Giuseppe Perrone

Summary

Affiliation: University Campus Bio-Medico
Country: Italy

Publications

  1. ncbi COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast
    Giuseppe Perrone
    Surgical Pathology, Università Campus Bio Medico di Roma, Via Alvaro del Portillo, 200, 00128 Rome, Italy
    Virchows Arch 451:1039-45. 2007
  2. ncbi COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification
    G Perrone
    Surgical Pathology, Oncology Unit, University Campus Bio Medico, La Sapienza University, Rome, Italy
    Histopathology 51:33-9. 2007
  3. doi Caveolin-1 expression in human breast lobular cancer progression
    Giuseppe Perrone
    Department of Anatomical Pathology, Università Campus Bio Medico di Roma, Rome, Italy
    Mod Pathol 22:71-8. 2009
  4. ncbi Immunohistochemistry and differential diagnosis of a solitary flat laryngeal xanthoma: a case report
    Giuseppe Perrone
    Surgical Pathology, Campus Bio Medico University, Rome, Italy
    In Vivo 21:119-21. 2007
  5. ncbi Reelin expression in human prostate cancer: a marker of tumor aggressiveness based on correlation with grade
    Giuseppe Perrone
    Department of Surgical Pathology, Campus Bio Medico University, Rome, Italy
    Mod Pathol 20:344-51. 2007
  6. ncbi COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters
    Giuseppe Perrone
    Surgical Pathology, Campus Bio Medico University, Via Emilio Longoni, Rome, 83 00155, Italy
    Virchows Arch 449:334-40. 2006
  7. pmc Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes
    G Perrone
    Department of Anatomical Pathology, Campus Bio Medico University, Via Alvaro del Portillo 200, Rome, Italy
    Eur J Histochem 54:e38. 2010
  8. pmc COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables
    G Perrone
    Surgical Pathology, Campus Bio Medico University, Rome, Italy
    J Clin Pathol 59:492-6. 2006
  9. ncbi Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinico-pathological features in colon cancer
    G Perrone
    Service of Histopathology, Campus Bio Medico University, Rome, Italy
    Cancer Lett 208:227-34. 2004
  10. ncbi Breast-like vulvar lesion with concurrent breast cancer: a case report and critical literature review
    Giuseppe Perrone
    Department of Anatomical Pathology, Università Campus Bio Medico di Roma, Via Alvaro del Portillo, 200, 00128 Roma, Italy
    In Vivo 23:629-34. 2009

