic feature that helps to protect ultra-centenarians against cardiovascular disease...
  21. ncbi request reprint Autonomic modulation and QT interval dispersion in hypertensive subjects with anxiety
    G Piccirillo
    IClinica Medica, Policlinico Umberto I, Rome, Italy
    Hypertension 34:242-6. 1999
    ..This condition could favor an increase in left ventricular mass. Myocardial hypertrophy alone or combined with neuroautonomic imbalance may lead to QT dispersion...
  22. ncbi request reprint Influence of aging and other cardiovascular risk factors on baroreflex sensitivity
    G Piccirillo
    Istituto di Prima Clinica Medica, , Rome, Italy
    J Am Geriatr Soc 49:1059-65. 2001
    ..001), and LDL cholesterol (P <.01), but of BSphe only with age (P <.001) and heart rate (P <.01). CONCLUSION: These findings indicate that some risk factors for coronary heart disease adversely influence baroreflex sensitivity...
  23. ncbi request reprint QT-interval variability and autonomic control in hypertensive subjects with left ventricular hypertrophy
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, 00161 Rome, Italy
    Clin Sci (Lond) 102:363-71. 2002
    ..As already noted in patients with HCM, the increased QTVI could be a factor responsible for triggering malignant ventricular arrhythmias in subjects with hypertension...
  24. ncbi request reprint Effects of sildenafil citrate (viagra) on cardiac repolarization and on autonomic control in subjects with chronic heart failure
    Gianfranco Piccirillo
    Dipartimento di Scienze, dell Invecchiamento, I Clinica Medica, Policlinico Umberto I, Rome, Italy
    Am Heart J 143:703-10. 2002
    ..Changes in these variables could predispose patients to malignant ventricular arrhythmias...
  25. doi request reprint Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects
    Gianfranco Piccirillo
    Dipartimento di Scienze dell Invecchiamento, Dipartimento di Scienze Cardiovascolari, Respiratorie e Morfologiche, Policlinico Umberto I, Universita degli Studi di Roma La Sapienza, Roma, Italy
    Transl Res 151:267-72. 2008
    ..The potential proarrhythmic actions of pink grapefruit juice might be of concern in patients with major myocardial structural disorders...
  26. ncbi request reprint The Marigliano-Cacciafesta polypathology scale (MCPS): a tool for predicting the risk of developing disability
    A Amici
    Department of Aging Science, Policlinico Umberto I, University La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    Arch Gerontol Geriatr 47:201-6. 2008
    ..Both Groups 1 and 2 of cases over time developed greater disabilities, compared to the control Group 3; in particular, the subjects with "moderate-severe" polypathology were more disabled after 12 months...
  27. ncbi request reprint Effects of phlebotomy on a patient with secondary polycythemia and angina pectoris
    G Piccirillo
    Cattedra di Geriatria e Gerontologia Università, La Sapienza, Rome, Italy
    Int J Cardiol 44:175-7. 1994
    ..Although phlebotomy reduces arterial oxygen content, it also decreases blood viscosity, improves peripheral oxygen consumption and thus yields the clinical benefit...
  28. doi request reprint Primary prevention implantation of cardioverter defibrillator without defibrillation threshold testing: 2-year follow-up
    Stefano Bianchi
    Unità di Aritmologia ed Elettrofisiologia Cardiaca, Ospedale Fatebenefratelli, Rome, Italy
    Pacing Clin Electrophysiol 32:573-8. 2009
    ..We compared the outcome of ICD recipients who underwent defibrillation threshold testing (DFT) with that of patients in whom no testing was performed...
  29. ncbi request reprint Circadian blood pressure pattern and cognitive function in newly diagnosed older hypertensives
    P Cicconetti
    Department of Geriatrics, 1st Institute of Medicine, La Sapienza University, Rome, Italy
    Blood Press 12:168-74. 2003
    ....
  30. ncbi request reprint The association between metabolic syndrome and restrictive ventilatory dysfunction in older persons
    Filippo Luca Fimognari
    Division of Internal Medicine, Leopoldo Parodi Delfino Hospital, and University Campus Biomedico of Rome, Via dei Compositori 130, 00128, Rome, Italy
    J Gerontol A Biol Sci Med Sci 62:760-5. 2007
    ....
  31. ncbi request reprint Is it possible to predict one-year survival in centenarians? A neural network study
    Laura Tafaro
    Department of Aging Science, University La Sapienza, Rome, Italy
    Gerontology 51:199-205. 2005
    ..Human life expectancy is constantly increasing: the challenge for modern geriatric medicine is to identify the means to reach successfully extreme longevity...
  32. ncbi request reprint Event-related brain potentials in elderly dippers and nondippers with recently diagnosed hypertension
    Paolo Cicconetti
    Department of Geriatrics, La Sapienza University, Rome, Italy
    Hypertens Res 27:581-8. 2004
    ..47 in the Cz position, p =0.617; 251.56+/-25.86 vs. 246.58+/-25.46 in the Pz position, p =0.608). These data show no association between the nondipping pattern and lower cognitive function in elderly subjects with recent hypertension...
  33. ncbi request reprint Increased QT variability in young asymptomatic patients with beta-thalassemia major
    Damiano Magrì
    Dipartimento di Scienze Cardiovascolari, Respiratorie e Morfologiche, Policlinico Umberto I, Universita La Sapienza, Rome, Italy
    Eur J Haematol 79:322-9. 2007
    ..In this study we assessed whether the major indices of QT variability, emerging tools for risk stratification of sudden cardiac death, differ in young asymptomatic patients with TM and healthy persons...
  34. ncbi request reprint Emotions that afflict the heart: influence of the autonomic nervous system on temporal dispersion of myocardial repolarization
    Gianfranco Piccirillo
    J Cardiovasc Electrophysiol 19:185-7. 2008