Research Topics
| Giulio PerugiSummaryAffiliation: University of Pisa Country: Italy Publications
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Detail Information
Publications
The role of cyclothymia in atypical depression: toward a data-based reconceptualization of the borderline-bipolar II connectionGiulio Perugi
Department of Psychiatry, University of Pisa, Via Roma 67, 56100, Pisa, Italy
J Affect Disord 73:87-98. 2003....
Affective temperaments in heroin addictionIcro Maremmani
Vincent P Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Psychiatry, NPB, University of Pisa, 56100 Pisa Italy
J Affect Disord 117:186-92. 2009..Much of the literature has described personality disorder constructs for heroin addicts. Building on previous work we examine the relevance of affective temperament measures in these patients...
Bipolar co-morbidity in pediatric obsessive-compulsive disorder: clinical and treatment implicationsGabriele Masi
IRCCS Stella Maris, Scientific Institute Child Neurology and Psychiatry, 56018 Calambrone, Pisa, Italy
J Child Adolesc Psychopharmacol 17:475-86. 2007..The significance of the hoarding subtype deserves further research on larger samples of pediatric patients...
Pharmacotherapy in paediatric obsessive-compulsive disorder: a naturalistic, retrospective studyGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy
CNS Drugs 23:241-52. 2009..Effectiveness of serotonin reuptake inhibitors (SRIs) has been supported by several double-blind, placebo-controlled studies...
Long-term outcomes of treatment-resistant heroin addicts with and without DSM-IV axis I psychiatric comorbidity (dual diagnosis)Icro Maremmani
Vincent P Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Psychiatry, NPB, University of Pisa, Italy
Eur Addict Res 14:134-42. 2008..The aim of this study was to compare the long-term outcomes of treatment-resistant heroin addicts with and without DSM-IV axis I psychiatric comorbidity (dual diagnosis)...
Impulsivity in anxiety disorder patients: is it related to comorbid cyclothymia?Giulio Perugi
Department of Psychiatry, University of Pisa, Pisa, Italy
J Affect Disord 133:600-6. 2011..healthy controls. In the same sample we now explore the influence of comorbid soft bipolar spectrum disorders on the relationship between anxiety disorders and impulsivity...
Clinical and research implications of panic-bipolar comorbidity in children and adolescentsGabriele Masi
IRCCS Stella Maris, Scientific Institute Child Neurology and Psychiatry, Calambrone, Pisa, Italy
Psychiatry Res 153:47-54. 2007..The data are compatible with the hypothesis that Panic-BD and ADHD-BD might represent distinct developmental pathways of bipolar disorder. Further research on this question may prove rewarding...
Attention-deficit hyperactivity disorder -- bipolar comorbidity in children and adolescentsGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy
Bipolar Disord 8:373-81. 2006..The aim of our study was to analyze the cross-sectional and longitudinal implications of such comorbidity in children and adolescents with BD...
Use of street methadone in italian heroin addicts presenting for opioid agonist treatmentIcro Maremmani
Vincent P Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Psychiatry, NPB, University of Pisa, Via Roma, 67 56100 Pisa, Italy
J Addict Dis 28:382-8. 2009..This should be accounted for when deciding on take-home policies and issues of potential methadone diversion...
Developmental differences according to age at onset in juvenile bipolar disorderGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy
J Child Adolesc Psychopharmacol 16:679-85. 2006....
Toward a unitary perspective on the bipolar spectrum and substance abuse: opiate addiction as a paradigmIcro Maremmani
Santa Chiara University Hospital, Psychiatric Unit 1, University of Pisa, Italy, EU
J Affect Disord 93:1-12. 2006..We therefore submit that the present conceptualization of the link between bipolar spectrum and addictive disorders has not only heuristic and scientific values, but also an important message for the clinician...
Dual diagnosis and chronology of illness in treatment-seeking Italian patients dependent on heroinAngelo Giovanni Icro Maremmani
University of Pisa, Via Roma 67, 56100 Pisa, Italy
J Addict Dis 30:123-35. 2011..When treating patients with a dual diagnosis, clinicians should ensure that the same attention is given to the treatment of drug dependence as it is to the treatment of comorbid psychiatric conditions...
