E Perucca

Summary

Affiliation: University of Pavia
Country: Italy

Publications

  1. ncbi request reprint Pharmacokinetic variability of new antiepileptic drugs at different ages
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Ther Drug Monit 27:714-7. 2005
  2. ncbi request reprint Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Pharmacokinet 45:351-63. 2006
  3. ncbi request reprint Prenatal exposure to antiepileptic drugs
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Lancet 367:1467-9. 2006
  4. ncbi request reprint What clinical trial designs have been used to test antiepileptic drugs and do we need to change them?
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Epileptic Disord 14:124-31. 2012
  5. ncbi request reprint Effects of antiepileptic comedication on levetiracetam pharmacokinetics: a pooled analysis of data from randomized adjunctive therapy trials
    E Perucca
    Department of Internal Medicine and Therapeutics, Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
    Epilepsy Res 53:47-56. 2003
  6. doi request reprint Lacosamide
    Emilio Perucca
    Department of Internal Medicine and Therapeutics and Institute of Neurology, IRCCS C Mondino Foundation, University of Pavia, Italy
    Nat Rev Drug Discov 7:973-4. 2008
  7. ncbi request reprint Designing clinical trials to assess antiepileptic drugs as monotherapy : difficulties and solutions
    Emilio Perucca
    University of Pavia, Pavia, Italy
    CNS Drugs 22:917-38. 2008
  8. ncbi request reprint The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?
    Emilio Perucca
    Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
    Epileptic Disord 5:S17-26. 2003
  9. doi request reprint The treatment of the first seizure: the risks
    Emilio Perucca
    Clinical Pharmacology Unit and Institute of Neurology IRCCS C Mondino Foundation, University of Pavia, Pavia, Italy
    Epilepsia 49:29-34. 2008
  10. ncbi request reprint Overtreatment in epilepsy: adverse consequences and mechanisms
    Emilio Perucca
    Department of Internal Medicine and Therapeutics, Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
    Epilepsy Res 52:25-33. 2002

Detail Information

Publications85

  1. ncbi request reprint Pharmacokinetic variability of new antiepileptic drugs at different ages
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Ther Drug Monit 27:714-7. 2005
    ..These pharmacokinetic changes are clinically important and con-tribute to age-related differences in dosage requirements...
  2. ncbi request reprint Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Pharmacokinet 45:351-63. 2006
    ....
  3. ncbi request reprint Prenatal exposure to antiepileptic drugs
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Lancet 367:1467-9. 2006
  4. ncbi request reprint What clinical trial designs have been used to test antiepileptic drugs and do we need to change them?
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Epileptic Disord 14:124-31. 2012
    ..This article will review these issues in some detail and discuss how trial designs and regulatory approval processes may evolve in the future to address these concerns...
  5. ncbi request reprint Effects of antiepileptic comedication on levetiracetam pharmacokinetics: a pooled analysis of data from randomized adjunctive therapy trials
    E Perucca
    Department of Internal Medicine and Therapeutics, Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
    Epilepsy Res 53:47-56. 2003
    ..To assess the influence of commonly used antiepileptic drugs (AEDs) on levetiracetam pharmacokinetics at steady state...
  6. doi request reprint Lacosamide
    Emilio Perucca
    Department of Internal Medicine and Therapeutics and Institute of Neurology, IRCCS C Mondino Foundation, University of Pavia, Italy
    Nat Rev Drug Discov 7:973-4. 2008
    ..It was approved by the FDA as an adjunctive therapy for partial-onset seizures in October 2008...
  7. ncbi request reprint Designing clinical trials to assess antiepileptic drugs as monotherapy : difficulties and solutions
    Emilio Perucca
    University of Pavia, Pavia, Italy
    CNS Drugs 22:917-38. 2008
    ....
  8. ncbi request reprint The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come?
    Emilio Perucca
    Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
    Epileptic Disord 5:S17-26. 2003
    ..Although its half-life is relatively short (6 to 8 hours), its duration of action is longer than anticipated from its pharmacokinetics in plasma, and a twice-daily dosing regimen is adequate to produce the desired response...
  9. doi request reprint The treatment of the first seizure: the risks
    Emilio Perucca
    Clinical Pharmacology Unit and Institute of Neurology IRCCS C Mondino Foundation, University of Pavia, Pavia, Italy
    Epilepsia 49:29-34. 2008
    ....
