Research Topics
| Marina PerfumiSummaryAffiliation: University of Camerino Country: Italy Publications
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Detail Information
Publications
Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in ratsLaura Mattioli
Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
J Psychopharmacol 21:742-50. 2007..These findings strongly demonstrated that RHO is able selectively to attenuate stress-induced anorexia, providing functional evidence of claimed adaptogen and anti-stress properties of Rhodiola rosea L...- Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in miceMarina Perfumi
Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032 Camerino MC, Italy
Phytother Res 21:37-43. 2007..rosea extracts. Moreover, antidepressant-like and anxiolytic-like activities of R. rosea were shown in mice for the first time... - Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in ratsMarina Perfumi
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
J Psychopharmacol 19:448-54. 2005..These findings further support the view that clinical trials for extracts of Hypericum perforatum in the treatment of alcoholism should be considered... - Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring ratsMarina Perfumi
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, via Scalino 3, 62032 Camerino MC, Italy
Alcohol Alcohol 40:291-6. 2005.... - Hypericum perforatum CO2 extract and opioid receptor antagonists act synergistically to reduce ethanol intake in alcohol-preferring ratsMarina Perfumi
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino Macerata, Italy
Alcohol Clin Exp Res 27:1554-62. 2003..This study evaluated the effect on ethanol intake of the combined administration of a CO2 H. perforatum extract and naloxone or naltrexone in genetically selected Marchigian Sardinian alcohol-preferring rats... 
Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance and dependenceFabio Del Bello
Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S Agostino 1, 62032 Camerino, Italy
J Med Chem 53:7825-35. 2010..On the contrary, full α(2C)-activation appears advantageous in reducing morphine tolerance expression. Interestingly, the biological profile displayed by 4 (allyphenyline) and its eutomer (S)-(+)-4 has been found to be very unusual...- Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expressionGiorgio Santoni
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino, Italy
Neuroimmunomodulation 11:160-72. 2004.... - Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine?Claudia Cardinaletti
Dipartimento di Scienze Chimiche, Universita degli Studi di Camerino, Via S Agostino 1, 62032 Camerino, Italy
J Med Chem 52:7319-22. 2009..For their positive morphine analgesia modulation (due to alpha(2C)-AR stimulation) and sedation overcoming (due to alpha(2A)-AR antagonism), 8 and 11 might be useful as adjuvant agents in the management of pain with morphine... - Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancementValerio Mammoli
School of Pharmacy, Medicinal Chemistry Unit, University of Camerino, Via S Agostino 1, 62032 Camerino, Italy
Bioorg Med Chem 20:2259-65. 2012..In in vivo studies 2 strongly increased morphine analgesia. This interesting behaviour appeared to be induced by the favourable involvement of α(2A)-AR antagonism in the I(2)-IBS-mediated morphine analgesia enhancement... - Novel highly potent and selective sigma 1 receptor antagonists related to spipethianeAlessandro Piergentili
Dipartimento di Scienze Chimiche, Universita di Camerino, Via S Agostino 1, 62032 Camerino, Italy
J Med Chem 53:1261-9. 2010..28) and sigma(1)/sigma(2) selectivity ratio (29510), compound 9 might be a novel valuable tool for sigma receptor characterization and a suitable template for the rational design of potential therapeutically useful sigma(1) antagonists... - Blockade of gamma-aminobutyric acid receptors does not modify the inhibiton of ethanol intake induced by Hypericum perforatum in ratsMarina Perfumi
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino (MC, Italy
Alcohol Alcohol 37:540-6. 2002..p. injection at a dose of 5 mg/kg. CONCLUSIONS: These findings suggest that the inhibitory effects of HPE on ethanol intake are not mediated by GABA agonist actions... - Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in ratsDaina Economidou
Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032, Camerino, Italy
Psychopharmacology (Berl) 183:394-403. 2006..Overall, these observations demonstrate that the inhibition of operant behaviour following blockade of CB1 receptors by SR-141716A is linked to a reduction of reward-related responding and is not related to drug-induced motor deficits... - Effects of a Rhodiola rosea L. extract on acquisition and expression of morphine tolerance and dependence in miceLaura Mattioli
Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
J Psychopharmacol 25:411-20. 2011..These data suggest that Rhodiola rosea L. may have human therapeutic potential for treatment of opioid addiction... - Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functionsFrancesco Gentili
Dipartimento di Scienze Chimiche, Universita degli Studi di Camerino, Via S Agostino 1, 62032 Camerino, Italy
J Med Chem 51:5130-4. 2008..By comparative examination of rationally designed compounds, some analogies between binding site cavity of I2-IBS proteins and alpha 2C-adrenoreceptor emerged... - Effects of a Rhodiola rosea L. extract on the acquisition, expression, extinction, and reinstatement of morphine-induced conditioned place preference in miceLaura Mattioli
Pharmacognosy Unit, School of Pharmacy, University of Camerino, via Madonna delle Carceri 9, Camerino, MC, Italy
Psychopharmacology (Berl) 221:183-93. 2012..Prevention of relapse is the primary goal of addiction treatment and is still the major limitation in drug therapy... - Evaluation of Rhodiola rosea L. extract on affective and physical signs of nicotine withdrawal in miceLaura Mattioli
Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
J Psychopharmacol 25:402-10. 2011..In conclusion, our data encourage additional studies to define the use of R. rosea L. as a therapeutic approach in the treatment of smoking cessation... - Memory impairment following combined exposure to delta(9)-tetrahydrocannabinol and ethanol in ratsRoberto Ciccocioppo
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Sealzino 5, 62032 Camerino MC, Italy
Eur J Pharmacol 449:245-52. 2002..The present findings are in keeping with the notion that Cannabis derivatives impair memory processes and provide evidence for a synergic action of THC and ethanol, thus emphasizing the risks consequent to their co-administration... - Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effectsFrancesco Gentili
Dipartimento di Scienze Chimiche, , Via S. Agostino 1, 62032 Camerino, Italy
Eur J Pharmacol 553:73-81. 2006..Therefore, the results of this study indicate the crucial involvement of I(2)-IBS in the morphine analgesia modulatory effects of 1 and 2... - Expression of substance P and its neurokinin-1 receptor on thymocytes: functional relevance in the regulation of thymocyte apoptosis and proliferationGiorgio Santoni
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino, Italy
Neuroimmunomodulation 10:232-46. 2002..SP protein was detected on 40% of CD5+ thymocytes and identified as a band of 1.3 kD by Western blot analysis. Finally, thymocytes spontaneously released SP, which was increased upon ConA or CD3 stimulation... 
Effects of Brugmansia arborea Extract and Its Secondary Metabolites on Morphine Tolerance and Dependence in MiceLaura Mattioli
Pharmacognosy Unit, School of Pharmacy, University of Camerino, via Madonna delle Carceri 9, 62032 Camerino, Italy
Evid Based Complement Alternat Med 2012:741925. 2012..These data suggest that Brugmansia arborea Lagerh might have human therapeutic potential for treatment of opioid addiction...- Plant derivatives in the treatment of alcohol dependencyAmir H Rezvani
Department of Psychiatry, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
Pharmacol Biochem Behav 75:593-606. 2003..However, their role in the future of pharmacotherapy for alcoholism will depend upon the outcome of carefully conducted clinical trials...