Alcohol and cocaine use and abuse among opioid addicts engaged in a methadone maintenance treatment programIcro Maremmani
Department of Psychiatry NPB, University of Pisa, Pisa, 56100, Italy
J Addict Dis 26:61-70. 2007..Cessation of illicit opioid abuse and retention in treatment are positively correlated with decrease in alcohol and cocaine abuse and the absence of the psychosocial complications associated with such abuse...
Are "social drugs" (tobacco, coffee and chocolate) related to the bipolar spectrum?Icro Maremmani
Department of Psychiatry, University of Pisa and G De Lisio Institute of Behavioural Sciences, Pisa, Italy
J Affect Disord 133:227-33. 2011..These substances, notably caffeine, tobacco, alcohol and chocolate, can be labeled 'social drugs'...
Different measures of impulsivity in patients with anxiety disorders: a case control studyAlessandra Del Carlo
Department of Psychiatry, University of Pisa, Italy
Psychiatry Res 197:231-6. 2012..Further investigations are needed to assess the extent to which impulsivity might or might not be directly related to the anxiety disorder...
Discriminative hypomania checklist-32 factors in unipolar and bipolar major depressive patientsGiulio Perugi
Department of Psychiatry, University of Pisa, Pisa, Italy
Psychopathology 45:390-8. 2012..The Hypomania Checklist-32 (HCL-32) has therefore been developed and tested internationally to facilitate BD recognition...
Cocaine abuse and the bipolar spectrum in 1090 heroin addicts: clinical observations and a proposed pathophysiologic modelIcro Maremmani
Vincent P Dole Dual Diagnosis Team, Santa Chiara University Hospital, Department of Psychiatry, University of Pisa, Italy
J Affect Disord 106:55-61. 2008..This topic required further examination among heroin abusers because cocaine abuse is commonly comorbid with heroin abuse...
Is the bipolar spectrum the psychopathological substrate of suicidality in heroin addicts?Icro Maremmani
Santa Chiara University Hospital, Department of Psychiatry, University of Pisa, Pisa, Italy
Psychopathology 40:269-77. 2007..To describe the prevalence and the risk factors of suicidal ideation in a cohort of Italian opioid addicts presenting for treatment...
Temperamental traits of women applying for a type of job that has been characterized historically by male identity: the military career as case studyIcro Maremmani
Santa Chiara University Hospital, Department of Psychiatry, University of Pisa, Italy
J Affect Disord 130:275-9. 2011..In this study we inquire into the question whether gender differences in temperament have continued unchanged in a field, such as the military career, that has been historically characterized by a male identity...
Substance use and quality of life over 12 months among buprenorphine maintenance-treated and methadone maintenance-treated heroin-addicted patientsIcro Maremmani
Vincent P Dole Research Team, Department of Psychiatry NPB, Santa Chiara University Hospital, University of Pisa, Pisa, Italy
J Subst Abuse Treat 33:91-8. 2007..This study suggests the long-term efficacy of methadone treatment and buprenorphine treatment on symptoms of opioid addiction and quality of life...
Obsessive-compulsive bipolar comorbidity: focus on children and adolescentsGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy
J Affect Disord 78:175-83. 2004..The aim of the present study is to explore some clinical aspects of this interface in children and adolescents, as it appears in a setting of routine clinical practice...
Bulimia nervosa in atypical depression: the mediating role of cyclothymic temperamentGiulio Perugi
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, Psychiatry Section, University of Pisa, Pisa, Italy
J Affect Disord 92:91-7. 2006....
Mood stabilizers in the treatment of substance use disordersIcro Maremmani
Vincent P Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Psychiatry, University of Pisa, Italy
CNS Spectr 15:95-109. 2010..Valproate appears to be a potentially fruitful medication to study in these dual diagnosis patients due to preliminary evidence demonstrating its anticraving efficacy...
Obsessive-compulsive disorder and body dysmorphic disorder: a comparison of clinical featuresFranco Frare
Department of Psychiatry, University of Pisa, Via Roma 67, 56100 Pisa, Italy
Eur Psychiatry 19:292-8. 2004....
