Andrea Pession

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Real-time RT-PCR of tyrosine hydroxylase to detect bone marrow involvement in advanced neuroblastoma
    Andrea Pession
    Unità di Terapia Cellulare, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Policlinico S Orsola Malpighi, Bologna, Italy
    Oncol Rep 10:357-62. 2003
  2. ncbi The MYCN oncogene as a specific and selective drug target for peripheral and central nervous system tumors
    Andrea Pession
    Department of Pediatrics, University of Bologna, S Orsola Hospital, Bologna, Italy
    Curr Cancer Drug Targets 5:273-83. 2005
  3. ncbi Non-radiolabelled PCR consensus primers and automatic sequencing enable rapid identification of tumor-specific V(H) CDR3 in aggressive B-cell malignancies
    Andrea Pession
    Department of Pediatrics, University of Bologna, Ospedale S Orsola, Via Massarenti 11, 40100 Bologna, Italy
    Leuk Lymphoma 44:1597-601. 2003
  4. ncbi MLL-AF9 oncogene expression affects cell growth but not terminal differentiation and is downregulated during monocyte-macrophage maturation in AML-M5 THP-1 cells
    Andrea Pession
    Department of Paediatrics, University of Bologna, Policlinico S Orsola Malpighi, 40138 Bologna, Italy
    Oncogene 22:8671-6. 2003
  5. ncbi Treatment and prevention of tumor lysis syndrome in children. Experience of Associazione Italiana Ematologia Oncologia Pediatrica
    Andrea Pession
    Oncoematologia Pediatrica, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Universita di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    Contrib Nephrol 147:80-92. 2005
  6. ncbi Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis
    Roberto Tonelli
    Unità di Terapia Cellulare, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Policlinico Sant Orsola Malpighi, Via Massarenti 11, 40138 Bologna, Italy
    Mol Cancer Ther 4:779-86. 2005
  7. ncbi Hematopoietic stem cell transplantation in childhood: report from the bone marrow transplantation group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    A Pession
    Department of Pediatrics, University of Bologna, Ospedle Sant Orsola, Bologna, Italy
    Haematologica 85:638-46. 2000
  8. ncbi Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis
    Andrea Pession
    Department of Pediatrics, University of Bologna, S Orsola Hospital, I 40138 Bologna, Italy
    Int J Oncol 24:265-72. 2004
  9. ncbi Role of a hematopoietic stem cell transplant registry in childhood: the experience of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    Andrea Pession
    Department of Pediatrics, University of Bologna, Ospedale Sant'Orsola, Bologna, Italy
    Haematologica 87:42-6. 2002
  10. ncbi Allogeneic stem cell transplantation for children with acute myeloid leukemia in second complete remission
    Franca Fagioli
    Oncoematologia Pediatrica, Ospedale Infantile Regina Margherita, Torino, Italy
    J Pediatr Hematol Oncol 30:575-83. 2008

Detail Information

Publications109 found, 100 shown here

  1. ncbi Real-time RT-PCR of tyrosine hydroxylase to detect bone marrow involvement in advanced neuroblastoma
    Andrea Pession
    Unità di Terapia Cellulare, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Policlinico S Orsola Malpighi, Bologna, Italy
    Oncol Rep 10:357-62. 2003
    ..Real-time TH RT-PCR could therefore be of clinical value for the assessment of a patient's prognosis by monitoring minimal residual disease (MRD)...
  2. ncbi The MYCN oncogene as a specific and selective drug target for peripheral and central nervous system tumors
    Andrea Pession
    Department of Pediatrics, University of Bologna, S Orsola Hospital, Bologna, Italy
    Curr Cancer Drug Targets 5:273-83. 2005
    ..Encouraging results have been reported utilizing a PNA-based antisense strategy for inhibition of N-Myc expression in neuroblastoma...
  3. ncbi Non-radiolabelled PCR consensus primers and automatic sequencing enable rapid identification of tumor-specific V(H) CDR3 in aggressive B-cell malignancies
    Andrea Pession
    Department of Pediatrics, University of Bologna, Ospedale S Orsola, Via Massarenti 11, 40100 Bologna, Italy
    Leuk Lymphoma 44:1597-601. 2003
    ..The procedure showed rapidity, reliability and reproducibility. The characteristics of the methodology applied widen the possibility of developing anti-idiotypic therapeutic strategies, even in these B-cell malignancies...
  4. ncbi MLL-AF9 oncogene expression affects cell growth but not terminal differentiation and is downregulated during monocyte-macrophage maturation in AML-M5 THP-1 cells
    Andrea Pession
    Department of Paediatrics, University of Bologna, Policlinico S Orsola Malpighi, 40138 Bologna, Italy
    Oncogene 22:8671-6. 2003
    ....
  5. ncbi Treatment and prevention of tumor lysis syndrome in children. Experience of Associazione Italiana Ematologia Oncologia Pediatrica
    Andrea Pession
    Oncoematologia Pediatrica, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Universita di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    Contrib Nephrol 147:80-92. 2005
    ..We investigated the safety and efficacy of rasburicase in the AIEOP centers' experience...
  6. ncbi Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis
    Roberto Tonelli
    Unità di Terapia Cellulare, Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Policlinico Sant Orsola Malpighi, Via Massarenti 11, 40138 Bologna, Italy
    Mol Cancer Ther 4:779-86. 2005
    ..These findings could encourage research into development of an anti-gene PNA-based tumor-specific agent for neuroblastoma (and other neoplasms) with MYCN expression...
