Giancarlo Pepeu

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi request reprint Cholinesterase inhibitors and beyond
    Giancarlo Pepeu
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Curr Alzheimer Res 6:86-96. 2009
  2. doi request reprint Effect of cholinesterase inhibitors on attention
    Giancarlo Pepeu
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Chem Biol Interact 203:361-4. 2013
  3. doi request reprint Cholinesterase inhibitors and memory
    Giancarlo Pepeu
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Chem Biol Interact 187:403-8. 2010
  4. ncbi request reprint Changes in acetylcholine extracellular levels during cognitive processes
    Giancarlo Pepeu
    Department of Pharmacology, University of Florence, 50139 Florence, Italy
    Learn Mem 11:21-7. 2004
  5. ncbi request reprint Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice
    Arianna Bellucci
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Neurobiol Dis 23:260-72. 2006
  6. ncbi request reprint Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway
    Maria Grazia Giovannini
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Neurobiol Dis 11:257-74. 2002
  7. ncbi request reprint S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat
    Susanna Rosi
    Department of Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Neurosci Lett 361:120-3. 2004
  8. ncbi request reprint N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine
    Francesca Cerbai
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur J Pharmacol 572:142-50. 2007
  9. ncbi request reprint Neuronal control of the cardiac responses to osmotic stress in the gastropod limpet Patella caerulea
    Giada Bini
    Department of Animal Biology and Genetics, University of Florence, 50125 Florence, Italy
    J Exp Zool A Comp Exp Biol 305:472-9. 2006
  10. ncbi request reprint A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone
    Maria Rita Luparini
    Department of Pharmacology, ACRAF Angelini Ricerche, 00040 S Palomba Pomezia, Rome, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 28:1117-27. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Cholinesterase inhibitors and beyond
    Giancarlo Pepeu
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Curr Alzheimer Res 6:86-96. 2009
    ....
  2. doi request reprint Effect of cholinesterase inhibitors on attention
    Giancarlo Pepeu
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Chem Biol Interact 203:361-4. 2013
    ..Finally, the electrophysiological and neurochemical mechanisms through which the activation of the cholinergic forebrain neurons enhance attention and create the condition for information acquisition are reviewed...
  3. doi request reprint Cholinesterase inhibitors and memory
    Giancarlo Pepeu
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Chem Biol Interact 187:403-8. 2010
    ..Therefore, considering that in AD the degeneration of the cholinergic system is associated with alteration of other neurotransmitter systems and a diffuse synaptic loss, a limited efficacy of ChEIs on memory processes should be expected...
  4. ncbi request reprint Changes in acetylcholine extracellular levels during cognitive processes
    Giancarlo Pepeu
    Department of Pharmacology, University of Florence, 50139 Florence, Italy
    Learn Mem 11:21-7. 2004
    ....
  5. ncbi request reprint Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice
    Arianna Bellucci
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Neurobiol Dis 23:260-72. 2006
    ..These findings demonstrate that neuronal damage and cholinergic dysfunction in vivo underlie the impairment in learning and memory functions in this mouse model of Alzheimer's disease...
  6. ncbi request reprint Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway
    Maria Grazia Giovannini
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Neurobiol Dis 11:257-74. 2002
    ..We show here for the first time in vivo the pivotal role played by the p38MAPK microglial signal transduction pathway in the inflammatory response to the Abeta(1-42) deposit...
  7. ncbi request reprint S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat
    Susanna Rosi
    Department of Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Neurosci Lett 361:120-3. 2004
    ..S 18986 did not modify GABA and glutamate release. No effect on general behavior was observed, but S 18986 at both doses prevented the disrupting effect of scopolamine (1 mg/kg i.p.) on passive avoidance acquisition...
  8. ncbi request reprint N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine
    Francesca Cerbai
    Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur J Pharmacol 572:142-50. 2007
    ..The importance of butyrylcholinesterase as a "co-regulator" of synaptic acetylcholine levels should thus be reconsidered...
  9. ncbi request reprint Neuronal control of the cardiac responses to osmotic stress in the gastropod limpet Patella caerulea
    Giada Bini
    Department of Animal Biology and Genetics, University of Florence, 50125 Florence, Italy
    J Exp Zool A Comp Exp Biol 305:472-9. 2006
    ..caerulea to variations in external salinity are regulated by an extrinsic neuronal control involving the serotoninergic and the cholinergic systems in the tachycardic and acardic responses, respectively...
  10. ncbi request reprint A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone
    Maria Rita Luparini
    Department of Pharmacology, ACRAF Angelini Ricerche, 00040 S Palomba Pomezia, Rome, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 28:1117-27. 2004
    ..A further increase also results from 5-HT uptake inhibition caused by higher doses of TRZ. The ensuing high 5-HT levels enhance GABA release, which in turn inhibits 5-HT release...
  11. ncbi request reprint Neutrophils CD11b and fibroblasts PGE(2) are elevated in Alzheimer's disease
    Carla Scali
    Department of Pharmacology, University of Florence, Viale Pieraccini, 6, 50139, Italy
    Neurobiol Aging 23:523-30. 2002
    ..Our findings provide further evidence of the presence of inflammatory and immuno-related markers in the periphery of AD patients and support those studies indicating the beneficial effects of anti-inflammatory therapy in AD...
  12. ncbi request reprint Tetrodotoxin prevents copper-induced bradycardia in gastropod limpets
    Giada Bini
    Department of Animal Biology and Genetics, University of Florence, 50125 Florence, Italy
    Environ Pollut 139:79-85. 2006
    ..5mg l(-1) of copper for 6h. These results are consistent with the hypothesis that the inhibitory action of copper on limpet cardiac activity involves an extrinsic, cholinergic neuronal control...
  13. pmc Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent
    Nigel H Greig
    Laboratory of Neurosciences and Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 102:17213-8. 2005
    ..Selective, reversible inhibition of brain BChE may represent a treatment for Alzheimer's disease, improving cognition and modulating neuropathological markers of the disease...
  14. ncbi request reprint Acetylcholine release from fetal tissue homotopically grafted to the motoneuron-depleted lumbar spinal cord. An in vivo microdialysis study in the awake rat
    Rosario Gulino
    Department of Physiological Sciences, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Exp Neurol 204:326-38. 2007
    ..This may be of importance for future studies involving intraspinal stem cell grafts...
  15. doi request reprint Extracellular levels of brain aspartate, glutamate and GABA during an inhibitory avoidance response in the rat
    Chiara Ballini
    Dipartimento di Farmacologia Preclinica e Clinica M Aiazzi Mancini, Universita degli Studi di Firenze, Viale G Pieraccini, Firenze, Italia
    J Neurochem 106:1035-43. 2008
    ....
  16. ncbi request reprint Bidirectional modulation of spatial working memory by ethanol
    Zvani L Rossetti
    Department of Neuroscience and C N R Centre for Neuropharmacology, University of Cagliari, Cagliari, Italy
    Alcohol Clin Exp Res 26:181-5. 2002
    ..It is common knowledge that ethanol causes cognitive and memory impairments. Although these deficits are attributed to its central depressant properties, ethanol has biphasic effects and at low doses can produce excitatory actions...