R Pedrinelli

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi Heterogeneous effect of calcium antagonists on leg oedema: a comparison of amlodipine versus lercanidipine in hypertensive patients
    Roberto Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, 56100 Pisa, Italy
    J Hypertens 21:1969-73. 2003
  2. ncbi Transvascular albumin leakage and forearm vasodilatation to acetylcholine in essential hypertension
    R Pedrinelli
    Department of Cardiotoracico, Universita di Pisa, Italy
    Am J Hypertens 13:256-61. 2000
  3. ncbi Amlodipine, enalapril, and dependent leg edema in essential hypertension
    R Pedrinelli
    Dipartimento Cardiotoracico, Medicina Interna, Azienda Ospedaliera, Universita di Pisa, Italy
    Hypertension 35:621-5. 2000
  4. ncbi Microalbuminuria and pulse pressure in hypertensive and atherosclerotic men
    R Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, Pisa, Italy
    Hypertension 35:48-54. 2000
  5. ncbi Calcium channel blockers, postural vasoconstriction and dependent oedema in essential hypertension
    R Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, Italy
    J Hum Hypertens 15:455-61. 2001
  6. ncbi Microalbuminuria and transcapillary albumin leakage in essential hypertension
    R Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, Italy
    Hypertension 34:491-5. 1999
  7. ncbi Fibrinogen and mortality in chronic critical limb ischaemia
    R Pedrinelli
    V Unità Operativa di Chirurgia, Azienda Ospedaliera Pisana, University of Pisa, Italy
    J Intern Med 245:75-81. 1999
  8. ncbi Microalbuminuria, an integrated marker of cardiovascular risk in essential hypertension
    R Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, Italy
    J Hum Hypertens 16:79-89. 2002
  9. ncbi Dissociation between microalbuminuria and common carotid thickness in essential hypertensive men
    R Pedrinelli
    Dipartimento Cardio Toracico, Universita di Pisa, Pisa, Italy
    J Hum Hypertens 14:831-5. 2000
  10. ncbi Microalbuminuria, a parameter independent of metabolic influences in hypertensive men
    Roberto Pedrinelli
    Dipartimento Cardio Toracico, Universita di Pisa, Italy
    J Hypertens 21:1163-9. 2003

Collaborators

Detail Information

Publications58

  1. ncbi Heterogeneous effect of calcium antagonists on leg oedema: a comparison of amlodipine versus lercanidipine in hypertensive patients
    Roberto Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, 56100 Pisa, Italy
    J Hypertens 21:1969-73. 2003
    ....
  2. ncbi Transvascular albumin leakage and forearm vasodilatation to acetylcholine in essential hypertension
    R Pedrinelli
    Department of Cardiotoracico, Universita di Pisa, Italy
    Am J Hypertens 13:256-61. 2000
    ..The dissociation between TERalb and forearm responsiveness to acetylcholine also demonstrates that different endothelial-dependent biologic parameters do not behave uniformly in human hypertension...
  3. ncbi Amlodipine, enalapril, and dependent leg edema in essential hypertension
    R Pedrinelli
    Dipartimento Cardiotoracico, Medicina Interna, Azienda Ospedaliera, Universita di Pisa, Italy
    Hypertension 35:621-5. 2000
    ..Enalapril per se did not affect cutaneous vasomotion or leg weight but reduced the amount of dependent fluid extravasation by the CCB despite a persistent antagonism for postural vasoconstrictor responses...
  4. ncbi Microalbuminuria and pulse pressure in hypertensive and atherosclerotic men
    R Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, Pisa, Italy
    Hypertension 35:48-54. 2000
    ..The independence from concomitant vascular disease also suggests that wider pulse pressure, rather than representing a simple marker for atherosclerotic disease, influences albuminuria directly...
  5. ncbi Calcium channel blockers, postural vasoconstriction and dependent oedema in essential hypertension
    R Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, Italy
    J Hum Hypertens 15:455-61. 2001
    ....
