Marina Perfumi

Summary

Affiliation: University of Camerino
Country: Italy

Publications

  1. ncbi request reprint Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats
    Laura Mattioli
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    J Psychopharmacol 21:742-50. 2007
  2. ncbi request reprint Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice
    Marina Perfumi
    Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032 Camerino MC, Italy
    Phytother Res 21:37-43. 2007
  3. ncbi request reprint Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
    J Psychopharmacol 19:448-54. 2005
  4. ncbi request reprint Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, via Scalino 3, 62032 Camerino MC, Italy
    Alcohol Alcohol 40:291-6. 2005
  5. ncbi request reprint Hypericum perforatum CO2 extract and opioid receptor antagonists act synergistically to reduce ethanol intake in alcohol-preferring rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino Macerata, Italy
    Alcohol Clin Exp Res 27:1554-62. 2003
  6. doi request reprint Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence
    Fabio Del Bello
    Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 53:7825-35. 2010
  7. ncbi request reprint Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression
    Giorgio Santoni
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino, Italy
    Neuroimmunomodulation 11:160-72. 2004
  8. doi request reprint Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?
    Claudia Cardinaletti
    Dipartimento di Scienze Chimiche, Universita degli Studi di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 52:7319-22. 2009
  9. doi request reprint Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement
    Valerio Mammoli
    School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S Agostino 1, 62032 Camerino, Italy
    Bioorg Med Chem 20:2259-65. 2012
  10. doi request reprint Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane
    Alessandro Piergentili
    Dipartimento di Scienze Chimiche, Universita di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 53:1261-9. 2010

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats
    Laura Mattioli
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    J Psychopharmacol 21:742-50. 2007
    ..These findings strongly demonstrated that RHO is able selectively to attenuate stress-induced anorexia, providing functional evidence of claimed adaptogen and anti-stress properties of Rhodiola rosea L...
  2. ncbi request reprint Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice
    Marina Perfumi
    Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032 Camerino MC, Italy
    Phytother Res 21:37-43. 2007
    ..rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time...
  3. ncbi request reprint Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
    J Psychopharmacol 19:448-54. 2005
    ..These findings further support the view that clinical trials for extracts of Hypericum perforatum in the treatment of alcoholism should be considered...
  4. ncbi request reprint Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, via Scalino 3, 62032 Camerino MC, Italy
    Alcohol Alcohol 40:291-6. 2005
    ....
  5. ncbi request reprint Hypericum perforatum CO2 extract and opioid receptor antagonists act synergistically to reduce ethanol intake in alcohol-preferring rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino Macerata, Italy
    Alcohol Clin Exp Res 27:1554-62. 2003
    ..This study evaluated the effect on ethanol intake of the combined administration of a CO2 H. perforatum extract and naloxone or naltrexone in genetically selected Marchigian Sardinian alcohol-preferring rats...
  6. doi request reprint Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence
    Fabio Del Bello
    Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 53:7825-35. 2010
    ..On the contrary, full α(2C)-activation appears advantageous in reducing morphine tolerance expression. Interestingly, the biological profile displayed by 4 (allyphenyline) and its eutomer (S)-(+)-4 has been found to be very unusual...
  7. ncbi request reprint Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression
    Giorgio Santoni
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino, Italy
    Neuroimmunomodulation 11:160-72. 2004
    ....
  8. doi request reprint Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?
    Claudia Cardinaletti
    Dipartimento di Scienze Chimiche, Universita degli Studi di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 52:7319-22. 2009
    ..For their positive morphine analgesia modulation (due to alpha(2C)-AR stimulation) and sedation overcoming (due to alpha(2A)-AR antagonism), 8 and 11 might be useful as adjuvant agents in the management of pain with morphine...
  9. doi request reprint Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement
    Valerio Mammoli
    School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S Agostino 1, 62032 Camerino, Italy
    Bioorg Med Chem 20:2259-65. 2012
    ..In in vivo studies 2 strongly increased morphine analgesia. This interesting behaviour appeared to be induced by the favourable involvement of α(2A)-AR antagonism in the I(2)-IBS-mediated morphine analgesia enhancement...
  10. doi request reprint Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane
    Alessandro Piergentili
    Dipartimento di Scienze Chimiche, Universita di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 53:1261-9. 2010
    ..28) and sigma(1)/sigma(2) selectivity ratio (29510), compound 9 might be a novel valuable tool for sigma receptor characterization and a suitable template for the rational design of potential therapeutically useful sigma(1) antagonists...
  11. ncbi request reprint Blockade of gamma-aminobutyric acid receptors does not modify the inhibiton of ethanol intake induced by Hypericum perforatum in rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino MC, Italy
    Alcohol Alcohol 37:540-6. 2002
    ....
  12. ncbi request reprint Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032, Camerino, Italy
    Psychopharmacology (Berl) 183:394-403. 2006
    ..It has been suggested that endocannabinoid mechanisms are involved in the control of ethanol consumption...
  13. doi request reprint Effects of a Rhodiola rosea L. extract on acquisition and expression of morphine tolerance and dependence in mice
    Laura Mattioli
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
    J Psychopharmacol 25:411-20. 2011
    ..These data suggest that Rhodiola rosea L. may have human therapeutic potential for treatment of opioid addiction...
  14. doi request reprint Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions
    Francesco Gentili
    Dipartimento di Scienze Chimiche, Universita degli Studi di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 51:5130-4. 2008
    ..By comparative examination of rationally designed compounds, some analogies between binding site cavity of I2-IBS proteins and alpha 2C-adrenoreceptor emerged...
  15. doi request reprint Effects of a Rhodiola rosea L. extract on the acquisition, expression, extinction, and reinstatement of morphine-induced conditioned place preference in mice
    Laura Mattioli
    Pharmacognosy Unit, School of Pharmacy, University of Camerino, via Madonna delle Carceri 9, Camerino, MC, Italy
    Psychopharmacology (Berl) 221:183-93. 2012
    ..Prevention of relapse is the primary goal of addiction treatment and is still the major limitation in drug therapy...
  16. doi request reprint Evaluation of Rhodiola rosea L. extract on affective and physical signs of nicotine withdrawal in mice
    Laura Mattioli
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    J Psychopharmacol 25:402-10. 2011
    ..In conclusion, our data encourage additional studies to define the use of R. rosea L. as a therapeutic approach in the treatment of smoking cessation...
  17. ncbi request reprint Memory impairment following combined exposure to delta(9)-tetrahydrocannabinol and ethanol in rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Sealzino 5, 62032 Camerino MC, Italy
    Eur J Pharmacol 449:245-52. 2002
    ..The present findings are in keeping with the notion that Cannabis derivatives impair memory processes and provide evidence for a synergic action of THC and ethanol, thus emphasizing the risks consequent to their co-administration...
  18. ncbi request reprint Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects
    Francesco Gentili
    Dipartimento di Scienze Chimiche, Universita degli Studi di Camerino, Via S Agostino 1, 62032 Camerino, Italy
    Eur J Pharmacol 553:73-81. 2006
    ..Therefore, the results of this study indicate the crucial involvement of I(2)-IBS in the morphine analgesia modulatory effects of 1 and 2...
  19. ncbi request reprint Expression of substance P and its neurokinin-1 receptor on thymocytes: functional relevance in the regulation of thymocyte apoptosis and proliferation
    Giorgio Santoni
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino, Italy
    Neuroimmunomodulation 10:232-46. 2002
    ..SP protein was detected on 40% of CD5+ thymocytes and identified as a band of 1.3 kD by Western blot analysis. Finally, thymocytes spontaneously released SP, which was increased upon ConA or CD3 stimulation...
  20. pmc Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in Mice
    Laura Mattioli
    Pharmacognosy Unit, School of Pharmacy, University of Camerino, via Madonna delle Carceri 9, 62032 Camerino, Italy
    Evid Based Complement Alternat Med 2012:741925. 2012
    ..These data suggest that Brugmansia arborea Lagerh might have human therapeutic potential for treatment of opioid addiction...
  21. ncbi request reprint Plant derivatives in the treatment of alcohol dependency
    Amir H Rezvani
    Department of Psychiatry, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
    Pharmacol Biochem Behav 75:593-606. 2003
    ..However, their role in the future of pharmacotherapy for alcoholism will depend upon the outcome of carefully conducted clinical trials...