A Pessina


Affiliation: University of Milan
Country: Italy


  1. Coccè V, Franzé S, Brini A, Gianni A, Pascucci L, Ciusani E, et al. In Vitro Anticancer Activity of Extracellular Vesicles (EVs) Secreted by Gingival Mesenchymal Stromal Cells Primed with Paclitaxel. Pharmaceutics. 2019;11: pubmed publisher
    ..This research may contribute to develop new strategies of cell-mediated drug delivery by EVs that are easy to store without losing function, and could have a superior safety profile in therapy. ..
  2. Marei H, Casalbore P, Althani A, Coccè V, Cenciarelli C, Alessandri G, et al. Human Olfactory Bulb Neural Stem Cells (Hu-OBNSCs) Can Be Loaded with Paclitaxel and Used to Inhibit Glioblastoma Cell Growth. Pharmaceutics. 2019;11: pubmed publisher
    ..This indicates their potential to be used as a carrier/vehicle for targeted anti-cancer therapy within the CNS. ..
  3. Pessina A, Sisto F, Coccè V, Cavicchini L, Ciusani E, Gribaldo L, et al. A mesenchymal stromal cell line resistant to paclitaxel that spontaneously differentiates into osteoblast-like cells. Cell Biol Toxicol. 2011;27:169-80 pubmed publisher
    ..Taken together, our results indicated that SR-4987 line is a very interesting cell model useful to investigate both drug sensitivity resistance and physiopathological aspects related to mesenchymal cell function. ..
  4. Pessina A, Bonomi A, Casati S, Collotta A, Croera C, Marafante E, et al. Mitochondrial function, apoptosis and cell cycle delay in the WEHI-3B leukaemia cell line and its variant Ciprofloxacin-resistant WEHI-3B/CPX. Cell Prolif. 2007;40:568-79 pubmed
    ..The toxic effect on sensitive cells could be mediated by the cell cycle arrest whereas in the resistant clone, the prolonged G(2) phase could play a key role to favour cell cycle progression and proliferation. ..
  5. Bonomi A, Lisini D, Navone S, Frigerio S, Dossena M, Ciusani E, et al. Human CD14+ cells loaded with Paclitaxel inhibit in vitro cell proliferation of glioblastoma. Cytotherapy. 2015;17:310-9 pubmed publisher
    ..Our results are the first demonstration that peripheral blood-derived CD14+ and DCs, in addition to their application for immunotherapy for GB, could also be used to delivery anti-cancer drugs, such as PTX, to kill GB cells. ..
  6. Pacioni S, D Alessandris Q, Giannetti S, Morgante L, De Pascalis I, Coccè V, et al. Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts. Stem Cell Res Ther. 2015;6:194 pubmed publisher
    ..MSCs appear particularly suited for anti-neoplastic drug delivery in the brain since PTX-specific damage of GBM cells can be achieved avoiding side effects to the normal tissue. ..
  7. Pessina A, Malerba I, Gribaldo L. Hematotoxicity testing by cell clonogenic assay in drug development and preclinical trials. Curr Pharm Des. 2005;11:1055-65 pubmed
  8. Bonomi A, Silini A, Vertua E, Signoroni P, Coccè V, Cavicchini L, et al. Human amniotic mesenchymal stromal cells (hAMSCs) as potential vehicles for drug delivery in cancer therapy: an in vitro study. Stem Cell Res Ther. 2015;6:155 pubmed publisher
    ..Taken together, for the first time our results show that placental stem cells can be used as vehicles for the delivery of cytotoxic agents. ..
  9. Bonomi A, Sordi V, Dugnani E, Ceserani V, Dossena M, Coccè V, et al. Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells. Cytotherapy. 2015;17:1687-95 pubmed publisher

More Information


  1. Pessina A, Croera C, Bayo M, Malerba I, Passardi L, Cavicchini L, et al. A methylcellulose microculture assay for the in vitro assessment of drug toxicity on granulocyte/macrophage progenitors (CFU-GM). Altern Lab Anim. 2004;32:17-23 pubmed
  2. Bonomi A, Ghezzi E, Pascucci L, Aralla M, Ceserani V, Pettinari L, et al. Effect of canine mesenchymal stromal cells loaded with paclitaxel on growth of canine glioma and human glioblastoma cell lines. Vet J. 2017;223:41-47 pubmed publisher
    ..cMSCs-PTC inhibited proliferation of the canine glioma cell line J3T, and the human glioblastoma cell lines T98G and U87MG. The potential of canine cMSCs-PTX for treatment of canine gliomas should be investigated further. ..
  3. Crivelli B, Chlapanidas T, Perteghella S, Lucarelli E, Pascucci L, Brini A, et al. Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system. J Control Release. 2017;262:104-117 pubmed publisher
    ..Special attention is devoted to the illustration of innovative therapeutic approaches in which nanomedicine is successfully combined with stem cell therapy, thus creating a novel class of "next generation drug delivery systems." ..
  4. Coccè V, Farronato D, Brini A, Masia C, Gianni A, Piovani G, et al. Drug Loaded Gingival Mesenchymal Stromal Cells (GinPa-MSCs) Inhibit In Vitro Proliferation of Oral Squamous Cell Carcinoma. Sci Rep. 2017;7:9376 pubmed publisher
    ..In particular, gemcitabine loaded GinPa-MSCs provide a good "cell-mediated drug delivery system" for a future potential application in the context of the oral oncology. ..