Collaborators

Detail Information

Publications42

  1. ncbi COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast
    Giuseppe Perrone
    Surgical Pathology, Università Campus Bio Medico di Roma, Via Alvaro del Portillo, 200, 00128 Rome, Italy
    Virchows Arch 451:1039-45. 2007
    ..Because caveolae are rich in signaling molecules, this COX-2 compartment may play an important role in diverse breast cancer carcinogenesis processes...
  2. ncbi COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification
    G Perrone
    Surgical Pathology, Oncology Unit, University Campus Bio Medico, La Sapienza University, Rome, Italy
    Histopathology 51:33-9. 2007
    ....
  3. doi Caveolin-1 expression in human breast lobular cancer progression
    Giuseppe Perrone
    Department of Anatomical Pathology, Università Campus Bio Medico di Roma, Rome, Italy
    Mod Pathol 22:71-8. 2009
    ....
  4. ncbi Immunohistochemistry and differential diagnosis of a solitary flat laryngeal xanthoma: a case report
    Giuseppe Perrone
    Surgical Pathology, Campus Bio Medico University, Rome, Italy
    In Vivo 21:119-21. 2007
    ..CD68, S-100 protein and cytokeratin immunoreactivities were investigated. Immuno-histochemically, foamy cells were positive for CD68, indicating a histiocytic origin...
  5. ncbi Reelin expression in human prostate cancer: a marker of tumor aggressiveness based on correlation with grade
    Giuseppe Perrone
    Department of Surgical Pathology, Campus Bio Medico University, Rome, Italy
    Mod Pathol 20:344-51. 2007
    ..This suggests reelin may behave as a specific histological marker and may represent a useful biomarker to predict aggressive phenotypic behavior of prostatic cancer cells...
  6. ncbi COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters
    Giuseppe Perrone
    Surgical Pathology, Campus Bio Medico University, Via Emilio Longoni, Rome, 83 00155, Italy
    Virchows Arch 449:334-40. 2006
    ..Furthermore, the high rate of COX-2 expression in the intestinal subtype of ampullary carcinoma may represent the rational for a histotype-tailored therapy targeting COX-2...
  7. pmc Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes
    G Perrone
    Department of Anatomical Pathology, Campus Bio Medico University, Via Alvaro del Portillo 200, Rome, Italy
    Eur J Histochem 54:e38. 2010
    ....
  8. pmc COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables
    G Perrone
    Surgical Pathology, Campus Bio Medico University, Rome, Italy
    J Clin Pathol 59:492-6. 2006
    ..Objective: To investigate by immunohistochemistry the expression of COX-2 and the angiogenesis process in a series of primary untreated ampullary carcinomas...
  9. ncbi Correlation of p53 and bcl-2 expression with vascular endothelial growth factor (VEGF), microvessel density (MVD) and clinico-pathological features in colon cancer
    G Perrone
    Service of Histopathology, Campus Bio Medico University, Rome, Italy
    Cancer Lett 208:227-34. 2004
    ..0001 and P=0.009). Our data confirm the central role of VEGF in angiogenesis and suggest direct correlations among p53, bcl-2 and VEGF expression in colon cancer...
  10. ncbi Breast-like vulvar lesion with concurrent breast cancer: a case report and critical literature review
    Giuseppe Perrone
    Department of Anatomical Pathology, Università Campus Bio Medico di Roma, Via Alvaro del Portillo, 200, 00128 Roma, Italy
    In Vivo 23:629-34. 2009
    ..The main diagnostic criteria for differential diagnosis between primary or metastatic breast-like vulvar carcinoma are also discussed...
  11. ncbi COX-2 expression in DCIS: correlation with VEGF, HER-2/neu, prognostic molecular markers and clinicopathological features
    G Perrone
    Surgical Pathology, Campus Bio Medico University, Rome, Italy
    Histopathology 46:561-8. 2005
    ....
  12. doi Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer
    Daniele Santini
    Medical Oncology, University Campus Bio Medico, Rome, Italy
    J Cell Physiol 223:384-8. 2010
    ..Immunohistochemistry for the hENT1 protein carries prognostic information in patients with resected gastric cancer and holds promise as a predictive factor in chemotherapy decisions...
  13. doi PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients
    Bruno Vincenzi
    Department of Oncology, University Campus Bio Medico, Rome, Italy
    J Cell Physiol 227:927-33. 2012
    ..This study represents the first evidence of a possible correlation between PML protein expression and outcome of metastatic colorectal cancer patients treated with oxaliplatin/fluoropyrimidine-based first line therapy...
  14. doi Carcinoma of the ampulla of Vater: morphological and immunophenotypical classification predicts overall survival
    Sergio Morini
    Unit of Human Anatomy, CIR, Campus Bio Medico University of Rome, Rome, Italy
    Pancreas 42:60-6. 2013
    ..The objective of the study was to verify if histopathological differentiation of ampullary carcinoma after surgical resection may be related to survival...
  15. ncbi Thymidylate synthase expression in normal colonic mucosa: a predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy
    Daniele Santini
    Medical Oncology Unit, University Campus Bio Medico, Rome, Italy
    Oncology 67:135-42. 2004
