S Pavanello

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Role of metabolic polymorphisms NAT2 and CYP1A2 on urinary mutagenicity after a pan-fried hamburger meal
    S Pavanello
    Section of Occupational Health, Department of Environmental Medicine and Public Health, University of Padova, Italy
    Food Chem Toxicol 40:1139-44. 2002
  2. ncbi request reprint Complex relationships between occupation, environment, DNA adducts, genetic polymorphisms and bladder cancer in a case-control study using a structural equation modeling
    Stefano Porru
    Department of Medical Surgical Specialties, Radiological Sciences and Public Health, Section of Public Health and Human Sciences, University of Brescia, Brescia, Italy
    PLoS ONE 9:e94566. 2014
  3. ncbi request reprint [New perspectives in monitoring of exposures to carcinogens]
    Sofia Pavanello
    Universita degli Studi di Padova, Dipartimento di medicina ambientale e Sanitg Pubblica, Sede di Medicina del Lavoro, Via Giustiniani 2, Padova
    G Ital Med Lav Ergon 33:88-91. 2011
  4. doi request reprint Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study
    Sofia Pavanello
    Occupational Health Section, Department of Cardiological, Thoracic and Vascular Sciences, Universita di Padova, Italy
    Cancer Genet 205:278-84. 2012
  5. doi request reprint Biological monitoring of carcinogens: current status and perspectives
    Sofia Pavanello
    Dipartimento di Medicina Ambientale e Sanità Pubblica, Università degli Studi Padova, Via Giustiniani 2, 35128 Padova, Italy
    Arch Toxicol 86:535-41. 2012
  6. doi request reprint Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers
    Sofia Pavanello
    Department of Environmental Medicine and Public Health, Occupational Health Section, Universita di Padova, Via Giustiniani 2, Padova 35128, Italy
    Alcohol 46:61-8. 2012
  7. pmc A study protocol for the evaluation of occupational mutagenic/carcinogenic risks in subjects exposed to antineoplastic drugs: a multicentric project
    Massimo Moretti
    Department of Medical Surgical Specialties and Public Health, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    BMC Public Health 11:195. 2011
  8. ncbi request reprint Interaction between CYP1A2-T2467DELT polymorphism and smoking in adenocarcinoma and squamous cell carcinoma of the lung
    Sofia Pavanello
    Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Lung Cancer 57:266-72. 2007
  9. ncbi request reprint Influence of GSTM1 null and low repair XPC PAT+ on anti-B[a]PDE-DNA adduct in mononuclear white blood cells of subjects low exposed to PAHs through smoking and diet
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Mutat Res 638:195-204. 2008
  10. doi request reprint Micronuclei related to anti-B[a]PDE-DNA adduct in peripheral blood lymphocytes of heavily polycyclic aromatic hydrocarbon-exposed nonsmoking coke-oven workers and controls
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, Padova, 35128 Italy
    Cancer Epidemiol Biomarkers Prev 17:2795-9. 2008

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Role of metabolic polymorphisms NAT2 and CYP1A2 on urinary mutagenicity after a pan-fried hamburger meal
    S Pavanello
    Section of Occupational Health, Department of Environmental Medicine and Public Health, University of Padova, Italy
    Food Chem Toxicol 40:1139-44. 2002
    ..In conclusion, this study indicates that CYP1A2 and NAT2 activities influence the presence of urinary mutagens after a meal of pan-fried hamburger (rich in HHAs) and consequently their potential genotoxic risk...
  2. ncbi request reprint Complex relationships between occupation, environment, DNA adducts, genetic polymorphisms and bladder cancer in a case-control study using a structural equation modeling
    Stefano Porru
    Department of Medical Surgical Specialties, Radiological Sciences and Public Health, Section of Public Health and Human Sciences, University of Brescia, Brescia, Italy
    PLoS ONE 9:e94566. 2014
    ..This would envisage new scenarios for biomarker discovery and new challenges such as repeated measurements at different critical life stages. ..
  3. ncbi request reprint [New perspectives in monitoring of exposures to carcinogens]
    Sofia Pavanello
    Universita degli Studi di Padova, Dipartimento di medicina ambientale e Sanitg Pubblica, Sede di Medicina del Lavoro, Via Giustiniani 2, Padova
    G Ital Med Lav Ergon 33:88-91. 2011
    ..Based on these premises it is possible to envisage personalized biomonitoring procedures, as those already actuated in nutrition and clinical oncology, allowing a better predictivity of biomarkers in the preventive settings...
  4. doi request reprint Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study
    Sofia Pavanello
    Occupational Health Section, Department of Cardiological, Thoracic and Vascular Sciences, Universita di Padova, Italy
    Cancer Genet 205:278-84. 2012
    ..e. lung carcinogen activation and lung inflammation)...
  5. doi request reprint Biological monitoring of carcinogens: current status and perspectives
    Sofia Pavanello
    Dipartimento di Medicina Ambientale e Sanità Pubblica, Università degli Studi Padova, Via Giustiniani 2, 35128 Padova, Italy
    Arch Toxicol 86:535-41. 2012
    ..In conclusion, it is possible to envisage personalized biomonitoring procedures, such as those already implemented in the context of nutrition and clinical oncology...