  10. ncbi request reprint Overtreatment in epilepsy: adverse consequences and mechanisms
    Emilio Perucca
    Department of Internal Medicine and Therapeutics, Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
    Epilepsy Res 52:25-33. 2002
    ....
  11. ncbi request reprint Role of valproate across the ages. Treatment of epilepsy in the elderly
    E Perucca
    Institute of Neurology IRCCS C Mondino Foundation, and Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Piazza Botta 10, 27100 Pavia, Italy
    Acta Neurol Scand Suppl 184:28-37. 2006
    ..There was no consensus, however, on whether valproate should be considered among the preferred first-line treatments in the elderly...
  12. ncbi request reprint Recommendations of the Italian League against Epilepsy working group on generic products of antiepileptic drugs
    Emilio Perucca
    Clinical Pharmacology Unit and Institute of Neurology IRCCS C Mondino Foundation, University of Pavia, Pavia, Italy
    Epilepsia 47:16-20. 2006
    ....
  13. pmc Clinically relevant drug interactions with antiepileptic drugs
    Emilio Perucca
    Institute of Neurology IRCCS C Mondino Foundation, Pavia, and Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Br J Clin Pharmacol 61:246-55. 2006
    ..In particular, neurotoxic effects appear to be more likely with coprescription of AEDs sharing the same primary mechanism of action...
  14. ncbi request reprint An introduction to antiepileptic drugs
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia and Institute of Neurology, IRCCS C Mondino Foundation, Pavia, Italy
    Epilepsia 46:31-7. 2005
    ..While a fully mechanistic approach to the clinical use of these agents is not yet feasible, knowledge of mechanisms of action offers useful clues in predicting their efficacy profile and spectrum of potential adverse effects...
  15. ncbi request reprint Can drug resistance in epilepsy be minimized? Challenging commonly held beliefs
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Laboratories for Diagnostics and Applied Biological Research, Institute of Neurology, IRCCS C Mondino Foundation, Pavia, Italy
    Epileptic Disord 7:S14-21. 2005
    ....
  16. ncbi request reprint Pharmacological and clinical aspects of antiepileptic drug use in the elderly
    E Perucca
    Institute of Neurology IRCCS C Mondino Foundation and Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, 27100 Pavia, Italy
    Epilepsy Res 68:S49-63. 2006
    ..Individualization of dosage, avoidance of unnecessary polypharmacy, and careful observation of clinical response are essential for an effective and safe utilization of AEDs in an elderly population...
  17. ncbi request reprint Adverse effects of antiepileptic drugs
    E Perucca
    Department of Internal Medicine and Therapeutics, Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
    Acta Neurol Scand Suppl 181:30-5. 2005
    ..However, further research is needed to confirm the apparent improvement in tolerability offered by some of the newer AEDs...
  18. ncbi request reprint Birth defects after prenatal exposure to antiepileptic drugs
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, and Laboratories for Diagnostics and Applied Biological Research, Institute of Neurology, IRCCS C Mondino Foundation, Pavia, Italy
    Lancet Neurol 4:781-6. 2005
    ..Finally, studies are urgently needed to investigate other potential adverse effects of AED exposure, with special reference to effects on postnatal intellectual development...
  19. doi request reprint The teratogenic risk of antiepileptic drug polytherapy
    Frank J E Vajda
    Department of Medicine and Neurosciences, Royal Melbourne Hospital and University of Melbourne, Parkville, Victoria, Australia
    Epilepsia 51:805-10. 2010
    ..To compare the risks of fetal malformation during pregnancy associated with antiepileptic drug (AED) polytherapy and monotherapy...
  20. ncbi request reprint What can we learn from clinical trials of anticonvulsant drugs in epilepsy?
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Piazza Botta 10, 27100 Pavia, Italy
    Eur J Pain 6:35-44. 2002
    ..Physicians need to be alerted about the importance of these issues, and they should make every possible effort to interpret critically the medical literature on which they rely to guide and support their therapeutic decisions...
  21. doi request reprint New and forthcoming anti-epileptic drugs
    Paolo Prunetti
    National Neurological Institute IRCCS C Mondino Foundation, University of Pavia, Pavia, Italy
    Curr Opin Neurol 24:159-64. 2011
    ..There is a need for newer anti-epileptic drugs (AEDs) with improved efficacy and tolerability. This article reviews AEDs introduced since 2007 and investigational compounds in clinical development...
  22. doi request reprint When clinical trials make history: demonstrating efficacy of new antiepileptic drugs as monotherapy
    Emilio Perucca
    Clinical Pharmacology Unit, University of Pavia, and Clinical Trial Center, Institute of Neurology IRCCS C Mondino Foundation, Pavia, Italy
    Epilepsia 51:1933-5. 2010
    ..Although the avoidance of suboptimal treatments in future trials is a welcome development, the conversion-to-monotherapy design is still far from being fully satisfactory and is not exempt from methodologic concerns...
  23. ncbi request reprint Harnessing the clinical potential of antiepileptic drug therapy: dosage optimisation
    E Perucca
    Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
    CNS Drugs 15:609-21. 2001
    ..For patients considered 'difficult to treat' (i.e. those in whom seizures remain incompletely controlled after several attempts at treatment), referral to a specialist is recommended...
  24. ncbi request reprint The management of refractory idiopathic epilepsies
    E Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Piazza Botta 10, 27100 Pavia, Italy
    Epilepsia 42:31-5. 2001
    ....
  25. ncbi request reprint Trials in the elderly
    E Perucca
    Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
    Epilepsy Res 45:149-51; discussion 153-4. 2001
    ....
  26. ncbi request reprint Trial duration and follow-up
    E Perucca
    Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
    Epilepsy Res 45:123-7; discussion 129-31. 2001
    ..In view of ethical concerns, the rationale for this practice should also be questioned...
  27. ncbi request reprint Is there a role for therapeutic drug monitoring of new anticonvulsants?
    E Perucca
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Clin Pharmacokinet 38:191-204. 2000
    ..Prospective studies, using preferably a randomised concentration-controlled design, are necessary to better characterise concentration-effect relationships for these agents...
  28. ncbi request reprint Marketed new antiepileptic drugs: are they better than old-generation agents?
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Ther Drug Monit 24:74-80. 2002
    ..This view has been challenged in light of the evidence that pharmacokinetic variability contributes to an important extent to differences in dosage requirements for most of these drugs...
  29. ncbi request reprint Clinical pharmacology and therapeutic use of the new antiepileptic drugs
    E Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Fundam Clin Pharmacol 15:405-17. 2001
    ..Due to serious toxicity risks, felbamate and vigabatrin should be prescribed only in patients refractory to other drugs. In the case of vigabatrin, however, first line use may be justified in infants with spasms...
  30. ncbi request reprint Increased apparent oral clearance of valproic acid during intake of combined contraceptive steroids in women with epilepsy
    Carlo Andrea Galimberti
    IRCCS Institute of Neurology C Mondino Foundation, Pavia, Italy
    Epilepsia 47:1569-72. 2006
    ..To determine potential changes in total and unbound serum valproic acid (VPA) concentrations at steady-state during a cycle of intake of combined hormonal contraceptive (HC) steroids...
  31. doi request reprint Genetic basis for idiosyncratic reactions to antiepileptic drugs
    Diego Franciotta
    Foundation Neurological Institute C Mondino, IRCCS, Pavia, Italy
    Curr Opin Neurol 22:144-9. 2009
    ..This article will focus on recent findings concerning genetic factors affecting susceptibility to idiosyncratic reactions to antiepileptic drugs...
  32. doi request reprint Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy
    Emilio Perucca
    Institute of Neurology IRCCS C Mondino Foundation and Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
    Epilepsia 49:1123-41. 2008
    ..The probability of adverse effects also appears to be concentration-related...
  33. ncbi request reprint Improved enantioselective assay for the determination of fluoxetine and norfluoxetine enantiomers in human plasma by liquid chromatography
    Giuliana Gatti
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Piazza Botta 10, 27100, Pavia, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 784:375-83. 2003
    ..Standard curves are linear for each enantiomer (r(2)>/=0.992) over the range of 10-1000 ng/ml with a limit of quantification of 10 ng/ml for each enantiomer. Within-day and between-day CV% are </=10% for each enantiomer...
  34. ncbi request reprint Plasma gabapentin concentrations in children with epilepsy: influence of age, relationship with dosage, and preliminary observations on correlation with clinical response
    Giuliana Gatti
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Ther Drug Monit 25:54-60. 2003
    ..There seems to be a large variation in the plasma concentrations of the drug associated with a favorable therapeutic response...
  35. ncbi request reprint Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    CNS Drugs 16:695-714. 2002
    ..However, the precise relevance of the latter findings remains to be evaluated in large, prospective, randomised studies...
  36. ncbi request reprint Overtreatment in epilepsy: how it occurs and how it can be avoided
    Emilio Perucca
    Institute of Neurology IRCCS, C Mondino Foundation, Pavia, ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    CNS Drugs 19:897-908. 2005
    ..Even though the importance of complete seizure control cannot be overemphasised, no patient should be made to suffer more from the adverse effects of treatment than from the manifestations of the seizure disorder...
  37. ncbi request reprint The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data
    Cinzia Fattore
    Clinical Pharmacology Unit, University of Pavia, Piazza Botta 10, Pavia, Italy
    Epilepsy Res 70:153-60. 2006
    ..To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication...
  38. ncbi request reprint Pharmacokinetics of dextromoramide in surgical patients
    I Pagani
    Department of Pharmacology and Anesthesiology, University of Pavia, Italy
    Fundam Clin Pharmacol 3:27-35. 1989
    ..Less than 0.06% of the dose was excreted unchanged in urine within 8 h of administration. The concentration of the drug in a CSF sample collected 1 h after dosing was below the limit of detection (2 micrograms/L) in all subjects...
  39. ncbi request reprint Effects on cimetidine bioavailability of metoclopramide and antacids given two hours apart
    N Barzaghi
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Eur J Clin Pharmacol 37:409-10. 1989
    ..The bioavailability of cimetidine was not significantly affected by metoclopramide and it was marginally reduced by the antacid...
  40. pmc The disposition of primidone in elderly patients
    C Martines
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Br J Clin Pharmacol 30:607-11. 1990
    ..Elderly patients excreted a reduced proportion of unchanged primidone and an increased proportion of PEMA in urine. 5. Ageing is associated with a greater accumulation of PEMA, which is unlikely to have a major clinical significance...
  41. ncbi request reprint Changes in the disposition of oxcarbazepine and its metabolites during pregnancy and the puerperium
    Iolanda Mazzucchelli
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Epilepsia 47:504-9. 2006
    ..To determine potential changes in the plasma concentrations of oxcarbazepine (OXC) and its metabolites during pregnancy and puerperium...
  42. doi request reprint Characteristics of a large population of patients with refractory epilepsy attending tertiary referral centers in Italy
    Veriano Alexandre
    Institute of Neurology IRCCS C Mondino Foundation, Pavia, Italy
    Epilepsia 51:921-5. 2010
    ..2%) in adults, and disorders of cortical development (14.7%) and nonprogressive encephalopathies (6.8%) in children. More than three-fourths of subjects in both age groups were on antiepileptic drug (AED) polytherapy...
  43. ncbi request reprint Current trends in antiepileptic drug therapy
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Epilepsia 44:41-7. 2003
    ..Additional important developments may come from the discovery of novel, more efficacious AEDs and from exploration of potential new targets, such as prevention of epileptogenesis...
  44. ncbi request reprint Development of new antiepileptic drugs: challenges, incentives, and recent advances
    Emilio Perucca
    Institute of Neurology, IRCCS C Mondino Foundation, Pavia, Italy
    Lancet Neurol 6:793-804. 2007
    ....
  45. doi request reprint Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures
    E Perucca
    Department of Internal Medicine and Therapeutics, University of Pavia, and Clinical Trial Center, National Institute of Neurology IRCCS C Mondino Foundation, Pavia, Italy
    Epilepsy Res 96:132-9. 2011
    ..To evaluate the pharmacokinetics of eslicarbazepine acetate (ESL) at steady-state in adults with partial-onset seizures who have taken ESL for at least 1 year with one or two concomitant antiepileptic drugs (AEDs)...
  46. ncbi request reprint Single-dose pharmacokinetics of lamotrigine in children: influence of age and antiepileptic comedication
    D Battino
    Carlo Besta Neurological Institute, Milan; and Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
    Ther Drug Monit 23:217-22. 2001
    ..On the other hand, the lower plasma lamotrigine levels in children than in adolescents and older patients may not be explainable solely by differences in metabolic rate...
  47. ncbi request reprint A novel enantioselective microassay for the high-performance liquid chromatography determination of oxcarbazepine and its active metabolite monohydroxycarbazepine in human plasma
    Iolanda Mazzucchelli
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Ther Drug Monit 29:319-24. 2007
    ..However, because the two enantiomers of monohydroxycarbazepine exhibit similar pharmacologic activity, nonenantioselective assays are likely to be more cost-effective for therapeutic drug monitoring purposes...
  48. ncbi request reprint Age-related changes in pharmacokinetics: predictability and assessment methods
    Emilio Perucca
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Int Rev Neurobiol 81:183-99. 2007
    ....
  49. doi request reprint Changes in lamotrigine pharmacokinetics during pregnancy and the puerperium
    Valentina Franco
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Ther Drug Monit 30:544-7. 2008
    ....
  50. ncbi request reprint Effects of phenytoin on the in vivo kinetics of thiamine and its phosphoesters in rat nervous tissues
    C Patrini
    Institute of Human Physiology, University of Pavia, Italy
    Brain Res 628:179-86. 1993
    ....
  51. ncbi request reprint Stereoselective determination of vigabatrin enantiomers in human plasma by high performance liquid chromatography using UV detection
    Valentina Franco
    Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 854:63-7. 2007
    ..999) over the range of 0.5-40 microg/mL for each enantiomer, with a limit of quantification of 0.5 microg/mL for both analytes. The assay is suitable for therapeutic drug monitoring and for single-dose pharmacokinetic studies in man...
  52. ncbi request reprint Old versus new antiepileptic drugs: the SANAD study
    Emilio Perucca
    Lancet 370:313; author reply 315-6. 2007
  53. ncbi request reprint Influence of aging on serum phenytoin concentrations: a pharmacokinetic analysis based on therapeutic drug monitoring data
    Dina Battino
    Carlo Besta National Neurological Institute, Via Celoria 11, 20133 Milan, Italy
    Epilepsy Res 59:155-65. 2004
    ..Interpretation of the latter, however, should take into account the possibility of an increase in the fraction of unbound drug...
  54. doi request reprint Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats
    Jean Bernard Manent
    INSERM U29, INMED, Marseille F 13009, France
    Epilepsy Res 78:131-9. 2008
    ..These observations raise concerns about potential clinical correlates and call for detailed comparative investigations on the consequences of AED use during pregnancy...
  55. ncbi request reprint Influence of dosage, age, and co-medication on plasma topiramate concentrations in children and adults with severe epilepsy and preliminary observations on correlations with clinical response
    Anna Rita Ferrari
    IRCCS Stella Maris Foundation, University of Pisa, Pisa, Italy
    Ther Drug Monit 25:700-8. 2003
    ..The marked increase in TPM clearance caused by enzyme-inducing co-medication was confirmed...
  56. doi request reprint Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
    Philip N Patsalos
    Institute of Neurology The National Hospital for Neurology and Neurosurgery, London and The Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom
    Epilepsia 49:1239-76. 2008
    ..g., in pregnancy, or when an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-dependent pharmacokinetics, particularly phenytoin...
  57. ncbi request reprint Translating monotherapy trials into clinical practice: a look into the abyss
    Santiago Arroyo
    Department of Neurology, Medical College of Wisconsin, Froedtert Hospital, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Epilepsy Behav 4:457-63. 2003
    ..Such information becomes available only through general clinical experience, well-designed phase IV studies, and postmarketing surveillance...
  58. ncbi request reprint Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine
    Maria G Scordo
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
    Basic Clin Pharmacol Toxicol 97:296-301. 2005
    ..05). These results suggest that CYP2D6 and CYP2C9 polymorphisms contribute to the interindividual variability in fluoxetine pharmacokinetics at steady-state...
  59. doi request reprint Pregnancy registries in epilepsy: a consensus statement on health outcomes
    K J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Neurology 71:1109-17. 2008
    ..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...