  7. ncbi Hematopoietic stem cell transplantation in childhood: report from the bone marrow transplantation group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    A Pession
    Department of Pediatrics, University of Bologna, Ospedle Sant Orsola, Bologna, Italy
    Haematologica 85:638-46. 2000
    ..Transplant procedures and indications have changed considerably during recent years. Monitoring of information about these changes is useful for interpretation of nationwide collected data...
  8. ncbi Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis
    Andrea Pession
    Department of Pediatrics, University of Bologna, S Orsola Hospital, I 40138 Bologna, Italy
    Int J Oncol 24:265-72. 2004
    ..Selectivity of the PNA was demonstrated by altering three point mutations. These findings should encourage development of a PNA-based tumor-specific agent for neuroblastoma (or other neoplasms) with N-myc overexpression...
  9. ncbi Role of a hematopoietic stem cell transplant registry in childhood: the experience of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    Andrea Pession
    Department of Pediatrics, University of Bologna, Ospedale Sant'Orsola, Bologna, Italy
    Haematologica 87:42-6. 2002
  10. ncbi Allogeneic stem cell transplantation for children with acute myeloid leukemia in second complete remission
    Franca Fagioli
    Oncoematologia Pediatrica, Ospedale Infantile Regina Margherita, Torino, Italy
    J Pediatr Hematol Oncol 30:575-83. 2008
    ..Both leukemia recurrence and TRM contributed to treatment failure. Optimization of donor selection and of strategies for both prophylaxis and treatment of graft-versus-host disease may improve the results of unrelated donor allo-HSCT...
  11. ncbi Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia
    Francesca Chiarini
    Department of Human Anatomy, University of Bologna, Bologna, Italy
    Cancer Res 70:8097-107. 2010
    ....
  12. ncbi Generation and characterization of bioluminescent xenograft mouse models of MLL-related acute leukemias and in vivo evaluation of luciferase-targeting siRNA nanoparticles
    Raffaella Fazzina
    Department of Pediatric Oncology and Hematology, Sant Orsola Hospital, University of Bologna, Bologna, Italy
    Int J Oncol 41:621-8. 2012
    ....
  13. ncbi Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)
    Vincenzo Martino
    Department of Paediatrics, University of Bologna, Policlinico S Orsola Malpighi, Italy
    Oncol Rep 15:207-11. 2006
    ..RT-PCR analysis indicated that down-regulation of MLL-AF9, MLL or MYC is not necessary to abolish malignant phenotypes by induction of terminal monocyte-macrophage differentiation in leukaemic cells carrying t(9;11)(p22;q23)...
  14. ncbi Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: eliminating activity by targeting at different levels
    Daniela Bressanin
    Department of Human Anatomy, University of Bologna, Bologna, Italy
    Oncotarget 3:811-23. 2012
    ..This observation indicates that vertical inhibition at different levels of the PI3K/Akt/mTOR network could be considered as a future innovative strategy for treating T-ALL patients...
  15. ncbi Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial
    Franco Locatelli
    Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    Blood 105:410-9. 2005
    ..Disease recurrence remains the major cause of treatment failure. Outcome of UD-HSCT recipients is comparable to that of children receiving transplants from an HLA-identical sibling...
  16. ncbi Factors influencing outcome and incidence of long-term complications in children who underwent autologous stem cell transplantation for acute myeloid leukemia in first complete remission
    Franco Locatelli
    Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Universita di Pavia, Italy
    Blood 101:1611-9. 2003
    ..The results obtained in this analysis can be of help in designing prospective studies of autologous HSCT in children with AML in first CR...
  17. ncbi Antitumor activity of sustained N-myc reduction in rhabdomyosarcomas and transcriptional block by antigene therapy
    Roberto Tonelli
    Department of Pediatric Hematology, University of Bologna, Bologna, Italy
    Clin Cancer Res 18:796-807. 2012
    ..Our aim was to determine the prevalence of N-Myc protein expression and the potential therapeutic effects of reducing expression in rhabdomyosarcomas, including use of an antigene strategy that inhibits transcription...
  18. ncbi The outcome of children with Fanconi anemia given hematopoietic stem cell transplantation and the influence of fludarabine in the conditioning regimen: a report from the Italian pediatric group
    Franco Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Pavia, Italy
    Haematologica 92:1381-8. 2007
    ..While in the past HSCT from an HLA-identical sibling was proven to cure many patients, a higher incidence of treatment failure has been reported in recipients of an unrelated donor (UD) or HLA-partially matched related allograft...
  19. ncbi Long-term results of a randomized trial on extended use of high dose L-asparaginase for standard risk childhood acute lymphoblastic leukemia
    Andrea Pession
    Associazione Italiana di Ematologia Oncologia Pediatrica AIEOP, University of Bologna, Bologna, Italy
    J Clin Oncol 23:7161-7. 2005
    ....
  20. ncbi Chronic graft-versus-host disease in children: incidence, risk factors, and impact on outcome
    Marco Zecca
    Oncoematologia Pediatrica, Universita di Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Blood 100:1192-200. 2002
    ..Use of CB stem cells and preparative regimens without radiotherapy may prevent its development. In patients affected by ALL, cGVHD was associated with a strong graft-versus-leukemia effect, improving DFS...
