Antonio M Persico

Summary

Affiliation: University Campus Bio-Medico
Country: Italy

Publications

  1. ncbi request reprint Reelin is a serine protease of the extracellular matrix
    Carlo C Quattrocchi
    Laboratory of Neuroscience, Department of Physiology and Neuroscience, Università Campus Bio Medico, Via Longoni 83, 00155 Roma, Italy
    J Biol Chem 277:303-9. 2002
  2. ncbi request reprint Multiple receptors mediate the trophic effects of serotonin on ventroposterior thalamic neurons in vitro
    Antonio M Persico
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Emilio Longoni 83, I 00155 Rome, Italy
    Brain Res 1095:17-25. 2006
  3. ncbi request reprint Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
    Antonio M Persico
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155, Rome, Italy
    Trends Neurosci 29:349-58. 2006
  4. ncbi request reprint Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study
    C Altamura
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
    Cereb Cortex 17:1394-401. 2007
  5. pmc A genetic variant that disrupts MET transcription is associated with autism
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 103:16834-9. 2006
  6. pmc Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder
    Valerio Napolioni
    Neurogenomics Division, The Translational Genomics Research Institute TGen, 445 N Fifth Street, Phoenix, AZ 85004, USA
    J Neuroinflammation 10:38. 2013
  7. doi request reprint Autism genetics
    Antonio M Persico
    Child and Adolescent NeuroPsychiatry Unit, University Campus Bio Medico, Rome, Italy
    Behav Brain Res 251:95-112. 2013
  8. doi request reprint Urinary p-cresol in autism spectrum disorder
    Antonio M Persico
    Child and Adolescent NeuroPsychiatry Unit, University Campus Bio Medico, Rome, Italy
    Neurotoxicol Teratol 36:82-90. 2013
  9. pmc Candidate gene study of HOXB1 in autism spectrum disorder
    Lucia A Muscarella
    Medical Genetics Service, IRCCS Casa Sollievo dalla Sofferenza, San Giovanni Rotondo, FG, Italy
    Mol Autism 1:9. 2010
  10. pmc Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
    Simon G Gregory
    Duke Center for Human Genetics, DUMC, Durham, NC, USA
    BMC Med 7:62. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Reelin is a serine protease of the extracellular matrix
    Carlo C Quattrocchi
    Laboratory of Neuroscience, Department of Physiology and Neuroscience, Università Campus Bio Medico, Via Longoni 83, 00155 Roma, Italy
    J Biol Chem 277:303-9. 2002
    ..The proteolytic activity of Reelin on adhesion molecules of the extracellular matrix and/or receptors on neurons may explain how Reelin regulates neuronal migration and synaptic plasticity...
  2. ncbi request reprint Multiple receptors mediate the trophic effects of serotonin on ventroposterior thalamic neurons in vitro
    Antonio M Persico
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Emilio Longoni 83, I 00155 Rome, Italy
    Brain Res 1095:17-25. 2006
    ..Trophic 5-HT effects on embryonic VPT neurons are thus much more prominent than previously reported, and can be mediated by multiple 5-HT receptor subtypes...
  3. ncbi request reprint Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
    Antonio M Persico
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155, Rome, Italy
    Trends Neurosci 29:349-58. 2006
    ..This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/)...
  4. ncbi request reprint Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study
    C Altamura
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
    Cereb Cortex 17:1394-401. 2007
    ..These results provide evidence of 5-HTT gene effects on neocortical morphology in epistatic interaction with genetic variants at other loci and may model the effect of functional 5-HTT gene variants on neocortical development in autism...
  5. pmc A genetic variant that disrupts MET transcription is associated with autism
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37203, USA
    Proc Natl Acad Sci U S A 103:16834-9. 2006
    ..These data implicate reduced MET gene expression in autism susceptibility, providing evidence of a previously undescribed pathophysiological basis for this behaviorally and medically complex disorder...
  6. pmc Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder
    Valerio Napolioni
    Neurogenomics Division, The Translational Genomics Research Institute TGen, 445 N Fifth Street, Phoenix, AZ 85004, USA
    J Neuroinflammation 10:38. 2013
    ..In the current study, we used plasma-cytokine profiling for 25 discordant sibling pairs to evaluate whether these alterations occur within families with ASD...
  7. doi request reprint Autism genetics
    Antonio M Persico
    Child and Adolescent NeuroPsychiatry Unit, University Campus Bio Medico, Rome, Italy
    Behav Brain Res 251:95-112. 2013
    ..Finally, the recent contributions of genome-wide association and whole exome sequencing studies will be highlighted. ..