  6. ncbi Microalbuminuria and transcapillary albumin leakage in essential hypertension
    R Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, Italy
    Hypertension 34:491-5. 1999
    ..However, this abnormality is dissociated from the amount of albuminuria, which is contrary to the hypothesis that a higher albumin excretion reflects a greater degree of systemic microvascular damage in essential hypertension...
  7. ncbi Fibrinogen and mortality in chronic critical limb ischaemia
    R Pedrinelli
    V Unità Operativa di Chirurgia, Azienda Ospedaliera Pisana, University of Pisa, Italy
    J Intern Med 245:75-81. 1999
    ....
  8. ncbi Microalbuminuria, an integrated marker of cardiovascular risk in essential hypertension
    R Pedrinelli
    Dipartimento Cardiotoracico, Universita di Pisa, Italy
    J Hum Hypertens 16:79-89. 2002
    ....
  9. ncbi Dissociation between microalbuminuria and common carotid thickness in essential hypertensive men
    R Pedrinelli
    Dipartimento Cardio Toracico, Universita di Pisa, Pisa, Italy
    J Hum Hypertens 14:831-5. 2000
    ....
  10. ncbi Microalbuminuria, a parameter independent of metabolic influences in hypertensive men
    Roberto Pedrinelli
    Dipartimento Cardio Toracico, Universita di Pisa, Italy
    J Hypertens 21:1163-9. 2003
    ..To evaluate the relationship of albuminuria and microalbuminuria (overnight urine albumin > or = 15 micro g/min) with insulin resistance and related metabolic abnormalities in patients with essential hypertension...
  11. ncbi Non-diabetic microalbuminuria, endothelial dysfunction and cardiovascular disease
    R Pedrinelli
    Dipartimento Cardio Toracico, Universita di Pisa, Italy
    Vasc Med 6:257-64. 2001
    ....
  12. ncbi Low-grade inflammation and microalbuminuria in hypertension
    Roberto Pedrinelli
    Dipartimento Cardio Toracico, Laboratorio Analisi Chimiche e Microbiologiche, Universita di Pisa, Italy
    Arterioscler Thromb Vasc Biol 24:2414-9. 2004
    ..In contrast, isolated microalbuminuria may represent a distinct pathophysiological condition characterized by a more benign profile and possibly a better prognosis...
  13. ncbi Transvascular and urinary leakage of albumin in atherosclerotic and hypertensive men
    R Pedrinelli
    Dipartimento di Cardiologia, Angiologia, e Pneumologia, Universita di Pisa, Italy
    Hypertension 32:318-23. 1998
    ..Thus, systemic capillary permeability is altered in nondiabetic atherosclerotic patients independently from blood pressure levels, but this abnormality is not reflected by proportionate changes in albuminuria...
  14. ncbi Ultrasonic myocardial texture versus Doppler analysis in hypertensive heart: a preliminary study
    V Di Bello
    Dipartimento di Medicina Interna, University of Pisa, Italy
    Hypertension 33:66-73. 1999
    ..In comparison with Doppler-derived indices of diastolic filling, the videodensitometric parameters showed a significantly higher ability to discriminate between hypertensive subjects and normal controls...
  15. ncbi Can insulin action induce myocardial texture alterations in essential hypertension?
    V Di Bello
    Dipartimento di Medicina Interna, Centro di Medicina Nucleare, Universita di Pisa, Italy
    Am J Hypertens 12:283-90. 1999
    ..Hyperinsulinemia/insulin resistance could cause an altered collagen/muscular ratio, which could potentially explain, at least in part, the CVI alterations detected in hypertensive patients...
  16. ncbi The potential prognostic value of ultrasonic characterization (videodensitometry) of myocardial tissue in essential arterial hypertension
    V Di Bello
    Department of Internal Medicine, University of Pisa, Rome, Italy
    Coron Artery Dis 11:513-21. 2000
    ..Videodensitometry is an alternate echocardiographic approach to the study of myocardial structural and functional alterations in essential hypertension...
  17. ncbi Microalbuminuria, pulse pressure, left ventricular hypertrophy, and myocardial ultrasonic tissue characterization in essential hypertension
    V Di Bello
    Dipartimento di Medicina Interna, University of Pisa, Italy
    Angiology 52:175-83. 2001
    ....