  21. ncbi Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia
    Franco Locatelli
    Oncoematologia Pediatrica, Fondazione IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Br J Haematol 147:371-8. 2009
    ..01). These data suggest that the clofarabine/cyclophosphamide/etoposide regimen is well tolerated and can induce clinical response in a relevant proportion of children with refractory/multiple relapsed ALL...
  22. ncbi Risk evaluation, prophylaxis, and treatment of tumor lysis syndrome: consensus of an Italian expert panel
    Andrea Pession
    Pediatric Oncology and Hematology Lalla Seràgnoli, Ospedale Sant Orsola Malpighi, Policlinico S Orsola Malpighi, Azienda Ospedaliera Universitaria di Bologna, Pediatric Unit, University of Bologna, Italy
    Adv Ther 28:684-97. 2011
    ..Identification of risk groups as well as early detection of TLS is crucial for the establishment of appropriate strategies of prophylaxis and treatment...
  23. ncbi Differential gene expression in classic giant cell tumours of bone: Tenascin C as biological risk factor for local relapses and metastases
    Laura Pazzaglia
    Laboratory of Experimental Oncology, Istituto Ortopedico Rizzoli, University of Bologna, Bologna, Italy
    Histopathology 57:59-72. 2010
    ..GCT specimens with different behaviour associated with an increased risk of local and/or distant relapses were studied...
  24. ncbi p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells
    Paola Rocchi
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Oncol Rep 13:1139-44. 2005
    ..Moreover, p21(Cip1) could be applied in the molecular monitoring of drug action in the possible therapeutic application of these short-chain fatty acid members of HDAC inhibitors for human NB treatment...
  25. ncbi Retinoids in pediatric onco-hematology: the model of acute promyelocytic leukemia and neuroblastoma
    Riccardo Masetti
    Paediatric Oncology and Haematology Unit Lalla Seràgnoli, University of Bologna, Sant Orsola Malpighi Hospital, Via Massarenti 11, 40137, Bologna, Italy
    Adv Ther 29:747-62. 2012
    ....
  26. ncbi Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a
    Francesca Buontempo
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, Italy
    Cell Cycle 11:2467-75. 2012
    ..For these features, BMS-345541 could be used alone or in combination with traditional therapies in the treatment of T-ALL...
  27. ncbi Foreign children with cancer in Italy
    Roberto Rondelli
    Paediatric Oncology Haematology Lalla Seràgnoli, Policlinico S Orsola Malpighi, Bologna, Italy
    Ital J Pediatr 37:44. 2011
    ..1.01 Registry since 1989...
  28. ncbi TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-zeta-dependent cell cycle arrest
    Camilla Evangelisti
    Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell Apparato Locomotore, Cell Signalling Laboratory, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Cell Signal 21:801-9. 2009
    ..In summary, these data identify TIS21/BTG2/PC3 and cyclin D1 as downstream effectors of nuclear DGK-zeta and highlight the importance of this DGK isoform in the regulation of myoblast proliferation and differentiation...
  29. ncbi Validation by RQ-PCR and flow cytometry of alpha-defensin1-3 (DEFA1-3) overexpression in relapsed and refractory acute lymphoblastic leukemia
    Geertruy Te Kronnie
    Department of Pediatrics, University of Padova, Via Giustiniani 3, I 35128 Padova, Italy
    Oncol Rep 15:341-6. 2006
    ..Results suggest that high levels of DEFA1-3 mRNA and alpha-defensin1-3 protein expression are correlated with disease progression and failure of adequate response to conventional chemotherapy...
  30. ncbi Phytosterol supplementation reduces metabolic activity and slows cell growth in cultured rat cardiomyocytes
    Francesca Danesi
    Department of Food Sciences, Campus di Scienze degli Alimenti, Universita di Bologna, Cesena, Italy
    Br J Nutr 106:540-8. 2011
    ....
  31. ncbi All-trans retinoic acid in the treatment of pediatric acute promyelocytic leukemia
    Riccardo Masetti
    Paediatric Oncology and Haematology Unit Lalla Seràgnoli, University of Bologna Sant Orsola Malpighi Hospital, Bologna, Italy
    Expert Rev Anticancer Ther 12:1191-204. 2012
    ..Here we provide an overview of the role of ATRA in the treatment of pediatric APL, summarizing the most relevant clinical results of recent decades and investigating future therapeutic perspectives for children with APL...
  32. ncbi FLAG-liposomal doxorubicin (Myocet) regimen for refractory or relapsed acute leukemia pediatric patients
    Paola Quarello
    Regina Margherita Children s Hospital, Turin, Italy
    J Pediatr Hematol Oncol 34:208-16. 2012
    ..The promising results shown in our study need to be confirmed by larger and possibly randomized trials...
  33. ncbi Emerging targeted therapies for pediatric acute myeloid leukemia
    Riccardo Masetti
    Paediatric Oncology and Haematology Unit Lalla Seràgnoli, University of Bologna Sant Orsola Malpighi Hospital, 40138 Bologna, Italy
    Recent Pat Anticancer Drug Discov 6:354-66. 2011
    ..For these recently patented agents, we also provide a detailed analysis of the published preclinical data and the clinical trials that have been completed...
