Alessandro Peri

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. pmc Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis
    Giovanni Corona
    Endocrinology Unit, Maggiore Bellaria Hospital, Bologna, Italy
    PLoS ONE 8:e80451. 2013
  2. ncbi request reprint Management of euvolemic hyponatremia attributed to SIADH in the hospital setting
    A Peri
    Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences University of Florence, Florence, Italy
    Minerva Endocrinol 39:33-41. 2014
  3. doi request reprint Clinical review: the use of vaptans in clinical endocrinology
    Alessandro Peri
    Endocrine Unit, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 98:1321-32. 2013
  4. pmc Exendin-4 induces cell adhesion and differentiation and counteracts the invasive potential of human neuroblastoma cells
    Paola Luciani
    Endocrine Unit, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
    PLoS ONE 8:e71716. 2013
  5. ncbi request reprint Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures
    Paola Luciani
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Florence, Italy
    Endocrinology 149:4256-66. 2008
  6. pmc Seladin-1 expression is regulated by promoter methylation in adrenal cancer
    Lisa Simi
    Clinical Biochemistry, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence, 50139 Italy
    BMC Cancer 10:201. 2010
  7. ncbi request reprint New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm
    Alessandro Peri
    Department of Clinical Physiopathology, Endocrine Unit, Center for Research, University of Florence, Florence, Italy
    Front Neuroendocrinol 30:119-29. 2009
  8. ncbi request reprint Low extracellular sodium causes neuronal distress independently of reduced osmolality in an experimental model of chronic hyponatremia
    Susanna Benvenuti
    Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy
    Neuromolecular Med 15:493-503. 2013
  9. doi request reprint Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer
    Lorella Bonaccorsi
    Unit of Andrology, Department of Clinical Physiopathology, Center for Transfer, High Education and Technology DeNothe, University of Florence, Florence, Italy
    Lab Invest 88:1049-56. 2008
  10. doi request reprint Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness
    Francesca Nuti
    Andrology Unit, University of Florence, 50139 Florence, Italy
    J Pathol 219:491-500. 2009

Collaborators

Detail Information

Publications30

  1. pmc Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis
    Giovanni Corona
    Endocrinology Unit, Maggiore Bellaria Hospital, Bologna, Italy
    PLoS ONE 8:e80451. 2013
    ..The aim of our study was to perform a meta-analysis that included the published studies that compared mortality rates in subjects with or without hyponatremia of any degree...
  2. ncbi request reprint Management of euvolemic hyponatremia attributed to SIADH in the hospital setting
    A Peri
    Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences University of Florence, Florence, Italy
    Minerva Endocrinol 39:33-41. 2014
    ....
  3. doi request reprint Clinical review: the use of vaptans in clinical endocrinology
    Alessandro Peri
    Endocrine Unit, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 98:1321-32. 2013
    ..Vasopressin receptor antagonists, known as vaptans, represent a new and interesting class of drugs for the treatment of the euvolemic and hypervolemic forms of hyponatremia...
  4. pmc Exendin-4 induces cell adhesion and differentiation and counteracts the invasive potential of human neuroblastoma cells
    Paola Luciani
    Endocrine Unit, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
    PLoS ONE 8:e71716. 2013
    ..Furthermore, we demonstrated that exendin-4 reduced cell migration and counteracted anchorage-independent growth in neuroblastoma cells. Overall, these data indicate for the first time that exendin-4 may have anti-tumoral properties. ..
  5. ncbi request reprint Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures
    Paola Luciani
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, University of Florence, Florence, Italy
    Endocrinology 149:4256-66. 2008
    ..Our data provide for the first time a direct demonstration that seladin-1 may be considered a fundamental mediator of the neuroprotective effects of estrogen...
  6. pmc Seladin-1 expression is regulated by promoter methylation in adrenal cancer
    Lisa Simi
    Clinical Biochemistry, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, Florence, 50139 Italy
    BMC Cancer 10:201. 2010
    ..Since up to now seladin-1 mutations were not described, we investigated whether promoter methylation could account for the down-regulation of seladin-1 expression in ACC...
  7. ncbi request reprint New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm
    Alessandro Peri
    Department of Clinical Physiopathology, Endocrine Unit, Center for Research, University of Florence, Florence, Italy
    Front Neuroendocrinol 30:119-29. 2009
    ..This review describes how this protein interacts with cholesterol and estrogens, thus generating a neuroprotective network, that might open new possibilities in the prevention/treatment of neurodegenerative diseases...
  8. ncbi request reprint Low extracellular sodium causes neuronal distress independently of reduced osmolality in an experimental model of chronic hyponatremia
    Susanna Benvenuti
    Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy
    Neuromolecular Med 15:493-503. 2013
    ..These findings further support the recommendation to effectively correct hyponatremia, even when mild and chronic...
  9. doi request reprint Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer
    Lorella Bonaccorsi
    Unit of Andrology, Department of Clinical Physiopathology, Center for Transfer, High Education and Technology DeNothe, University of Florence, Florence, Italy
    Lab Invest 88:1049-56. 2008
    ..These findings, together with the results previously obtained in metastatic disease, suggest an involvement of this gene in CaP...
  10. doi request reprint Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness
    Francesca Nuti
    Andrology Unit, University of Florence, 50139 Florence, Italy
    J Pathol 219:491-500. 2009
    ..In conclusion, we have demonstrated for the first time an important role for seladin-1 in the biology of TGCTs and provided new insights into cisplatin responsiveness of these tumours...
  11. doi request reprint High recovery of mesenchymal progenitor cells with non-density gradient separation of human bone marrow
    Simone Dal Pozzo
    Department of Hematology, Careggi Hospital, Florence, Italy
    Cytotherapy 12:579-86. 2010
    ..We compared the feasibility and reproducibility of two gravity separation techniques, with or without the use of a density gradient, in terms of both hematopoietic and mesenchymal human BM progenitors...
  12. doi request reprint Neuroprotective effects of the Alzheimer's disease-related gene seladin-1
    Alessandro Peri
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Mol Endocrinol 41:251-61. 2008
    ..In particular, the relationship between seladin-1-mediated neuroprotection and estrogens, IGF1 and thyroid hormones, will be described and discussed...
  13. ncbi request reprint Estrogen and selective estrogen receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer's disease indicator-1, a recently discovered antiapoptotic gene, in human neuroblast long-term cell cultures
    Susanna Benvenuti
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini, 6, 50139 Florence, Italy
    J Clin Endocrinol Metab 90:1775-82. 2005
    ..Our results add new evidence, using human neuronal cells, for a beneficial effect of estrogen in preventing neurodegenerative diseases and suggest for the first time that seladin-1 may mediate this effect...
  14. doi request reprint Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model
    Paola Luciani
    Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, University of Florence, Florence, Italy
    Cell Mol Life Sci 67:3711-23. 2010
    ..Noteworthy, our data support the claimed favorable role of exendin-4 against diabetic neuropathy as well as against different neurodegenerative diseases...
  15. doi request reprint Gonadotropin-releasing hormone modulates cholesterol synthesis and steroidogenesis in SH-SY5Y cells
    Fabiana Rosati
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, Viale G Pieraccini 6, 50139 Firenze, Italy
    J Steroid Biochem Mol Biol 124:77-83. 2011
    ..These data indicate for the first time that GnRH regulates both cholesterol and steroid biosynthesis in human neuronal-like cells and suggest a new physiological role for GnRH in the brain...
  16. ncbi request reprint A case of hyponatremia caused by central hypocortisolism
    Gabriele Parenti
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Nat Clin Pract Endocrinol Metab 3:369-75. 2007
    ..Initial laboratory investigations revealed hypoglycemia and hyponatremia. The patient was, therefore, transferred to the Endocrine Unit of the same hospital for further evaluation of the case...
  17. ncbi request reprint Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1
    Susanna Benvenuti
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    Exp Cell Res 312:2592-604. 2006
    ..These original results demonstrate for the first time that seladin-1 is abundantly expressed by stem cells and appear to suggest that reduced expression in AD might be due to an altered pool of multipotent cells...
  18. doi request reprint Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aβ42 aggregate toxicity
    Cristina Cecchi
    Department of Biochemical Sciences, and Research Centre on the Molecular Basis of Neurodegeneration CIMN, Florence, Italy
    J Alzheimers Dis 27:651-64. 2011
    ..These findings extend our knowledge of stem cell vulnerability to amyloid species, which remains a controversial issue, and confirm that amyloid-GM1 interactions play an important role in cell impairment...
  19. ncbi request reprint Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas
    Paola Luciani
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 89:1332-9. 2004
    ..In summary, this is the first demonstration that seladin-1/DHCR24 expression is reduced in adrenal cancer, suggesting that it might be viewed as a new potential marker of adrenal malignancies...
  20. ncbi request reprint The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin
    Alessandro Peri
    Department of Clinical Physiopathology, Endocrine Unit, University of Florence, Italy
    Hum Cell 16:95-9. 2003
  21. pmc PPARgamma in Neuroblastoma
    Alessandro Peri
    Endocrine Unit, Department of Clinical Physiopathology, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, 50139 Florence, Italy
    PPAR Res 2008:917815. 2008
    ..The studies that addressed the role and the possible mechanism(s) of action of PPARgamma in NB cells are reviewed...
  22. ncbi request reprint Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas
    Paola Luciani
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Clin Endocrinol Metab 90:6156-61. 2005
    ..Although seladin-1 is expressed in the pituitary gland, no study addressed the expression or the function of this gene in pituitary adenomas...
  23. doi request reprint Considerations regarding the management of hyponatraemia secondary to SIADH
    Alessandro Peri
    Department of Clinical Physiopathology, Endocrine Unit, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for Development of Novel Therapies DENOThe, University of Florence, 50139 Florence, Italy
    Best Pract Res Clin Endocrinol Metab 26:S16-26. 2012
    ....
  24. ncbi request reprint Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease
    Andrea Tedde
    Department of Neurological and Psychiatric Sciences, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, University of Florence, Florence, Italy
    Am J Med Genet B Neuropsychiatr Genet 147:117-9. 2008
    ..Our preliminary results suggest the absence of an association between DHCR24/seladin-1 genotypes and AD in the Italian population...
  25. ncbi request reprint Identification of a novel mutation in the arginine vasopressin-neurophysin II gene affecting the sixth intrachain disulfide bridge of the neurophysin II moiety
    Silvana Baglioni
    Medical Genetics, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    Eur J Endocrinol 151:605-11. 2004
    ..The father of the patient was affected by diabetes insipidus and was under desmopressin treatment until the time of his death. Nevertheless, the patient had never been subjected to endocrine evaluation...
  26. ncbi request reprint Expression of uteroglobin and matrix metalloproteinase-9 genes in endometrial cancer: relationship to estrogen and progesterone receptor status
    Federica Cioppi
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, I 50139 Florence, Italy
    Oncol Rep 11:427-33. 2004
    ..Thus, our results indicate that the presence of UG in the majority of cases of endometrial carcinoma that were investigated, hypothetically a favorable disease marker, appears to be counteracted by high levels of MMP-9 expression...
  27. ncbi request reprint Adrenal incidentaloma: the influence of a decision-making algorithm on the short-term outcome of laparoscopy
    Andrea Valeri
    Department of General and Vascular Surgery, Careggi Hospital, and Department of Clinical Physiopathology, University of Florence, Italy
    J Laparoendosc Adv Surg Tech A 15:451-9. 2005
    ..The most controversial issue is the role of laparoscopy in the treatment of potentially malignant and large adrenal masses. Trying to address these questions, we retrospectively examined a group of patients with AIs...
  28. ncbi request reprint Multifaceted roles of BDNF and FGF2 in human striatal primordium development. An in vitro study
    Erica Sarchielli
    Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
    Exp Neurol 257:130-47. 2014
    ..We propose that BDNF and FGF2 play an important autocrine-paracrine role during early striatum development in vivo and that their release by fetal striatal grafts may be relevant in the setting of HD cell therapy. ..
  29. pmc Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1
    Alessandro Peri
    Department of Clinical Physiopathology, Endocrine Unit, Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, University of Florence Florence, Italy
    Neuropsychiatr Dis Treat 4:817-24. 2008
    ..This review will summarize the current knowledge regarding the neuroprotective effects of seladin-1 and the relationship between this protein and estrogen...
  30. ncbi request reprint Cushing's syndrome in a patient with bilateral macronodular adrenal hyperplasia responding to cisapride: an in vivo and in vitro study
    Massimo Mannelli
    Endocrine Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 88:4616-22. 2003
    ..In addition, it is noteworthy that hypocortisolism ensued after the removal of the most enlarged adrenal gland, but the in vivo response to cisapride persisted...