Is unipolar mania a distinct subtype?Giulio Perugi
Department of Psychiatry, University of Pisa, 56100 Pisa, Italy
Compr Psychiatry 48:213-7. 2007..Literature on this topic is still scarce, although this was a matter of debate since several decades...
Comparative response to electroconvulsive therapy in medication-resistant bipolar I patients with depression and mixed statePierpaolo Medda
Department of Psychiatry, University of Pisa, Pisa, Italy
J ECT 26:82-6. 2010..We compared the response with electroconvulsive therapy (ECT) of bipolar I patients resistant to pharmacological treatment, who presented depression or mixed state (MS)...
Externalizing disorders in consecutively referred children and adolescents with bipolar disorderGabriele Masi
IRCCS Stella Maris, Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy
Compr Psychiatry 44:184-9. 2003..ADHD can be viewed as a precursor of a child-onset subtype of BD, while CD might represent a prodromal or a concomitant behavioral complication that identifies a more malignant and refractory form of BD...
Effectiveness of adjunctive gabapentin in resistant bipolar disorder: is it due to anxious-alcohol abuse comorbidity?Giulio Perugi
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, Psychiatry Section, University of Pisa, Pisa, Italy
J Clin Psychopharmacol 22:584-91. 2002..What is new in the present report is the suggestion that the utility of GBP in resistant bipolar disorder resides in its effectiveness against comorbid panic disorder and alcohol abuse...
Discriminant and convergent validity of TEMPS-A[P] correlation with MMPI and the emotional-affective state following a stressful situationIcro Maremmani
Department of Psychiatry, University of Pisa, Italy
J Affect Disord 129:27-33. 2011....
Obsessive-compulsive-bipolar comorbidity: a systematic exploration of clinical features and treatment outcomeGiulio Perugi
Department of Psychiatry, University of Pisa, Pisa, Italy
J Clin Psychiatry 63:1129-34. 2002..The aim of the present study is to address this challenge as it appears in a setting of routine clinical practice...
Lifetime mood symptoms and adult separation anxiety in patients with complicated grief and/or post-traumatic stress disorder: a preliminary reportLiliana Dell'Osso
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
Psychiatry Res 198:436-40. 2012..No significant differences were reported in the WSAS scores. Our results support differences between CG and PTSD that are important for the consideration of including CG as a new disorder in the DSM-V...
Subtyping patients with heroin addiction at treatment entry: factor derived from the Self-Report Symptom Inventory (SCL-90)Icro Maremmani
Vincent P Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Psychiatry, NPB, University of Pisa, Pisa, Italy
Ann Gen Psychiatry 9:15. 2010..CONCLUSIONS: This study supports the hypothesis that mood, anxiety and impulse-control dysregulation are the core of the clinical phenomenology of addiction and should be incorporated into its nosology...
Diagnosis and treatment of agoraphobia with panic disorderGiulio Perugi
Department of Psychiatry, University of Pisa, Pisa, Italy
CNS Drugs 21:741-64. 2007..Cognitive-behavioural therapy is the best studied non-pharmacological approach and can be applied to many patients, depending on its availability...
QTc interval prolongation in patients on long-term methadone maintenance therapyIcro Maremmani
PISA SIA Study and Intervention on Addictions Group Santa Chiara, University Hospital, Department of Psychiatry, NFB, University of Pisa, Italy
Eur Addict Res 11:44-9. 2005....
A naturalistic exploratory study of the impact of demographic, phenotypic and comorbid features in pediatric obsessive-compulsive disorderGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Italy
Psychopathology 43:69-78. 2010..In this naturalistic study we consider these characteristics of OCD in the framework of the 4 OCD phenotypes (contamination/cleaning, order/symmetry, obsessions/checking and hoarding) proposed by Leckman et al...
Pharmacological response in juvenile bipolar disorder subtypes: A naturalistic retrospective examinationGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Via dei Giacinti 2, 56018 Calambrone Pisa, Italy
Psychiatry Res 177:192-8. 2010..Such naturalistic data from an ordinary clinical setting have relevance to clinical practice...