  34. ncbi Organizing pneumonia primed by high-dose chemotherapy and lung irradiation: two pediatric cases
    Riccardo Masetti
    Paediatric Oncology and Haematology Unit Lalla Seràgnoli, Sant Orsola Malpighi Hospital, Bologna, Italy
    J Pediatr Hematol Oncol 33:e202-4. 2011
    ..This report provides a useful description for the evaluation and treatment of pediatric patients with pulmonary infiltrates after chemotherapy and radiotherapy...
  35. ncbi Focal nodular hyperplasia of the liver after intensive treatment for pediatric cancer: is hematopoietic stem cell transplantation a risk factor?
    Riccardo Masetti
    Paediatric Oncology and Haematology Unit Lalla Seràgnoli, University of Bologna Sant Orsola Malpighi Hospital, Bologna, Italy
    Eur J Pediatr 170:807-12. 2011
    ..The aim of this report is to provide useful diagnostic tools to facilitate accurate diagnosis of FNH and suggest a correct management of this benign lesion during postcancer follow-up...
  36. ncbi Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Paediatric Haematology and Oncology (AIEOP)
    Andrea Pession
    Paediatric Oncology and Haematology Unit Lalla Seràgnoli, University of Bologna, Bologna, Italy
    Eur J Cancer 44:1282-9. 2008
    ....
  37. ncbi Clinical effectiveness of early treatment with hyperbaric oxygen therapy for severe late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation in pediatric patients
    Daniele Zama
    Pediatric Oncology and Hematology Unit Lalla Seràgnoli, Departement of Pediatrics, University of Bologna Sant Orsola Malpighi Hospital, Bologna, Italy
    Pediatr Transplant 17:86-91. 2013
    ..HOT is a well-tolerated procedure also in the pediatric setting. The early start of HOT might be effective in the treatment of HC offering advantages in terms of duration of symptoms and hospitalization...
  38. ncbi Hematopoietic stem cell transplantation for curing children with severe autoimmune diseases: is this a valid option?
    Andrea Pession
    Paediatric Oncology and Haematology Unit Lalla Seràgnoli, Department of Paediatrics, University of Bologna Sant Orsola Malpighi Hospital, Bologna, Italy
    Pediatr Transplant 16:413-25. 2012
    ..The aim of this review is to summarize the published studies and to try to answer the question as to whether this procedure can be considered a promising approach...
  39. ncbi Feasibility of carbidopa premedication in pediatric patients: a pilot study
    Egesta Lopci
    Department of Nuclear Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Cancer Biother Radiopharm 27:729-33. 2012
    ..To verify the potential role and feasibility of carbidopa premedication in pediatric patients undergoing ¹⁸F-DOPA (Fluorine-18 fluorodihydroxyphenylalanine) PET scanning...
  40. ncbi Status epilepticus as a main manifestation of posterior reversible encephalopathy syndrome after pediatric hematopoietic stem cell transplantation
    Duccio Maria Cordelli
    Child Neurology and Psychiatry Unit, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Pediatr Blood Cancer 58:785-90. 2012
    ..The aim of this study was to describe the clinical and electroencephalographic features of SE as a manifestation of PRES in children after allo-HSCT...
  41. ncbi Graft rejection after unrelated donor hematopoietic stem cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction
    Katharina Fleischhauer
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, P le Golgi 2, 27100 Pavia, Italy
    Blood 107:2984-92. 2006
    ..82; P = .01). These data suggest that in patients with thalassemia, the incidence of graft failure after HSCT may be reduced by appropriate selection of UDs, with such selection taking into account the functional rules of immunogenetics...
  42. ncbi Granulocytic sarcoma of the knee and the spine as aleukemic relapse of acute myeloid leukemia in a child
    Riccardo Masetti
    Paediatric Oncology and Haematology Unit Lalla Seràgnoli, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Pediatr Hematol Oncol 33:480-1. 2011
    ..We report interesting magnetic resonance images of a nonleukemic relapse of acute myeloid leukemia in a child presenting as a granulocytic sarcoma unusually localized to the knee and spine...
  43. ncbi Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
    Francesca Chiarini
    Department of Human Anatomical Sciences, University of Bologna, Italy
    Cancer Res 69:3520-8. 2009
    ....
  44. ncbi High proliferative activity and chromosomal instability in oral lichen planus
    L Montebugnoli
    Department of Oral Sciences, University of Bologna, Bologna, Italy
    Int J Oral Maxillofac Surg 35:1140-4. 2006
    ....
  45. ncbi Treatment and long-term results in children with acute myeloid leukaemia treated according to the AIEOP AML protocols
    A Pession
    Clinica Pediatrica, Universita di Bologna, Policlinico Sant Orsola Malpighi, Bologna, Italy
    Leukemia 19:2043-53. 2005
    ....
  46. ncbi Collection and transfer of data: the AIEOP model
    A Pession
    Clinica Pediatrica, Universita di Bologna, Policlinico Sant Orsola Malpighi, Bologna, Italy
    Bone Marrow Transplant 41:S35-8. 2008
    ..The AMR AIEOP network represents a model of Information Based Medicine, a crucial tool for well-informed pediatricians, essential to guarantee better childcare in a setting of patients such as children with cancer...
  47. ncbi [Thoracoscopic management of suspected thoraco-pulmonary malignant diseases in pediatric age]
    M Lima
    Chirurgia Pediatrica, Universita degli Studi, Bologna
    Pediatr Med Chir 26:132-5. 2004
    ..Thoracoscopic is indicated in cases of suspected oncological diseases in children both for diagnosis and treatment...