  18. ncbi Ultrasonic myocardial texture in hypertensive mild-to-moderate left ventricular hypertrophy: a videodensitometric study
    V Di Bello
    Istituto di Clinica Medica II, University of Pisa, Italy
    Am J Hypertens 11:155-64. 1998
    ..Further work is needed to establish the clinical, therapeutic, and prognostic implications of these findings...
  19. ncbi Ultrasonic myocardial tissue characterization: a methodological review
    V Di Bello
    Cardio Thoracic Department, University of Pisa, Italy
    Ital Heart J 2:333-43. 2001
    ..In the present review the technological evolution of the method and comparison with other research groups' experience with the specific pathophysiological models, are shown and discussed...
  20. ncbi Cyclic variation of the myocardial integrated backscatter signal in hypertensive cardiopathy: a preliminary study
    V Di Bello
    Cardiac and Thoracic Department, University of Pisa, Italy
    Coron Artery Dis 12:267-75. 2001
    ..The aim of the present study was to analyze the ultrasonic backscatter myocardial indexes both as peak end-diastolic signal intensity and as cardiac-cyclic variation in two models of LVH: hypertensive cardiopathy and athlete's heart...
  21. ncbi Coronary microcirculation in essential hypertension: a quantitative myocardial contrast echocardiographic approach
    V Di Bello
    Cardiac and Thoracic Department, University of Pisa, Italy
    Eur J Echocardiogr 3:117-27. 2002
    ....
  22. ncbi Blood pressure independent association of microalbuminuria and left ventricular hypertrophy in hypertensive men
    D Giorgi
    Dipartimento Cardio Toracico, , Pisa, Italy
    J Intern Med 254:76-84. 2003
    ..The extent to which LVH explains the predictive power of MA for morbid events independent of the BP load remains unknown...
  23. ncbi Dysglycaemia in non-diabetic hypertensive patients: comparison of the impact of two different classifications of impaired fasting glucose on the cardiovascular risk profile
    G Dell'omo
    Dipartimento Cardio Toracico e Vascolare, Universita di Pisa, Pisa, Italy
    J Hum Hypertens 23:332-8. 2009
    ..Because of its prediabetic nature, dysglycaemia should prompt measures to prevent new-onset diabetes, although the role of IFG as an independent risk factor awaits specifically designed intervention trials...
  24. ncbi ACE gene insertion/deletion polymorphism modulates capillary permeability in hypertension
    Giulia Dell'Omo
    Dipartimento Cardio Toracico, Universita di Pisa, Pisa, Italy
    Clin Sci (Lond) 111:357-64. 2006
    ..The parallel behaviour of TERalb and albuminuria suggests some shared genetically mediated determinant of renal and systemic microvascular abnormalities in hypertension...
  25. ncbi Abnormal capillary permeability and endothelial dysfunction in hypertension with comorbid Metabolic Syndrome
    Giuseppe Penno
    Dipartimento Cardiotoracico, , 56100 Pisa, Italy
    Atherosclerosis 172:383-9. 2004
    ..That defect, which may promote early atherosclerosis development, coexists with blunted endothelial-mediated vasodilation, indicating a pervasive abnormality of endothelial function...
  26. ncbi Increased myocardial ultrasonic reflectivity is associated with extreme hypertensive left ventricular hypertrophy: a tissue characterization study in humans
    A R Lucarini
    Consiglio Nazionale delle Ricerche, Institute of Clinical Physiology, I Clinica Medica, University of Pisa, Italy
    Am J Hypertens 11:1442-9. 1998
    ..1 +/- 5.9; P < .02 v II; P < .0001 v I). An increased myocardial wall reflectivity is detectable only in the presence of extreme forms of hypertensive left ventricular hypertrophy...