    ..We retrospectively evaluated the relevance of thymidylate synthase (TS) expression in normal colonic mucosa as a predictive factor of toxicity in colorectal cancer patients receiving adjuvant fluorouracil (5-FU)-based chemotherapy...
  16. doi Dicer and Drosha expression and response to Bevacizumab-based therapy in advanced colorectal cancer patients
    Bruno Vincenzi
    Medical Oncology, University Hospital Campus Bio Medico, Via Alvaro del Portillo 200, 00128 Rome, Italy
    Eur J Cancer 49:1501-8. 2013
    ..We aimed to investigate the potential role of Dicer and Drosha in predicting response to Bevacizumab-based therapy in advanced colorectal cancer (CRC) patients...
  17. pmc In situ identification of CD44+/CD24- cancer cells in primary human breast carcinomas
    Giuseppe Perrone
    Department of Pathology, Campus Bio Medico University of Rome, Rome, Italy
    PLoS ONE 7:e43110. 2012
    ....
  18. pmc Receptor activator of NF-kB (RANK) expression in primary tumors associates with bone metastasis occurrence in breast cancer patients
    Daniele Santini
    Department of Medical Oncology, University Campus Bio Medico of Rome, Rome, Italy
    PLoS ONE 6:e19234. 2011
    ..RANKL stimulates migration of RANK-expressing tumor cells in vitro, conversely inhibited by OPG...
  19. doi The role of macrophages polarization in predicting prognosis of radically resected gastric cancer patients
    Francesco Pantano
    Department of Medical Oncology, Campus Bio Medico University of Rome, Rome, Italy
    J Cell Mol Med 17:1415-21. 2013
    ..The M1 macrophage density and M1/M2 ratio, as confirmed in multivariate analysis, are factors that can help in predicting patients survival time after radical surgery for gastric cancer. ..
  20. doi Toll-like receptor-4 expression by hepatic progenitor cells and biliary epithelial cells in HCV-related chronic liver disease
    Umberto Vespasiani-Gentilucci
    Clinical Medicine and Hepatology Unit, University Campus Bio Medico of Rome, Rome, Italy
    Mod Pathol 25:576-89. 2012
    ..05) and inflammation (P<0.05). The present results suggest that TLR4 expression by hepatic progenitor cells and biliary epithelial cells contributes to the progression of liver damage in the course of chronic HCV-related infection...
  21. ncbi Pleomorphic adenoma of the breast
    Enrico De Dominicis
    Surgical Pathology, Senology Unit, University Campus Bio Medico, Rome, Italy
    Breast J 11:513-4. 2005
  22. ncbi An increase of CA 19.9 as the first clinical sign of ileocecal valve metastasis from breast cancer
    Daniele Santini
    Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
    In Vivo 20:165-8. 2006
    ..After eleven months, the patient presented with signs of intestinal obstruction, requiring an ileocolic bypass. At definitive histological examination, the tumor exhibited features of mammary metastases...
  23. doi Promyelocytic leukemia (PML) gene expression is a prognostic factor in ampullary cancer patients
    B Vincenzi
    Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
    Ann Oncol 20:78-83. 2009
    ..Promyelocytic leukemia (PML) tumor suppressor gene plays a key role in acute PML pathogenesis but its involvement in pathogenesis and prognosis of solid cancers has not been defined yet...
  24. doi Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases
    Daniele Santini
    Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
    J Cell Physiol 226:780-4. 2011
    ..These data highlight the central role of RANK/RANKL/OPG pathway as potential therapeutic target not only in bone metastasis management, but also in the adjuvant setting...
  25. doi PML down-regulation in soft tissue sarcomas
    Bruno Vincenzi
    Department of Oncology, University Campus Bio Medico, Rome, Italy
    J Cell Physiol 224:644-8. 2010
    ..Further investigations are needed to confirm these data and to assess the possible value of PML expression as a prognostic factor in these extremely aggressive diseases...
  26. ncbi Vocal cord metastasis from breast cancer
    Rosario Francesco Grasso
    Interdisciplinary Center for Biomedical Research, Department of Radiology, Otolaryngology Head and Neck Surgery and Pathology, Università Campus Bio Medico di Roma, Rome, Italy
    J Clin Oncol 25:1803-5. 2007
  27. ncbi Dynamic contrast enhanced magnetic resonance imaging of the terminal ileum: differentiation of activity of Crohn's disease
    Riccardo Del Vescovo
    Department of Radiology, University Campus Bio Medico, Rome, Italy
    Abdom Imaging 33:417-24. 2008
    ..To prospectively investigate a new high resolution MRI technique for dynamic evaluation of the enhancement kinetics of bowel parietal layers and to correlate it with CDAI, CRP, endoscopic activity and histologic features...
  28. doi Human equilibrative nucleoside transporter 1 (hENT1) protein is associated with short survival in resected ampullary cancer
    D Santini
    Department of Medical Oncology, University Campus Bio Medico, via Emilio Longoni 81, 00155 Rome, Italy
    Ann Oncol 19:724-8. 2008
    ....
  29. ncbi Cell cycle alterations and lung cancer
    B Vincenzi
    Medical Oncology, Campus Bio Medico University, Rome, Italy
    Histol Histopathol 21:423-35. 2006
    ....
  30. doi Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer
    Giuseppe Perrone
    Department of Histopathology, University Campus Biomedico, Rome, Italy
    Eur J Cancer 44:1875-82. 2008