  48. ncbi Synthesis and antiproliferative activity of some thiazolylbenzimidazole-4,7-diones
    L Garuti
    Department of Pharmaceutical Science, University of Bologna, Via Belmeloro 6, I 40126, Bologna, Italy
    Bioorg Med Chem Lett 11:3147-9. 2001
    ..The importance of the methoxy group on the quinone moiety is confirmed and the function at 4-position of the thiazole ring plays a determining role for the activity...
  49. ncbi Human leucocyte antigen I expression in spermatozoa from infertile men
    R Paradisi
    Department of Obstetrics and Gynecology and Reproductive Biology, S Orsola Hospital, University Alma Mater Studiorum of Bologna, I 40138 Bologna, Italy
    Int J Androl 24:8-14. 2001
    ....
  50. ncbi Polynucleotide:adenosine glycosidase activity of saporin-L1: effect on various forms of mammalian DNA
    L Barbieri
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo, 14, I 40126, Bologna, Italy
    Biochim Biophys Acta 1480:258-66. 2000
    ..Mitochondrial nucleic acids are heavily depurinated in intact mitochondria, although the contribute of mtDNA to the deadenylation events is not known. The kinetic constants for several substrates were determined...
  51. ncbi Nucleolar size indicates the rapidity of cell proliferation in cancer tissues
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    J Pathol 191:181-6. 2000
    ..Evaluation of nucleolar size after silver staining of AgNOR proteins represents a unique parameter for the histological assessment of rapidity of cell proliferation in tumour lesions...
  52. ncbi Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease
    F Licastro
    Dipartimento di Patologia Sperimentale, School of Medicine, University of Bologna, Italy
    Neurosci Lett 270:129-32. 1999
    ..Present findings indicated that subjects with ACT TT genotype had an increased risk of developing AD and suggested that this genotype influenced the risk of an early onset of the disease by affecting the production of ACT molecules...
  53. ncbi Nucleolar function and size in cancer cells
    M Derenzini
    Department of Experimental Pathology, S Orsola Hospital, University of Bologna, Italy
    Am J Pathol 152:1291-7. 1998
    ..Quantitative distribution of nucleolar structures within the cell represents a cytohistological parameter of the rapidity of cell proliferation...
  54. ncbi gamma-Linolenic acid supplementation can affect cancer cell proliferation via modification of fatty acid composition
    S Hrelia
    Department of Biochemistry G Moruzzi, University of Bologna, Italy
    Biochem Biophys Res Commun 225:441-7. 1996
    ..The highest cytostatic effect was reached when GLA was not transformed into its metabolites, suggesting that the GLA toxicity to tumor cells is not dependent on metabolites but is due to GLA itself...
  55. ncbi p120 expression provides a reliable indication of the rapidity of cell duplication in cancer cells independently of tumour origin
    D Trere
    Department of Experimental Pathology, University of Bologna, Italy
    J Pathol 192:216-20. 2000
    ..98, p<0.0001). These results indicate that in cancer cells, the quantitative expression of p120 is directly related to the rapidity of cell duplication, independently of the tumour origin...
  56. ncbi Improvement over time in outcome for children with acute lymphoblastic leukemia in second remission given hematopoietic stem cell transplantation from unrelated donors
    F Locatelli
    Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, , Italy
    Leukemia 16:2228-37. 2002
    ..EFS of unrelated donor HSCT in children with ALL in second CR has improved in the last few years, mainly due to a decreased TRM. This information is of value for counseling of patients with relapsed ALL...
  57. ncbi Gonadal function and pubertal development after treatment of a childhood malignancy
    A Cicognani
    Department of Pediatrics, University of Bologna, Italy
    J Pediatr Endocrinol Metab 16:321-6. 2003
    ..High dosage hypothalamic-pituitary irradiation causes delayed puberty and hypogonadism in males and females, whereas lower dosages may be associated with early puberty, particularly in females...
  58. ncbi aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia
    D Grifoni
    Dipartimento di Biologia Evoluzionistica Sperimentale, Alma Mater Studiorum, Via Selmi 3, 40126 Bologna, Italy
    Oncogene 26:5960-5. 2007
    ....
  59. ncbi Unbalance of intestinal microbiota in atopic children
    Marco Candela
    Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
    BMC Microbiol 12:95. 2012
    ..In order to investigate the gastrointestinal microbial ecology of atopic disease, here we performed a pilot comparative molecular analysis of the faecal microbiota in atopic children and healthy controls...
  60. ncbi Perfluoroalkyl substances in human milk: a first survey in Italy
    Andrea Barbarossa
    CABA Lab, Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell Emilia BO, Italy
    Environ Int 51:27-30. 2013
    ..Finally, comparing these results with previous data, PFOS gradual decrease over time since year 2000 was confirmed...
  61. ncbi End point prick test: could this new test be used to predict the outcome of oral food challenge in children with cow's milk allergy?
    Federica Bellini
    Pediatric Unit, Department of Gynecologic, Obstetric and Pediatric Sciences, University of Bologna, Bologna, Italy
    Ital J Pediatr 37:52. 2011
    ..Although food allergy can be easily diagnosed, it is difficult to predict the outcome of the oral food challenge (OFC), that remains the gold standard in the diagnosis of food allergy, by allergometric tests...
  62. ncbi In vivo bioluminescence imaging of murine xenograft cancer models with a red-shifted thermostable luciferase
    Laura Mezzanotte
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Mol Imaging Biol 12:406-14. 2010
    ..In vivo bioluminescence imaging performance of red- and green-emitting luciferases were compared in two different xenograft mouse models for cancer...