  27. ncbi Perioperative prognostic value of dipyridamole echocardiography in vascular surgery: A large-scale multicenter study in 509 patients. EPIC (Echo Persantine International Cooperative) Study Group
    R Sicari
    CNR Institute of Clinical Physiology, Pisa, Italy
    Circulation 100:II269-74. 1999
    ..The aim of the current study was to evaluate the value of dipyridamole echocardiography test (up to 0.84 mg/kg over 10 minutes) in predicting cardiac events in a large-scale, multicenter, prospective, observational study design...
  28. ncbi Persistence of sympathetic-mediated forearm vasoconstriction after alpha-blockade in hypertensive patients
    S Taddei
    Hypertension Unit, I Clinica Medica, University of Pisa, Italy
    Circulation 80:485-90. 1989
    ..abstract truncated at 250 words)..
  29. ncbi Ultrasonic tissue characterization and Doppler tissue imaging in the analysis of left ventricular function in essential arterial hypertension: a preliminary study
    Davide Giorgi
    Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    Echocardiography 19:187-98. 2002
    ..This study demonstrated that diastolic abnormalities of left ventricular function, in arterial hypertension, are related and progress with systolic intrinsic dysfunction...
  30. ncbi Incremental value of ultrasonic tissue characterization (backscatter) in the evaluation of left ventricular myocardial structure and mechanics in essential arterial hypertension
    Vitantonio Di Bello
    Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    Circulation 107:74-80. 2003
    ....
  31. ncbi The vascular effects of doxazosin in hypertension complicated by metabolic syndrome
    Giuseppe Penno
    Dipartimento Cardio Toracico, Universita' di Pisa, 56100 Pisa, Italy
    Coron Artery Dis 16:67-73. 2005
    ..CONCLUSIONS: Doxazosin improved endothelial-mediated vasomotor function and reversed abnormal arteriolar structure in hypertensive patients with metabolic syndrome while improving lipid profile and blunting post-glucose hyperinsulinemia...
  32. ncbi Association between high-normal albuminuria and risk factors for cardiovascular and renal disease in essential hypertensive men
    Giuseppe Penno
    Dipartimentos Cardio Toracico and Diabetologia, , Italy
    Am J Kidney Dis 40:1-8. 2002
    ..Overall, these data confirm the appropriateness to shift downward the limits for diagnosing microalbuminuria in essential hypertension, as indicated from previous prospective studies...
  33. ncbi Soluble vascular cell adhesion molecule-1 as a biohumoral correlate of atherosclerosis
    R De Caterina
    CNR Institute of Clinical Physiology, University of Pisa, Italy
    Arterioscler Thromb Vasc Biol 17:2646-54. 1997
    ..Its potential value as a surrogate for global risk assessment and its behavior in intervention studies remain to be determined...
  34. ncbi Is transcutaneous oxygen and carbon dioxide monitoring indispensable in short- and long-term therapeutic management of non-reconstructable lower critical limb ischemia?
    E Melillo
    Angiology Unit, Cardio Thoracic Department Azienda Ospedaliero Universitaria Pisana, Pisa, Italy
    Minerva Cardioangiol 54:481-98. 2006
    ....
  35. ncbi Coronary microcirculation into different models of left ventricular hypertrophy-hypertensive and athlete's heart: a contrast echocardiographic study
    V Di Bello
    Cardiac and Thoracic Department of University of Pisa, Italy
    J Hum Hypertens 17:253-63. 2003
    ..Angiogenesis and several different functional adaptations are the mechanisms that allow an optimal distribution of oxygen and of substrates to the hypertrophied myocardium of the athletes...
  36. ncbi Early impairment of myocardial blood flow reserve in men with essential hypertension: a quantitative myocardial contrast echocardiography study
    Vitantonio Di Bello
    Cardiac and Thoracic Department, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Am Soc Echocardiogr 17:1037-43. 2004
    ....
  37. ncbi Lack of association between endothelial nitric oxide synthase gene polymorphisms, microalbuminuria and endothelial dysfunction in hypertensive men
    Giulia Dell'Omo
    Department of Cardiothoracics, University of Pisa, Pisa, Italy
    J Hypertens 25:1389-95. 2007
    ..We also tested their impact on systemic NO availability, as reflected by endothelial-mediated forearm vasodilatation...