  6. doi request reprint Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers
    Sofia Pavanello
    Department of Environmental Medicine and Public Health, Occupational Health Section, Universita di Padova, Via Giustiniani 2, Padova 35128, Italy
    Alcohol 46:61-8. 2012
    ..This suggests that drunk drivers with augmented MCV modulated by the alcohol metabolic ADH1B*1/*1 genotype may be at higher risk of driving incapability and of alcohol-related cancer...
  7. pmc A study protocol for the evaluation of occupational mutagenic/carcinogenic risks in subjects exposed to antineoplastic drugs: a multicentric project
    Massimo Moretti
    Department of Medical Surgical Specialties and Public Health, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    BMC Public Health 11:195. 2011
    ....
  8. ncbi request reprint Interaction between CYP1A2-T2467DELT polymorphism and smoking in adenocarcinoma and squamous cell carcinoma of the lung
    Sofia Pavanello
    Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Lung Cancer 57:266-72. 2007
    ..Our results suggest that CYP1A2-T2467delT polymorphism has an important role in lung carcinogenesis, especially SCC, among smokers...
  9. ncbi request reprint Influence of GSTM1 null and low repair XPC PAT+ on anti-B[a]PDE-DNA adduct in mononuclear white blood cells of subjects low exposed to PAHs through smoking and diet
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Mutat Res 638:195-204. 2008
    ....
  10. doi request reprint Micronuclei related to anti-B[a]PDE-DNA adduct in peripheral blood lymphocytes of heavily polycyclic aromatic hydrocarbon-exposed nonsmoking coke-oven workers and controls
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, Padova, 35128 Italy
    Cancer Epidemiol Biomarkers Prev 17:2795-9. 2008
    ..Our results substantiate, with the use of an early indicator of biological effect as well, that workers are at higher cancer risk than controls...
  11. ncbi request reprint Global and gene-specific promoter methylation changes are related to anti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy
    Int J Cancer 125:1692-7. 2009
    ..We also evaluated whether PAH-induced DNA methylation states were in turn associated with micronuclei in PBLs, an indicator of chromosomal instability...
  12. pmc Shorter telomere length in peripheral blood lymphocytes of workers exposed to polycyclic aromatic hydrocarbons
    Sofia Pavanello
    Department of Environmental Medicine and Public Health, Università of Padova, Padova, Italy
    Carcinogenesis 31:216-21. 2010
    ..Our results indicate that shorter TL is associated with chronic PAH exposure. The interrelations with other genetic and epigenetic mechanisms in our data suggest that shorter TL could be a central event in PAH carcinogenesis...
  13. doi request reprint CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, 35128, Padova, Italy
    Eur J Epidemiol 25:491-500. 2010
    ..No effects were shown with -163C/A genotype as well as no overall effect of CYP1A2 by itself on BC risk. This is the first study suggesting that CYP1A2 -2467T/delT modifies the effect of cigarette smoking on BC risk...
  14. pmc Shortened telomeres in individuals with abuse in alcohol consumption
    Sofia Pavanello
    Department of Environmental Medicine and Public Health, Occupational Health Section, Universita di Padova, Via Giustiniani 2, 35128 Padova, Italy
    Int J Cancer 129:983-92. 2011
    ..The decrease in PBL-TL modulated by the alcohol metabolic genotype ADH1B*1/*1 may represent a novel mechanism potentially related to alcohol carcinogenesis in alcohol abusers...
  15. ncbi request reprint Mutagenic activity of overnight urine from healthy non-smoking subjects
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Italy
    Environ Mol Mutagen 48:143-50. 2007
    ..e., bladder) in non-smokers. Accurate control of histidine content and bacterial inoculum size is strongly recommended when investigating the mutagenic activity of urine from non-smokers...
  16. ncbi request reprint Determinants of anti-benzo[a]pyrene diol epoxide-DNA adduct formation in lymphomonocytes of the general population
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Mutat Res 611:54-63. 2006
    ..g., lung) and their increase may also be predictive of higher risk for PAH-related cancers...
  17. ncbi request reprint [Anti-B[a]PDE-DNA formation in lymphomonocytes of humans environmentally exposed to polycyclic aromatic hydrocarbons]
    S Pavanello
    Universita degli Studi di Padova, Dipartimento di Medicina Ambientale e Sanità Pubblica, Sede di Medicina del Lavoro
    G Ital Med Lav Ergon 27:312-4. 2005
    ....
  18. ncbi request reprint Influence of the genetic polymorphism in the 5'-noncoding region of the CYP1A2 gene on CYP1A2 phenotype and urinary mutagenicity in smokers
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, Padova 35128, Italy
    Mutat Res 587:59-66. 2005
    ..This information is of interest for future studies assessing the possible role of tobacco smoke-inducible CYP1A2 genotypes as individual susceptibility factors in exposure to carcinogens...