    ..006). FOXP3-positive Tregs may be a novel marker for identifying high-risk gastric cancer patients. Present findings deserve additional investigation as Tregs may also represent an innovative therapeutic target...
  31. doi High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice
    Daniele Santini
    Department of Oncology, University Campus Bio Medico, Rome, Italy
    Oncologist 13:1270-5. 2008
    ..Nevertheless, most experiences were conducted on samples from primaries. The aim of this study was to evaluate the grade of concordance in terms of KRAS status between primaries and related metastases...
  32. ncbi Differential modulation of Ku70/80 DNA-binding activity in a patient with multiple basal cell carcinomas
    Paola Mazzarelli
    Laboratory for Molecular Medicine and Biotechnology, Interdisciplinary Center for Biomedical Research, Università Campus Bio Medico, Rome, Italy
    J Invest Dermatol 121:628-33. 2003
    ..001). Although these results are limited to only one patient, together with other recent studies they support the hypothesis that downregulation of the nonhomologous end-joining pathway may be associated with tumor progression...
  33. pmc Tumour proliferation, angiogenesis, and ploidy status in human colon cancer
    E Cristi
    Surgical Pathology, Campus Bio Medico University, Via Emilio Longoni, Rome 83 00155, Italy
    J Clin Pathol 58:1170-4. 2005
    ..To gain further insight into the effects of microvessel density and VEGF expression in colon cancer, their relation with tumour proliferation, ploidy status, and p53 expression was investigated in colon cancer...
  34. doi Malignant transformation of well-differentiated papillary mesothelioma 13 years after the diagnosis: a case report
    Luisa Costanzo
    Chair of Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio Medico University, Rome, Italy
    Clin Respir J 8:124-9. 2014
    ..Finally, the role of immunohistochemistry in the diagnosis of WDPM and the possible mechanisms leading to this unique way of metastatisation are discussed. ..
  35. ncbi Collagen changes in the ureteropelvic junction after failed antegrade endopyelotomy
    Federico Sergi
    Urology Unit, Campus Bio Medico University of Rome, Rome, Italy
    J Endourol 21:103-7. 2007
    ..We evaluated the collagen content and differentiation of the ureteropelvic junction (UPJ) of patients who underwent Anderson-Hynes dismembered pyeloplasty after failure of antegrade endopyelotomy...
  36. pmc Solitary fibrous tumour of thyroid: report of two cases with immunohistochemical features and literature review
    Giuseppe Santeusanio
    Dipartimento di Biopatologia e Diagnostica per Immagini, Sezione di Anatomia Patologica and UOC Anatomia Patologica, Universita degli Studi di Roma Tor Vergata, Ospedale S Eugenio, Piazzale dell Umanesimo n 10, Rome, Italy
    Head Neck Pathol 2:231-5. 2008
    ..However, the morphologic and immunohistochemical findings of SFT are so characteristic that this diagnosis seldom represent a difficulty...
  37. pmc Non-cirrhotic portal hypertension with large regenerative nodules: a diagnostic challenge
    Umberto Vespasiani Gentilucci
    Clinical Medicine and Hepatology Unit, University Campus Bio Medico of Rome, 00128 Rome, Italy
    World J Gastroenterol 17:2580-4. 2011
    ..More flexibility in classification should derive from this etiopathogenic background...
  38. ncbi Urinary complications from breast cancer metastasis: case report and review of the literature
    E Vulcano
    Department of Senology, Universita Campus BioMedico, Rome, Italy
    G Chir 31:243-5. 2010
    ..To date this is the seventh reported case of isolated metastatis of breast carcinoma to the bladder...
  39. doi Intercellular space diameters of the oesophageal epithelium in NERD patients: head to head comparison between light and electron microscopy analysis
    M Ribolsi
    Department of Digestive Diseases, Campus Bio Medico University, Rome, Italy
    Dig Liver Dis 41:9-14. 2009
    ..Semi-quantitative evaluation of intercellular space diameters using light microscopy seems to provide promising results...
  40. doi Effects of either tibolone or continuous combined transdermal estradiol with medroxyprogesterone acetate on coagulatory factors and lipoprotein(a) in menopause
    G Perrone
    Department of Gynecology and Obstetrics, University Sapienza, Rome, Italy
    Gynecol Obstet Invest 68:33-9. 2009
    ..The aim of this prospective controlled study was to compare the effects of two therapies for menopause on factor VII (FVII) and hemostatic variables...
  41. ncbi Subcellular shift of the hepatic growth hormone receptor with progression of hepatitis C virus-related chronic liver disease
    U Vespasiani Gentilucci
    Internal Medicine and Hepatology Laboratory, Centre of Interdisciplinary Research CIR, Rome, Italy
    Histopathology 48:822-30. 2006
    ..To evaluate the cytoplasmic and nuclear expression of hepatic growth hormone receptor (GHR) in different stages (S0, S1, S3 and S4, according to Knodell's classification) of chronic liver disease (CLD) and in hepatocellular carcinoma (HCC)...
  42. ncbi DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor
    Paola Mazzarelli
    Laboratory of Molecular Medicine and Biotechnology, Università Campus Bio Medico, Via Longoni, 83, Rome 00155, Italy
    World J Gastroenterol 11:6694-700. 2005
    ..To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis...