Research Topics
Genomes and Genes | Antonio M PersicoSummaryAffiliation: University Campus Bio-Medico Country: Italy Publications
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Detail Information
Publications
Reelin is a serine protease of the extracellular matrixCarlo C Quattrocchi
Laboratory of Neuroscience, Department of Physiology and Neuroscience, Università Campus Bio Medico, Via Longoni 83, 00155 Roma, Italy
J Biol Chem 277:303-9. 2002..The proteolytic activity of Reelin on adhesion molecules of the extracellular matrix and/or receptors on neurons may explain how Reelin regulates neuronal migration and synaptic plasticity...- Multiple receptors mediate the trophic effects of serotonin on ventroposterior thalamic neurons in vitroAntonio M Persico
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Emilio Longoni 83, I 00155 Rome, Italy
Brain Res 1095:17-25. 2006..Trophic 5-HT effects on embryonic VPT neurons are thus much more prominent than previously reported, and can be mediated by multiple 5-HT receptor subtypes... - Searching for ways out of the autism maze: genetic, epigenetic and environmental cluesAntonio M Persico
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155, Rome, Italy
Trends Neurosci 29:349-58. 2006..This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/)... - Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation studyC Altamura
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
Cereb Cortex 17:1394-401. 2007..These results provide evidence of 5-HTT gene effects on neocortical morphology in epistatic interaction with genetic variants at other loci and may model the effect of functional 5-HTT gene variants on neocortical development in autism... 
A genetic variant that disrupts MET transcription is associated with autismDaniel B Campbell
Department of Pharmacology, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37203, USA
Proc Natl Acad Sci U S A 103:16834-9. 2006..These data implicate reduced MET gene expression in autism susceptibility, providing evidence of a previously undescribed pathophysiological basis for this behaviorally and medically complex disorder...- Candidate gene study of HOXB1 in autism spectrum disorderLucia A Muscarella
Medical Genetics Service, IRCCS Casa Sollievo dalla Sofferenza, San Giovanni Rotondo, FG, Italy
Mol Autism 1:9. 2010..An initial report, suggesting that HOXB1 could confer autism vulnerability in interaction with HOXA1, was not confirmed by five small association studies... - Genomic and epigenetic evidence for oxytocin receptor deficiency in autismSimon G Gregory
Duke Center for Human Genetics, DUMC, Durham, NC, USA
BMC Med 7:62. 2009..Although numerous approaches have been used to identify genes implicated in the development of autism, less than 10% of autism cases have been attributed to single gene disorders... 
Methodological factors influencing measurement and processing of plasma reelin in humansGiovanni Lugli
Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, MC 912, 1601 W, Taylor Street, Chicago, IL 60612, USA
BMC Biochem 4:9. 2003..Here we describe the methodological and biological foundation for carrying out and interpreting clinical studies of plasma reelin...- Enhanced APOE2 transmission rates in families with autistic probandsA M Persico
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
Psychiatr Genet 14:73-82. 2004.... - Reduced programmed cell death in brains of serotonin transporter knockout miceAntonio M Persico
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Italy
Neuroreport 14:341-4. 2003.... 
Cluster analysis of autistic patients based on principal pathogenetic componentsRoberto Sacco
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
Autism Res 5:137-47. 2012..7 x 10(-45)), followed by "stereotypic behaviors." These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment...- Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypesValerio Napolioni
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
Eur J Hum Genet 19:353-9. 2011..Our results also raise interest into ITGB3 influences on feto-maternal immune interactions in autism... - Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1Roberto Sacco
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
BMC Med Genet 8:11. 2007..Hyperserotoninemia, macrocephaly, and peptiduria represent some of the best-characterized endophenotypes in autism research... - Clinical, morphological, and biochemical correlates of head circumference in autismRoberto Sacco
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, and I R C C S Fondazione Santa Lucia, Rome, Italy
Biol Psychiatry 62:1038-47. 2007..Head growth rates are often accelerated in autism. This study is aimed at defining the clinical, morphological, and biochemical correlates of head circumference in autistic patients... - Principal pathogenetic components and biological endophenotypes in autism spectrum disordersRoberto Sacco
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
Autism Res 3:237-52. 2010.... - Neocortical RELN promoter methylation increases significantly after pubertyCarla Lintas
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, IRCCS Fondazione Santa Lucia, Rome, Italy
Neuroreport 21:114-8. 2010..Sex hormones thus seemingly boost DNA methylation at the RELN promoter. This physiological change could significantly contribute to the onset of schizophrenia and the worsening of autistic behaviors, both typically occurring at puberty... - Urinary p-cresol is elevated in small children with severe autism spectrum disorderLaura Altieri
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Alvaro del Portillo 21, Rome, Italy
Biomarkers 16:252-60. 2011..Hence, elevated urinary p-cresol may serve as a biomarker of autism liability in small children, especially females and more severely affected males... - Decreased serum arylesterase activity in autism spectrum disordersLaura Gaita
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
Psychiatry Res 180:105-13. 2010.... - Lack of infection with XMRV or other MLV-related viruses in blood, post-mortem brains and paternal gametes of autistic individualsCarla Lintas
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
PLoS ONE 6:e16609. 2011..Recently, the xenotropic murine leukemia virus-related virus (XMRV) has been implicated in chronic fatigue syndrome (CFS) and in prostate cancer by several, though not all studies... - Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancyValerio Napolioni
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
Cytokine 56:481-8. 2011..In conclusion, we report that a combination of functional SNPs within ADA and TNF-α genes can influence life-expectancy in a gender-specific manner and that males and females follow different pathways to attain longevity... - The neurobiological context of autismFlavio Keller
Laboratory of Developmental Neuroscience and Neural Plasticity, Università Campus Bio Medico, Roma, Italy
Mol Neurobiol 28:1-22. 2003..These considerations suggest that a non-deterministic conceptual framework is highly appropriate for autism research... - Association of autism with polyomavirus infection in postmortem brainsCarla Lintas
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
J Neurovirol 16:141-9. 2010..7%, respectively; P = .08). Follow-up studies exploring vertical viral transmission as a possible pathogenetic mechanism in autistic disorder should focus on, but not be limited to, the role of polyomaviruses... - Genome-wide expression studies in autism spectrum disorder, Rett syndrome, and Down syndromeCarla Lintas
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Rome, Italy
Neurobiol Dis 45:57-68. 2012..This conclusion may be important for the definition of pharmacological therapies able to ameliorate clinical symptoms across these disorders... - The mitochondrial aspartate/glutamate carrier AGC1 and calcium homeostasis: physiological links and abnormalities in autismValerio Napolioni
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Alvaro del Portillo 21, 00128 Rome, Italy
Mol Neurobiol 44:83-92. 2011..Here, we review the physiological roles of AGC1, its links to calcium homeostasis, and its involvement in autism pathogenesis... - Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autismMonica Conciatori
Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio Medico, Via Longoni 83, I 00155 Rome, Italy
Biol Psychiatry 55:413-9. 2004..The HOXA1 gene plays a major role in brainstem and cranial morphogenesis. The G allele of the HOXA1 A218G polymorphism has been previously found associated with autism... - Transmission disequilibrium study of an oligodendrocyte and myelin glycoprotein gene allele in 431 families with an autistic probandIsabelle Martin
INSERM, U619, Universite Francois Rabelais de Tours, CHRU de Tours, Faculte de Medecine, 10 boulevard Tonnelle, BP3223, 37032, Tours Cedex, France
Neurosci Res 59:426-30. 2007..The associations observed in Japanese and French patients, the linkage studies and the present work speak in favor of the existence of a susceptibility gene for autism in the NF1 locus... - HOXA1 gene variants influence head growth rates in humansLucia Anna Muscarella
Medical Genetics Service, I R C C S Casa Sollievo dalla Sofferenza, S Giovanni Rotondo, Foggia, Italy
Am J Med Genet B Neuropsychiatr Genet 144:388-90. 2007..This influence does not differ between normal and autistic children, whereas the lack of FMRP seemingly overwhelms HOXA1 effects in fragile-X patients... - Immune transcriptome alterations in the temporal cortex of subjects with autismKrassimira Garbett
Department of Psychiatry, Vanderbilt University, Nashville, TN 37203 USA
Neurobiol Dis 30:303-11. 2008.... - Association of a functional deficit of the BKCa channel, a synaptic regulator of neuronal excitability, with autism and mental retardationFrederic Laumonnier
INSERM U619 Génétique de l autisme et des déficiences mentales, Laboratoire de génétique chromosomique, CHR La Source BP86709 45067 Orléans cedex 2, France
Am J Psychiatry 163:1622-9. 2006..In this study, the authors analyzed a balanced reciprocal translocation arising de novo in a subject with autism and mental retardation... - A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth diseaseAntony E Shrimpton
Department of Clinical Pathology, State University of New York, Upstate Medical University, Syracuse, 13210, USA
Am J Hum Genet 75:92-6. 2004..In the study family, this mutation was fully penetrant and exhibited significant evidence of linkage (LOD 6.33; theta =0), and it very likely accounts for both CVT and CMT in heterozygotes... - Serotonergic regulation of somatosensory cortical development: lessons from genetic mouse modelsXiaoyan Luo
Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7090, USA
Dev Neurosci 25:173-83. 2003..Here we review evidence from these genetic mouse models and, based on the accumulated evidence, propose a testable model for future studies of mechanisms underlying serotonergic regulation of cortical development... - Disruption of cerebral cortex MET signaling in autism spectrum disorderDaniel B Campbell
Department of Pharmacology, Vanderbilt University, Nashville, TN 37203, USA
Ann Neurol 62:243-50. 2007..Here we examined expression levels of MET and members of the MET signaling pathway in postmortem cerebral cortex from ASD cases and healthy control subjects...