  63. ncbi HLA-mismatched hematopoietic stem cell tranplantation for pediatric solid tumors
    Andrea Pession
    Pediatric Oncology and Hematology Lalla Seràgnoli Unit, University of Bologna, Bologna, Italy
    Pediatr Rep 3:e12. 2011
    ..We here report an experimental study design of HLA-mismatched HSCT for the treatment of pediatric solid tumors and the inherent preliminary results...
  64. ncbi Consensus conference on the management of tumor lysis syndrome
    Patrizia Tosi
    Hematology Unit, Istituto Seragnoli, Ospedale Sant Orsola Malpighi, Bologna, Italy
    Haematologica 93:1877-85. 2008
    ..In conclusion, the Panel recommended rasburicase for tumor lysis syndrome prophylaxis in selected patients based on the drug efficacy profile. Methodologically rigorous studies are needed to clarify its cost-effectiveness profile...
  65. ncbi Graft versus host disease prophylaxis with low-dose cyclosporine-A reduces the risk of relapse in children with acute leukemia given HLA-identical sibling bone marrow transplantation: results of a randomized trial
    F Locatelli
    Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    Blood 95:1572-9. 2000
    ..15). Our data demonstrate that the use of low Cs-A doses is associated with a statistically significant reduction of leukemia relapse, probably due to an increased graft versus leukemia effect. (Blood. 2000;95:1572-1579)..
  66. ncbi 18F-DOPA PET/CT in neuroblastoma: comparison of conventional imaging with CT/MR
    Egesta Lopci
    PET Unit, Nuclear Medicine Department, University Hospital S Orsola Malpighi, Bologna, Italy
    Clin Nucl Med 37:e73-8. 2012
    ..Role of 18F-DOPA PET/CT in neuroblastoma (NB) compared with CT/MR...
  67. ncbi SDHA loss-of-function mutations in KIT-PDGFRA wild-type gastrointestinal stromal tumors identified by massively parallel sequencing
    Maria A Pantaleo
    Department of Hematology and Oncological Sciences L A Seragnoli, Sant Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Natl Cancer Inst 103:983-7. 2011
    ..This is the first report, to our knowle dge, that identifies SDHA inactivation as a common oncogenic event in GISTs that lack a mutation in KIT and PDGFRA...
  68. ncbi Diagnosis of bloodstream infections in immunocompromised patients by real-time PCR
    Stefania Varani
    Unit of Microbiology, Department of Haematology and Oncology L e A Seràgnoli, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Infect 58:346-51. 2009
    ..Here, we tested a novel method for diagnosing BSIs in a large cohort of immunodepressed patients...
  69. ncbi Treatment reduction in highly selected standard-risk childhood acute lymphoblastic leukemia. The AIEOP ALL-9501 study
    Maurizio Arico
    Oncoematologia Pediatrica, Ospedale dei Bambini G Di Cristina, 90134 Palermo, Italy
    Haematologica 90:1186-91. 2005
    ..The aim of this study was to evaluate the efficacy of treatment reduction in a subset of children with ALL at minimal risk of failure...
  70. ncbi N-3 PUFAs modulate global gene expression profile in cultured rat cardiomyocytes. Implications in cardiac hypertrophy and heart failure
    Alessandra Bordoni
    Nutrition Research Center, Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio, 48 40126 Bologna, Italy
    FEBS Lett 581:923-9. 2007
    ..Our data allow to speculate that the cardioprotective effect of n-3 PUFAs is related to a direct modulation of genes in cardiac cells...
  71. ncbi Pooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma
    Giampaolo Ricci
    Pediatric Unit, Department of Gynecologic, Obstetric and Pediatric Sciences, University of Bologna, Bologna, Italy
    PLoS ONE 6:e16912. 2011
    ..No such study was up to now applied to childhood allergic asthma, even if the very high complexity of asthma genetics is an appropriate field to explore the potential of pooled GWAS approach...
  72. ncbi The role of HDACs inhibitors in childhood and adolescence acute leukemias
    Riccardo Masetti
    Pediatric Oncology and Hematology Lalla Seràgnoli Unit, Department of Pediatrics, University of Bologna, 40137 Bologna, Italy
    J Biomed Biotechnol 2011:148046. 2011
    ..Here we review the main preclinical and clinical studies regarding the use of HDIs in treating childhood and adolescence leukemia...
  73. ncbi Establishment of a human medulloblastoma cell line (BO-101) demonstrating skeletal muscle differentiation
    F Giangaspero
    Institute of Anatomic Pathology, University of Bologna, Italy
    Tumori 77:196-205. 1991
    ..1). The BO-101 line differs phenotypically and genotypically from previously established medulloblastoma cell lines and further supports the heterogeneous biologic properties of the cell populations that constitute these neoplasms...
  74. ncbi Total body irradiation, thiotepa, and cyclophosphamide as a conditioning regimen for children with acute lymphoblastic leukemia in first or second remission undergoing bone marrow transplantation with HLA-identical siblings
    M Zecca
    Department of Pediatrics, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy
    J Clin Oncol 17:1838-46. 1999
    ....
  75. ncbi Citrus allergy from pollen to clinical symptoms
    Rosa Anna Iorio
    Department of Biological, Earth and Environmental Sciences, University of Bologna, Bologna, Italy
    PLoS ONE 8:e53680. 2013
    ....
  76. ncbi Negative pressure treatment for necrotizing fasciitis after chemotherapy
    Fraia Melchionda
    Pediatric Oncology and Hematology Unit, Institute Lalla Seràgnoli, University of Bologna, Italy
    Pediatr Rep 3:e33. 2011
    ..Treatment with topical negative pressure therapy with silver foam dressing, together with large spectrum antibiotics, resolved the problem with complete closure of the wound after 30 and 36 days of treatment, respectively...
  77. ncbi Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation
    Claudio Graziano
    Unitá Operativa Genetica Medica, Policlinico Sant Orsola Malpighi, Dipartimento di Scienze Ginecologiche, Ostetriche Pediatriche Università degli Studi di Bologna, Bologna, Italy
    Blood 114:1655-7. 2009
    ..This is the first report showing that vascular disruptions could be secondary to specific gene derangements...
  78. ncbi FDG small animal PET permits early detection of malignant cells in a xenograft murine model
    Cristina Nanni
    Nuclear Medicine, Azienda Ospedaliera di Bologna Policlinico S Orsola Malpighi, Bologna, Italy
    Eur J Nucl Med Mol Imaging 34:755-62. 2007
    ..A second goal was to analyse the metabolic behaviour of this xenograft tumour over time...
  79. ncbi The italian network of primary immunodeficiencies
    Alessandro Plebani
    Department of Pediatrics, University of Brescia, Italy
    Iran J Allergy Asthma Immunol 3:165-8. 2004
    ....
  80. ncbi TT virus-related acute recurrent hepatitis. Histological features of a case and review of the literature
    M P Foschini
    Department of Oncology, Section of Pathology, University of Bologna, Italy
    Virchows Arch 439:752-5. 2001
    ..On histological analysis, the liver parenchyma showed a preserved architecture. The histological features were those of a mild acute hepatitis. The clinicopathological findings suggest th..
  81. ncbi Compound heterozygosity for two different amino-acid substitution mutations in the thrombopoietin receptor (c-mpl gene) in congenital amegakaryocytic thrombocytopenia (CAMT)
    R Tonelli
    Department of Pediatrics, University of Bologna, Italy
    Hum Genet 107:225-33. 2000
    ..The present study provides important confirmation that CAMT can be associated with (c-mpl) mutations...
  82. ncbi Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience
    P Rosito
    Department of Pediatrics, University of Bologna, Italy
    Cancer 86:421-8. 1999
    ..8% vs. 60.7%). In addition, the better outcome also could be explained by the change in treatment strategy with a trend toward the use of more surgery than radiation therapy compared with the authors' previous protocol...
  83. ncbi Allogeneic bone marrow transplantation for chronic myelomonocytic leukemia in childhood: a report from the European Working Group on Myelodysplastic Syndrome in Childhood
    F Locatelli
    Department of Pediatrics, University of Pavia, Instituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Italy
    J Clin Oncol 15:566-73. 1997
    ..To evaluate the role of allogeneic bone marrow transplantation (BMT) in children with chronic myelomonocytic leukemia (CMML)...
  84. ncbi Prognostic relevance of pretreatment proliferative rapidity of marrow blast cells in childhood acute lymphoblastic leukaemia
    D Trere
    Centro di Patologia Cellulare, Dipartimento di Patologia Sperimentale, Bologna, Italy
    Br J Cancer 70:1198-202. 1994
    ..01). Our results indicate that the rapidity of marrow blast cell proliferation is an important prognostic parameter in childhood ALL and should be routinely introduced in the group risk definition...
  85. ncbi Correlation between histologic staging, hepatitis C virus genotypes and clinical features in HCV chronic hepatitis: evidence of a new pattern
    L Di Tommaso
    Department of Oncology, Section of Anatomic Pathology Marcello Malpighi, University of Bologna, Italy
    Int J Surg Pathol 11:197-204. 2003
    ..The latter could be the profile of HCV infection in the near future...
  86. ncbi Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia
    V Conter
    Department of Pediatrics, University of Milano Bicocca, Ospedale S Gerardo, Monza, Italy
    Leukemia 24:255-64. 2010
    ..The introduction of minimal residual disease monitoring and evaluation of common randomized questions by AIEOP and BFM groups in the protocol AIEOP-BFM-ALL 2000 are expected to further ameliorate treatment of children with ALL...
  87. ncbi Fibrinogen storage disease without hypofibrinogenaemia associated with acute infection
    G Marucci
    Section of Pathology, Department of Oncology, University of Bologna, Bellaria Hospital, Bologna, Italy
    Histopathology 42:22-5. 2003
    ..CONCLUSIONS: These cases suggest that, on rare occasions, hepatocytes may accumulate fibrinogen during an infectious disease...
  88. ncbi Treatment of childhood acute lymphoblastic leukemia. Long-term results of the AIEOP-ALL 87 study
    G Paolucci
    , Bologna, Italy
    Haematologica 86:478-84. 2001
    ....
  89. ncbi Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    E Franceschi
    1Department of Medical Oncology, Bellaria Hospital, Bologna, Italy
    Br J Cancer 96:1047-51. 2007
    ..Gefitinib showed limited activity in patients affected by HGGs. Epidermal growth factor receptor expression or gene status, and p-Akt expression do not seem to predict activity of this drug...