  38. ncbi Doxazosin in metabolically complicated hypertension
    Giulia Dell'Omo
    Universita di Pisa, Dipartimento Cardio Toracico e Vascolare, 56100 Pisa, Italy
    Expert Rev Cardiovasc Ther 5:1027-35. 2007
    ..Whether long-term treatment with the drug might delay, or possibly prevent, incident Type II diabetes in hypertension complicated by metabolic syndrome is an intriguing possibility to be tested in appropriately designed clinical trials...
  39. ncbi Tissue factor modulation by Angiotensin II: a clue to a better understanding of the cardiovascular effects of renin-angiotensin system blockade?
    Alessandro Celi
    Dipartimento Cardio Toracico e Vascolare, Universita di Pisa, Italy
    Endocr Metab Immune Disord Drug Targets 8:308-13. 2008
    ..This property may contribute to the protection exerted by renin-angiotensin blockers from acute ischemic events in patients with hypertension and other cardiovascular diseases...
  40. ncbi Alpha-adducin and angiotensin-converting enzyme polymorphisms in hypertension: evidence for a joint influence on albuminuria
    Roberto Pedrinelli
    Dipartimento Cardio Toracico, Universita di Pisa, Pisa, Italy
    J Hypertens 24:931-7. 2006
    ..The angiotensin-converting enzyme (ACE) insertion/deletion (ID) polymorphism was also evaluated because of its interactive potential with the ADD1 genotype...
  41. ncbi Lack of association between TGF-beta-1 genotypes and microalbuminuria in essential hypertensive men
    Giulia Dell'Omo
    Dipartimento Cardio Toracico e Vascolare, Universita di Pisa, Italy
    Nephrol Dial Transplant 24:1864-9. 2009
    ..Because of the close pathophysiological link of TGF-beta-1 with the renin-angiotensin system, we also tested the behaviour of the angiotensin converting enzyme (ACE) deletion/insertion (D/I) polymorphism...
  42. ncbi Systemic hypertension and the right-sided cardiovascular system: a review of the available evidence
    Roberto Pedrinelli
    Dipartimento Cardio Toracico e Vascolare, Universita di Pisa, Pisa, Italy
    J Cardiovasc Med (Hagerstown) 10:115-21. 2009
    ....
  43. ncbi Soluble CD40 ligand levels in essential hypertensive men: evidence of a possible role of insulin resistance
    Giuseppe Penno
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Am J Hypertens 22:1007-13. 2009
    ..Metabolic abnormalities might also account for increased sCD40L in subjects with essential hypertension...
  44. ncbi Early left ventricular mechanics abnormalities in prehypertension: a two-dimensional strain echocardiography study
    Vitantonio Di Bello
    Cardiac and Thoracic and Vascular Department, University of Pisa, Pisa, Italy
    Am J Hypertens 23:405-12. 2010
    ....
  45. ncbi Right ventricular dysfunction in early systemic hypertension: a tissue Doppler imaging study in patients with high-normal and mildly increased arterial blood pressure
    Roberto Pedrinelli
    Dipartimento Cardio Toracico e Vascolare and Endocrinologia e Metabolismo, Universita di Pisa, Pisa, Italy
    J Hypertens 28:615-21. 2010
    ..To analyze the relationship between increasing systemic blood pressure (BP) and right ventricular (RV) function...
  46. ncbi Abnormal right ventricular mechanics in early systemic hypertension: a two-dimensional strain imaging study
    Roberto Pedrinelli
    Dipartimento Cardio Toracico e Vascolare, Universita di Pisa, 56100 Pisa, Italy
    Eur J Echocardiogr 11:738-42. 2010
    ..To analyse the relationship between increasing systemic blood pressure (BP) and right ventricular (RV) function as assessed by two-dimensional strain imaging...