  19. ncbi request reprint Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Carcinogenesis 26:169-75. 2005
    ....
  20. ncbi request reprint [Individual susceptibility to occupational carcinogens: the evidence from biomonitoring and molecular epidemiology studies]
    S Pavanello
    Dipartimento di Medicina Ambientale e Sanità Pubblica, Sezione Medicina del Lavoro, Universita degli Studi di Padova
    G Ital Med Lav Ergon 26:311-21. 2004
    ..with the aim of identifying subjects who are susceptible due to the high concentrations of carcinogens found in their working environment...
  21. ncbi request reprint [CYP1A2, NAT2, and GSTM1 phenotype/genotype modulate human exposure and various environmental mutagens: our experience]
    S Pavanello
    Dipartimento di Medicina Ambientale e Sanità Pubblica, Sezione Medicina del Lavoro, Universita degli Studi di Padova
    G Ital Med Lav Ergon 25:344-5. 2003
    ..People exposed to aromatic amines will be volunteers after a meal of pan-fried hamburgers and smokers. An overview of the results we found until now will be presented...
  22. ncbi request reprint GSTM1 null genotype as a risk factor for anti-BPDE-DNA adduct formation in mononuclear white blood cells of coke-oven workers
    Sofia Pavanello
    Occupational Health Section, Department of Environmental and Public Health, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    Mutat Res 558:53-62. 2004
    ..This is invaluable for future environmental-occupational studies using this biomarker of PAH exposure...
  23. pmc Lung cancer risk in workers exposed to poly(vinyl chloride) dust: a nested case-referent study
    G Mastrangelo
    Department of Environmental Medicine and Public Health, Section of Occupational Medicine, University of Padua, Italy
    Occup Environ Med 60:423-8. 2003
    ..There have been few investigations of an association between poly(vinyl chloride) (PVC) dust exposure and an increase in lung cancer incidence, and their conclusions have been inconsistent...
  24. ncbi request reprint Tobacco-smoke exposure indicators and urinary mutagenicity
    Sofia Pavanello
    Section of Occupational Health, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, I 35128 Padova, Italy
    Mutat Res 521:1-9. 2002
    ..However, as these biomarkers cannot be analysed the amount of daily tobacco intake represent the best valuable index of external (presumptive) exposure to tobacco-smoke genotoxins...
  25. ncbi request reprint Relationship between benzo(a)pyrene-DNA adducts and somatic mutation and recombination in Drosophila melanogaster
    M Zordan
    Department of Biology, University of Padova, Italy
    Environ Mol Mutagen 23:171-8. 1994
    ....
  26. ncbi request reprint Polyaromatic hydrocarbons administered in humans by dermal route increase total IgE
    G Mastrangelo
    Department of Environmental Medicine and Public Health Section of Occupational Health, University of Padua, Italy
    Int J Immunopathol Pharmacol 16:145-50. 2003
    ..028) influence: the younger the age, the higher the IgE response to PAHs. We conclude that whatever the source and the route of entry (skin or respiratory tract), PAHs increase total serum IgE, mainly in younger age groups...
  27. ncbi request reprint Exposure to diesel exhaust enhances total IgE in non-atopic dockers
    Giuseppe Mastrangelo
    Department of Environmental Medicine and Public Health, Section of Occupational Medicine, University of Padua, Via Giustiniani 2, 35128 Padua, Italy
    Int Arch Occup Environ Health 76:63-8. 2003
    ..The aim of the present study was to ascertain whether long-standing occupational exposure to DEPs carries a risk of enhanced serum IgE, and of rhinitis or asthma...
  28. ncbi request reprint Exposure levels and cytochrome P450 1A2 activity, but not N-acetyltransferase, glutathione S-transferase (GST) M1 and T1, influence urinary mutagen excretion in smokers
    Sofia Pavanello
    Section of Occupational Health, Department of Environmental Medicine and Public Health, University of Padua, I 35128 Padua, Italy
    Cancer Epidemiol Biomarkers Prev 11:998-1003. 2002
    ..This study suggests that CYP1A2 should definitely be determined in future studies involving urinary mutagenicity in cases in which smoking is a factor...
  29. doi request reprint How to prevent immunological reactions in leprosy patients and interrupt transmission of Mycobacterium leprae to healthy subjects: two hypotheses
    G Mastrangelo
    Department of Environmental Medicine and Public Health, Padova University Medical School, Via Giustiniani 2, 35128 Padova, Italy
    Med Hypotheses 71:551-63. 2008
    ..leprae to healthy subjects and to leprosy patients in whom it may trigger an immune response...
  30. ncbi request reprint [Molecular epidemiology in occupational medicine: methodological features and impact of individual genetic susceptibility]
    E Clonfero
    Universita degli Studi di Padova, Dipartimento di Medicina Ambientale e Sanità Pubblica, Sede di Medicina del Lavoro, Padova
    G Ital Med Lav Ergon 25:279-84. 2003
    ..To achieve this objective it is necessary to demonstrate a stronger association with the endpoint that perhaps the future development of genetic and molecular epidemiology will make possible...