  8. doi request reprint Urinary p-cresol in autism spectrum disorder
    Antonio M Persico
    Child and Adolescent NeuroPsychiatry Unit, University Campus Bio Medico, Rome, Italy
    Neurotoxicol Teratol 36:82-90. 2013
    ..P-cresol may contribute to worsen autism severity and gut dysfunction, often present in autistic children. It may also contribute to a multibiomarker diagnostic panel useful in small autistic children...
  9. pmc Candidate gene study of HOXB1 in autism spectrum disorder
    Lucia A Muscarella
    Medical Genetics Service, IRCCS Casa Sollievo dalla Sofferenza, San Giovanni Rotondo, FG, Italy
    Mol Autism 1:9. 2010
    ..An initial report, suggesting that HOXB1 could confer autism vulnerability in interaction with HOXA1, was not confirmed by five small association studies...
  10. pmc Genomic and epigenetic evidence for oxytocin receptor deficiency in autism
    Simon G Gregory
    Duke Center for Human Genetics, DUMC, Durham, NC, USA
    BMC Med 7:62. 2009
    ..Although numerous approaches have been used to identify genes implicated in the development of autism, less than 10% of autism cases have been attributed to single gene disorders...
  11. pmc Methodological factors influencing measurement and processing of plasma reelin in humans
    Giovanni Lugli
    Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, MC 912, 1601 W, Taylor Street, Chicago, IL 60612, USA
    BMC Biochem 4:9. 2003
    ..Here we describe the methodological and biological foundation for carrying out and interpreting clinical studies of plasma reelin...
  12. ncbi request reprint Reduced programmed cell death in brains of serotonin transporter knockout mice
    Antonio M Persico
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Italy
    Neuroreport 14:341-4. 2003
    ....
  13. ncbi request reprint Enhanced APOE2 transmission rates in families with autistic probands
    A M Persico
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    Psychiatr Genet 14:73-82. 2004
    ....
  14. pmc Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes
    Valerio Napolioni
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    Eur J Hum Genet 19:353-9. 2011
    ..Our results also raise interest into ITGB3 influences on feto-maternal immune interactions in autism...
  15. doi request reprint Cluster analysis of autistic patients based on principal pathogenetic components
    Roberto Sacco
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    Autism Res 5:137-47. 2012
    ..7 x 10(-45)), followed by "stereotypic behaviors." These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment...
  16. pmc Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1
    Roberto Sacco
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
    BMC Med Genet 8:11. 2007
    ..Hyperserotoninemia, macrocephaly, and peptiduria represent some of the best-characterized endophenotypes in autism research...
  17. doi request reprint Urinary p-cresol is elevated in small children with severe autism spectrum disorder
    Laura Altieri
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Alvaro del Portillo 21, Rome, Italy
    Biomarkers 16:252-60. 2011
    ..Hence, elevated urinary p-cresol may serve as a biomarker of autism liability in small children, especially females and more severely affected males...
  18. doi request reprint Principal pathogenetic components and biological endophenotypes in autism spectrum disorders
    Roberto Sacco
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    Autism Res 3:237-52. 2010
    ....
  19. ncbi request reprint Clinical, morphological, and biochemical correlates of head circumference in autism
    Roberto Sacco
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, and I R C C S Fondazione Santa Lucia, Rome, Italy
    Biol Psychiatry 62:1038-47. 2007
    ..Head growth rates are often accelerated in autism. This study is aimed at defining the clinical, morphological, and biochemical correlates of head circumference in autistic patients...
  20. doi request reprint Decreased serum arylesterase activity in autism spectrum disorders
    Laura Gaita
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    Psychiatry Res 180:105-13. 2010
    ....
  21. doi request reprint Neocortical RELN promoter methylation increases significantly after puberty
    Carla Lintas
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuroreport 21:114-8. 2010
    ..Sex hormones thus seemingly boost DNA methylation at the RELN promoter. This physiological change could significantly contribute to the onset of schizophrenia and the worsening of autistic behaviors, both typically occurring at puberty...
  22. pmc Lack of infection with XMRV or other MLV-related viruses in blood, post-mortem brains and paternal gametes of autistic individuals
    Carla Lintas
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    PLoS ONE 6:e16609. 2011
    ..Recently, the xenotropic murine leukemia virus-related virus (XMRV) has been implicated in chronic fatigue syndrome (CFS) and in prostate cancer by several, though not all studies...
  23. doi request reprint Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy
    Valerio Napolioni
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    Cytokine 56:481-8. 2011
    ..In conclusion, we report that a combination of functional SNPs within ADA and TNF-α genes can influence life-expectancy in a gender-specific manner and that males and females follow different pathways to attain longevity...
  24. ncbi request reprint The neurobiological context of autism
    Flavio Keller
    Laboratory of Developmental Neuroscience and Neural Plasticity, Università Campus Bio Medico, Roma, Italy
    Mol Neurobiol 28:1-22. 2003
    ..These considerations suggest that a non-deterministic conceptual framework is highly appropriate for autism research...
  25. ncbi request reprint Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autism
    Monica Conciatori
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
    Biol Psychiatry 55:413-9. 2004
    ..The HOXA1 gene plays a major role in brainstem and cranial morphogenesis. The G allele of the HOXA1 A218G polymorphism has been previously found associated with autism...
  26. doi request reprint Association of autism with polyomavirus infection in postmortem brains
    Carla Lintas
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    J Neurovirol 16:141-9. 2010
    ..7%, respectively; P = .08). Follow-up studies exploring vertical viral transmission as a possible pathogenetic mechanism in autistic disorder should focus on, but not be limited to, the role of polyomaviruses...
  27. doi request reprint Genome-wide expression studies in autism spectrum disorder, Rett syndrome, and Down syndrome
    Carla Lintas
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
    Neurobiol Dis 45:57-68. 2012
    ..This conclusion may be important for the definition of pharmacological therapies able to ameliorate clinical symptoms across these disorders...
  28. doi request reprint The mitochondrial aspartate/glutamate carrier AGC1 and calcium homeostasis: physiological links and abnormalities in autism
    Valerio Napolioni
    Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Alvaro del Portillo 21, 00128 Rome, Italy
    Mol Neurobiol 44:83-92. 2011
    ..Here, we review the physiological roles of AGC1, its links to calcium homeostasis, and its involvement in autism pathogenesis...
  29. ncbi request reprint HOXA1 gene variants influence head growth rates in humans
    Lucia Anna Muscarella
    Medical Genetics Service, I R C C S Casa Sollievo dalla Sofferenza, S Giovanni Rotondo, Foggia, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:388-90. 2007
    ..This influence does not differ between normal and autistic children, whereas the lack of FMRP seemingly overwhelms HOXA1 effects in fragile-X patients...
  30. ncbi request reprint Transmission disequilibrium study of an oligodendrocyte and myelin glycoprotein gene allele in 431 families with an autistic proband
    Isabelle Martin
    INSERM, U619, Universite Francois Rabelais de Tours, CHRU de Tours, Faculte de Medecine, 10 boulevard Tonnelle, BP3223, 37032, Tours Cedex, France
    Neurosci Res 59:426-30. 2007
    ..The associations observed in Japanese and French patients, the linkage studies and the present work speak in favor of the existence of a susceptibility gene for autism in the NF1 locus...
  31. pmc Immune transcriptome alterations in the temporal cortex of subjects with autism
    Krassimira Garbett
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37203 USA
    Neurobiol Dis 30:303-11. 2008
    ....
  32. ncbi request reprint Disruption of cerebral cortex MET signaling in autism spectrum disorder
    Daniel B Campbell
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37203, USA
    Ann Neurol 62:243-50. 2007
    ..Here we examined expression levels of MET and members of the MET signaling pathway in postmortem cerebral cortex from ASD cases and healthy control subjects...
  33. ncbi request reprint Association of a functional deficit of the BKCa channel, a synaptic regulator of neuronal excitability, with autism and mental retardation
    Frederic Laumonnier
    INSERM U619 Génétique de l autisme et des déficiences mentales, Laboratoire de génétique chromosomique, CHR La Source BP86709 45067 Orléans cedex 2, France
    Am J Psychiatry 163:1622-9. 2006
    ..In this study, the authors analyzed a balanced reciprocal translocation arising de novo in a subject with autism and mental retardation...
  34. pmc A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease
    Antony E Shrimpton
    Department of Clinical Pathology, State University of New York, Upstate Medical University, Syracuse, 13210, USA
    Am J Hum Genet 75:92-6. 2004
    ..In the study family, this mutation was fully penetrant and exhibited significant evidence of linkage (LOD 6.33; theta =0), and it very likely accounts for both CVT and CMT in heterozygotes...
  35. ncbi request reprint Serotonergic regulation of somatosensory cortical development: lessons from genetic mouse models
    Xiaoyan Luo
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Dev Neurosci 25:173-83. 2003
    ..Here we review evidence from these genetic mouse models and, based on the accumulated evidence, propose a testable model for future studies of mechanisms underlying serotonergic regulation of cortical development...