G Perugi

..This study aimed to ascertain predictors of nonresponse to electroconvulsive therapy (ECT) in a large sample of major depressive patients resistant to pharmacologic treatment...

..Our data confirm the effectiveness and tolerability of SR-VF in mixed anxiety-depressive states. The differential response suggests a pathophysiologic and clinical distinction between GAD with comorbid MD or dysthymia...

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..Cognitive-behavioural therapy is the best studied non-pharmacological approach and can be applied to many patients, depending on its availability...

..The results of the study support the hypothesis of resistance to antidepressant treatment being related to mood instability...

..The aim of the present study is to address this challenge as it appears in a setting of routine clinical practice...

..Open studies and case observations have suggested that gabapentin may be effective in the treatment of bipolar disorder. However, the adjunctive use of the drug in bipolar mixed states has not been specifically addressed before...

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..What is new in the present report is the suggestion that the utility of GBP in resistant bipolar disorder resides in its effectiveness against comorbid panic disorder and alcohol abuse...

..By contrast, the depressive temperament seemed to mute the expression of mania into a depressive-manic phenomenology...

..In a significant minority of cases, protracted social anxiety may hypothetically have represented, along with inhibited depression, the dimensional opposite of gregarious hypomania...

..We explored difference of response to ECT in unipolar (UP), bipolar I (BP I) and bipolar II (BP II) depression, in a sample of patients resistant to pharmacological treatment...

..In this paper we attempt to delineate the clinical profile of such depressive mixed states in the context of bipolar I disorder...

..This is also true for putative temperamental (e.g. cyclothymia, interpersonal sensitivity) and personality (e.g. histrionic and borderline) factors, which might play a predisposing role in several clinically comorbid syndromes...

..3%) were considered responders. The mean change on the CGI-Severity scale was statistically significant (p < 0.0001). Paroxetine was well tolerated and effective in the treatment of PD in these children and adolescents...

..CONCLUSION: The emerging multidimensional structure of phobia is congruent with, and further enriches, the existing literature...

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..The present report examines the temporal sequence of hypomania to panic (PD), obsessive-compulsive (OCD) and social phobic (SP) disorders...

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..The implications of these findings for the now largely abandoned category of "involutional melancholia" are discussed...

..This correlation has implications for treatment and research strategies on the aetiology within a subpopulation of OCD...

..ADHD can be viewed as a precursor of a child-onset subtype of BD, while CD might represent a prodromal or a concomitant behavioral complication that identifies a more malignant and refractory form of BD...

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..Despite several research reports on incongruent psychotic features in mania, whether such features define a distinct disorder is unsettled...

..We compared the response with electroconvulsive therapy (ECT) of bipolar I patients resistant to pharmacological treatment, who presented depression or mixed state (MS)...

..The cyclothymic disposition turned out to be the most 'morbid', and associated with both internalizing and externalizing disturbances...

..The aim of this study was to compare the long-term outcomes of treatment-resistant heroin addicts with and without DSM-IV axis I psychiatric comorbidity (dual diagnosis)...

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..This topic required further examination among heroin abusers because cocaine abuse is commonly comorbid with heroin abuse...

..To describe the prevalence and the risk factors of suicidal ideation in a cohort of Italian opioid addicts presenting for treatment...

..We explore the clinical implications of this subtyping in a naturalistic sample of referred youths with BD I, BD II, and BD-NOS...

..Much of the literature has described personality disorder constructs for heroin addicts. Building on previous work we examine the relevance of affective temperament measures in these patients...

..Effectiveness of serotonin reuptake inhibitors (SRIs) has been supported by several double-blind, placebo-controlled studies...

..The significance of the hoarding subtype deserves further research on larger samples of pediatric patients...

..In this naturalistic study we consider these characteristics of OCD in the framework of the 4 OCD phenotypes (contamination/cleaning, order/symmetry, obsessions/checking and hoarding) proposed by Leckman et al...

..Literature on this topic is still scarce, although this was a matter of debate since several decades...

..This should be accounted for when deciding on take-home policies and issues of potential methadone diversion...

..Such naturalistic data from an ordinary clinical setting have relevance to clinical practice...

..CONCLUSIONS: This study supports the hypothesis that mood, anxiety and impulse-control dysregulation are the core of the clinical phenomenology of addiction and should be incorporated into its nosology...

..Valproate appears to be a potentially fruitful medication to study in these dual diagnosis patients due to preliminary evidence demonstrating its anticraving efficacy...

..The data are compatible with the hypothesis that Panic-BD and ADHD-BD might represent distinct developmental pathways of bipolar disorder. Further research on this question may prove rewarding...

..This study suggests the long-term efficacy of methadone treatment and buprenorphine treatment on symptoms of opioid addiction and quality of life...

..The aim of this study was to describe prototypical symptomatology and comorbidity of DD, according to DSM-IV criteria, in a consecutive series of referred children and adolescents, as a function of age and sex...

..These findings suggest that both Emotionality and Shyness are prominent temperamental features in adolescents with anxiety with or without depression, and in their parents and siblings...

..These data indicate that chronic, psychosis, whether associated with past or with current use of cannabis, is frequently associated with bipolar spectrum disorders and tends to display less blunted affect and more clastic behavior...

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..Follow-up studies with a larger sample size with BD and/or externalizing disorders appropriately managed with different treatment options and/or combinations are warranted...

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..irritable) or course (episodic vs. chronic)...

..We therefore submit that the present conceptualization of the link between bipolar spectrum and addictive disorders has not only heuristic and scientific values, but also an important message for the clinician...

..The aim of the present study is to explore some clinical aspects of this interface in children and adolescents, as it appears in a setting of routine clinical practice...

..The aim of our study was to analyze the cross-sectional and longitudinal implications of such comorbidity in children and adolescents with BD...

..Cessation of illicit opioid abuse and retention in treatment are positively correlated with decrease in alcohol and cocaine abuse and the absence of the psychosocial complications associated with such abuse...

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..The aim of this study was to explore the prevalence and impact of unexplained somatic symptoms during major depression...

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..There is considerable uncertainty in the current literature about the relationship between personality dimensions and affective temperaments...

..Results show a direct relationship between cocaine abuse and a higher rate of psychiatric disorders, but a negative correlation with the severity of self-rated psychopathology...

..This association has genetic-familial implications, which we believe must be incorporated in refining the BP-II phenotype suitable for genotyping purposes...

..S., Mallya, G., 1987. Criteria for the "soft" bipolar spectrum: treatment implications. Psychopharmacol Bull. 23, 68-73]...

..16%), constipation (27% vs. 22%), and insomnia (26% vs. 22%). CONCLUSION: Reboxetine was effective and well tolerated in the treatment of panic disorder...

..In addition, newer AEDs appear to have a more favourable tolerability and drug interaction profile as compared to older compounds, so thus improving compliance to treatment...

..To assess in a national sample the ability of GPs to detect psychiatric disorders using a clinical vs. a standardized interview and to characterize the patients that were falsely diagnosed with an anxiety or affective disorder...