Adjunctive valproate in panic disorder patients with comorbid bipolar disorder or otherwise resistant to standard antidepressants: a 3-year "open" follow-up studyGiulio Perugi
Institute of Behavioural Sciences G De Lisio, Carrara, MS, Italy
Eur Arch Psychiatry Clin Neurosci 260:553-60. 2010..The results of the study support the hypothesis of resistance to antidepressant treatment being related to mood instability...
Phenomenology and comorbidity of dysthymic disorder in 100 consecutively referred children and adolescents: beyond DSM-IVGabriele Masi
IRCCS Stella Maris, Division of Child Neurology and Psychiatry, Via dei Giacinti 2, 56018 Calambrone Pisa, Italy
Can J Psychiatry 48:99-105. 2003..The aim of this study was to describe prototypical symptomatology and comorbidity of DD, according to DSM-IV criteria, in a consecutive series of referred children and adolescents, as a function of age and sex...
The soft bipolar spectrum redefined: focus on the cyclothymic, anxious-sensitive, impulse-dyscontrol, and binge-eating connection in bipolar II and related conditionsGiulio Perugi
Institute of Behavioral Sciences G De Lisio, Viale Monzone 3, 54031 Carrara, Italy
Psychiatr Clin North Am 25:713-37. 2002....
Predictors of treatment nonresponse in bipolar children and adolescents with manic or mixed episodesGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone Pisa, Italy
J Child Adolesc Psychopharmacol 14:395-404. 2004..Follow-up studies with a larger sample size with BD and/or externalizing disorders appropriately managed with different treatment options and/or combinations are warranted...
Open-label evaluation of venlafaxine sustained release in outpatients with generalized anxiety disorder with comorbid major depression or dysthymia: effectiveness, tolerability and predictors of responseGiulio Perugi
Institute of Behavioral Sciences G De Lisio, Carrara, Italy
Neuropsychobiology 46:145-9. 2002..Our data confirm the effectiveness and tolerability of SR-VF in mixed anxiety-depressive states. The differential response suggests a pathophysiologic and clinical distinction between GAD with comorbid MD or dysthymia...
The clinical phenotypes of juvenile bipolar disorder: toward a validation of the episodic-chronic-distinctionGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone Pisa, Italy
Biol Psychiatry 59:603-10. 2006..irritable) or course (episodic vs. chronic)...
Temperament in adolescents with anxiety and depressive disorders and in their familiesGabriele Masi
Division of Child Neurology and Psychiatry, Scientific Institute of Child Neurology and Psychiatry, IRCCS Stella Maris, Via dei Giacinti 2 56018 Calambrone Pisa, Italy
Child Psychiatry Hum Dev 33:245-59. 2003..These findings suggest that both Emotionality and Shyness are prominent temperamental features in adolescents with anxiety with or without depression, and in their parents and siblings...
Clinical implications of DSM-IV subtyping of bipolar disorders in referred children and adolescentsGabriele Masi
IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone Pisa, Italy
J Am Acad Child Adolesc Psychiatry 46:1299-306. 2007..We explore the clinical implications of this subtyping in a naturalistic sample of referred youths with BD I, BD II, and BD-NOS...
A case of deep venous thrombosis following protracted catatonic immobility recovered with electroconvulsive therapy: the relevance for an early interventionPierpaolo Medda
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Italy
Gen Hosp Psychiatry 34:209.e5-7. 2012....
Unexplained somatic symptoms during major depression: prevalence and clinical impact in a national sample of Italian psychiatric outpatientsGiulio Perugi
Dipartimento di Psichiatria, Universita di Pisa, Institute of Behavioural Sciences G De Lisio, Pisa, Italy
Psychopathology 44:116-24. 2011..The aim of this study was to explore the prevalence and impact of unexplained somatic symptoms during major depression...
Dopamine agonists and delusional jealousy in Parkinson's disease: a cross-sectional prevalence studyMichele Poletti
Department of Neuroscience, University of Pisa, Pisa, Italy
Mov Disord 27:1679-82. 2012..Delusional jealousy (DJ) has been described in patients with Parkinson's disease (PD) on dopaminergic therapy, but a role for dopaminergic therapy in DJ has not been established...