  47. ncbi Insulin resistance causes impaired vasodilation and hypofibrinolysis in young women with polycystic ovary syndrome
    Franco Carmassi
    Department of Internal Medicine, University of Pisa, Via Roma 67, I 56126 Pisa, Italy
    Thromb Res 116:207-14. 2005
    ..The present study explores the relationship between insulin-induced vasodilatory and fibrinolytic properties of the endothelium in women with polycystic ovary syndrome, frequently affected by insulin resistance and early atherosclerosis...
  48. ncbi Left ventricular hypertrophy and its regression in essential arterial hypertension. A tissue Doppler imaging study
    Vitantonio Di Bello
    Cardiac and Thoracic Department, University of Pisa, Pisa, Italy
    Am J Hypertens 17:882-90. 2004
    ..With regard to this, more extensive randomized studies are needed to evaluate the effect of different pharmacologic treatments (calcium antagonists, beta-blockers, angiotensin I and II inhibitors) on TDI parameters...
  49. ncbi LDL cholesterol and global risk stratification in referred hypertensive patients
    Roberto Pedrinelli
    Dipartimento Cardio Toracico, Universita di Pisa, Pisa, Italy
    Atherosclerosis 180:137-43. 2005
    ..However, the distribution of circulating low density lipoproteins (LDL) levels as a function of risk profile and lipid-lowering treatment in hypertensive patients is unclear...
  50. ncbi Chlorthalidone improves endothelial-mediated vascular responses in hypertension complicated by nondiabetic metabolic syndrome
    Giuseppe Penno
    Dipartimento Cardio Toracico, , Pisa, Italy
    J Cardiovasc Pharmacol Ther 10:265-72. 2005
    ..CONCLUSIONS: Chlorthalidone improved endothelial function, reversed abnormal arteriolar structure, and slowed albumin permeation in hypertensive patients with nondiabetic metabolic syndrome...
  51. ncbi Further evidence for the existence of alpha 2-mediated adrenergic vasoconstriction in human vessels
    S Taddei
    Hypertension Unit I, University of Pisa, Italy
    Eur J Clin Pharmacol 34:407-10. 1988
    ..The data provide further evidence of the existence of alpha 2-mediated vasoconstriction in human forearm vessels...
  52. ncbi Reactive hyperemia and tissue-type plasminogen activator release in hypertensive men
    Giulia Dell'Omo
    Dipartimento Cardio Toracico, Universita di Pisa, Italy
    Blood Coagul Fibrinolysis 14:19-25. 2003
    ..Release of t-PA is independent of forearm vasodilatation, adenosine or biological products of muscarinic stimulation and may, perhaps, be related to the activity of the endogenous kininogen/kinin system...
  53. ncbi Theophylline is an antagonist of adenosine in human forearm arterioles
    S Taddei
    I Clinica Medica, University of Pisa, Italy
    Am J Hypertens 4:256-9. 1991
    ..Our data show that theophylline acts as a specific antagonist of adenosine in humans, an effect which might be relevant for its pharmacological action...
  54. ncbi Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis
    Jacopo Gianetti
    C. N. R. Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Am Heart J 143:467-74. 2002
    ....
  55. ncbi Transcutaneous oxygen and carbon dioxide levels with iloprost administration in diabetic critical limb ischemia
    Elio Melillo
    Dipartimento Cadio Toracico, , Pisa, Italy
    Vasc Endovascular Surg 40:303-11. 2006
    ....
  56. ncbi The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man
    Alessandra Del Fiorentino
    Dipartimento Cardio Toracico e Vascolare, Universita di Pisa, Italy
    Vasc Health Risk Manag 5:233-42. 2009
    ....
  57. ncbi Transcutaneous gases determination in diabetic critical limb ischemia
    Elio Melillo
    Diabetes Care 28:2081-2. 2005
  58. ncbi Quantification of topological changes in retinal vascular architecture in essential and malignant hypertension
    Alun D Hughes
    Clinical Pharmacology, NHLI Division, Faculty of Medicine, Imperial College London, UK
    J Hypertens 24:889-94. 2006
    ..We investigated whether essential hypertension (EHT) and malignant phase hypertension (MHT) were associated with quantifiable abnormalities of the topology and architecture of the retinal circulation...