  60. ncbi request reprint Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs
    Philip N Patsalos
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK
    Lancet Neurol 2:473-81. 2003
    ..Careful monitoring of clinical response is recommended whenever a drug is added or removed from a patient's AED regimen...
  61. ncbi request reprint Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs
    Philip N Patsalos
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK
    Lancet Neurol 2:347-56. 2003
    ..Interactions involving enzyme inhibition include the increase in plasma concentrations of lamotrigine and phenobarbital caused by valproic acid. Among AEDs, the least potential interaction is associated with gabapentin and levetiracetam...
  62. ncbi request reprint Serum carbamazepine concentrations in elderly patients: a case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data
    Dina Battino
    Carlo Besta National Neurological Institute, Milan, Italy
    Epilepsia 44:923-9. 2003
    ..To assess the influence of aging on the steady-state pharmacokinetics of carbamazepine (CBZ) in a large population of patients evaluated in a therapeutic drug monitoring (TDM) setting...
  63. ncbi request reprint Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical response
    Giovanna Jannuzzi
    Clinical Pharmacology Unit and University of Pavia, Italy
    Ther Drug Monit 24:616-27. 2002
    ..In addition, a considerable variability was found in the enantiomers' concentrations associated with a favorable therapeutic response...
  64. ncbi request reprint Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction
    Edoardo Spina
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Messina, Italy
    J Clin Psychopharmacol 22:419-23. 2002
    ..This interaction may lead to toxic plasma risperidone concentrations. In addition to careful clinical observation, monitoring plasma risperidone levels may be of value in patients given adjunctive therapy with fluoxetine...
  65. ncbi request reprint Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: a randomized controlled study
    Antonio de Santis
    Institute of Neurosurgery, Policlinico IRCCS, University of Milan, Italy
    Epilepsia 43:175-82. 2002
    ..To determine the potential effectiveness of phenytoin (PHT) in preventing early postoperative seizures in patients undergoing craniotomy for supratentorial brain tumors...
  66. ncbi request reprint Vigabatrin and epilepsy: lessons learned
    John M Wild
    Cardiff School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
    Epilepsia 48:1318-27. 2007
    ..The risk factors for visual field loss attributable to vigabatrin (VAVFL) are equivocal. This multinational, prospective, observational study aimed to clarify the principal/major factors for VAVFL...
  67. ncbi request reprint An international multicenter randomized double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly
    Erik Saetre
    The Epilepsy Unit, Ullevaal University Hospital, Oslo, Norway
    Epilepsia 48:1292-302. 2007
    ..To assess the comparative effectiveness, efficacy, and tolerability of lamotrigine (LTG) and sustained-release carbamazepine (CBZ) in the treatment of newly diagnosed epilepsy in the elderly...
  68. ncbi request reprint A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy
    Dorit Mimrod
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Epilepsia 46:1046-54. 2005
    ..To compare the influence of enzyme-inducing comedication and valproic acid (VPA) on topiramate (TPM) pharmacokinetics and metabolism at steady state...
  69. ncbi request reprint Topiramate pharmacokinetics in children and adults with epilepsy: a case-matched comparison based on therapeutic drug monitoring data
    Dina Battino
    Carlo Besta National Neurological Institute, Milan, Italy
    Clin Pharmacokinet 44:407-16. 2005
    ..To compare the steady-state pharmacokinetics of topiramate in a large population of children and adults with epilepsy in a therapeutic drug monitoring setting...
  70. ncbi request reprint Effect of levetiracetam on the pharmacokinetics of adjunctive antiepileptic drugs: a pooled analysis of data from randomized clinical trials
    Barry E Gidal
    School of Pharmacy and Department of Neurology, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    Epilepsy Res 64:1-11. 2005
    ..Consequently, no need for adjusting the dosages of these AEDs is anticipated when levetiracetam is added on or removed from a patient's therapeutic regimen...
  71. pmc Epilepsy after head injury
    RAIMONDO D'AMBROSIO
    Department of Neurological Surgery and Regional Epilepsy Center, University of Washington, Seattle, Washington, USA
    Curr Opin Neurol 17:731-5. 2004
    ..The purpose of this short review is to provide an update on the epidemiology of posttraumatic epilepsy, associated risk factors, data from prevention studies, and recent breakthroughs in experimental research...
  72. ncbi request reprint Measurement of seizure freedom in adjunctive therapy studies in refractory partial epilepsy: the levetiracetam experience
    Ilo Leppik
    University of Minnesota and MINCEP Epilepsy Care, Minneapolis, Minnesota, USA
    Epileptic Disord 8:118-30. 2006
    ....
  73. ncbi request reprint ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes
    Tracy Glauser
    Division of Neurology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Epilepsia 47:1094-120. 2006
    ..To assess which antiepileptic medications (AEDs) have the best evidence for long-term efficacy or effectiveness as initial monotherapy for patients with newly diagnosed or untreated epilepsy...
  74. ncbi request reprint Pharmacokinetic and metabolic investigation of topiramate disposition in healthy subjects in the absence and in the presence of enzyme induction by carbamazepine
    Malka Britzi
    Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Epilepsia 46:378-84. 2005
    ..To characterize the metabolic profile of topiramate (TPM) in humans and to assess the influence of enzyme induction by carbamazepine (CBZ) on the pharmacokinetics and metabolic profile of TPM...
  75. ncbi request reprint Treatment of status epilepticus in adults: guidelines of the Italian League against Epilepsy
    Fabio Minicucci
    Clinical Neurophysiology, San Raffaele Hospital, Milan, Italy
    Epilepsia 47:9-15. 2006
    ..In refractory SE, general anesthesia may be required. Propofol and thiopental represent first line agents in this setting, after careful assessment of potential risks and benefits...
  76. ncbi request reprint Phenobarbital pharmacokinetics in old age: a case-matched evaluation based on therapeutic drug monitoring data
    Sara Messina
    Carlo Besta National Neurological Institute, Milan, Italy
    Epilepsia 46:372-7. 2005
    ..To assess the influence of aging on the pharmacokinetics of phenobarbital (PB) at steady state in patients receiving long-term therapy...
  77. ncbi request reprint Idiosyncratic adverse reactions to antiepileptic drugs
    Gaetano Zaccara
    Neurology Unit, ASL 10, Firenze, Italy
    Epilepsia 48:1223-44. 2007
    ..Serious consequences of idiosyncratic reactions can be minimized by knowledge of risk factors, avoidance of specific AEDs in subpopulations at risk, cautious dose titration, and careful monitoring of clinical response...
  78. ncbi request reprint Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII)
    Meir Bialer
    Department of Pharmaceutics, Faculty of Medicine, School of Pharmacy and David R Bloom Center for Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
    Epilepsy Res 61:1-48. 2004
    ....
  79. ncbi request reprint Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias
    Jean Bernard Manent
    INMED, INSERM U29, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Epilepsia 48:684-93. 2007
    ..The purpose of this study was to investigate the consequences of prenatal exposure to (a) different AEDs and (b) maternal seizures on brain maturational processes in rats...
  80. ncbi request reprint Navigating toward fetal and maternal health: the challenge of treating epilepsy in pregnancy
    Torbjorn Tomson
    Department of Neurology, Karolinska Hospital, Stockholm, Sweden torbjorn tomson kus se
    Epilepsia 45:1171-5. 2004
    ....
  81. ncbi request reprint EURAP: an international registry of antiepileptic drugs and pregnancy
    Torbjorn Tomson
    Epilepsia 45:1463-4. 2004
  82. ncbi request reprint Pharmacology of antiepileptic drugs during pregnancy and lactation
    Page B Pennell
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Epilepsy Behav 11:263-9. 2007
    ..The report provides an overview of these key topics, highlights gaps in the current knowledge, and provides future directions for needed research...
  83. ncbi request reprint Hormone replacement therapy in women with epilepsy
    Hadi Meeran Hussain
    Epilepsia 48:1030-1; author reply 1031-2. 2007
  84. ncbi request reprint Epilepsy in elderly people: management issues
    Ray Tallis
    Department of Gerontology, University of Manchester, UK
    Epileptic Disord 4:S33-9. 2002
    ..Together with a growing array of antiepileptic medication from which to choose, these factors make the management of epilepsy in elderly people particularly challenging...
  85. pmc Treatment of epilepsy in developing countries
    Emilio Perucca
    BMJ 334:1175-6. 2007