Diagnostic and symptomatological features in chronic psychotic patients according to cannabis use statusIcro Maremmani
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Italy
J Psychoactive Drugs 36:235-41. 2004..These data indicate that chronic, psychosis, whether associated with past or with current use of cannabis, is frequently associated with bipolar spectrum disorders and tends to display less blunted affect and more clastic behavior...
Adult separation anxiety in patients with complicated grief versus healthy control subjects: relationships with lifetime depressive and hypomanic symptomsLiliana Dell'Osso
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
Ann Gen Psychiatry 10:29. 2011..abstract:..
Is comorbid borderline personality disorder in patients with major depressive episode and bipolarity a developmental subtype? Findings from the international BRIDGE studyGiulio Perugi
Department of Psychiatry, University of Pisa, Pisa, Italy
J Affect Disord 144:72-8. 2013..The aim of this study was to characterize the clinical profile of patients with BD and comorbid BPD in a world-wide sample selected during a major depressive episode (MDE)...
Alcohol abuse in social phobic patients: is there a bipolar connection?Giulio Perugi
Department of Psychiatry, University of Pisa, Via Roma 67, 56100 Pisa, Italy
J Affect Disord 68:33-9. 2002....
A systematic, updated review on the antidepressant agomelatine focusing on its melatonergic modulationMichele Fornaro
Department of Psychiatry, University of Genova, Genoa, Italy
Curr Neuropharmacol 8:287-304. 2010..To present an updated, comprehensive review on clinical and pre-clinical studies on agomelatine...
Bipolar II and anxious reactive "comorbidity": toward better phenotypic characterization suitable for genotypingHagop S Akiskal
Department of Psychiatry at the University of California at San Diego, and Veterans Administration Medical Center, La Jolla, CA, USA
J Affect Disord 96:239-47. 2006..This association has genetic-familial implications, which we believe must be incorporated in refining the BP-II phenotype suitable for genotyping purposes...
Reboxetine, a selective norepinephrine reuptake inhibitor, is an effective and well-tolerated treatment for panic disorderMarcio Versiani
Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil
J Clin Psychiatry 63:31-7. 2002..16%), constipation (27% vs. 22%), and insomnia (26% vs. 22%). CONCLUSION: Reboxetine was effective and well tolerated in the treatment of panic disorder...
Affective temperament traits measured by TEMPS-I and emotional-behavioral problems in clinically-well children, adolescents, and young adultsSalvatore Signoretta
Institute of Behavioral Sciences, Carrara, Italy
J Affect Disord 85:169-80. 2005..The cyclothymic disposition turned out to be the most 'morbid', and associated with both internalizing and externalizing disturbances...
Agitated "unipolar" depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversyHagop S Akiskal
Department of Psychiatry and International Mood Center, University of California, La Jolla, CA, USA
J Affect Disord 85:245-58. 2005..S., Mallya, G., 1987. Criteria for the "soft" bipolar spectrum: treatment implications. Psychopharmacol Bull. 23, 68-73]...
Comparison between heroin and heroin-cocaine polyabusers: a psychopathological studyAdolfo Bandettini di Poggio
Department of Human Morphology and Applied Biology, Via Roma 55, 56126 Pisa, Italy
Ann N Y Acad Sci 1074:438-45. 2006..Results show a direct relationship between cocaine abuse and a higher rate of psychiatric disorders, but a negative correlation with the severity of self-rated psychopathology...
Antiepileptic drugs: indications other than epilepsyEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
Epileptic Disord 6:57-75. 2004..In addition, newer AEDs appear to have a more favourable tolerability and drug interaction profile as compared to older compounds, so thus improving compliance to treatment...
Clinical vs. structured interview on anxiety and affective disorders by primary care physicians. understanding diagnostic discordanceMatteo Balestrieri
Clinica di Psichiatria e PMP, Dipartimento di Patologia e Medicina Sperimentale e Clinica, University of Udine, Udine, Italy
Epidemiol Psichiatr Soc 16:144-51. 2007..To assess in a national sample the ability of GPs to detect psychiatric disorders using a clinical vs. a standardized interview and to characterize the patients that were falsely diagnosed with an anxiety or affective disorder...