  90. ncbi N-myc and c-myc oncogenes amplification in medulloblastomas. Evidence of particularly aggressive behavior of a tumor with c-myc amplification
    M Badiali
    Department of Pediatrics, University of Bologna, Italy
    Tumori 77:118-21. 1991
    ..Medulloblastomas with c-myc activation may represent a subgroup of tumors with a more aggressive behavior...
  91. ncbi Efficacy and safety of recombinant urate oxidase (rasburicase) for treatment and prophylaxis of hyperuricemia in children undergoing chemotherapy
    Andrea Pession
    Haematologica 90:141-2. 2005
    ..Tolerance of treatment was excellent. Rasburicase is a safe, highly and rapidly effective agent in the treatment and prevention of malignancies-associated acute hyperuricemia...
  92. ncbi Unrelated donor marrow transplantation in childhood: a report from the Associazione Italiana Ematologia e Oncologia Pediatrica (AIEOP) and the Gruppo Italiano per il Trapianto Midollo Osseo (GITMO)
    Giorgio Dini
    U O Ematologia Oncologia Pediatrica, IRCCS G Gaslini, Genova, Italy
    Haematologica 87:51-7. 2002
    ....
  93. ncbi GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children
    Anna Maria Testi
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita La Sapienza, Via Benevento 6, 00161 Rome, Italy
    Blood 106:447-53. 2005
    ..A white blood cell (WBC) count at diagnosis of greater than 10 x 10(9)/L had a significant impact on EFS (59% vs 83% at 10 years). These results highlight the efficacy and feasibility of the AIDA protocol in the pediatric APL population...
  94. ncbi The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma
    Andrew Slack
    Center for Cell and Gene Therapy, Texas Children s Cancer Center, Baylor College of Medicine, 1102 Bates Street, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:731-6. 2005
    ..Our finding that MYCN directly modulates baseline MDM2 levels suggests a mechanism contributing to the pathogenesis of neuroblastoma and other MYC-driven malignancies through inhibition of MYC-stimulated apoptosis...
  95. ncbi Unrelated bone marrow transplantation for beta-thalassemia patients: The experience of the Italian Bone Marrow Transplant Group
    Giorgio La Nasa
    Centro Trapianti Midollo Osseo, Ospedale R Binaghi ASL 8, Via Is Guadazzonis 3, 09126 Cagliari, Italy
    Ann N Y Acad Sci 1054:186-95. 2005
    ..These data show that when donor selection is based on stringent compatibility criteria, the results of unrelated transplantation in thalassemia patients are comparable to those obtained when the donor is a compatible sibling...
  96. ncbi Disseminated neuroblastoma in children older than one year at diagnosis: comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for Neuroblastoma
    Bruno De Bernardi
    Giannina Gaslini Children s Hospital, Largo Gerolamo Gaslini 5, 16147 Genova, Italy
    J Clin Oncol 21:1592-601. 2003
    ..To compare the outcomes associated with modifications in three consecutive protocols employed by the Italian Co-Operative Group for Neuroblastoma (ICGNB) in disseminated neuroblastoma...
  97. ncbi Long-term results of the AIEOP-ALL-95 Trial for Childhood Acute Lymphoblastic Leukemia: insight on the prognostic value of DNA index in the framework of Berlin-Frankfurt-Muenster based chemotherapy
    Maurizio Arico
    Pediatric Hematology Oncology, Ospedale dei Bambini G Di Cristina, Palermo, Italy
    J Clin Oncol 26:283-9. 2008
    ..The prognostic value of DNA index was explored in this setting...
  98. ncbi Neuroblastic tumors associated with opsoclonus-myoclonus syndrome: histological, immunohistochemical and molecular features of 15 Italian cases
    Claudio Gambini
    Service of Pathology, Giannina Gaslini Children s Hospital, Largo Gerolamo Gaslini 5, 16148, Genova, Italy
    Virchows Arch 442:555-62. 2003
    ..In conclusion, ganglioneuroblastoma, intermixed subtype, lack of MYCN amplification, aneuploid DNA content and presence of lymphoid infiltrates may contribute to favorable prognosis in NTs associated with OMS...
  99. ncbi Treatment of high-risk relapsed Wilms tumor with dose-intensive chemotherapy, marrow-ablative chemotherapy, and autologous hematopoietic stem cell support: experience by the Italian Association of Pediatric Hematology and Oncology
    Filippo Spreafico
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 51:23-8. 2008
    ..We evaluated an intensified chemotherapy strategy in children with Wilms tumor who relapsed with high-risk features...
  100. ncbi Circular dichroism study of DNA binding by a potential anticancer peptide nucleic acid targeted against the MYCN oncogene
    Andrea Faccini
    Dipartimento di Chimica, Organica e Industriale, Universita di Parma, Parma, Italy
    Chirality 20:494-500. 2008
    ..The present results support the possibility of an analogous mechanism of action of this antitumor PNA in vivo...
  101. ncbi Improved outcome in high-risk childhood acute lymphoblastic leukemia defined by prednisone-poor response treated with double Berlin-Frankfurt-Muenster protocol II
    Maurizio Arico
    Onco Ematologia Pediatrica, Ospedale dei Bambini G Di Cristina, Palermo, Italy
    Blood 100:420-6. 2002
    ..This modified therapy may lead to high cure rates for patients defined as at high risk for intrinsic resistance to corticosteroids only...